The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis

American Journal of Sports Medicine

Volumn 42, Issue 1, 2014, Pages 35-41

  Sundman, Emily A ^a   Cole, Brian J ^b   Karas, Vasili ^b   Della Valle, Craig ^b   Tetreault, Mathew W ^b   Mohammed, Hussni O ^a   Fortier, Lisa A ^a  

^a Cornell University ^*  (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

articular cartilage; biology of cartilage; growth factors healing enhancement; knee; platelet rich plasma; regenerative medicine; synovium

Indexed keywords

AGGRECAN; ANTIINFLAMMATORY AGENT; COLLAGEN; COLLAGENASE 3; HYALURONIC ACID; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERSTITIAL COLLAGENASE; TUMOR NECROSIS FACTOR ALPHA;

AGED; ARTICLE; ARTICULAR CARTILAGE; BIOLOGY OF CARTILAGE; COCULTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENETICS; GROWTH FACTORS/HEALING ENHANCEMENT; HUMAN; KNEE; MALE; METABOLISM; MIDDLE AGED; OSTEOARTHRITIS; REGENERATIVE MEDICINE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNOVIUM; THROMBOCYTE RICH PLASMA;

ARTICULAR CARTILAGE; BIOLOGY OF CARTILAGE; GROWTH FACTORS/HEALING ENHANCEMENT; KNEE; PLATELET-RICH PLASMA; REGENERATIVE MEDICINE; SYNOVIUM;

AGED; AGGRECANS; ANTI-INFLAMMATORY AGENTS; CARTILAGE, ARTICULAR; COCULTURE TECHNIQUES; COLLAGEN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HUMANS; HYALURONIC ACID; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 13; MIDDLE AGED; OSTEOARTHRITIS; PLATELET-RICH PLASMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNOVIAL MEMBRANE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84892615247     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546513507766     Document Type: Article

References (47)

1. Aigner T, McKenna L. Molecular pathology and pathobiology of osteoarthritic cartilage. Cell Mol Life Sci. 2002 ; 59 (1). 5-18
2. Anitua E, Sanchez M, Nurden AT, et al. Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients. Rheumatology (Oxford). 2007 ; 46 (12). 1769-1772
3. Bendinelli P, Matteucci E, Dogliotti G, et al. Molecular basis of anti-inflammatory action of platelet rich plasma on human chondrocytes: mechanisms of NF-kB inhibition via HGF. J Cell Physiol. 2010 ; 225: 757-766
4. Billinghurst RC, Dahlberg L, Ionescu M, et al. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest. 1997 ; 99 (7). 1534-1545
5. Boswell SG, Cole BJ, Sundman EA, et al. Platelet-rich plasma: a milieu of bioactive factors. Arthroscopy. 2012 ; 28 (3). 429-439
6. Brenner SS, Klotz U, Alscher DM, et al. Osteoarthritis of the knee: clinical assessments and inflammatory markers. Osteoarthritis Cartilage. 2004 ; 12 (6). 469-475
7. Brew CJ, Clegg PD, Boot-Handford RP, et al. Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy. Ann Rheum Dis. 2010 ; 69 (1). 234-240
8. Brzusek D, Petron D. Treating knee osteoarthritis with intra-articular hyaluronans. Curr Med Res Opin. 2008 ; 24 (12). 3307-3322
9. Campo GM, Avenoso A, D'Ascola A, et al. Hyaluronan differently modulates TLR-4 and the inflammatory response in mouse chondrocytes. Biofactors. 2012 ; 38 (1). 69-76
10. Cerza F, Carni S, Carcangiu A, et al. Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis. Am J Sports Med. 2012 ; 40 (12). 2822-2827
11. Cheng T, Maddox NC. Comparison of gene expression patterns in articular cartilage and dedifferentiated articular chondrocytes. J Orthop Res. 2012 ; 30 (2). 234-245
12. Dahl LB, Dahl IMS, Engstrom-Laurent A, et al. Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies. Ann Rheum Dis. 1985 ; 44: 817-822
13. Davidson RK, Waters JG, Kevorkian L, et al. Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage. Arthritis Res Ther. 2006 ; 8 (4). R124
14. Filardo G, Kon E, Buda R, et al. Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2011 ; 19 (4). 528-535
15. Ghosh P. The role of hyaluronic acid (hyaluronan) in health and disease: interactions with cells, cartilage and components of synovial fluid. Clin Exp Rheumatol. 1994 ; 12: 75-82
16. Gotoh S, Onaya J, Abe M, et al. Effects of the molecular weight of hyaluronic acid and its action mechanisms on experimental joint pain in rats. Ann Rheum Dis. 1993 ; 52: 817-822
17. Guidolin DD, Ronchetti IP, Lini E, et al. Morphological analysis of articular cartilage biopsies from a randomized, clinical study comparing the effects of 500-730 kDa sodium hyaluronate (Hyalgan) and methylprednisolone acetate on primary osteoarthritis of the knee. Osteoarthritis Cartilage. 2001 ; 9 (4). 371-381
18. Hui AY, McCarty WJ, Masuda K, et al. A systems biology approach to synovial joint lubrication in health, injury, and disease. Wiley Interdiscip Rev Syst Biol Med. 2012 ; 4 (1). 15-37
19. Itano N, Kimata K. Mammalian hyaluronan synthases. IUBMB Life. 2002 ; 54 (4). 195-199
20. Itano N, Sawai T, Yoshida M, et al. Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties. J Biol Chem. 1999 ; 274 (35). 25085-25092
21. Julovi SM, Ito H, Nishitani K, et al. Hyaluronan inhibits matrix metalloproteinase-13 in human arthritic chondrocytes via CD44 and P38. J Orthop Res. 2011 ; 29 (2). 258-264
22. Kamm JL, Nixon AJ, Witte TH. Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpi. Equine Vet J. 2010 ; 42 (8). 693-699
23. Kapoor M, Martel-Pelletier J, Lajeunesse D, et al. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011 ; 7 (1). 33-42
24. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957 ; 16 (4). 494-502
25. Kon E, Mandelbaum B, Buda R, et al. Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis. Arthroscopy. 2011 ; 27 (11). 1490-1501
26. Leung L, Cahill CM. TNF-alpha and neuropathic pain: a review. J Neuroinflammation. 2010 ; 7: 27
27. Lippross S, Moeller B, Haas H, et al. Intraarticular injection of platelet-rich plasma reduces inflammation in a pig model of rheumatoid arthritis of the knee joint. Arthritis Rheum. 2011 ; 63 (11). 3344-3353
28. Lopez-Vidriero E, Goulding KA, Simon DA, et al. The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment. Arthroscopy. 2010 ; 26 (2). 269-278
29. Lorenz H, Richter W. Osteoarthritis: cellular and molecular changes in degenerating cartilage. Prog Histochem Cytochem. 2006 ; 40 (3). 135-163
30. Lorenz H, Wenz W, Ivancic M, et al. Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading. Arthritis Res Ther. 2005 ; 7 (1). R156 - R165
31. Mankin HJ, Dorfman H, Lippiello L, et al. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips, II: correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am. 1971 ; 53 (3). 523-537
32. McCarrel TM, Minas T, Fortier LA. Optimization of leukocyte concentration in platelet-rich plasma for the treatment of tendinopathy. J Bone Joint Surg Am. 2012 ; 94 ( 19 ):
33. Meehan JP, Danielsen B, Tancredi DJ, et al. A population-based comparison of the incidence of adverse outcomes after simultaneous-bilateral and staged-bilateral total knee arthroplasty. J Bone Joint Surg Am. 2011 ; 93 (23). 2203-2213
34. Mei-Dan O, Carmont MR, Laver L, et al. Platelet-rich plasma or hyaluronate in the management of osteochondral lesions of the talus. Am J Sports Med. 2012 ; 40: 534-541
35. Murphy G, Knauper V, Atkinson S, et al. Matrix metalloproteinases in arthritic disease. Arthritis Res. 2002 ;: S39 - S49
36. Ohtori S, Takahashi K, Moriya H, et al. TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord. Spine (Phila Pa 1976). 2004 ; 29 (10). 1082-1088
37. Pasquali Ronchetti I, Guerra D, Taparelli F, et al. Morphological analysis of knee synovial membrane biopsies from a randomized controlled clinical study comparing the effects of sodium hyaluronate (Hyalgan) and methylprednisolone acetate (Depomedrol) in osteoarthritis. Rheumatology (Oxford). 2001 ; 40 (2). 158-169
38. Patel S, Dhillon MS, Aggarwal S, et al. Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. Am J Sports Med. 2013 ; 41 (2). 356-364
39. Recklies AD, White C, Melching L, et al. Differential regulation and expression of hyaluronan synthases in human articular chondrocytes, synovial cells and osteosarcoma cells. Biochem J. 2001 ; 354 (Pt 1). 17-24
40. Sampson S, Reed M, Silvers H, et al. Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: a pilot study. Am J Phys Med Rehabil. 2010 ; 89 (12). 961-969
41. Sundman EA, Cole BJ, Fortier LA. Growth factor and catabolic cytokine concentrations are influenced by the cellular composition of platelet-rich plasma. Am J Sports Med. 2011 ; 39 (10). 2135-2140
42. Tetlow LC, Adlam DJ, Woolley DE. Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum. 2001 ; 44 (3). 585-594
43. Venn G, Nietfeld JJ, Duits AJ, et al. Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis. Arthritis Rheum. 1993 ; 36 (6). 819-826
44. Wang Y, Hall S, Hanna F, et al. Effects of Hylan G-F 20 supplementation on cartilage preservation detected by magnetic resonance imaging in osteoarthritis of the knee: a two-year single-blind clinical trial. BMC Musculoskelet Disord. 2011 ; 12: 195
45. Wells MR, Racis SP, Vaidya U. Changes in plasma cytokines associated with peripheral nerve injury. J Neuroimmunol. 1992 ; 39 (3). 261-268
46. Wu W, Billinghurst RC, Pidoux I, et al. Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13. Arthritis Rheum. 2002 ; 46 (8). 2087-2094
47. Xing Z, Gauldie J, Cox G, et al. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest. 1998 ; 101 (2). 311-320