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Volumn 13, Issue 1, 2013, Pages 249-259

MRP1 overexpression determines poor prognosis in prospectively treated patients with localized high-risk soft tissue sarcoma of limbs and trunk wall: An ISG/GEIS study

(22)  Martin Broto, Javier a   Gutierrez, Antonio M a   Ramos, Rafael F a   Lopez Guerrero, José A b   Ferrari, Stefano c   Stacchiotti, Silvia d   Picci, Piero c   Calabuig, Silvia a   Collini, Paola e   Gambarotti, Marco c   Bague, Silvia f   Dei Tos, Angelo P g   Palassini, Elena d   Luna, Pablo a   Cruz, Josefina h   Cubedo, Ricardo i   Martinez Trufero, Javier j   Poveda, Andres k   Casali, Paolo G d   Fernandez Serra, Antonio b   more..


Author keywords

[No Author keywords available]

Indexed keywords

EPIRUBICIN; GLUTATHIONE TRANSFERASE A1; IFOSFAMIDE; MESSENGER RNA; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1;

EID: 84892608351     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-13-0406     Document Type: Article
Times cited : (23)

References (44)
  • 1
    • 84866603440 scopus 로고    scopus 로고
    • Soft tissue and visceral sarcomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up
    • Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2012;23 Suppl 7: vii92-9.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 7
  • 2
    • 0344110204 scopus 로고    scopus 로고
    • Dose-intensive chemotherapy with ifosfamide, epirubicin, and filgrastim for adult patients with metastatic or locally advanced soft tissue sarcoma: A phase II study
    • Reichardt P, Tilgner J, Hohenberger P, Dorken B. Dose-intensive chemotherapy with ifosfamide, epirubicin, and filgrastim for adult patients with metastatic or locally advanced soft tissue sarcoma: a phase II study. J Clin Oncol 1998;16: 1438-43.
    • (1998) J Clin Oncol , vol.16 , pp. 1438-1443
    • Reichardt, P.1    Tilgner, J.2    Hohenberger, P.3    Dorken, B.4
  • 3
    • 0033941746 scopus 로고    scopus 로고
    • Randomized phase III study comparing conventional-dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus ifosfamide plus recombinant human granulocyte-macrophage colony-stimulating factor in advanced soft tissue sarcomas: A trial of the European organization for research and treatment of cancer/soft tissue and bone sarcoma group
    • Le Cesne A, Judson I, Crowther D, Rodenhuis S, Keizer HJ, Van Hoesel Q, et al. Randomized phase III study comparing conventional-dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus ifosfamide plus recombinant human granulocyte-macrophage colony-stimulating factor in advanced soft tissue sarcomas: a trial of the European Organization for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group. J Clin Oncol 2000; 18:2676-84.
    • (2000) J Clin Oncol , vol.18 , pp. 2676-2684
    • Le Cesne, A.1    Judson, I.2    Crowther, D.3    Rodenhuis, S.4    Keizer, H.J.5    Van Hoesel, Q.6
  • 4
    • 0033066042 scopus 로고    scopus 로고
    • Advanced soft tissue sarcoma: How many more trials with anthracyclines and ifosfamide?
    • Santoro A. Advanced soft tissue sarcoma: how many more trials with anthracyclines and ifosfamide? Ann Oncol 1999;10:151-4.
    • (1999) Ann Oncol , vol.10 , pp. 151-154
    • Santoro, A.1
  • 5
    • 39749097290 scopus 로고    scopus 로고
    • Role of the MRP1/ABCC1 multidrug transporter protein in cancer
    • Munoz M, Henderson M, Haber M, Norris M. Role of the MRP1/ABCC1 multidrug transporter protein in cancer. IUBMB Life 2007; 59:752-7.
    • (2007) IUBMB Life , vol.59 , pp. 752-757
    • Munoz, M.1    Henderson, M.2    Haber, M.3    Norris, M.4
  • 6
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: The multidrug resistance-associated proteins
    • Borst P, Evers R, Kool M, Wijnholds J. A family of drug transporters: the multidrug resistance-associated proteins. J Natl Cancer Inst 2000;92:1295-302.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3    Wijnholds, J.4
  • 7
    • 0345863723 scopus 로고    scopus 로고
    • Structure of multidrug-resistance proteins of the ATPbinding cassette (ABC) superfamily
    • Altenberg GA. Structure of multidrug-resistance proteins of the ATPbinding cassette (ABC) superfamily. Curr Med Chem Anticancer Agents 2004;4:53-62.
    • (2004) Curr Med Chem Anticancer Agents , vol.4 , pp. 53-62
    • Altenberg, G.A.1
  • 8
    • 57349152178 scopus 로고    scopus 로고
    • Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3)
    • Grant CE, Gao M, DeGorter MK, Cole SP, Deeley RG. Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). Drug Metab Dispos 2008;36:2571-81.
    • (2008) Drug Metab Dispos , vol.36 , pp. 2571-2581
    • Grant, C.E.1    Gao, M.2    Degorter, M.K.3    Cole, S.P.4    Deeley, R.G.5
  • 9
    • 34548067158 scopus 로고    scopus 로고
    • Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance
    • Lo HW, Ali-Osman F. Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance. Curr Opin Pharmacol 2007;7:367-74.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 367-374
    • Lo, H.W.1    Ali-Osman, F.2
  • 10
    • 0029561598 scopus 로고
    • The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
    • Hayes JD, Pulford DJ. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 1995;30:445-600.
    • (1995) Crit Rev Biochem Mol Biol , vol.30 , pp. 445-600
    • Hayes, J.D.1    Pulford, D.J.2
  • 11
    • 0033568161 scopus 로고    scopus 로고
    • Multidrug resistance phenotype in high grade soft tissue sarcoma: Correlation of P-glycoprotein immunohistochemistry with pathologic response to chemotherapy
    • Jimenez RE, Zalupski MM, Frank JJ, Du W, Ryan JR, Lucas DR. Multidrug resistance phenotype in high grade soft tissue sarcoma: correlation of P-glycoprotein immunohistochemistry with pathologic response to chemotherapy. Cancer 1999;86:976-81.
    • (1999) Cancer , vol.86 , pp. 976-981
    • Jimenez, R.E.1    Zalupski, M.M.2    Frank, J.J.3    Du, W.4    Ryan, J.R.5    Lucas, D.R.6
  • 12
    • 0347298787 scopus 로고    scopus 로고
    • Expression of multidrug resistance proteins, P-gp, MRP1 and LRP, in soft tissue sarcomas analysed according to their histological type and grade
    • Komdeur R, Plaat BE, van der Graaf WT, Hoekstra HJ, Hollema H, van den Berg E, et al. Expression of multidrug resistance proteins, P-gp, MRP1 and LRP, in soft tissue sarcomas analysed according to their histological type and grade. Eur J Cancer 2003;39:909-16.
    • (2003) Eur J Cancer , vol.39 , pp. 909-916
    • Komdeur, R.1    Plaat, B.E.2    Van Der Graaf, W.T.3    Hoekstra, H.J.4    Hollema, H.5    Van Den Berg, E.6
  • 13
    • 20144388316 scopus 로고    scopus 로고
    • ATPbinding cassette superfamily transporter gene expression in human soft tissue sarcomas
    • Oda Y, Saito T, Tateishi N, Ohishi Y, Tamiya S, Yamamoto H, et al. ATPbinding cassette superfamily transporter gene expression in human soft tissue sarcomas. Int J Cancer 2005;114:854-62.
    • (2005) Int J Cancer , vol.114 , pp. 854-862
    • Oda, Y.1    Saito, T.2    Tateishi, N.3    Ohishi, Y.4    Tamiya, S.5    Yamamoto, H.6
  • 14
    • 0037317566 scopus 로고    scopus 로고
    • Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities
    • Serra M, Scotlandi K, Reverter-Branchat G, Ferrari S, Manara MC, Benini S, et al. Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities. J Clin Oncol 2003;21:536-42.
    • (2003) J Clin Oncol , vol.21 , pp. 536-542
    • Serra, M.1    Scotlandi, K.2    Reverter-Branchat, G.3    Ferrari, S.4    Manara, M.C.5    Benini, S.6
  • 15
    • 36049026825 scopus 로고    scopus 로고
    • May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian sarcoma group 1 treatment protocol
    • Serra M, Pasello M, Manara MC, Scotlandi K, Ferrari S, Bertoni F, et al. May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian Sarcoma Group 1 treatment protocol. Int J Oncol 2006;29:1459-68.
    • (2006) Int J Oncol , vol.29 , pp. 1459-1468
    • Serra, M.1    Pasello, M.2    Manara, M.C.3    Scotlandi, K.4    Ferrari, S.5    Bertoni, F.6
  • 16
    • 84862878619 scopus 로고    scopus 로고
    • Expression of multidrug resistance-associated proteins in paediatric soft tissue sarcomas before and after chemotherapy
    • Citti A, Boldrini R, Inserra A, Alisi A, Pessolano R, Mastronuzzi A, et al. Expression of multidrug resistance-associated proteins in paediatric soft tissue sarcomas before and after chemotherapy. Int J Oncol 2012;41:117-24.
    • (2012) Int J Oncol , vol.41 , pp. 117-124
    • Citti, A.1    Boldrini, R.2    Inserra, A.3    Alisi, A.4    Pessolano, R.5    Mastronuzzi, A.6
  • 17
    • 84863360945 scopus 로고    scopus 로고
    • Short, full-dose adjuvant chemotherapy in high-risk adult soft tissue sarcomas: A randomized clinical trial from the Italian sarcoma group and the Spanish sarcoma group
    • Gronchi A, Frustaci S, Mercuri M, Martin J, Lopez-Pousa A, Verderio P, et al. Short, full-dose adjuvant chemotherapy in high-risk adult soft tissue sarcomas: a randomized clinical trial from the Italian Sarcoma Group and the Spanish Sarcoma Group. J Clin Oncol 2012;30:850-6.
    • (2012) J Clin Oncol , vol.30 , pp. 850-856
    • Gronchi, A.1    Frustaci, S.2    Mercuri, M.3    Martin, J.4    Lopez-Pousa, A.5    Verderio, P.6
  • 18
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 22DDCT method
    • Livak KJ, Schmittgen TD. Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 22DDCT Method. Methods 2001;25:402-8.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 19
    • 1242335471 scopus 로고    scopus 로고
    • The MRP-related and BCRP/ABCG2 multidrug resistance proteins: Biology, substrate specificity and regulation
    • Haimeur A, Conseil G, Deeley RG, Cole SP. The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation. Curr Drug Metab 2004;5:21-53.
    • (2004) Curr Drug Metab , vol.5 , pp. 21-53
    • Haimeur, A.1    Conseil, G.2    Deeley, R.G.3    Cole, S.P.4
  • 20
    • 0029585739 scopus 로고
    • Effect of ifosfamide treatment on glutathione and glutathione conjugation activity in patients with advanced cancers
    • Mulders TM, Keizer, Ouwerkerk J, van der Velde EA, Breimer DD, Mulder GJ. Effect of ifosfamide treatment on glutathione and glutathione conjugation activity in patients with advanced cancers. Clin Cancer Res 1995;1:1525-36.
    • (1995) Clin Cancer Res , vol.1 , pp. 1525-1536
    • Mulders, T.M.1    Keizer2    Ouwerkerk, J.3    Van Der Velde, E.A.4    Breimer, D.D.5    Mulder, G.J.6
  • 21
    • 33745897902 scopus 로고    scopus 로고
    • Transport of glutathione and glutathione conjugates by MRP1
    • Cole SP, Deeley RG. Transport of glutathione and glutathione conjugates by MRP1. Trends Pharmacol Sci 2006;27:438-46.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 438-446
    • Cole, S.P.1    Deeley, R.G.2
  • 22
    • 0032744001 scopus 로고    scopus 로고
    • Structural, mechanistic and clinical aspects of MRP1
    • Hipfner DR, Deeley RG, Cole SP. Structural, mechanistic and clinical aspects of MRP1. Biochim Biophys Acta 1999;1461:359-76.
    • (1999) Biochim Biophys Acta , vol.1461 , pp. 359-376
    • Hipfner, D.R.1    Deeley, R.G.2    Cole, S.P.3
  • 23
    • 76649129015 scopus 로고    scopus 로고
    • Expression of MRP1, BCRP, LRP and ERCC1 as prognostic factors in non-small cell lung cancer patients receiving postoperative cisplatin-based chemotherapy
    • Li XQ, Li J, Shi SB, Chen P, Yu LC, Bao QL. Expression of MRP1, BCRP, LRP and ERCC1 as prognostic factors in non-small cell lung cancer patients receiving postoperative cisplatin-based chemotherapy. Int J Biol Markers 2009;24:230-7.
    • (2009) Int J Biol Markers , vol.24 , pp. 230-237
    • Li, X.Q.1    Li, J.2    Shi, S.B.3    Chen, P.4    Yu, L.C.5    Bao, Q.L.6
  • 24
    • 0029096212 scopus 로고
    • Expression of the multidrug resistance-associated protein (MRP) gene in non-smallcell lung cancer
    • Ota E, Abe Y, Oshika Y, Ozeki Y, Iwasaki M, Inoue H, et al. Expression of the multidrug resistance-associated protein (MRP) gene in non-smallcell lung cancer. Br J Cancer 1995;72:550-4.
    • (1995) Br J Cancer , vol.72 , pp. 550-554
    • Ota, E.1    Abe, Y.2    Oshika, Y.3    Ozeki, Y.4    Iwasaki, M.5    Inoue, H.6
  • 25
    • 77953363931 scopus 로고    scopus 로고
    • Association of expression of MRP1, BCRP, LRP and ERCC1 with outcome of patients with locally advanced non-small cell lung cancer who received neoadjuvant chemotherapy
    • Li J, Li ZN, Yu LC, Bao QL, Wu JR, Shi SB, et al. Association of expression of MRP1, BCRP, LRP and ERCC1 with outcome of patients with locally advanced non-small cell lung cancer who received neoadjuvant chemotherapy. Lung Cancer 2010;69:116-22.
    • (2010) Lung Cancer , vol.69 , pp. 116-122
    • Li, J.1    Li, Z.N.2    Yu, L.C.3    Bao, Q.L.4    Wu, J.R.5    Shi, S.B.6
  • 27
    • 33344456074 scopus 로고    scopus 로고
    • Prognostic impact of multidrug resistance gene expression on the management of breast cancer in the context of adjuvant therapy based on a series of 171 patients
    • Moureau-Zabotto L, Ricci S, Lefranc JP, Coulet F, Genestie C, Antoine M, et al. Prognostic impact of multidrug resistance gene expression on the management of breast cancer in the context of adjuvant therapy based on a series of 171 patients. Br J Cancer 2006;94:473-80.
    • (2006) Br J Cancer , vol.94 , pp. 473-480
    • Moureau-Zabotto, L.1    Ricci, S.2    Lefranc, J.P.3    Coulet, F.4    Genestie, C.5    Antoine, M.6
  • 29
    • 0037316870 scopus 로고    scopus 로고
    • Nuclear expression of Y-box-binding protein-1 correlates with Pglycoprotein and topoisomerase IIa expression, and with poor prognosis in synovial sarcoma
    • Oda Y, Ohishi Y, Saito T, Hinoshita E, Uchiumi T, Kinukawa N, et al. Nuclear expression of Y-box-binding protein-1 correlates with Pglycoprotein and topoisomerase IIa expression, and with poor prognosis in synovial sarcoma. J Pathol 2003;199:251-8.
    • (2003) J Pathol , vol.199 , pp. 251-258
    • Oda, Y.1    Ohishi, Y.2    Saito, T.3    Hinoshita, E.4    Uchiumi, T.5    Kinukawa, N.6
  • 30
    • 0034092081 scopus 로고    scopus 로고
    • Incidence of P-glycoprotein overexpression and multidrug resistance (MDR) reversal in adult soft tissue sarcoma
    • Coley HM, Verrill MW, Gregson SE, Odell DE, Fisher C, Judson IR. Incidence of P-glycoprotein overexpression and multidrug resistance (MDR) reversal in adult soft tissue sarcoma. Eur J Cancer 2000;36:881-8.
    • (2000) Eur J Cancer , vol.36 , pp. 881-888
    • Coley, H.M.1    Verrill, M.W.2    Gregson, S.E.3    Odell, D.E.4    Fisher, C.5    Judson, I.R.6
  • 31
    • 24344451265 scopus 로고    scopus 로고
    • Improved prognostication in soft tissue sarcoma: Independent information from vascular invasion, necrosis, growth pattern, and immunostaining using whole-tumor sections and tissue microarrays
    • Engellau J, Bendahl PO, Persson A, Domanski HA, Akerman M, Gustafson P, et al. Improved prognostication in soft tissue sarcoma: independent information from vascular invasion, necrosis, growth pattern, and immunostaining using whole-tumor sections and tissue microarrays. Hum Pathol 2005;36:994-1002.
    • (2005) Hum Pathol , vol.36 , pp. 994-1002
    • Engellau, J.1    Bendahl, P.O.2    Persson, A.3    Domanski, H.A.4    Akerman, M.5    Gustafson, P.6
  • 32
    • 0030961092 scopus 로고    scopus 로고
    • Synovial sarcoma: Immunohistochemical expression of Pglycoprotein and glutathione S transferase-pi and clinical drug resistance
    • Lopes JM, Bruland OS, Bjerkehagen B, Silva MC, Holm R, Pettersen EO, et al. Synovial sarcoma: immunohistochemical expression of Pglycoprotein and glutathione S transferase-pi and clinical drug resistance. Pathol Res Pract 1997;193:21-36.
    • (1997) Pathol Res Pract , vol.193 , pp. 21-36
    • Lopes, J.M.1    Bruland, O.S.2    Bjerkehagen, B.3    Silva, M.C.4    Holm, R.5    Pettersen, E.O.6
  • 33
    • 0027970782 scopus 로고
    • Immunohistochemical localization of glutathione S-transferases in sarcomas
    • McKay JA, Murray GI, Ewen SW, Melvin WT, Burke MD. Immunohistochemical localization of glutathione S-transferases in sarcomas. J Pathol 1994;174:83-7.
    • (1994) J Pathol , vol.174 , pp. 83-87
    • McKay, J.A.1    Murray, G.I.2    Ewen, S.W.3    Melvin, W.T.4    Burke, M.D.5
  • 34
    • 1442277078 scopus 로고    scopus 로고
    • Multidrug resistance proteins in primary and metastatic soft-tissue sarcomas: Down-regulation of P-glycoprotein during metastatic progression
    • Komdeur R, Molenaar WM, Zwart N, Hoekstra HJ, van den Berg E, van der Graaf WT. Multidrug resistance proteins in primary and metastatic soft-tissue sarcomas: down-regulation of P-glycoprotein during metastatic progression. Anticancer Res 2004;24: 291-5.
    • (2004) Anticancer Res , vol.24 , pp. 291-295
    • Komdeur, R.1    Molenaar, W.M.2    Zwart, N.3    Hoekstra, H.J.4    Van Den Berg, E.5    Van Der Graaf, W.T.6
  • 35
    • 0029987631 scopus 로고    scopus 로고
    • Location of a protease-hypersensitive region in the multidrug resistance protein (MRP) by mapping of the epitope of MRP-specific monoclonal antibody QCRL-1
    • Hipfner DR, Almquist KC, Stride BD, Deeley RG, Cole SP. Location of a protease-hypersensitive region in the multidrug resistance protein (MRP) by mapping of the epitope of MRP-specific monoclonal antibody QCRL-1. Cancer Res 1996;56:3307-14.
    • (1996) Cancer Res , vol.56 , pp. 3307-3314
    • Hipfner, D.R.1    Almquist, K.C.2    Stride, B.D.3    Deeley, R.G.4    Cole, S.P.5
  • 36
    • 84869505292 scopus 로고    scopus 로고
    • Tumor response assessment by modified Choi criteria in localized high-risk soft tissue sarcoma treated with chemotherapy
    • Stacchiotti S, Verderio P, Messina A, Morosi C, Collini P, Llombart-Bosch A, et al. Tumor response assessment by modified Choi criteria in localized high-risk soft tissue sarcoma treated with chemotherapy. Cancer 2012;118:5857-66.
    • (2012) Cancer , vol.118 , pp. 5857-5866
    • Stacchiotti, S.1    Verderio, P.2    Messina, A.3    Morosi, C.4    Collini, P.5    Llombart-Bosch, A.6
  • 37
    • 8944261743 scopus 로고    scopus 로고
    • Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: Consensus recommendations
    • Beck WT, Grogan TM, Willman CL, Cordon-Cardo C, Parham DM, Kuttesch JF, et al. Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations. Cancer Res 1996;56:3010-20.
    • (1996) Cancer Res , vol.56 , pp. 3010-3020
    • Beck, W.T.1    Grogan, T.M.2    Willman, C.L.3    Cordon-Cardo, C.4    Parham, D.M.5    Kuttesch, J.F.6
  • 38
    • 0028328859 scopus 로고
    • MDR1 gene-specific monoclonal antibody C494 cross-reacts with pyruvate carboxylase
    • Rao VV, Anthony DC, Piwnica-Worms D. MDR1 gene-specific monoclonal antibody C494 cross-reacts with pyruvate carboxylase. Cancer Res 1994;54:1536-41.
    • (1994) Cancer Res , vol.54 , pp. 1536-1541
    • Rao, V.V.1    Anthony, D.C.2    Piwnica-Worms, D.3
  • 40
    • 79960566297 scopus 로고    scopus 로고
    • FK506 confers chemosensitivity to anticancer drugs in glioblastoma multiforme cells by decreasing the expression of the multiple resistance-associated protein-1
    • Garrido W, Munoz M, San Martin R, Quezada C. FK506 confers chemosensitivity to anticancer drugs in glioblastoma multiforme cells by decreasing the expression of the multiple resistance-associated protein-1. Biochem Biophys Res Commun 2011;411:62-8.
    • (2011) Biochem Biophys Res Commun , vol.411 , pp. 62-68
    • Garrido, W.1    Munoz, M.2    San Martin, R.3    Quezada, C.4
  • 41
    • 80051614348 scopus 로고    scopus 로고
    • Anti-MDR1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines
    • Perez J, Bardin C, Rigal C, Anthony B, Rousseau R, Dutour A. Anti-MDR1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines. Anticancer Res 2011;31: 2813-20.
    • (2011) Anticancer Res , vol.31 , pp. 2813-2820
    • Perez, J.1    Bardin, C.2    Rigal, C.3    Anthony, B.4    Rousseau, R.5    Dutour, A.6
  • 42
    • 0036190730 scopus 로고    scopus 로고
    • Safety and efficacy of the multidrug-resistance inhibitor biricodar (VX-710) with concurrent doxorubicin in patients with anthracycline-resistant advanced soft tissue sarcoma
    • Bramwell VH, Morris D, Ernst DS, Hings I, Blackstein M, Venner PM, et al. Safety and efficacy of the multidrug-resistance inhibitor biricodar (VX-710) with concurrent doxorubicin in patients with anthracycline-resistant advanced soft tissue sarcoma. Clin Cancer Res 2002;8:383-93.
    • (2002) Clin Cancer Res , vol.8 , pp. 383-393
    • Bramwell, V.H.1    Morris, D.2    Ernst, D.S.3    Hings, I.4    Blackstein, M.5    Venner, P.M.6
  • 43
    • 77956544799 scopus 로고    scopus 로고
    • Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma
    • Susa M, Iyer AK, Ryu K, Choy E, Hornicek FJ, Mankin H, et al. Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. PLoS One 2010;5:e10764.
    • (2010) PLoS One , vol.5
    • Susa, M.1    Iyer, A.K.2    Ryu, K.3    Choy, E.4    Hornicek, F.J.5    Mankin, H.6
  • 44
    • 84861473905 scopus 로고    scopus 로고
    • Nilotinib counteracts P-glycoproteinmediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas
    • Villar VH, Vogler O, Martinez-Serra J, Ramos R, Calabuig-Farinas S, Gutierrez A, et al. Nilotinib counteracts P-glycoproteinmediated multidrug resistance and synergizes the antitumoral effect of doxorubicin in soft tissue sarcomas. PLoS One 2012;7: e37735.
    • (2012) PLoS One , vol.7
    • Villar, V.H.1    Vogler, O.2    Martinez-Serra, J.3    Ramos, R.4    Calabuig-Farinas, S.5    Gutierrez, A.6


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