Quinic acid derivative KZ-41 exhibits radiomitigating activity in preclinical models of radiation injury

Drug Development Research

Volumn 75, Issue 1, 2014, Pages 29-36

  Thompson, Karin E ^a   Zeng, Kui ^b   Wilson, Christy M ^c   Gaber, Mostafa W ^d   Miller, Duane D ^a   Yates, Charles R ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c DUKE UNIVERSITY   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

radiation combined injury; radiomitigant; total body irradiation; vascular injury; wound healing

Indexed keywords

KZ 41; QUINIC ACID; RADIOPROTECTIVE AGENT; UNCLASSIFIED DRUG; KZ 41 COMPOUND; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; BLOOD FLOW; BLOOD VESSEL INJURY; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; LEUKOCYTE COUNT; MOUSE; NONHUMAN; OVERALL SURVIVAL; RADIATION INJURY; RADIATION PROTECTION; SKINFOLD; THROMBOCYTE COUNT; VASCULARIZATION; VENULE; WHOLE BODY RADIATION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD CELL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; FEMALE; METABOLISM; PATHOLOGY; RADIATION INJURIES, EXPERIMENTAL; VASCULAR SYSTEM INJURIES;

ANIMALS; BLOOD CELLS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FEMALE; MICE; MICE, INBRED C57BL; QUINIC ACID; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR SYSTEM INJURIES; VENULES;

EID: 84892592217     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.21164     Document Type: Article

References (23)

1. Akesson C, Lindgren H, Pero RW, Leanderson T, Ivars F,. 2003a. An extract of Uncaria tomentosa inhibiting cell division and NF-kappa B activity without inducing cell death. Int Immunopharmacol 3: 1889 - 1900.
2. Akesson C, Pero RW, Ivars F,. 2003b. C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo. Phytomedicine 10: 23 - 33.
3. Akesson C, Lindgren H, Pero RW, Leanderson T, Ivars F,. 2005. Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100. Int Immunopharmacol 5: 219 - 229.
4. Animal and Plant Health Inspection Service, United States. 2005. Animal Welfare Act and animal welfare regulations. Washington, DC, US, Dept. of Agriculture, Animal and Plant Health Inspection Service. x, 136 pp.
5. Bertho JM, Roy L, Souidi M, Benderitter M, Bey E, Racine R, Fagot T, Gourmelon P,. 2009. Initial evaluation and follow-up of acute radiation syndrome in two patients from the Dakar accident. Biomarkers 14: 94 - 102.
6. Coleman CN, Blakely WF, Fike JR, MacVittie TJ, Metting NF, Mitchell JB, Moulder JE, Preston RJ, Seed TM, Stone HB,. 2003. Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001. Radiat Res 159: 812 - 834.
7. Dainiak N, Waselenko JK, Armitage JO, MacVittie TJ, Farese AM,. 2003. The hematologist and radiation casualties. Hematology Am Soc Hematol Educ Program 1: 473 - 496.
8. Drouet M, Herodin F,. 2010. Radiation victim management and the haematologist in the future: time to revisit therapeutic guidelines? Int J Radiat Biol 86: 636 - 648.
9. Fliedner TM,. 2006. Nuclear terrorism: the role of hematology in coping with its health consequences. Curr Opin Hematol 13: 436 - 444.
10. Ishikawa M, Cooper D, Arumugam TV, Zhang JH, Nanda A, Granger DN,. 2004. Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion. J Cereb Blood Flow Metab 24: 907 - 915.
11. Jacob A, Shah KG, Wu R, Wang P,. 2010. Ghrelin as a Novel Therapy for Radiation Combined Injury. Mol Med 16: 137 - 143.
12. Koenig KL, Goans RE, Hatchett RJ, Mettler JFA, Schumacher TA, Noji EK, Jarrett DG,. 2005. Medical Treatment of Radiological Casualties: current Concepts. Ann Emerg Med 45: 643 - 652.
13. Kupatt C, Wichels R, Horstkotte J, Krombach F, Habazettl H, Boekstegers P,. 2002. Molecular mechanisms of platelet-mediated leukocyte recruitment during myocardial reperfusion. J Leukoc Biol 72: 455 - 461.
14. Makale M, David AC,. 2007. Intravital imaging and cell invasion. Methods in Enzymology. 426: 375 - 401.
15. National Research Council (U.S.), Committee for the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research (U.S.), National Academies Press (U.S.). 2011. Guide for the care and use of laboratory animals. Washington, DC, National Academies Press. xxv, 220 pp.
16. Sheng Y, Bryngelsson C, Pero RW,. 2000a. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol 69: 115 - 126.
17. Sheng Y, Pero RW, Wagner H,. 2000b. Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. Phytomedicine 7: 137 - 143.
18. Sheng Y, Akesson C, Holmgren K, Bryngelsson C, Giamapa V, Pero RW,. 2005. An active ingredient of Cat's Claw water extracts identification and efficacy of quinic acid. J Ethnopharmacol 96: 577 - 584.
19. Sorensen DK, Bond VP, Cronkite EP, Perman V,. 1960. An Effective Therapeutic Regimen for the Hemopoietic Phase of the Acute Radiation Syndrome in Dogs. Radiat Res 13: 669 - 685.
20. Stone HB, Moulder JE, Coleman CN, Ang KK, Anscher MS, Barcellos-Hoff MH, Dynan WS, Fike JR, Grdina DJ, Greenberger JS,. 2004. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res 162: 711 - 728.
21. Tia KS, Bernard C, Julio CRSJ, Nelson JS, Kathryn O, Kristen MK,. 2006. Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens. Lasers Surg Med 38: 532 - 539.
22. Waselenko JK, MacVittie TJ, Blakely WF, Pesik N, Wiley AL, Dickerson WE, Tsu H, Confer DL, Coleman CN, Seed T,. 2004. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med 140: 1037 - 1051.
23. Zeng K, Thompson KE, Yates CR, Miller DD,. 2009. Synthesis and biological evaluation of quinic acid derivatives as anti-inflammatory agents. Bioorg Med Chem Lett 19: 5458 - 5460.