δ-thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors

Journal of Medicinal Chemistry

Volumn 57, Issue 1, 2014, Pages 243-247

  Ferraris, Dana V ^a,c   Majer, Pavel ^c,d   Ni, Chiyou ^c   Slusher, C Ethan ^a   Rais, Rana ^a   Wu, Ying ^a,c   Wozniak, Krystyna M ^a,c   Alt, Jesse ^a,c   Rojas, Camilo ^a,c   Slusher, Barbara S ^a,b,c   Tsukamoto, Takashi ^a,b,c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EISAI INC   (United States)

^d INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 MERCAPTOPROPYL)PENTANEDIOIC ACID; 3 (2 OXOTETRAHYDROTHIOPYRAN 3 YL)PROPIONIC ACID; ENZYME INHIBITOR; GLUTAMIC ACID DERIVATIVE; PRODRUG; THIOL; THIOLACTONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; LIVER MICROSOME; NEUROPATHIC PAIN; NONHUMAN; PLASMA; RAT;

ANIMALS; ENZYME INHIBITORS; GLUTAMATE CARBOXYPEPTIDASE II; LACTONES; MICROSOMES, LIVER; NEURALGIA; PRODRUGS; RATS;

EID: 84892591433     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401703a     Document Type: Article

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