Molecular dynamics guided design of tocoflexol: A new radioprotectant tocotrienol with enhanced bioavailability

Drug Development Research

Volumn 75, Issue 1, 2014, Pages 10-22

  Compadre, Cesar M ^a   Singh, Awantika ^a   Thakkar, Shraddha ^a,b   Zheng, Guangrong ^a   Breen, Philip J ^a   Ghosh, Sanchita ^c   Kiaei, Mahmoud ^b   Boerma, Marjan ^a   Varughese, Kottayil I ^b   Hauer Jensen, Martin ^a,d  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^d CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

bioavailability; countermeasures; molecular dynamics; radiation protection; tocoflexol; tocotrienol

Indexed keywords

ALPHA TOCOTRIENOL; TOCOFLEXOL; TOCOL; UNCLASSIFIED DRUG; ALPHA TOCOPHEROL; ALPHA-TOCOPHEROL TRANSFER PROTEIN; CARRIER PROTEIN; DELTA-TOCOFLEXOL; RADIOPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BILIARY EXCRETION; BINDING AFFINITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CONFORMATION; DRUG HALF LIFE; MOLECULAR DYNAMICS; NONHUMAN; RADIATION PROTECTION; RAT; SYSTEMIC CIRCULATION; ANALOGS AND DERIVATIVES; ANIMAL; BINDING SITE; BIOAVAILABILITY; CHEMICAL STRUCTURE; DRUG DESIGN; HALF LIFE TIME; HUMAN; LIVER; METABOLISM; WISTAR RAT;

ANIMALS; BINDING SITES; BIOLOGICAL AVAILABILITY; CARRIER PROTEINS; DRUG DESIGN; HALF-LIFE; HUMANS; LIVER; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; RADIATION-PROTECTIVE AGENTS; RATS; RATS, WISTAR; TOCOTRIENOLS; VITAMIN E;

EID: 84892589590     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.21162     Document Type: Article

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