SUMOylation of PPARγ by rosiglitazone prevents LPS-induced NCoR degradation mediating down regulation of chemokines expression in renal proximal tubular cells

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Lu, Ying ^a,b   Zhou, Qiao ^a   Shi, Yongbing ^b   Liu, Jian ^a   Zhong, Fang ^a   Hao, Xu ^a   Li, Cong ^a   Chen, Nan ^a   Wang, Weiming ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CHEMOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; NUCLEAR RECEPTOR COREPRESSOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN INHIBITOR; ROSIGLITAZONE; STAT1 PROTEIN; SUMO PROTEIN; SYNAPTOTAGMIN I;

ARTICLE; CELL INFILTRATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DOWN REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; INFLAMMATION; INFLAMMATORY CELL; KIDNEY INTERSTITIUM; KIDNEY PROXIMAL TUBULE; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SUMOYLATION;

ANTI-INFLAMMATORY AGENTS; CELL LINE; CHEMOKINE CCL2; CHEMOKINES; CO-REPRESSOR PROTEINS; DOWN-REGULATION; HUMANS; KIDNEY TUBULES, PROXIMAL; LIGASES; LIPOPOLYSACCHARIDES; PPAR GAMMA; PROMOTER REGIONS, GENETIC; PROTEOLYSIS; STAT1 TRANSCRIPTION FACTOR; SUMOYLATION; THIAZOLIDINEDIONES;

EID: 84892582805     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079815     Document Type: Article

References (22)

1. Zhang YJ, Yang X, Kong QY, Zhang YF, Chen WY et al. (2006) Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells (HK-2). Am J Nephrol 26: 356-362. doi:10.1159/000094735. PubMed: 16864989.
2. Anders HJ, Ninichuk V, Schlöndorff D (2006) Progression of kidney disease: blocking leukocyte recruitment with chemokine receptor CCR1 antagonists. Kidney Int 69: 29-32. doi:10.1038/sj.ki.5000053. PubMed: 16374420.
3. Segerer S, Nelson PJ, Schlöndorff D (2000) Chemokines, chemokine receptors, and renal disease: from basic science to pathophysiologic and therapeutic studies. J Am Soc Nephrol 11: 152-176. PubMed: 10616852.
4. Lehrke M, Lazar MA (2005) The many faces of PPARgamma. Cell 123: 993-999. doi:10.1016/j.cell.2005.11.026. PubMed: 16360030.
5. Szanto A, Nagy L (2008) The many faces of PPARgamma: anti-inflammatory by any means? Immunobiology 213: 789-803. doi: 10.1016/j.imbio.2008.07.015. PubMed: 18926294.
6. Renga B, Mencarelli A, Migliorati M, Cipriani S, D'Amore C et al. (2011) SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-gamma by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts. Inflamm Res 60: 577-587. doi:10.1007/s00011-010-0306-1. PubMed: 21279417.
7. Wang WM, Chen H, Zhong F, Lu Y, Han L et al. (2011) Inhibitory effects of rosiglitazone on lipopolysaccharide-induced inflammation in a murine model and HK-2 cells. Am J Nephrol 34: 152-162. doi: 10.1159/000329120. PubMed: 21734368.
8. Bae EH, Kim IJ, Ma SK, Kim SW (2010) Rosiglitazone prevents the progression of renal injury in DOCA-salt hypertensive rats. Hypertens Res 33: 255-262. doi:10.1038/hr.2009.217. PubMed: 20057489.
9. Yoshihara D, Kurahashi H, Morita M, Kugita M, Hiki Y et al. (2011) PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease. Am J Physiol Renal Physiol 300: F465-F474. doi:10.1152/ajprenal.00460.2010. PubMed: 21147840.
10. Lee S, Kim W, Moon SO, Sung MJ, Kim DH et al. (2006) Rosiglitazone ameliorates cisplatin-induced renal injury in mice. Nephrol Dial Transplant 21: 2096-2105. doi:10.1093/ndt/gfl194. PubMed: 16728429.
11. Ogawa S, Lozach J, Jepsen K, Sawka-Verhelle D, Perissi V et al. (2004) A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc Natl Acad Sci U S A 101: 14461-14466. doi:10.1073/pnas.0405786101. PubMed: 15452344.
12. Pascual G, Fong AL, Ogawa S, Gamliel A, Li AC et al. (2005) A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 437: 759-763. doi:10.1038/nature03988. PubMed: 16127449.
13. Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME et al. (2007) Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell 25: 57-70. doi:10.1016/j.molcel.2006.11.022. PubMed: 17218271.
14. Banba N, Nakamura T, Matsumura M, Kuroda H, Hattori Y et al. (2000) Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy. Kidney Int 58: 684-690. doi:10.1046/j.1523-1755.2000.00214.x. PubMed: 10916091.
15. Chow FY, Nikolic-Paterson DJ, Ma FY, Ozols E, Rollins BJ et al. (2007) Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice. Diabetologia 50: 471-480. doi:10.1007/s00125-006-0497-8. PubMed: 17160673.
16. Panzer U, Steinmetz OM, Stahl RA, Wolf G (2006) Kidney diseases and chemokines. Curr Drug Targets 7: 65-80. doi: 10.2174/138945006775270213. PubMed: 16454700.
17. Straus DS, Glass CK (2007) Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol 28: 551-558. doi:10.1016/j.it.2007.09.003. PubMed: 17981503.
18. Efrati S, Berman S, Chachashvili A, Cohen N, Averbukh Z et al. (2008) Rosiglitazone treatment attenuates expression of inflammatory hallmarks in the remaining kidney following contralateral nephrectomy. Am J Nephrol 28: 238-245. doi:10.1159/000110681. PubMed: 17975301.
19. Efrati S, Berman S, Chachashvili A, Cohen N, Siman-Tov Y et al. (2009) Rosiglitazone treatment attenuates renal tissue inflammation generated by urinary tract obstruction. Nephrology (Carlton) 14: 189-197. doi:10.1111/j.1440-1797.2008.01032.x. PubMed: 19143945.
20. Necela BM, Su W, Thompson EA (2008) Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in macrophages. Immunology 125: 344-358. doi:10.1111/j.1365-2567. 2008.02849.x. PubMed: 18422969.
21. Nareika A, He L, Game BA, Slate EH, Sanders JJ et al. (2005) Sodium lactate increases LPS-stimulated MMP and cytokine expression in U937 histiocytes by enhancing AP-1 and NF-kappaB transcriptional activities. Am J Physiol Endocrinol Metab 289: E534-E542. doi: 10.1152/ajpendo.00462.2004. PubMed: 15941782.
22. Jennewein C, Kuhn AM, Schmidt MV, Meilladec-Jullig V, von Knethen A et al. (2008) Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines. J Immunol 181: 5646-5652. PubMed: 18832723.