Functional cooperation between vitamin D receptor and Runx2 in vitamin D-induced vascular calcification

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Han, Min Su ^a   Che, Xiangguo ^a   Cho, Gyoung Ho ^a   Park, Hye Ri ^a   Lim, Kyung Eun ^a   Park, Na Rae ^a   Jin, Jung Sook ^a   Jung, Youn Kwan ^a   Jeong, Jae Hwan ^a   Lee, In Kyu ^a   Kato, Shigeaki ^b   Choi, Je Yong ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLECALCIFEROL; MESSENGER RNA; MYOSIN HEAVY CHAIN; TRANSCRIPTION FACTOR RUNX2; VITAMIN D RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL CALCIFICATION; CELL CULTURE; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; CELLS, CULTURED; CHOLECALCIFEROL; CORE BINDING FACTOR ALPHA 1 SUBUNIT; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RATS; RECEPTORS, CALCITRIOL; VASCULAR CALCIFICATION;

EID: 84892567806     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083584     Document Type: Article

References (52)

1. Vattikuti R, Towler DA (2004) Osteogenic regulation of vascular calcification: an early perspective. Am J Physiol Endocrinol Metab 286: E686-E696. doi:10.1152/ajpendo.00552.2003. PubMed: 15102615.
2. Mody N, Tintut Y, Radcliff K, Demer LL (2003) Vascular calcification and its relation to bone calcification: possible underlying mechanisms. J Nucl Cardiol 10: 177-183. doi:10.1067/mnc.2003.0012. PubMed: 12673183.
3. Collin-Osdoby P (2004) Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res 95: 1046-1057. doi:10.1161/01.RES.0000149165.99974.12. PubMed: 15564564.
4. Shao JS, Cheng SL, Sadhu J, Towler DA (2010) Inflammation and the osteogenic regulation of vascular calcification: a review and perspective. Hypertension 55: 579-592. doi:10.1161/HYPERTENSIONAHA.109.134205. PubMed: 20101002.
5. Khosla S (2011) The bone and beyond: a shift in calcium. Nat Med 17: 430-431. doi:10.1038/nm0411-430. PubMed: 21475237.
6. Tintut Y, Patel J, Territo M, Saini T, Parhami F et al. (2002) Monocyte/macrophage regulation of vascular calcification in vitro. Circulation 105: 650-655. doi:10.1161/hc0502.102969. PubMed: 11827934.
7. Sage AP, Tintut Y, Demer LL (2010) Regulatory mechanisms in vascular calcification. Nat Rev Cardiol 7: 528-536. doi:10.1038/nrcardio.2010.115. PubMed: 20664518.
8. Parhami F, Boström K, Watson K, Demer LL (1996) Role of molecular regulation in vascular calcification. J Atheroscler Thromb 3: 90-94. PubMed: 9226460.
9. Proudfoot D, Davies JD, Skepper JN, Weissberg PL, Shanahan CM (2002) Acetylated low-density lipoprotein stimulates human vascular smooth muscle cell calcification by promoting osteoblastic differentiation and inhibiting phagocytosis. Circulation 106: 3044-3050. doi:10.1161/01.CIR.0000041429.83465. 41. PubMed: 12473549.
10. Speer MY, Yang HY, Brabb T, Leaf E, Look A et al. (2009) Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries. Circ Res 104: 733-741. doi:10.1161/CIRCRESAHA.108.183053. PubMed: 19197075.
11. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K et al. (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89: 755-764. doi:10.1016/S0092-8674(00) 80258-5. PubMed: 9182763.
12. Choi JY, Pratap J, Javed A, Zaidi SK, Xing L et al. (2001) Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development. Proc Natl Acad Sci U S A 98: 8650-8655. doi:10.1073/pnas.151236498. PubMed: 11438701.
13. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC et al. (1997) Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89: 765-771. doi:10.1016/S0092-8674(00)80259-7. PubMed: 9182764.
14. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89: 747-754. doi:10.1016/S0092-8674(00)80257-3. PubMed: 9182762.
15. Boström K, Watson KE, Horn S, Wortham C, Herman IM et al. (1993) Bone morphogenetic protein expression in human atherosclerotic lesions. J Clin Invest 91: 1800-1809. doi:10.1172/JCI116391. PubMed: 8473518.
16. Bini A, Mann KG, Kudryk BJ, Schoen FJ (1999) Noncollagenous bone matrix proteins, calcification, and thrombosis in carotid artery atherosclerosis. Arterioscler Thromb Vasc Biol 19: 1852-1861. doi:10.1161/01.ATV.19.8.1852. PubMed: 10446063.
17. Steitz SA, Speer MY, Curinga G, Yang HY, Haynes P et al. (2001) Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res 89: 1147-1154. doi:10.1161/hh2401.101070. PubMed: 11739279.
18. Sierra OL, Towler DA (2010) Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3. Mol Endocrinol 24: 1478-1497. doi:10.1210/me.2010-0029. PubMed: 20484411.
19. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E et al. (1997) Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386: 78-81. doi:10.1038/386078a0. PubMed: 9052783.
20. Bucay N, Sarosi I, Dunstan CR, Morony S, Tarpley J et al. (1998) osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 12: 1260-1268. doi:10.1101/gad.12.9.1260. PubMed: 9573043.
21. Dietrich H, Hu Y, Zou Y, Huemer U, Metzler B et al. (2000) Rapid development of vein graft atheroma in ApoE-deficient mice. Am J Pathol 157: 659-669. doi:10.1016/S0002-9440(10)64576-2. PubMed: 10934168.
22. Luo XH, Zhao LL, Yuan LQ, Wang M, Xie H et al. (2009) Development of arterial calcification in adiponectin-deficient mice: adiponectin regulates arterial calcification. J Bone Miner Res 24: 1461-1468. doi:10.1359/jbmr.090227. PubMed: 19257834.
23. Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD et al. (1998) The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res 13: 325-349. doi:10.1359/jbmr.1998.13.3. 325. PubMed: 9525333.
24. Boyle WJ, Simonet WS, Lacey DL (2003) Osteoclast differentiation and activation. Nature 423: 337-342. doi:10.1038/nature01658. PubMed: 12748652.
25. Paredes R, Arriagada G, Cruzat F, Villagra A, Olate J et al. (2004) Bone-specific transcription factor Runx2 interacts with the 1alpha,25- dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells. Mol Cell Biol 24: 8847-8861. doi:10.1128/MCB.24.20.8847- 8861.2004. PubMed: 15456860.
26. Shen Q, Christakos S (2005) The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin. J Biol Chem 280: 40589-40598. doi:10.1074/jbc.M504166200. PubMed: 16195230.
27. Barthel TK, Mathern DR, Whitfield GK, Haussler CA, Hopper HAt, et Barthel TK, Mathern DR, Whitfield GK, Haussler CA, Hopper HA, Hsieh JC, Slater SA, Hsieh G, Kaczmarska M, Jurutka PW, Kolek OI, Ghishan FK, Haussler M.Ral (2007) 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. J Steroid Biochem Mol Biol 103: 381-388 doi:10.1016/j.jsbmb.2006.12.054. PubMed: 17293108. doi:10.1016/j.jsbmb.2006.12.054. PubMed: 17293108.
28. Ignat M, Teletin M, Tisserand J, Khetchoumian K, Dennefeld C et al. (2008) Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha. Proc Natl Acad Sci U S A 105: 2598-2603. doi:10.1073/pnas.0712030105. PubMed: 18287084.
29. Shroff R, Egerton M, Bridel M, Shah V, Donald AE et al. (2008) A bimodal association of vitamin D levels and vascular disease in children on dialysis. J Am Soc Nephrol 19: 1239-1246. doi:10.1681/ASN.2007090993. PubMed: 18337484.
30. Schmidt N, Brandsch C, Kühne H, Thiele A, Hirche F et al. (2012) Vitamin D receptor deficiency and low vitamin D diet stimulate aortic calcification and osteogenic key factor expression in mice. PLOS ONE 7: e35316. doi:10.1371/journal.pone.0035316. PubMed: 22536373.
31. Tentori F, Hunt WC, Stidley CA, Rohrscheib MR, Bedrick EJ et al. (2006) Mortality risk among hemodialysis patients receiving different vitamin D analogs. Kidney Int 70: 1858-1865. doi:10.1038/sj.ki.5001868. PubMed: 17021609.
32. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM et al. (2011) The 2011 Dietary Reference Intakes for Calcium and Vitamin D: what dietetics practitioners need to know. J Am Diet Assoc 111: 524-527. doi:10.1016/j.jada. 2011.01.004. PubMed: 21443983.
33. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K et al. (1997) Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 16: 391-396. doi:10.1038/ng0897-391. PubMed: 9241280.
34. Campbell JH, Campbell GR (1993) Culture techniques and their applications to studies of vascular smooth muscle. Clin Sci (Lond) 85: 501-513. PubMed: 8287636.
35. Murshed M, Schinke T, McKee MD, Karsenty G (2004) Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. J Cell Biol 165: 625-630. doi:10.1083/jcb.200402046. PubMed: 15184399.
36. Jung YK, Han SW, Kim GW, Jeong JH, Kim HJ et al. (2012) DICAM inhibits osteoclast differentiation through attenuation of the integrin alphaVbeta3 pathway. J Bone Miner Res 27: 2024-2034. doi:10.1002/jbmr.1632. PubMed: 22492581.
37. Jeong JH, Jung YK, Kim HJ, Jin JS, Kim HN et al. (2010) The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues. Mol Cell Biol 30: 2365-2375. doi:10.1128/MCB.00672-09. PubMed: 20231365.
38. Han MS, Kim HJ, Wee HJ, Lim KE, Park NR et al. (2010) The cleidocranial dysplasia-related R131G mutation in the Runt-related transcription factor RUNX2 disrupts binding to DNA but not CBF-beta. J Cell Biochem 110: 97-103. PubMed: 20225274.
39. Song Y, Kato S, Fleet JC (2003) Vitamin D receptor (VDR) knockout mice reveal VDR-independent regulation of intestinal calcium absorption and ECaC2 and calbindin D9k mRNA. J Nutr 133: 374-380. PubMed: 12566470.
40. Price PA, Buckley JR, Williamson MK (2001) The amino bisphosphonate ibandronate prevents vitamin D toxicity and inhibits vitamin D-induced calcification of arteries, cartilage, lungs and kidneys in rats. J Nutr 131: 2910-2915. PubMed: 11694617.
41. Price PA, Roublick AM, Williamson MK (2006) Artery calcification in uremic rats is increased by a low protein diet and prevented by treatment with ibandronate. Kidney Int 70: 1577-1583. doi:10.1038/sj.ki.5001841. PubMed: 16955099.
42. Hoenderop JG, van der Kemp AW, Urben CM, Strugnell SA, Bindels RJ (2004) Effects of vitamin D compounds on renal and intestinal Ca2+ transport proteins in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice. Kidney Int 66: 1082-1089. doi:10.1111/j.1523-1755.2004.00858.x. PubMed: 15327402.
43. Kim JE, Han MS, Bae YC, Kim HK, Kim TI et al. (2007) Anterior segment dysgenesis after overexpression of transforming growth factor-beta-induced gene, beta igh3, in the mouse eye. Mol Vis 13: 1942-1952. PubMed: 17982418.
44. Medici D, Shore EM, Lounev VY, Kaplan FS, Kalluri R et al. (2010) Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med 16: 1400-1406. doi:10.1038/nm.2252. PubMed: 21102460.
45. Drissi H, Pouliot A, Koolloos C, Stein JL, Lian JB et al. (2002) 1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter. Exp Cell Res 274: 323-333. doi:10.1006/excr.2002.5474. PubMed: 11900492.
46. Yamamoto Y, Yoshizawa T, Fukuda T, Shirode-Fukuda Y, Yu T et al. (2013) Vitamin d receptor in osteoblasts is a negative regulator of bone mass control. Endocrinology 154: 1008-1020. doi:10.1210/en.2012-1542. PubMed: 23389957.
47. Oury F, Ferron M, Huizhen W, Confavreux C, Xu L et al. (2013) Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Invest, 123: 2421-33. PubMed: 23728177.
48. Clemens TL, Karsenty G (2011) The osteoblast: an insulin target cell controlling glucose homeostasis. J Bone Miner Res 26: 677-680. doi:10.1002/jbmr.321. PubMed: 21433069.
49. Byon CH, Sun Y, Chen J, Yuan K, Mao X et al. (2011) Runx2-upregulated receptor activator of nuclear factor kappaB ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages. Arterioscler Thromb Vasc Biol 31: 1387-1396. doi:10.1161/ATVBAHA.110.222547. PubMed: 21454810.
50. Osako MK, Nakagami H, Koibuchi N, Shimizu H, Nakagami F et al. (2010) Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification. Circ Res 107: 466-475. doi:10.1161/CIRCRESAHA.110.216846. PubMed: 20595654.
51. Mathew S, Lund RJ, Chaudhary LR, Geurs T, Hruska KA (2008) Vitamin D receptor activators can protect against vascular calcification. J Am Soc Nephrol 19: 1509-1519. doi:10.1681/ASN.2007080902. PubMed: 18448587.
52. Sun Y, Byon CH, Yuan K, Chen J, Mao X et al. (2012) Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification. Circ Res 111: 543-552. doi:10.1161/CIRCRESAHA.112.267237. PubMed: 22773442.