Systems analysis utilising pathway interactions identifies sonic hedgehog pathway as a primary biomarker and oncogenic target in hepatocellular carcinoma

IET Systems Biology

Volumn 7, Issue 6, 2013, Pages 243-251

  Efroni, Sol ^a   Meerzaman, Daoud ^b   Schaefer, Carl F ^c   Greenblum, Sharon ^c   Soo Lyu, Myung ^b   Hu, Ying ^b   Cultraro, Constance ^b   Meshorer, Eran ^d   Buetow, Kenneth H ^b,c,e  

^a BAR ILAN UNIVERSITY   (Israel)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^e ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL NETWORKS; COMPUTATIONAL APPROACH; EXPRESSION LEVELS; HEPATOCELLULAR CARCINOMA; HUMAN HEPATOCELLULAR CARCINOMA (HCC); LIVER CANCER CELLS; PATHWAY INTERACTIONS; WESTERN-BLOT ANALYSIS;

CELL CULTURE; CELL PROLIFERATION; DISEASES; GENE EXPRESSION; SYSTEMS ANALYSIS;

TUMORS;

CCNB1 PROTEIN, HUMAN; CYCLIN B1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE ACTIVATING KINASE; CYCLIN-DEPENDENT KINASE-ACTIVATING KINASE; SHH PROTEIN, HUMAN; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; TUMOR MARKER;

ARTICLE; CELL PROLIFERATION; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENE SILENCING; HUMAN; LIVER; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PHOSPHORYLATION; SYSTEM ANALYSIS; TUMOR CELL LINE;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN B1; CYCLIN-DEPENDENT KINASES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; GENE SILENCING; HEDGEHOG PROTEINS; HUMANS; LIVER; LIVER NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; RNA, SMALL INTERFERING; SYSTEMS ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84892498652     PISSN: 17518849     EISSN: None     Source Type: Journal    
DOI: 10.1049/iet-syb.2010.0078     Document Type: Article

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