Emergence of the virulence-associated PB2 E627K substitution in a fatal human case of highly pathogenic avian influenza virus A(H7N7) infection as determined by illumina ultra-deep sequencing

Journal of Virology

Volumn 88, Issue 3, 2014, Pages 1694-1702

  Jonges, Marcel ^a,b   Welkers, Matthijs R A ^c   Jeeninga, Rienk E ^c   Meijer, Adam ^a   Schneeberger, Peter ^d   Fouchier, Ron A M ^b   de Jong, Menno D ^c   Koopmans, Marion ^a,b  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d JEROEN BOSCH HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC PROTEIN; POLYMERASE BASIC 2 PROTEIN; UNCLASSIFIED DRUG; VIRUS RNA;

ADAPTATION; ANIMAL TISSUE; ARTICLE; CASE REPORT; CHICKEN MODEL; CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO; ENVIRONMENTAL EXPOSURE; GENETIC DAMAGE; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLUENZA VIRUS A H7N7; INFLUENZA VIRUS A H7N7 INFECTION; MALE; MUTATIONAL ANALYSIS; NONHUMAN; PARAINFLUENZA VIRUS INFECTION; POULTRY; PRIORITY JOURNAL; RNA DEFECT; RNA SYNTHESIS; SEQUENCE ANALYSIS; VIRUS MUTATION; VIRUS VIRULENCE;

AMINO ACID SUBSTITUTION; ANIMALS; CHICKENS; FATAL OUTCOME; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INFLUENZA A VIRUS, H7N7 SUBTYPE; INFLUENZA IN BIRDS; INFLUENZA, HUMAN; MALE; MUTATION RATE; MUTATION, MISSENSE; POULTRY DISEASES; RNA REPLICASE; VIRAL PROTEINS; VIRULENCE;

EID: 84892472510     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02044-13     Document Type: Article

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