Altered CpG methylation in sporadic alzheimer's disease is associated with APP and MAPT dysregulation

Human Molecular Genetics

Volumn 23, Issue 3, 2014, Pages 648-656

  Iwata, Atsushi ^a,b   Nagata, Kenichi ^c   Hatsuta, Hiroyuki ^d   Takuma, Hiroshi ^e   Bundo, Miki ^a   Iwamoto, Kazuya ^a,b   Tamaoka, Akira ^e   Murayama, Shigeo ^d   Saido, Takaomi ^c   Tsuji, Shoji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^d Tokyo Metropolitan Institute of Gerontology   (Japan)

^e UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; TAU PROTEIN;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BRAIN CELL CULTURE; CELL NUCLEUS; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GSK3B GENE; HUMAN; IN VITRO STUDY; MALE; NEUROPATHOLOGY; PRIORITY JOURNAL; PYROSEQUENCING;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; APOLIPOPROTEIN E4; BRAIN; CASE-CONTROL STUDIES; CELL NUCLEUS; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MALE; NEURONS; TAU PROTEINS;

EID: 84892465251     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddt451     Document Type: Article

References (35)

1. Karran, E., Mercken, M. and De Strooper, B. (2011) The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat. Rev. Drug. Discov., 10, 698-712.
2. Rovelet-Lecrux, A., Hannequin, D., Raux, G., Le Meur, N., Laquerriere, A., Vital, A., Dumanchin, C., Feuillette, S., Brice, A., Vercelletto, M. et al. (2006) APP Locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat. Genet., 38, 24-26.
3. Wisniewski, K.E., Wisniewski, H.M. and Wen, G.Y. (1985) Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann. Neurol., 17, 278-282.
4. Golde, T.E., Estus, S., Usiak, M., Younkin, L.H. and Younkin, S.G. (1990) Expression of beta amyloid protein precursormRNAs:recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR. Neuron, 4, 253-267.
5. Palmert, M.R., Podlisny, M.B., Golde, T.E., Cohen, M.L., Kovacs, D.M., Tanzi, R.E., Gusella, J.F., Whitehouse, P.J., Witker, D.S., Oltersdorf, T. et al. (1990) Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products. Adv. Neurol., 51, 181-184.
6. Koo, E.H., Sisodia, S.S., Cork, L.C., Unterbeck, A., Bayney, R.M. and Price, D.L. (1990) Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates. Neuron, 4, 97-104.
7. Harrison, P.J., Wighton-Benn, W.H., Heffernan, J.M., Sanders, M.W. and Pearson, R.C. (1996) Amyloid precursor protein mRNAs in Alzheimer's disease. Neurodegeneration, 5, 409-415.
8. Matsumoto, L., Takuma, H., Tamaoka, A., Kurisaki, H., Date, H., Tsuji, S. and Iwata, A. (2010) Cpg demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease. PLoS One, 5, e15522.
9. Hyman, B.T., Phelps, C.H., Beach, T.G., Bigio, E.H., Cairns, N.J., Carrillo, M.C., Dickson, D.W., Duyckaerts, C., Frosch, M.P., Masliah, E. et al. (2012) National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimers Dement., 8, 1-13.
10. Montine, T.J., Phelps, C.H., Beach, T.G., Bigio, E.H., Cairns, N.J., Dickson, D.W., Duyckaerts, C., Frosch, M.P., Masliah, E., Mirra, S.S. et al. (2012) National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathol., 123, 1-11.
11. De Strooper, B., Vassar, R. and Golde, T. (2010) The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat. Rev. Neurol., 6, 99-107.
12. Takai, D. and Jones, P.A. (2003) The CpG island searcher: a newWWW resource. In Silico Biol., 3, 235-240.
13. Iwamoto, K., Bundo, M., Ueda, J., Oldham, M.C., Ukai, W., Hashimoto, E., Saito, T., Geschwind, D.H. and Kato, T. (2011) Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons. Genome Res., 21, 688-696.
14. Boch, J., Scholze, H., Schornack, S., Landgraf, A., Hahn, S., Kay, S., Lahaye, T., Nickstadt, A. and Bonas, U. (2009) Breaking the code of DNA binding specificity of TAL-type III effectors. Science, 326, 1509-1512.
15. Moscou, M.J. and Bogdanove, A.J. (2009) A simple cipher governs DNA recognition by TAL effectors. Science, 326, 1501.
16. Sanjana, N.E., Cong, L., Zhou, Y., Cunniff, M.M., Feng, G. and Zhang, F. (2012) A transcription activator-like effector toolbox for genome engineering. Nat. Protoc., 7, 171-192.
17. Gowher, H. and Jeltsch, A. (2002) Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases. J. Biol. Chem., 277, 20409-20414.
18. Barrachina, M. and Ferrer, I. (2009)DNAMethylation of Alzheimer disease and tauopathy-related genes in postmortem brain. J. Neuropathol. Exp. Neurol., 68, 880-891.
19. Wang, S.C., Oelze, B. and Schumacher, A. (2008) Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS One, 3, e2698.
20. Rogaev, E.I., Lukiw, W.J., Lavrushina, O., Rogaeva, E.A. and St George-Hyslop, P.H. (1994) The upstream promoter of the beta-amyloid precursor protein gene (APP) shows differential patterns of methylation in human brain. Genomics, 22, 340-347.
21. Grunau, C., Clark, S.J. and Rosenthal, A. (2001) Bisulfite genomic sequencing: systematic investigation of critical experimental parameters. Nucleic. Acids. Res., 29, e65.
22. Warnecke, P.M., Stirzaker, C., Song, J., Grunau, C., Melki, J.R. and Clark, S.J. (2002) Identification and resolution of artifacts in bisulfite sequencing. Methods, 27, 101-107.
23. Gius, D., Cui, H., Bradbury, C.M., Cook, J., Smart, D.K., Zhao, S., Young, L., Brandenburg, S.A., Hu, Y., Bisht, K.S. et al. (2004) Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell, 6, 361-371.
24. Suzuki, M.M. and Bird, A. (2008) DNA Methylation landscapes: provocative insights from epigenomics. Nat. Rev. Genet., 9, 465-476.
25. Jones, P.A. (2012) Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat. Rev. Genet., 13, 484-492.
26. Lee, V.M. and Trojanowski, J.Q. (1992) The disordered neuronal cytoskeleton in Alzheimer's disease. Curr. Opin. Neurobiol., 2, 653-656.
27. Frost, B. and Diamond, M.I. (2010) Prion-like mechanisms in neurodegenerative diseases. Nat. Rev. Neurosci., 11, 155-159.
28. Verghese, P.B., Castellano, J.M. and Holtzman, D.M. (2011) Apolipoprotein E in Alzheimer's disease and other neurological disorders. Lancet Neurol., 10, 241-252.
29. Liu, C.C., Kanekiyo, T., Xu, H. and Bu, G. (2013) Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat. Rev. Neurol., 9, 106-118.
30. Castellano, J.M., Kim, J., Stewart, F.R., Jiang, H., DeMattos, R.B., Patterson, B.W., Fagan, A.M., Morris, J.C., Mawuenyega, K.G., Cruchaga, C. et al. (2011) Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance. Sci. Transl. Med., 3, 89ra57.
31. Wimo, A. and Price, M. (2010) World Alzheimer Report 2010. Alzheimer's Disease International, 1-54.
32. Iwata, A. and Iwatsubo, T. (2013) Disease-modifying therapy for Alzheimer's disease: challenges and hopes. Neurol. Clin. Neurocience, 1, 49-54.
33. Braak, H. and Braak, E. (1991) Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections. Brain Pathol., 1, 213-216.
34. McKeith, I.G., Galasko, D., Kosaka, K., Perry, E.K., Dickson, D.W., Hansen, L.A., Salmon, D.P., Lowe, J., Mirra, S.S., Byrne, E.J. et al. (1996) Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology, 47, 1113-1124.
35. Braak, H. and Braak, E. (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol., 82, 239-259.