Characterization of alginate beads loaded with ibuprofen lysine salt and optimization of the preparation method

International Journal of Pharmaceutics

Volumn 460, Issue 1-2, 2014, Pages 181-188

  Caballero, F ^a   Foradada, M ^a   Minarro M ^a   Perez Lozano P ^a   Garcia Montoya E ^a   Tico J R ^a   Sune Negre J M ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Alginate beads; Ibuprofen lysine; Microcapsules; pH sensitiveness; Slow release

Indexed keywords

ALGINIC ACID; BIOPOLYMER; IBUPROFEN; IBUPROFEN LYSINE;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; DRUG SYNTHESIS; ENCAPSULATION; FACTORIAL DESIGN; GELATION; HYDROGEL; PH; POROSITY; PRECIPITATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SCANNING ELECTRON MICROSCOPY; SURFACE TENSION; WATER TRANSPORT;

ALGINATE BEADS; IBUPROFEN LYSINE; MICROCAPSULES; PH SENSITIVENESS; SLOW RELEASE;

ALGINATES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALCIUM CHLORIDE; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; GLUCURONIC ACID; HEXURONIC ACIDS; HYDROGEN-ION CONCENTRATION; IBUPROFEN; LYSINE; MICROSCOPY, ELECTRON, SCANNING;

EID: 84892431550     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.10.034     Document Type: Article

References (28)

1. B. Arica, S. Çalis, P. Atilla, N.T. Durlu, N. Çakar, H.S. Kas, and A.A. Hincal In vitro and in vivo studies of ibuprofen-loaded biodegradable alginate beads J. Microencapsul. 22 2005 153 165 (Pubitemid 40775304)
2. A.A. Badwan, A. Abumalooh, E. Sallam, A. Abukalaf, and O. Jawan A sustained release drug delivery system using calcium alginate beads Drug. Devel. Ind. Pharm. 11 1985 239 256 (Pubitemid 15067826)
3. R. Bodmeier, and J. Wang Microencapsulation of drugs with aqueous colloidal polymer dispersions J. Pharm. Sci. 82 1993 191 194 (Pubitemid 23147749)
4. M.A. Burns, G.I. Kvesitadze, and D.J. Graves Dried calcium alginate/magnetite spheres: a new support for chromatographic separation and enzyme immobilization Biotechnol. Bioeng. 27 1985 137 145
5. M. Busson Update on ibuprofen: review J. Int. Med. Res. 14 1986 53 62
6. T. Coviello, P. Matricardi, C. Marianecci, and F. Alhaique Polysacharide hydrogels for modified release formulations J. Control. Release 119 2007 5 24 (Pubitemid 46561537)
7. T. Dolatabadi-Farahani, E. Vasheghani-Farahani, and H. Mirzadeh Swelling behaviour of alginate-N,O-carboxymethyl chitosan gel beads coated by chitosan Iran. Polym. J. 15 2006 405 415 (Pubitemid 44186026)
8. G. Fundueanu, C. Nastruzzi, A. Carpov, J. Desbrieres, and M. Rinaudo Physico-chemical characterisation of Ca-alginate microparticles produced with different methods Biomaterials 20 1999 1427 1435 (Pubitemid 29326814)
9. P. Gacesa Alginates Carbohydr. Polym. 8 1988 161 182
10. A. Gallardo, J.L. Eguiburu, M.J. Berridi, and J.S. Roman Preparation and in vitro release studies of ibuprofen loaded films and microspheres made from graft copolymers and poly(l-lactic acid) on acrylic backbones J. Control. Release 55 1998 171 179 (Pubitemid 28477608)
11. P. Gaudio, P. Colombo, G. Colombo, P. Russo, and F. Sonvico Mechanisms of formation and disintegration of alginate beads obtained by prilling Int. J. Pharm. 302 2005 1 9 (Pubitemid 41242747)
12. A. Haug, S. Myklestad, B. Larsen, and O. Smidsr∅d Correlation between chemical structure and physical properties of alginate Acta Chem. Scand. 21 1967 691 704
13. P. Heng, L. Chan, and T. Wong Formation of alginate microspheres produced using emulsification technique J. Microencapsul. 20 2003 401 413 (Pubitemid 36621480)
14. A. Hodson, J. Mitchell, M. Davies, and C. Melia Structure and behaviour of hydrophilic matrix sustained release dosage form 3. The influence of pH on the sustained-release performance and internal gel structure of sodium alginate matrices J. Control. Release 33 1995 143 152
15. S.J. Hwang, G.J. Rhee, K.M. Lee, K.H. Oh, and C.K. Kim Release characteristics of ibuprofen from excipient-loaded alginate gel beads Int. J. Pharm. 116 1995 125 128
16. A.R. Kulkarni, K.S. Soppimath, T.M. Aminabhavi, and W.E. Rudzinski In vitro release of cefadroxil-loaded sodium alginate interpenetrating network beads Eur. J. Pharm. 51 2001 127 133 (Pubitemid 32162491)
17. B.J. Lee, J.H. Cui, T.W. Kim, M.Y. Heo, and C.K. Kim Biphasic release characteristics of dual drug-loaded alginate beads Arch. Pharm. Res. 21 1998 645 650
18. D.R. Mehlisch, R.D. Jasper, P. Brown, S.H. Korn, K. McCarroll, and A.A. Murakami Comparative study of ibuprofen lysine and acetaminophen in patients with post operative dental pain Clin. Ther. 17 1995 852 860
19. N. Moore Forty years of ibuprofen use Int. J. Clin. Pract. Suppl. 135 2003 28 31 (Pubitemid 36458875)
20. T. Ostberg, and C. Graffner Calcium alginate matrices or oral multiple unit administration: II influence of calcium concentration, amount of drug added and alginate characteristics on drug release Int. J. Pharm. 111 1994 271 282 (Pubitemid 24292905)
21. S. Puttipipatkhachorn, T. Pongjanyakul, and A. Priprem Molecular interaction in alginate beads reinforced with sodium starch glycolate or magnesium aluminium silicate, and their physical characteristics Int. J. Pharm. 293 2005 51 62 (Pubitemid 40381080)
22. R. Ray, S. Maity, S. Mandal, T.K. Chatterjee, and B. Sa Development and evaluation of a new interpenetrating network bead of sodium carboxymethyl xantan and sodium alginate for ibuprofen release Pharmacol. Pharm. 1 2010 9 17
23. K. Redenbaugh, B.D. Paasch, J.W. Nichol, M.E. Kossler, P.R. Viss, and K.A. Walker Somatic seeds: encapsulation of asexual embryos Biotechnology 4 1986 797 801
24. W. Sabra, A.P. Zeng, and W.D. Deckwer Bacterial alginate: physiology, product quality and process aspects Appl. Microbiol. Biotechnol. 56 2001 315 325 (Pubitemid 32768594)
25. N. Segui, T. Yotsuyanagui, and K. Ikeda Interaction of calcium-induced gelation of alginic acid and pH sensitive reswelling of dried gels Chem. Pharm. Bull. 37 1989 3092 3095
26. N.M. Velings, and M.M. Mestdagh Protein adsorption in calcium alginate gel beads J. Bioact. Biocomp. Polym. 9 1994 133 141 (Pubitemid 24245218)
27. T. Visted, R. Bjerkvig, and P. Enger Cell encapsulation technology as a therapeutic strategy for CNS malignancies Neuro-Oncology 3 2001 201 210 (Pubitemid 33674112)
28. H. Zimmermann, D. Zimmermann, R. Reuss, P.J. Feilen, B. Manz, A. Katsen, M. Weber, F.R. Ihmig, F. Ehrhart, P. Gessner, M. Behringer, A. Steinbach, L.H. Wegner, V.L. Sukhorukov, J.A. Vásquez, S. Schneider, M.M. Weber, F. Volke, R. Wolf, and U. Zimmermann Towards a medically approved technology for alginate-based microcapsules allowing long-term immunoisolated transplantation J. Mater. Sci. Mater. Med. 16 2005 491 501 (Pubitemid 40884240)