Formation of alginate microspheres produced using emulsification technique

Journal of Microencapsulation

Volumn 20, Issue 3, 2003, Pages 401-413

  Heng, P W S ^a   Chan, L W ^a   Wong, T W ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Alginate microspheres; Calcium; Emulsification; pH; Tack

Indexed keywords

ALGINIC ACID; CALCIUM ACETATE; CALCIUM ALGINATE; CALCIUM CHLORIDE; CALCIUM LACTATE; CALCIUM SALT; DRUG; GLUCONATE CALCIUM; MICROSPHERE; SULFAGUANIDINE;

ARTICLE; CHEMICAL COMPOSITION; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS LINKING; DISSOCIATION CONSTANT; EMULSION; MICROENCAPSULATION; PARTICLE SIZE; PH; VISCOSITY;

ALGINATES; CALCIUM; CHEMISTRY, PHYSICAL; CROSS-LINKING REAGENTS; DRUG CARRIERS; DRUG COMPOUNDING; EMULSIONS; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; HYDROGEN-ION CONCENTRATION; MICROSPHERES; PARTICLE SIZE; VISCOSITY;

EID: 0038784356     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.1080/0265204031000093069     Document Type: Article

References (10)

1. CHAN, L. W., HENG, P. W. S. and WAN, L. S. C., 1997, Effect of cellulose derivatives on alginate microspheres prepared by emulsification. Journal of Microencapsulation, 14, 545-555.
2. CUSSLER, E.L., 1997, Diffusion: mass transfer in fluid systems (Cambridge: Cambridge University Press).
3. FUNDUEANU, G., ESPOSITO, E., MIHAI, D., CARPOR, A., DESBRIERES, J., RINAUDO, M. and NASTRUZZI, C., 1998, Preparation and characterization of Ca-alginate microspheres by a new emulsification method. International Journal of Pharmaceutics, 170, 11-21.
4. GOMBOTZ, W. R. and WEE, S. F., 1998, Protein release from alginate matrices. Advanced Drug Delivery Reviews, 31, 267-285.
5. THU, B., SKJÄK-BRÆK, G., MICALI, F., VITTUR, F. and RIZZO, R., 1997, The spatial distribution of calcium in alginate gel beads analysed by synchroton-radiation induced X-ray emission (SRIXE). Carbohydrate Research, 297, 101-105.
6. WAN, L. S. C., HENG, P. W. S. and CHAN, L. W., 1993, Influence of hydrophile-lipophile balance on alginate microspheres. International Journal of Pharmaceutics, 95, 77-83.
7. WAN, L. S. C., HENG, P. W. S. and CHAN, L. W., 1994, Surfactant effects on alginate microspheres. International Journal of Pharmaceutics, 103, 267-275.
8. WANG, X. and SPENCER, H. G., 1998, Calcium alginate gels: formation and stability in the presence of inert electrolyte. Polymer, 139, 2759-2764.
9. WONG, T. W., LEE, H. Y., CHAN, L. W. and HENG, P. W. S., 2002, Release characteristics of pectinate microspheres prepared by an emulsification technique. Journal of Microencapsulation, 19, 511-522.
10. WONG, T. W., WAN, L. S. C. and HENG, P. W. S., 1999, Effects of physical properties of PEG 6000 on pellets produced by melt pelletization. Pharmaceutical Development and Technology, 4, 449-456.