Preparation and in vitro release studies of ibuprofen-loaded films and microspheres made from graft copolymers of poly(l-lactic acid) on acrylic backbones

Journal of Controlled Release

Volumn 55, Issue 2-3, 1998, Pages 171-179

  Gallardo, Alberto ^a   Eguiburu, José Luis ^b   Fernandez Berridi, María José ^b   San Román, Julio ^a  

^a INSTITUTO DE CIENCIA Y TECNOLOGÍA DE POLÍMEROS   (Spain)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Biodegradable delivery systems; Controlled release; Films and microspheres; Ibuprofen; PLLA graft copolymers

Indexed keywords

1 VINYL 2 PYRROLIDINONE; COPOLYMER; IBUPROFEN; METHACRYLIC ACID; MICROSPHERE; NONSTEROID ANTIINFLAMMATORY AGENT;

BIODEGRADATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FILM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SHORT SURVEY;

EID: 0031751190     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(98)00047-9     Document Type: Article

References (20)

1. M. Chasin, in J.O. Hollinger (Editor), Biomedical Applications of Synthetic Biodegradable Polymers, CRC Press, NY, 1995, p. 1.
2. R.L. Dunn, in J.O. Hollinger (Editor), Biomedical Applications of Synthetic Biodegradable Polymers, CRC Press, NY, 1995, p. 17.
3. S.M. Li, S. Girod-Holland, M. Vert, Hydrolytic dedradation of poly(DL-lactic acid) in the presence of caffeine base, J. Control. Release 40 (1996) 41-53.
4. S.M. Li and M. Vert, in G. Scott and D. Gilead (Editors), Degradable Polymers - Principles and Applications, Chapman and Hall, London, 1995, p. 43.
5. T.M. Jackanicz, D.L. Nash, D.L. Wise, J.B. Gregory, Polylactic acid as a biodegradable carrier for contraceptive steroids, Contraception 8 (1973) 227-234.
6. L.R. Beck, D.R. Cowsar, D.H. Lewis, R.S. Cosgrove, C.T. Riddle, S.L. Lowry, T. Epperly, A new long-acting injectable microcapsule system for the administration of progesterone, Pert. Steril. 31 (1979) 545-551.
7. A.D. Schowpe, D.L. Wise, J.F. Howes, Lactic/glycolic acid polymers as narcotic antagonist delivery system, Life Sci. 17 (1975) 1877-1886.
8. J.L. Eguiburu, M.J. Fernández-Berridi, J. San Román, Graft copolymers for biomedical applications prepared by free radical polymerization of poly(L-lactide) macromonomers with vinyl and acrylic monomers, Polymer 37 (1996) 3615-3622.
9. P. Menei, A. Croué, V. Daniel, A. Pouplard-Barthelaix, J.P. Benoit, Fate and biocompatability of three types of microspheres implanted into the brain, J. Biomed. Mat. Res. 28 (1994) 1079-1085.
10. V. Bühler, Poly(vinyl pyrrolidone) for the Pharmaceutical Industry, BASF, Germany, 2nd ed., 1993.
11. D. Arcos, MV. Cabañas, C.V. Ragel, M. Vallet-Regí, J. San Román, Ibuprofen release from hydrophilic ceramic-polymer composites, Biomaterials 18 (1997) 1235-1242.
12. S. Keipert, R. Voigt, K.H. Schwarz, Interactions between macromolecular adjuvants and drugs, 20: propipocaine-polyvinylpyrrolidone associates, Pharmazie 35 (1980) 35.
13. E.I. Zaharieva, G.G. Georgiev, C.I. Konstantinov, Coated reactive carriers based on copolymers of N-vinyl-2-pyrrolidone and maleic anhydride for immobilization of enzymes, Biomaterials 17 (1996) 1609-1613.
14. J.A. Plaizier-Vercammen, R.E. De Neve, Interactions of povidone with aromatic compounds III: thermodynamics of the binding equilibria and interaction forces in buffer solutions at varying pH values and varying dielectric constant, J. Pharm. Sci. 71 (1982) 52-556.
15. A.A. Abdel Azin, H. Tenhu, J. Maerta, F. Sundholm, Flexibility and hydrodynamic properties of poly(vinyl pyrrolidone) in non-ideal solvents, Polym. Bull. 29 (1992) 461-467.
16. C.G. Pitt, in M. Vert, J. Feijen, A. Albertsson, G. Scott and E. Chiellini (Editors), Proceedings of the Second International Scientific Workshop on Biodegradable Polymers and Plastics, Montpellier, France, 1991.
17. E.A. Schmitt, D.R. Flanagan, R.J. Linhardt, Importance of distinct water environments in the hydrolysis of poly(DL-lactide-co-glycolide), Macromolecules 27 (1994) 743.
18. S.M. Li, H. Garreau, M. Vert, Structure-property relationships in the case of the degradation of massive poly (α-hydroxy acids) in the aqueous media. Part 1: Poly(DL-lactic acid), J. Mater. Sci. Mater. Med. 1 (1990) 123-130.
19. S.M. Li, H. Garreau, M. Vert, Structure-property relationships in the case of the degradation of massive poly (α-hydroxy acids) in the aqueous media. Part 2: Degradation of lactide/glycolide copolymers: PLA37.5GA25 and PLA75GA25, J. Mater. Sci. Mater. Med. 1 (1990) 131-136.
20. S.M. Li, H. Garreau, M. Vert, Structure-property relationships in the case of the degradation of massive poly (α-hydroxy acids) in the aqueous media. Part 3: Influence of the morphology of poly(L-lactic acid), J. Mater. Sci. Mater. Med. 1 (1990) 198-206.