Indatraline inhibits Rho- and calcium-mediated glioblastoma cell motility and angiogenesis

Biochemical and Biophysical Research Communications

Volumn 443, Issue 2, 2014, Pages 749-755

  Heo, Jin Chul ^a   Jung, Tae Hoon ^a,b   Jung, Dae Young ^a   Park, Woo Kyu ^a   Cho, Heeyeong ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

Glioblastoma multiforme; Indatraline; Proneural; Rho GTP

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM; INDATRALINE; NESTIN; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLEIOTROPHIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 2; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CELL MIGRATION; CELL MOTILITY; CELL SPREADING; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; DRUG POTENCY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL;

GBM; GLIOBLASTOMA MULTIFORME; IGFBP2; INDATRALINE; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2; PDGFRA; PLATELET-DERIVED GROWTH FACTOR RECEPTOR ALPHA; PLEIOTROPIN; PRONEURAL; PTN; RHO-GTP; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR; VEGFA; VEGFR;

ANGIOGENIC PROTEINS; CALCIUM; CELL MOVEMENT; DOWN-REGULATION; GLIOBLASTOMA; HUMANS; INDANS; METHYLAMINES; NEOVASCULARIZATION, PATHOLOGIC; RHO GTP-BINDING PROTEINS; TUMOR CELLS, CULTURED;

EID: 84892431106     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.12.046     Document Type: Article

References (38)

1. L.M. DeAngelis Brain tumors N. Engl. J. Med. 344 2001 114 123
2. R.V. Patwardhan, C. Shorter, and B.K. Willis et al. Survival trends in elderly patients with glioblastoma multiforme: resective surgery, radiation, and chemotherapy Surg. Neurol. 62 2004 207 213
3. J.D. van der Meulen, H.J. Houthoff, and E.J. Ebels Glial fibrillary acidic protein in human gliomas Neuropathol. Appl. Neurobiol. 4 1978 177 190
4. R.G. Verhaak, K.A. Hoadley, and E. Purdom et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 Cancer Cell 17 2010 98 110
5. J. Silber, A. Jacobsen, and T. Ozawa et al. MiR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis PLoS One 7 2012 e33844
6. S.R. Kim, M.K. Bae, and J.Y. Kim et al. Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells Biochem. Biophys. Res. Commun. 387 2009 342 347
7. H. Liu, D. Han, and Y. Liu et al. Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma J. Neurooncol. 112 2013 39 48
8. H. Jin, L. Liang, and L. Liu et al. HDAC inhibitor DWP0016 activates p53 transcription and acetylation to inhibit cell growth in U251 glioblastoma cells J. Cell. Biochem. 114 2013 1498 1509
9. G.R. Sareddy, D. Kesanakurti, and P.B. Kirti et al. Nonsteroidal anti-inflammatory drugs diclofenac and celecoxib attenuates Wnt/Beta-catenin/Tcf signaling pathway in human glioblastoma cells Neurochem. Res. 38 2013 2313 2322
10. D.N. Louis, H. Ohgaki, and O.D. Wiestler The 2007 WHO classification of tumours of the central nervous system Acta Neuropathol. 114 2007 97 109
11. K.M. Joo, S.Y. Kim, and X. Jin et al. Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas Lab. Invest. 88 2008 808 815
12. W. Gough, K.I. Hulkower, and R. Lynch et al. A quantitative, facile, and high-throughput image-based cell migration method is a robust alternative to the scratch assay J. Biomol. Screen. 16 2011 155 163
13. J.C. Heo, J.Y. Park, and S.U. Woo et al. Dykellic acid inhibits cell migration and tube formation by RhoA-GTP expression Biol. Pharm. Bull. 29 2006 2256 2259
14. P.T. Witkowski, L. Schuenadel, and J. Wiethaus et al. Cellular impedance measurement as a new tool for poxvirus titration, antibody neutralization testing and evaluation of antiviral substances Biochem. Biophys. Res. Commun. 401 2010 37 41
15. R. Maddala, V.N. Reddy, and D.L. Epstein et al. Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells Mol. Vis. 9 2003 329 336
16. J.C. Heo, and S.H. Lee Alleviation of asthma-related symptoms by a derivative of L-allo threonine Int. J. Mol. Med. 31 2013 881 887
17. R.A. Vongsa, N.P. Zimmerman, and M.B. Dwinell CCR6 regulation of the actin cytoskeleton orchestrates human beta defensin-2- and CCL20-mediated restitution of colonic epithelial cells J. Biol. Chem. 284 2009 10034 10045
18. E.E. Govek, S.E. Newey, and L. Van Aelst The role of the Rho GTPases in neuronal development Genes Dev. 19 2005 1 49
19. P.A. Geomela, C.K. Kontos, and I. Yiotakis et al. Quantitative expression analysis of the apoptosis-related gene, BCL2L12, in head and neck squamous cell carcinoma J. Oral Pathol. Med. 42 2013 154 161
20. M.R. Youn, M.H. Park, and C.K. Choi et al. Direct binding of recombinant plasminogen kringle 1-3 to angiogenin inhibits angiogenin-induced angiogenesis in the chick embryo CAM Biochem. Biophys. Res. Commun. 343 2006 917 923
21. M.S. Kleven, J.M. Kamenka, and J. Vignon et al. Pharmacological characterization of the discriminative stimulus properties of the phencyclidine analog, N-[1-(2-benzo(b)thiophenyl)-cyclohexyl]piperidine Psychopharmacology (Berl) 145 1999 370 377
22. Y. Yongjun, H. Shuyun, and C. Lei et al. Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression J. Neuroimmunol. 260 2013 1 8
23. V.F. Curtis, H. Wang, and P. Yang et al. A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer PLoS One 8 2013 e54916
24. K. Miekus, J. Kijowski, and M. Sekula et al. 17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion Oncol. Rep. 28 2012 1903 1909
25. M.G. Cattaneo, E. Cappellini, and L.M. Vicentini Silencing of Eps8 blocks migration and invasion in human glioblastoma cell lines Exp. Cell Res. 318 2012 1901 1912
26. F. Lefranc, S. Sauvage, and G. Van Goietsenoven et al. Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells Mol. Cancer Ther. 8 2009 1739 1750
27. T. Strojnik, G.V. Rosland, and P.O. Sakariassen et al. Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: correlation of nestin with prognosis of patient survival Surg. Neurol. 68 2007 133 143 discussion 143-134
28. T. Ishiwata, K. Teduka, and T. Yamamoto et al. Neuroepithelial stem cell marker nestin regulates the migration, invasion and growth of human gliomas Oncol. Rep. 26 2011 91 99
29. T. Fukushima, and H. Kataoka Roles of insulin-like growth factor binding protein-2 (IGFBP-2) in glioblastoma Anticancer Res. 27 2007 3685 3692
30. U. Ulbricht, M.A. Brockmann, and A. Aigner et al. Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas J. Neuropathol. Exp. Neurol. 62 2003 1265 1275
31. Y.H. Zhou, Y. Hu, and D. Mayes et al. PAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor A J. Neurooncol. 96 2010 191 200
32. G. Santoni, M. Santoni, and M. Nabissi Functional role of T-type calcium channels in tumour growth and progression: prospective in cancer therapy Br. J. Pharmacol. 166 2012 1244 1246
33. H.S. Jang, S. Lal, and J.A. Greenwood Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2 Neurochem. Res. 35 2010 1796 1804
34. 2+ and Rho GTPase signaling pathways underlying activity-dependent actin remodeling at dendritic spines Cytoskeleton (Hoboken) 69 2012 545 554
35. S.P. Fortin, M.J. Ennis, and C.A. Schumacher et al. Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells Mol. Cancer Res. 10 2012 958 968
36. E. Malchinkhuu, K. Sato, and T. Maehama et al. S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN Biochem. Biophys. Res. Commun. 366 2008 963 968
37. L. Goldberg, and Y. Kloog A Ras inhibitor tilts the balance between Rac and Rho and blocks phosphatidylinositol 3-kinase-dependent glioblastoma cell migration Cancer Res. 66 2006 11709 11717
38. M. Paez-Ribes, E. Allen, and J. Hudock et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis Cancer Cell 15 2009 220 231