The role of brain-derived neurotrophic factor in the pathophysiology of suicidal behavior

Psychiatria Danubina

Volumn 25, Issue SUPPL.2, 2013, Pages

  Paska, Alja Videtič ^a   Zupanc, Tomaž ^a   Pregelj, Peter ^a,b  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY PSYCHIATRIC HOSPITAL   (Slovenia)

Author keywords

Brain Derived Neurotrophic Factor; Polymorphism; Suicidal behaviour; Suicide; Tropomyosin related kinase B

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; RECEPTOR; TROPOMYOSIN RELATED KINASE B RECEPTOR; UNCLASSIFIED DRUG;

CONFERENCE PAPER; EPIGENETICS; GENE EXPRESSION; GENETIC POLYMORPHISM; HUMAN; META ANALYSIS (TOPIC); NERVE CELL PLASTICITY; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; RISK FACTOR; SUICIDAL BEHAVIOR;

EID: 84892420177     PISSN: 03535053     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (22)

1. Costanza A, D'Orta I, Perroud N, Burkhardt S, Malafosse A, et al. Neurobiology of suicide: do biomarkers exist? Int J Legal Med 2013 [Epub ahead of print].
2. de León-Guerrero SD, Pedraza-Alva G & Pérez- Martínez L. In sickness and in health: the role of methyl-CpG binding protein 2 in the central nervous system. Eur J Neurosci 2011; 33:1563-74.
3. Duman RS & Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006; 59:1116-27.
4. Duman RS, Heninger GR & Nestler EJ. A molecular and cellular theory of depression. Archives of General Psychiatry 1997; 54:597-606.
5. Dwivedi Y. Brain-Derived Neurotrophic Factor in Suicide Pathophysiology. In: Dwivedi Y, editor. The Neurobiological Basis of Suicide. Boca Raton (FL): CRC Press; 2012. Chapter 8. Frontiers in Neuroscience.
6. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al.: The BDNF Val66Met polymorphism affects activitydependent secretion of BDNF and human memory and hippocampal function. Cell 2003; 112:257-69.
7. Ernst C, Deleva V, Deng X, Sequeira A, Pomarenski A et al. Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers. Arch Gen Psychiatry 2009; 66:22-32.
8. Fernandes CC, Pinto-Duarte A, Ribeiro JA & Sebastião AM. Postsynaptic action of brain-derived neurotrophic factor attenuates alpha7 nicotinic acetylcholine receptor-mediated responses in hippocampal interneurons. J. Neurosci 2008; 28:5611-8.
9. Keller S, Sarchiapone M, Zarrilli F, Tomaiuolo R, Carli V, Angrisano T, et al.: TrkB gene expression and DNA methylation state in Wernicke area does not associate with suicidal behaviour. J Affect Disord 2011;135:400-4.
10. Keller S, Sarchiapone M, Zarrilli F, Videtic A, Ferraro A, Carli V, et al: Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry 2010; 67:258-67.
11. Kusenda B, Mraz M & Mayer J. Pospisilova S. MicroRNA biogenesis, functionality and cancer relevance. Biomedical papers 2006; 150:205-15.
12. Levi F, La Vecchia C, Lucchini F, Negri E, Saxena S, Maulik PK, et al.: Trends in mortality from suicide, 1965-99. Acta Psychiatr Scand 2003; 108:341-9.
13. Lönnqvist, J.K, Henriksson, M.M, Isometsä, E.T, Marttunen, M.J, Heikkinen, M.E, Aro, et al.: Mental disorders and suicide prevention. Psychiatry Clin. Neurosci 1995; 49(Suppl 1):111-6.
14. Mann JJ & Currier DM. Stress, genetics and epigenetic effects on the neurobiology of suicidal behavior and depression. Eur Psychiatry 2010; 25:268-71.
15. Patapoutian A & Reichardt LF. Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 2001; 11:272-80.
16. Pregelj P, Nedic G, Paska AV, Zupanc T, Nikolac M, Balažic J, et al.: The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide. J Affect Disord 2011; 128:287-90.
17. Ratta-Apha W, Hishimoto A, Yoshida M, Ueno Y, Asano M, et al. Association study of BDNF with completed suicide in the Japanese population. Psychiatry Res 2013; S0165-1781:307-7.
18. Riccio A. Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways. Nat Neurosci 2010; 13:1330-7.
19. Russo-Neustadt A: Brain-derived neurotrophic factor, behaviour, and new directions for the treatment of mental disorders. Semin Clin Neuropsychiatry 2003; 8:109-18.
20. Sher L. The role of brain-derived neurotrophic factor in the pathophysiology of adolescent suicidal behavior. Int J Adolesc Med Health 2011; 23:181-5.
21. van Heeringen C, Bijttebier S &Godfrin K. Suicidal brains: a review of functional and structural brain studies in association with suicidal behaviour. Neurosci Biobehav Rev. 2011; 35:688-98.
22. Zai CC, Manchia M, De Luca V, Tiwari AK, Chowdhury NI, Zai GC et al.: The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis. Int J Neuropsychopharmacol 2011; 30:1-6.