Neurobiology of suicide: Do biomarkers exist?

International Journal of Legal Medicine

Volumn 128, Issue 1, 2014, Pages 73-82

  Costanza, Alessandra ^a   D'Orta, Isabella ^a   Perroud, Nader ^a,b   Burkhardt, Sandra ^c   Malafosse, Alain ^a,b   Mangin, Patrice ^c   La Harpe, Romano ^c  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c UNIVERSITY CENTER OF LEGAL MEDICINE   (Switzerland)

Author keywords

Biomarkers; Suicide; Suicide behavior; Suicide completion

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; POLYAMINE; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

BLOOD; BRAIN; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC POLYMORPHISM; GENETICS; HUMAN; LEGAL ASPECT; PATHOPHYSIOLOGY; PREDICTIVE VALUE; PSYCHOLOGICAL ASPECT; REVIEW; RISK FACTOR; SUICIDE;

BIOLOGICAL MARKERS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; GENETIC ASSOCIATION STUDIES; GENETIC MARKERS; HUMANS; NERVE GROWTH FACTORS; NEUROTRANSMITTER AGENTS; POLYAMINES; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; RISK FACTORS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SUICIDE;

EID: 84891831659     PISSN: 09379827     EISSN: 14371596     Source Type: Journal    
DOI: 10.1007/s00414-013-0835-6     Document Type: Review

References (30)

1. Krug EG, Mercy JA, Dahlberg LL, Zwi AB (2002) The world report on violence and health. Lancet 360:1083-1088
2. Turecki G, Ernst C, Jollant F, Labonté B, Mechawar N (2012) The neurodevelopmental origins of suicidal behavior. Trends Neurosci 35:14-23
3. Hawton K, van Heeringen K (2009) Suicide. Lancet 373:1372-1381
4. Brezo J, Paris J, Vitaro F, Hébert M, Tremblay RE, Turecki G (2008) Predicting suicide attempts in young adults with histories of childhood abuse. Br J Psychiatry 193:134-139
5. Qin P, Agerbo E, Bo Mortensen PB (2003) Suicide risk in relation to socioeconomic, demographic, psychiatric, and familial factors: a national register-based study of all suicides in Denmark, 1981-1997. Am J Psychiatry 160:765-772
6. Mann JJ (2003) Neurobiology of suicidal behavior. Nat Rev Neurosci 4:819-828
7. Ernst C, Mechawar N, Turecki G (2009) Suicide neurobiology. Prog Neurobiol 89:315-333
8. Klempan TA, Sequeira A, Canetti L, Lalovic A, Ernst C, ffrench-Mullen J, Turecki G (2009) Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression. Mol Psychiatry 14:175-189
9. Fiori LM, Turecki G (2010) Gene expression profiling of suicide completers. Eur Psychiatry 25:287-290
10. Sequeira A, Morgan L, Walsh DM, Cartagena PM, Choudary P, Li J, Schatzberg AF, Watson SJ, Akil H, Myers RM, Jones EG, Bunney WE, Vaeter MP (2012) Gene expression changes in the prefrontal cortex, anterior cingulate cortex and nucleus accumbens of mood disorders subjects that committed suicide. PLoS One 7:e35367
11. Bondy B, Buettner A, Zill P (2006) Genetics of suicide. Mol Psychiatry 11:336-351
12. Leboyer M, Slama F, Siever BF (2005) Suicidal disorders: a nosological entity per se? Am J Med Genet C Semin Med Genet 133C:3-7
13. Perroud N, Neidhart E, Petit B, Vessaz M, Laforge T, Relecom C, La Harpe R, Malafosse A, Guipponi M (2010) Simultaneous analysis of serotonin transporter, tryptophan hydroxylase 1 and 2 gene expression in the ventral prefrontal cortex of suicide victims. Am J Med Genet Part B 153B:909-918
14. Bondy B, Erfurth A, de Jonge S, Krüger M, Meyer H (2000) Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide. Mol Psychiatry 5:193-195
15. Zalsman G, Molcho A, Huang Y, Dwork A, Li S, Mann JJ (2005) Postmortem mu-opioid receptor binding in suicide victims and controls. J Neural Transm 112:949-954
16. Coryell W, Schlesser M (2001) The dexamethasone suppression test and suicide prediction. Am J Psychiatry 158:748-753
17. Perroud N, Paoloni-Giacobino A, Prada P, Olié E, Salzmann A, Nicastro R, Guillaume S, Mouthon D, Stouder C, Dieben K, Huguelet P, Courtet P, Malafosse A (2011) Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma. Transl Psychiatry. doi: 10.1038/tp.2011.60
18. McGowan PO, Sasaki A, D'Alessio A, Dymov S, Labonté B, Szyf M, Turecki G, Meaney MJ (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12:342-348
19. H expression and methylation in suicide completers with a history of childhood abuse. Biol Psychiatry. doi: 10.1016/j.biopsych. 2012.01.034
20. Keller S, Sarchiapone M, Zarrilli F, Videtic A, Ferraro A, Carli V, Sacchetti S, Lembo F, Angiolillo A, Jovanovic N, Pisanti F, Tomaiuolo R, Monticelli A, Balazic J, Roy A, Marusic A, Cocozza S, Fusco A, Bruni CB, Castaldo G, Chiariotti L (2010) Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry 67:258-267
21. Karege F, Perroud N, Burkhardt S, Fernandez R, Ballmann E, La Harpe R, Malafosse A (2011) Alterations in phosphatidylinositol 3-kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims. Neuropsychobiology 63:224-231
22. Zhang L, Su TP, Choi K, Maree W, Li CT, Chung MY, Chen YS, Bai YM, Chou YH, Barker JL, Barrett JE, Li XX, Li H, Benedek DM, Ursano R (2011) P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide. J Psychiatr Res 45:435-441
23. Pandey GN, Dwivedi Y (2010) What can post-mortem studies tell us about the pathoetiology of suicide? Future Neurol 5:701-720
24. Fiori LM, Turecki G (2010) Genetic and epigenetic influences on expression of spermine synthase and spermine oxidase in suicide completers. Int J Neuropsychopharmacol 13:725-736
25. Torres-Platas SG, Hercher C, Davoli MA, Maussion G, Labonté B, Turecki G, Mechawar N (2011) Astrocytic hypertrophy in anterior cingulated white matter of depressed suicides. Neuropsychopharmachology 36:2650-2658
26. Ernst C, Nagy C, Kim S, Yang JP, Deng X, Hellstrom IC, Choi KH, Gershenfeld H, Meaney MJ, Turecki G (2011) Dysfunction of astrocyte connexins 30 and 43 in dorsal lateral prefrontal cortex of suicide completers. Biol Psychiatry 70:312-319
27. Underwood MD, Arango V (2011) Evidence for neurodegeneration and neuroplasticity as part of the neurobiology of suicide. Biol Psychiatry 70:306-307
28. Jollant F, Lawrence NL, Olié E, Guillaume S, Courtet P (2011) The suicidal mind and brain: a review of neuropsychological and neuroimaging studies. World J Biol Psychiatry 12:319-339
29. Courtet P, Gottesman II, Jollant F, Gould TD (2011) The neuroscience of suicidal behaviors: what can we expect from endophenotype strategies? Transl Psychiatry 1(5):e7. doi: 10.1038/tp.2011.6
30. Turecki G (2005) Dissecting the suicide phenotype: the role of impulsive-aggressive behaviors. J Psychiatry Neurosci 30:398-408