Platelet-rich plasma in orthopaedic applications: Evidence-based recommendations for treatment

Journal of the American Academy of Orthopaedic Surgeons

Volumn 21, Issue 12, 2013, Pages 739-748

  Hsu, Wellington K ^a   Mishra, Allan ^b   Rodeo, Scott R ^c   Fu, Freddie ^d   Terry, Michael A ^a   Randelli, Pietro ^e   Canale, S Terry ^f   Kelly, Frank B ^g  

^a NORTHWESTERN UNIVERSITY   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^c HOSPITAL FOR SPECIAL SURGERY   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MILAN   (Italy)

^f UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^g Forsyth Street Orthopaedics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN; ORTHOPEDIC SURGERY; PHYSIOLOGY; PRACTICE GUIDELINE; PROCEDURES; SOFT TISSUE INJURIES; THROMBOCYTE RICH PLASMA; WOUND HEALING; METHODOLOGY; REVIEW; SOFT TISSUE INJURY;

HUMANS; ORTHOPEDIC PROCEDURES; PLATELET-RICH PLASMA; PRACTICE GUIDELINES AS TOPIC; SOFT TISSUE INJURIES; WOUND HEALING;

EID: 84892396827     PISSN: 1067151X     EISSN: None     Source Type: Journal    
DOI: 10.5435/JAAOS-21-12-739     Document Type: Review

References (63)

1. PRP an Unproven Option, Say Experts. Available at: Http://www.aaos.org/ news/acadnews/2011/AAOS1-2-16.asp. Accessed September 23, 2013.
2. Patel S, Dhillon MS, Aggarwal S, Marwaha N, Jain A: Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: A prospective, double-blind, randomized trial. Am J Sports Med 2013;41(2):356-364.
3. Cerza F, Carnì S, Carcangiu A, et al: Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis. Am J Sports Med 2012; 40(12):2822-2827.
4. Filardo G, Kon E, Di Martino A, et al: Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: Study design and preliminary results of a randomized controlled trial. BMC Musculoskelet Disord 2012;13:229.
5. Thanasas C, Papadimitriou G, Charalambidis C, Paraskevopoulos I, Papanikolaou A: Platelet-rich plasma versus autologous whole blood for the treatment of chronic lateral elbow epicondylitis: A randomized controlled clinical trial. Am J Sports Med 2011; 39(10):2130-2134.
6. Gosens T, Peerbooms JC, van Laar W, den Oudsten BL: Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: A double-blind randomized controlled trial with 2-year follow-up. Am J Sports Med 2011;39(6): 1200-1208.
7. Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T: Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: Platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. Am J Sports Med 2010;38(2):255-262.
8. de Vos RJ, Weir A, van Schie HT, et al: Platelet-rich plasma injection for chronic Achilles tendinopathy: A randomized controlled trial. JAMA 2010;303(2):144-149.
9. de Jonge S, de Vos RJ, Weir A, et al: One-year follow-up of platelet-rich plasma treatment in chronic Achilles tendinopathy: A double-blind randomized placebo-controlled trial. Am J Sports Med 2011;39(8):1623-1629.
10. Gosens T, Den Oudsten BL, Fievez E, van 't Spijker P, Fievez A: Pain and activity levels before and after plateletrich plasma injection treatment of patellar tendinopathy: A prospective cohort study and the influence of previous treatments. Int Orthop 2012; 36(9):1941-1946.
11. Nin JR, Gasque GM, Azcárate AV, Beola JD, Gonzalez MH: Has platelet-rich plasma any role in anterior cruciate ligament allograft healing Arthroscopy 2009;25(11):1206-1213.
12. Cervellin M, de Girolamo L, Bait C, Denti M, Volpi P: Autologous plateletrich plasma gel to reduce donor-site morbidity after patellar tendon graft harvesting for anterior cruciate ligament reconstruction: A randomized, controlled clinical study. Knee Surg Sports Traumatol Arthrosc 2012;20(1):114-120.
13. de Almeida AM, Demange MK, Sobrado MF, Rodrigues MB, Pedrinelli A, Hernandez AJ: Patellar tendon healing with platelet-rich plasma: A prospective randomized controlled trial. Am J Sports Med 2012;40(6):1282-1288.
14. Castricini R, Longo UG, De Benedetto M, et al: Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: A randomized controlled trial. Am J Sports Med 2011;39(2):258-265.
15. Randelli P, Arrigoni P, Ragone V, Aliprandi A, Cabitza P: Platelet rich plasma in arthroscopic rotator cuff repair: A prospective RCT study, 2-year follow-up. J Shoulder Elbow Surg 2011; 20(4):518-528.
16. Everts PA, Devilee RJ, Brown Mahoney C, et al: Exogenous application of platelet-leukocyte gel during open subacromial decompression contributes to improved patient outcome: A prospective randomized double-blind study. Eur Surg Res 2008;40(2):203-210.
17. Bibbo C, Bono CM, Lin SS: Union rates using autologous platelet concentrate alone and with bone graft in high-risk foot and ankle surgery patients. J Surg Orthop Adv 2005;14(1):17-22.
18. Mei-Dan O, Carmont MR, Laver L, Mann G, Maffulli N, Nyska M: Plateletrich plasma or hyaluronate in the management of osteochondral lesions of the talus. Am J Sports Med 2012;40(3): 534-541.
19. Mishra A, Pavelko T: Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med 2006;34(11):1774-1778.
20. Silva A, Sampaio R: Anatomic ACL reconstruction: Does the platelet-rich plasma accelerate tendon healing Knee Surg Sports Traumatol Arthrosc 2009; 17(6):676-682.
21. Orrego M, Larrain C, Rosales J, et al: Effects of platelet concentrate and a bone plug on the healing of hamstring tendons in a bone tunnel. Arthroscopy 2008; 24(12):1373-1380.
22. Rodeo SA, Delos D, Williams RJ, Adler RS, Pearle A, Warren RF: The effect of platelet-rich fibrin matrix on rotator cuff tendon healing: A prospective, randomized clinical study. Am J Sports Med 2012;40(6):1234-1241.
23. Jo CH, Kim JE, Yoon KS, et al: Does platelet-rich plasma accelerate recovery after rotator cuff repair A prospective cohort study. Am J Sports Med 2011; 39(10):2082-2090.
24. Schepull T, Kvist J, Norrman H, Trinks M, Berlin G, Aspenberg P: Autologous platelets have no effect on the healing of human achilles tendon ruptures: A randomized single-blind study. Am J Sports Med 2011;39(1):38-47.
25. Tsai CH, Hsu HC, Chen YJ, Lin MJ, Chen HT: Using the growth factorsenriched platelet glue in spinal fusion and its efficiency. J Spinal Disord Tech 2009;22(4):246-250.
26. Carreon LY, Glassman SD, Anekstein Y, Puno RM: Platelet gel (AGF) fails to increase fusion rates in instrumented posterolateral fusions. Spine (Phila Pa 1976) 2005;30(9):E243-E246, discussion E247.
27. Weiner BK, Walker M: Efficacy of autologous growth factors in lumbar intertransverse fusions. Spine (Phila Pa 1976) 2003;28(17):1968-1970, discussion 1971.
28. Filardo G, Kon E, Della Villa S, Vincentelli F, Fornasari PM, Marcacci M: Use of platelet-rich plasma for the treatment of refractory jumper's knee. Int Orthop 2010;34(6):909-915.
29. Radice F, Yánez R, Gutiérrez V, Rosales J, Pinedo M, Coda S: Comparison of magnetic resonance imaging findings in anterior cruciate ligament grafts with and without autologous platelet-derived growth factors. Arthroscopy 2010;26(1): 50-57.
30. Sánchez M, Anitua E, Azofra J, Andía I, Padilla S, Mujika I: Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. Am J Sports Med 2007;35(2):245-251.
31. Marx RE: Platelet-rich plasma: Evidence to support its use. J Oral Maxillofac Surg 2004;62(4):489-496.
32. Tayapongsak P, O'Brien DA, Monteiro CB, Arceo-Diaz LY: Autologous fibrin adhesive in mandibular reconstruction with particulate cancellous bone and marrow. J Oral Maxillofac Surg 1994; 52(2):161-165, discussion 166.
33. Hall MP, Band PA, Meislin RJ, Jazrawi LM, Cardone DA: Platelet-rich plasma: Current concepts and application in sports medicine. J Am Acad Orthop Surg 2009;17(10):602-608.
34. Mazzocca AD, McCarthy MB, Chowaniec DM, et al: Platelet-rich plasma differs according to preparation method and human variability. J Bone Joint Surg Am 2012;94(4):308-316.
35. DeLong JM, Russell RP, Mazzocca AD: Platelet-rich plasma: The PAW classification system. Arthroscopy 2012; 28(7):998-1009.
36. Wasterlain AS, Braun HJ, Harris AH, Kim HJ, Dragoo JL: The systemic effects of platelet-rich plasma injection. Am J Sports Med 2013;41(1):186-193.
37. Harris SE, Bonewald LF, Harris MA, et al: Effects of transforming growth factor beta on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts. J Bone Miner Res 1994;9(6):855-863.
38. Han B, Woodell-May J, Ponticiello M, Yang Z, Nimni M: The effect of thrombin activation of platelet-rich plasma on demineralized bone matrix osteoinductivity. J Bone Joint Surg Am 2009;91(6):1459-1470.
39. Castillo TN, Pouliot MA, Kim HJ, Dragoo JL: Comparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systems. Am J Sports Med 2011;39(2):266-271.
40. Sundman EA, Cole BJ, Fortier LA: Growth factor and catabolic cytokine concentrations are influenced by the cellular composition of platelet-rich plasma. Am J Sports Med 2011;39(10): 2135-2140.
41. Metcalf KB, Mandelbaum BR, McIlwraith CW: Application of plateletrich plasma to disorders of the knee joint. Cartilage 2013;4(4):295-312.
42. Harvest Terumo: SmartPrep2: The Optimal Platelet Rich Plasma Composition. Available at: Http://www.harvesttech.com/pdf/SL-021-0961-PRPCorporateBrochure. pdf. Accessed October 3, 2013.
43. Fallouh L, Nakagawa K, Sasho T, et al: Effects of autologous platelet-rich plasma on cell viability and collagen synthesis in injured human anterior cruciate ligament. J Bone Joint Surg Am 2010;92(18):2909-2916.
44. Leitner GC, Koszik F, Rudnicki T, et al: Apheresis products of the Amicus and the AS.TEC 204 cell separators are comparable with regard to dendritic cells derived from the mononuclear cell collection. Vox Sang 2007;92(1):37-41.
45. Mazzucco L, Balbo V, Cattana E, Guaschino R, Borzini P: Not every PRPgel is born equal: Evaluation of growth factor availability for tissues through four PRP-gel preparations. Fibrinet, RegenPRP-Kit, Plateltex and one manual procedure. Vox Sang 2009;97(2):110-118.
46. Weibrich G, Kleis WK, Hitzler WE, Hafner G: Comparison of the platelet concentrate collection system with the plasma-rich-in-growth-factors kit to produce platelet-rich plasma: A technical report. Int J Oral Maxillofac Implants 2005;20(1):118-123.
47. Giusti I, Rughetti A, D'Ascenzo S, et al: Identification of an optimal concentration of platelet gel for promoting angiogenesis in human endothelial cells. Transfusion 2009; 49(4):771-778.
48. Mishra A, Harmon K, Woodall J, Vieira A: Sports medicine applications of platelet rich plasma. Curr Pharm Biotechnol 2012;13(7):1185-1195.
49. Okamoto S, Ikeda T, Sawamura K, et al: Positive effect on bone fusion by the combination of platelet-rich plasma and a gelatin -tricalcium phosphate sponge: A study using a posterolateral fusion model of lumbar vertebrae in rats. Tissue Eng Part A 2012;18(1-2):157-166.
50. Iqbal J, Pepkowitz SH, Klapper E: Platelet-rich plasma for the replenishment of bone. Curr Osteoporos Rep 2011;9(4):258-263.
51. Leitner GC, Gruber R, Neumüller J, et al: Platelet content and growth factor release in platelet-rich plasma: A comparison of four different systems. Vox Sang 2006;91(2):135-139.
52. American Academy of Orthopaedic Surgeons: Treatment of Osteoarthritis of the Knee: Evidence-Based Guideline, 2nd Edition. Available at: Http://www.aaos.org/research/guidelines/TreatmentofOsteoarthritisoftheKnee Guideline.pdf. Accessed October 3, 2013.
53. Pierce GF, Mustoe TA, Lingelbach J, Masakowski VR, Gramates P, Deuel TF: Transforming growth factor beta reverses the glucocorticoid-induced wound-healing deficit in rats: Possible regulation in macrophages by plateletderived growth factor. Proc Natl Acad Sci U S A 1989;86(7):2229-2233.
54. Marx RE: Platelet-rich plasma (PRP): What is PRP and what is not PRP Implant Dent 2001;10(4):225-228.
55. Murray MM, Spindler KP, Ballard P, Welch TP, Zurakowski D, Nanney LB: Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. J Orthop Res 2007;25(8):1007- 1017.
56. Sánchez M, Anitua E, Azofra J, Prado R, Muruzabal F, Andia I: Ligamentization of tendon grafts treated with an endogenous preparation rich in growth factors: Gross morphology and histology. Arthroscopy 2010;26(4):470-480.
57. Vavken P, Sadoghi P, Murray MM: The effect of platelet concentrates on graft maturation and graft-bone interface healing in anterior cruciate ligament reconstruction in human patients: A systematic review of controlled trials. Arthroscopy 2011;27(11):1573-1583.
58. Magnussen RA, Flanigan DC, Pedroza AD, Heinlein KA, Kaeding CC: Platelet rich plasma use in allograft ACL reconstructions: Two-year clinical results of a MOON cohort study. Knee 2013; 20(4):277-280.
59. Kartus J, Magnusson L, Stener S, Brandsson S, Eriksson BI, Karlsson J: Complications following arthroscopic anterior cruciate ligament reconstruction: A 2-5-year follow-up of 604 patients with special emphasis on anterior knee pain. Knee Surg Sports Traumatol Arthrosc 1999;7(1):2-8.
60. Visentini PJ, Khan KM, Cook JL, Kiss ZS, Harcourt PR, Wark JD; Victorian Institute of Sport Tendon Study Group: The VISA score: An index of severity of symptoms in patients with jumper's knee (patellar tendinosis). J Sci Med Sport 1998;1(1):22-28.
61. Chahal J, Van Thiel GS, Mall N, et al: The role of platelet-rich plasma in arthroscopic rotator cuff repair: A systematic review with quantitative synthesis. Arthroscopy 2012;28(11): 1718-1727.
62. GlobalData: Platelet Rich Plasma: A Market Snapshot. Available at: Http://www.docstoc.com/docs/47503668/Platelet-Rich-Plasma-A-Market-Snapshot. Accessed September 17, 2013.
63. Dougherty EJ: An evidence-based model comparing the cost-effectiveness of platelet-rich plasma gel to alternative therapies for patients with nonhealing diabetic foot ulcers. Adv Skin Wound Care 2008;21(12):568-575.