Tranexamic acid in patients with major injuries and blood loss

Emergency Nurse

Volumn 21, Issue 8, 2013, Pages 24-26

  Livingstone, Carl ^a  

^a NORTH BRISTOL NHS TRUST   (United Kingdom)

Author keywords

Blood loss; Major injury; Tranexamic acid; Trauma care

Indexed keywords

ANTIFIBRINOLYTIC AGENT; TRANEXAMIC ACID;

BLEEDING; HUMAN; MULTIPLE TRAUMA; REVIEW; TIME; UNITED KINGDOM; HEMORRHAGE;

ANTIFIBRINOLYTIC AGENTS; GREAT BRITAIN; HEMORRHAGE; HUMANS; MULTIPLE TRAUMA; TIME FACTORS; TRANEXAMIC ACID;

EID: 84892395481     PISSN: 13545752     EISSN: None     Source Type: Journal    
DOI: 10.7748/en2013.12.21.8.24.e12329     Document Type: Article

References (17)

1. Boling B, Moore K (2012) Tanexamic acid (TXA) use in trauma. Journal of Emergency Nursing. 38, 496-497.
2. Cap AP, Baer DG, Orman JA et al (2011) Tranexamic acid for trauma patients: a critical review of the literature. Journal of Trauma. 71, Supplement 1, S9-S14. doi: 10.1097/TA.0b013e31822114af
3. Davenport R, Curry N, Manson J et al (2011) Hemostatic effects of fresh frozen plasma may be maximal at red cell ratios of 1:2. Journal of Trauma. 70, 1, 90-95.
4. Henry D, Carless P, Fergusson D et al (2009) The safety of aprotinin and lysine-derived antifibrinolytic drugs in cardiac surgery: a meta-analysis. Canadian Medical Association Journal. 180, 2, 183-193.
5. Ide M, Bolliger D, Taketomi T et al (2010) Lessons from the aprotinin saga: current perspective on antifibrinolytic therapy in cardiac surgery. Journal of Anesthesia. 24, 1, 96-106.
6. Kagoma Y, Crowther M, Douketis J et al (2009) Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopaedic surgery: a systemic review of randomized trials. Thrombosis Research. 123, 5, 687-696. doi: 10.1016/j.thromres.2008.09.015
7. Kashuk JL, Moore EE, Sawyer M et al (2010) Primary fibrinolysis is integral in the pathogenesis of the acute coagulathy of trauma. Annals of Surgery. 252, 3, 434-44.
8. Ker K, Kiriya J, Perel P et al (2012) Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systemic literature review and data from CRASH-2 trail. BMC Emergency Medicine. 12, 3. doi:10.1186/1471-227X-12-3
9. Levy JH (2010) Antifibrinolytic therapy: new data and new concepts. The Lancet. 376, 9734, 3-4.
10. Martin K, Wiesner G, Breuer T et al (2008) The risks of aprotinin and tranexamic acid in cardiac surgery: a one-year follow-up of 1188 consecutive patients. Anesthesia and Analgesia. 107, 6, 1783-1790. doi: 10.1213/ane. 0b013e318184bc20
11. Martin K, Knorr J, Breuer T et al (2011) Seizures after open heart surgery: comparison of epsilon-aminocaproic acid and tranexamic acid. Journal of Cardiothoracic and Vascular Anesthesia. 25, 1, 20-25.
12. Mitra B, Cameron P, Mori A et al (2010) Acute coagulopathy and early deaths post major trauma. Injury. doi: 10.1016/j.injury.2010.10.015
13. Mitra B, Gruen R (2011) Tranexamic acid for trauma. The Lancet. doi:10.1016/S0140-6736 (11) 60396-6
14. Morrison JJ, Dubose JJ, Rasmussen TE et al (2012) Military application of tranexamic acid in trauma emergency resuscitation (MATTERs) study. Archives of Surgery. 147, 2, 113-119. doi: 10.1001/archsurg.2011.287
15. Sander M, Spies C, Martiny V et al (2010) Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: a retrospective analysis. Critical Care. 14, 4, 148. doi: 10.1186/cc9216
16. Shakur H, Roberts R, Bautista R et al (2010) Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. The Lancet. 376, 23-32.
17. Tsuei B, Kearny P (2004) Hypothermia in the trauma patient. Injury. 35, 1, 7-15. (Pubitemid 38064448)