Tranexamic Acid (TXA) Use in Trauma

Journal of Emergency Nursing

Volumn 38, Issue 5, 2012, Pages 496-497

  Boling, Bryan ^a   Moore, Kathryn ^b  

^a UNIVERSITY OF KENTUCKY COLLEGE OF NURSING   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBRINOLYTIC AGENT; TRANEXAMIC ACID;

ARTICLE; BLOOD CLOTTING DISORDER; BRAIN INJURY; CAUSE OF DEATH; COMPARATIVE STUDY; EMERGENCY HEALTH SERVICE; FEMALE; FOLLOW UP; HUMAN; INJURY SCALE; MALE; MORTALITY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT; SURVIVAL; TREATMENT OUTCOME;

ANTIFIBRINOLYTIC AGENTS; BLOOD COAGULATION DISORDERS; BRAIN INJURIES; CAUSE OF DEATH; EMERGENCY SERVICE, HOSPITAL; FEMALE; FOLLOW-UP STUDIES; HOSPITAL MORTALITY; HUMANS; INJURY SEVERITY SCORE; MALE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK ASSESSMENT; SURVIVAL ANALYSIS; TRANEXAMIC ACID; TREATMENT OUTCOME;

EID: 84865545580     PISSN: 00991767     EISSN: 15272966     Source Type: Journal    
DOI: 10.1016/j.jen.2012.06.001     Document Type: Article

References (15)

1. Acosta JA, Yang JC, Winchell RJ, et al. Lethal injuries and time to death in a level I trauma center. J Am Coll Surg. 1998, 186(5):528-533.
2. Sauaia A, Moore FA, Moore EE, et al. Epidemiology of trauma deaths: a reassessment. J Trauma. 1995, 38(2):185-193.
3. Dutton RP, Stansbury LG, Leone S, et al. Trauma mortality in mature trauma systems: are we doing better? An analysis of trauma mortality patterns, 1997-2008. J Trauma. 2010, 69(3):620-626.
4. Gunst M, Ghaemmaghami V, Gruszecki A, et al. Changing epidemiology of trauma deaths leads to a bimodal distribution. Proc (Bayl Univ Med Cent). 2010, 23(4):349-354.
5. Kashuk JL, Moore EE, Millikan JS, et al. Major abdominal vascular trauma-a unified approach. J Trauma. 1982, 22(8):672-679.
6. Moore KM The four horsemen of the apocalypse of trauma. J Emerg Nurs. 2011, 37(3):294-295.
7. Kashuk JL, Moore EE, Sawyer M, et al. Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma. Ann Surg. 2010, 252(3):434-444.
8. Brohi K, Singh J, Heron M, et al. Acute traumatic coagulopathy. J Trauma. 2003, 54(6):1127-1130.
9. Levy JH Antifibrinolytic therapy: new data and new concepts. Lancet. 2010, 376(9734):3-4.
10. Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010, 376(9734):23-32.
11. Cap AP, Baer DG, Orman JA, et al. Tranexamic acid for trauma patients: a critical review of the literature. J Trauma. 2011, 71(1 Suppl):S9-S14.
12. Roberts I, Shakur H, Afolabi A, et al. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011;377(9771):1096-1101, 1101.e1-1101.e2.
13. Morrison JJ, Dubose JJ, Rasmussen TE, et al. Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) study. Arch Surg. 2012, 147(2):113-119.
14. Sniecinski RM, Levy JH Bleeding and management of coagulopathy. J Thorac Cardiovasc Surg. 2011, 142(3):662-667.
15. Ker K, Kiriya J, Perel P, et al. Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial. BMC Emerg Med. 2012, 12:3.