Wnt1 inducible signalling pathway protein-2 (WISP-2/CCN5): Roles and regulation in human cancers (review)

Oncology Reports

Volumn 31, Issue 2, 2014, Pages 533-539

  Ji, Jiafu ^a,b,c   Jia, Shuqin ^a,c,d   Ji, Ke ^a,d   Jiang, Wen G ^a,d  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

^c INNER MONGOLIA MEDICAL UNIVERSITY   (China)

^d CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Angiogenesis; CCN5; Cellular migration; Epithelial mesenchymal transition; Metastasis; Wnt1 inducible signalling pathway protein 2

Indexed keywords

ESTROGEN; MESSENGER RNA; UNCLASSIFIED DRUG; WNT1 INDUCIBLE SIGNALLING PATHWAY PROTEIN 2; WNT1 PROTEIN;

BREAST CANCER; CANCER GROWTH; CARCINOGENESIS; CELL ADHESION; CELL MOTILITY; COLORECTAL CANCER; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HYPOPHYSIS TUMOR; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LIVER CELL CARCINOMA; MALIGNANT NEOPLASTIC DISEASE; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; STOMACH CANCER; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION; WISP 2 GENE; WNT SIGNALING PATHWAY;

CARCINOGENESIS; CCN INTERCELLULAR SIGNALING PROTEINS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; NEOPLASMS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION;

EID: 84892377937     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2909     Document Type: Review

References (56)

1. Pennica D, Swanson TA, Welsh JW, et al: WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci USA 95: 14717-14722, 1998.
2. Zhong N, Gersch RP and Hadjiargyrou M: Wnt signalling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation. Bone 39: 5-16, 2006.
3. Bork P: The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett 327: 125-130, 1993.
4. Brigstock DR: The CCN family: a new stimulus package. J Endocrinol 178: 169-175, 2003.
5. Zhang R, Averboukh L, Zhu W, et al: Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation. Mol Cell Biol 18: 6131-6141, 1998.
6. Kumar S, Hand AT, Connor JR, et al: Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. J Biol Chem 274: 17123-17131, 1999.
7. Joliot V, Martinerie C, Dambrine G, et al: Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas. Mol Cell Biol 12: 10-21, 1992.
8. Mancuso DJ, Tuley EA, Westfield LA, et al: Structure of the gene for human von Willebrand factor. J Biol Chem 264: 19514-19527, 1989.
9. Hashimoto G, Inoki I, Fujii Y, Aoki T, Ikeda E and Okada Y: Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165. J Biol Chem 277: 36288-36295, 2002.
10. de Winter P, Leoni P and Abraham D: Connective tissue growth factor: structure-function relationships of a mosaic, multifunctional protein. Growth Factors 26: 80-91, 2008.
11. 4)beta 1-1 Cer] and has a sequence homology with other proteins that bind sulfated glycoconjugates. J Biol Chem 265: 2852-2855, 1990.
12. Karagiannis ED and Popel AS: Peptides derived from type I thrombospondin repeat-containing proteins of the CCN family inhibit proliferation and migration of endothelial cells. Int J Biochem Cell Biol 39: 2314-2323, 2007.
13. Voorberg J, Fontijn R, Calafat J, Janssen H, van Mourik JA and Pannekoek H: Assembly and routing of von Willebrand factor variants: the requirements for disulfide-linked dimerization reside within the carboxy-terminal 151 amino acids. J Cell Biol 113: 195-205, 1991.
14. Brigstock DR, Steffen CL, Kim GY, Vegunta RK, Diehl JR and Harding PA: Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids. Identification as heparin-regulated Mr 10,000 forms of connective tissue growth factor. J Biol Chem 272: 20275-20282, 1997.
15. Holbourn KP, Perbal B and Ravi Acharya K: Proteins on the catwalk: modelling the structural domains of the CCN family of proteins. J Cell Commun Signal 3: 25-41, 2009.
16. Kubota S and Takigawa M: CCN family proteins and angiogenesis: from embryo to adulthood. Angiogenesis 10: 1-11, 2007.
17. Banerjee S, Sengupta K, Saxena NK, Dhar K and Banerjee SK: Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-α- positive breast tumor cells through multiple molecular cross-talks. Mol Cancer Res 3: 151-162, 2005.
18. Dhar K, Banerjee S, Dhar G, Sengupta K and Banerjee SK: Insulin-like growth factor-1 (IGF-1) induces WISP-2/CCN5 via multiple molecular cross-talks and is essential for mitogenic switch by IGF-1 axis in estrogen receptor-positive breast tumor cells. Cancer Res 67: 1520-1526, 2007.
19. Sengupta K, Banerjee S, Dhar K, et al: WISP-2/CCN5 is involved as a novel signalling intermediate in phorbol ester-protein kinase Cα-mediated breast tumor cell proliferation. Biochemistry 45: 10698-10709, 2006.
20. Lake AC, Bialik A, Walsh K and Castellot JJ Jr: CCN5 is a growth arrest-specific gene that regulates smooth muscle cell proliferation and motility. Am J Pathol 162: 219-231, 2003.
21. Dhar G, Mehta S, Banerjee S, et al: Loss of WISP-2/CCN5 signalling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal- transition. Cancer Lett 254: 63-70, 2007.
22. Banerjee S, Dhar G, Haque I, et al: CCN5/WISP-2 expression in breast adenocarcinoma is associated with less frequent progression of the disease and suppresses the invasive phenotypes of tumor cells. Cancer Res 68: 7606-7612, 2008.
23. Inadera H, Hashimoto S, Dong HY, et al: WISP-2 as a novel estrogen-responsive gene in human breast cancer cells. Biochem Biophys Res Commun 275: 108-114, 2000.
24. Inadera H, Dong HY and Matsushima K: WISP-2 is a secreted protein and can be a marker of estrogen exposure in MCF-7 cells. Biochem Biophys Res Commun 294: 602-608, 2002.
25. Banerjee S, Saxena N, Sengupta K, Tawfik O, Mayo MS and Banerjee SK: WISP-2 gene in human breast cancer: estrogen and progesterone inducible expression and regulation of tumor cell proliferation. Neoplasia 5: 63-73, 2003.
26. Zoubine MN, Banerjee S, Saxena NK, Campbell DR and Banerjee SK: WISP-2: a serum-inducible gene differentially expressed in human normal breast epithelial cells and in MCF-7 breast tumor cells. Biochem Biophys Res Commun 282: 421-425, 2001.
27. Ray G, Banerjee S, Saxena NK, Campbell DR, Van Veldhuizen P and Banerjee SK: Stimulation of MCF-7 tumor progression in athymic nude mice by 17β-estradiol induces WISP-2/CCN5 expression in xenografts: A novel signalling molecule in hormonal carcinogenesis. Oncol Rep 13: 445-448, 2005.
28. Davies SR, Watkins G, Mansel RE and Jiang WG: Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer. Ann Surg Oncol 14: 1909-1918, 2007.
29. Banerjee SK and Banerjee S: CCN5/WISP-2: a micromanager of breast cancer progression. J Cell Commun Signal 6: 63-71, 2012.
30. Saxena N, Banerjee S, Sengupta K, Zoubine MN and Banerjee SK: Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines. Mol Cell Biochem 228: 99-104, 2001.
31. Tanner MM, Tirkkonen M, Kallioniemi A, et al: Increased copy number at 20q13 in breast cancer: defining the critical region and exclusion of candidate genes. Cancer Res 54: 4257-4260, 1994.
32. Bischoff JR, Anderson L, Zhu Y, et al: A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J 17: 3052-3065, 1998.
33. Davies SR, Davies ML, Sanders A, Parr C, Torkington J and Jiang WG: Differential expression of the CCN family members WISP-1, WISP-2 and WISP-3 in human colorectal cancer and the prognostic implications. Int J Oncol 36: 1129-1136, 2010.
34. Cervello M, Giannitrapani L, Labbozzetta M, et al: Expression of WISPs and of their novel alternative variants in human hepatocellular carcinoma cells. Ann NY Acad Sci 1028: 432-439, 2004.
35. Fukutomi T, Zhou Y, Kawai S, Eguchi H, Wands JR and Li J: Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression. Hepatology 41: 1096-1105, 2005.
36. Tomimaru Y, Koga H, Yano H, de la Monte S, Wands JR and Kim M: Upregulation of T-cell factor-4 isoform-responsive target genes in hepatocellular carcinoma. Liver Int 33: 1100-1112, 2013.
37. Quan T, Shin S, Qin Z and Fisher GJ: Expression of CCN family of genes in human skin in vivo and alterations by solar-simulated ultraviolet irradiation. J Cell Commun Signal 3: 19-23, 2009.
38. Colli LM, Saggioro F, Serafini LN, et al: Components of the canonical and non-canonical Wnt pathways are not mis-expressed in pituitary tumors. PLoS One 8: e62424, 2013.
39. Ji J, Jia S and Jiang WG: WISP2 is an independent prognosis indicator of gastric cancer patients and regulates the biological function of gastric cancer cells via the JNK pathway. Eur J Cancer 49: S572, 2013.
40. Tanaka I, Morikawa M, Okuse T, Shirakawa M and Imai K: Expression and regulation of WISP2 in rheumatoid arthritic synovium. Biochem Biophys Res Commun 334: 973-978, 2005.
41. Russo JW and Castellot JJ: CCN5: biology and pathophysiology. J Cell Commun Signal 4: 119-130, 2010.
42. Bejsovec A: Wnt pathway activation: new relations and locations. Cell 120: 11-14, 2005.
43. 2+ signalling pathway: a brief overview. Acta Biochim Biophys Sin 43: 745-756, 2011.
44. Inadera H: Estrogen-induced genes, WISP-2 and pS2, respond divergently to protein kinase pathway. Biochem Biophys Res Commun 309: 272-278, 2003.
45. Wierer M, Verde G, Pisano P, et al: PLK1 signalling in breast cancer cells cooperates with estrogen receptor-dependent gene transcription. Cell Rep 3: 2021-2032, 2013.
46. Ferrand N, Stragier E, Redeuilh G and Sabbah M: Glucocorticoids induce CCN5/WISP-2 expression and attenuate invasion in oestrogen receptor-negative human breast cancer cells. Biochem J 447: 71-79, 2012.
47. Stiehl DP, Bordoli MR, Abreu-Rodriguez I, et al: Non-canonical HIF-2α function drives autonomous breast cancer cell growth via an AREG-EGFR/ErbB4 autocrine loop. Oncogene 31: 2283-2297, 2012.
48. Delmolino LM, Stearns NA and Castellot JJ Jr: COP-1, a member of the CCN family, is a heparin-induced growth arrest specific gene in vascular smooth muscle cells. J Cell Physiol 188: 45-55, 2001.
49. Ulrich C, Rolauffs B, Abele H, et al: Low osteogenic differentiation potential of placenta-derived mesenchymal stromal cells correlates with low expression of the transcription factors Runx2 and Twist2. Stem Cells Dev: Jul 20, 2013 (Epub ahead of print).
50. Bourdeau I, Antonini SR, Lacroix A, et al: Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators. Oncogene 23: 1575-1585, 2004.
51. Fritah A, Saucier C, De Wever O, et al: Role of WISP-2/CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast cancer cells. Mol Cell Biol 28: 1114-1123, 2008.
52. Dhar G, Banerjee S, Dhar K, et al: Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2. Cancer Res 68: 4580-4587, 2008.
53. Hugo H, Ackland ML, Blick T, et al: Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cell Physiol 213: 374-383, 2007.
54. Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890, 2009.
55. Ouelaa-Benslama R, De Wever O, Hendrix A, et al: Identification of a GαGβγ, AKT and PKCα signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to- mesenchymal transition. Int J Oncol 41: 189-200, 2012.
56. Sabbah M, Prunier C, Ferrand N, et al: CCN5, a novel transcriptional repressor of the transforming growth factor β signalling pathway. Mol Cell Biol 31: 1459-1469, 2011.