메뉴 건너뛰기




Volumn 46, Issue 1, 2014, Pages 18-24

Triple therapy with first-generation Protease Inhibitors for patients with genotype 1 chronic hepatitis C: Recommendations of the Italian Association for the Study of the Liver (AISF)

Author keywords

Boceprevir; Cirrhosis; Hepatitis C; Pegylated interferon; Ribavirin; Telaprevir

Indexed keywords

BOCEPREVIR; PROTEINASE INHIBITOR; TELAPREVIR;

EID: 84892373565     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2013.08.243     Document Type: Review
Times cited : (10)

References (47)
  • 1
    • 79953176289 scopus 로고    scopus 로고
    • Boceprevir for previously treated chronic HCV genotype 1 infection
    • Bacon B.R., Gordon S.C., Lawitz E., et al. Boceprevir for previously treated chronic HCV genotype 1 infection. The New England Journal of Medicine 2011, 364:1207-1217.
    • (2011) The New England Journal of Medicine , vol.364 , pp. 1207-1217
    • Bacon, B.R.1    Gordon, S.C.2    Lawitz, E.3
  • 2
    • 65449171953 scopus 로고    scopus 로고
    • Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    • Hezode C., Forestier N., Dusheiko G., et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. The New England Journal of Medicine 2009, 360:1839-1850.
    • (2009) The New England Journal of Medicine , vol.360 , pp. 1839-1850
    • Hezode, C.1    Forestier, N.2    Dusheiko, G.3
  • 4
    • 77956268467 scopus 로고    scopus 로고
    • Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial
    • Kwo P.Y., Lawitz E.J., McCone J., et al. Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial. Lancet 2010, 376:705-716.
    • (2010) Lancet , vol.376 , pp. 705-716
    • Kwo, P.Y.1    Lawitz, E.J.2    McCone, J.3
  • 7
    • 80052826527 scopus 로고    scopus 로고
    • Response-guided telaprevir combination treatment for hepatitis C virus infection
    • Sherman K.E., Flamm S.L., Afdhal N.H., et al. Response-guided telaprevir combination treatment for hepatitis C virus infection. The New England Journal of Medicine 2011, 365:1014-1024.
    • (2011) The New England Journal of Medicine , vol.365 , pp. 1014-1024
    • Sherman, K.E.1    Flamm, S.L.2    Afdhal, N.H.3
  • 9
    • 79960453276 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: management of hepatitis C virus infection
    • European Association for the Study of the Liver
    • EASL clinical practice guidelines: management of hepatitis C virus infection. Journal of Hepatology 2011, 55:245-264. European Association for the Study of the Liver.
    • (2011) Journal of Hepatology , vol.55 , pp. 245-264
  • 10
    • 80053339008 scopus 로고    scopus 로고
    • An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases
    • Ghany M.G., Nelson D.R., Strader D.B., et al. An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology 2011, 54:1433-1444.
    • (2011) Hepatology , vol.54 , pp. 1433-1444
    • Ghany, M.G.1    Nelson, D.R.2    Strader, D.B.3
  • 11
    • 84892373073 scopus 로고    scopus 로고
    • The multidisciplinary clinical approach to hepatocellular carcinoma
    • The Italian Association for the Study of the Liver (AISF), [in press]
    • The Italian Association for the Study of the Liver (AISF) The multidisciplinary clinical approach to hepatocellular carcinoma. Digestive and Liver Disease 2013, [in press].
    • (2013) Digestive and Liver Disease
  • 12
    • 33947360829 scopus 로고    scopus 로고
    • Sustained virological response to interferon-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study
    • Bruno S., Stroffolini T., Colombo M., et al. Sustained virological response to interferon-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study. Hepatology 2007, 45:579-587.
    • (2007) Hepatology , vol.45 , pp. 579-587
    • Bruno, S.1    Stroffolini, T.2    Colombo, M.3
  • 13
    • 77958507474 scopus 로고    scopus 로고
    • Prevalence and challenges of liver diseases in patients with chronic hepatitis C virus infection
    • Jacobson I.M., Davis G.L., El-Serag H., et al. Prevalence and challenges of liver diseases in patients with chronic hepatitis C virus infection. Clinical Gastroenterology and Hepatology 2010, 8:924-933.
    • (2010) Clinical Gastroenterology and Hepatology , vol.8 , pp. 924-933
    • Jacobson, I.M.1    Davis, G.L.2    El-Serag, H.3
  • 14
    • 79960720423 scopus 로고    scopus 로고
    • Telaprevir substantially improved SVR rates accross all IL28B genotypes in the ADVANCE trial
    • Jacobson I.M., Catlett I., Marcellin P., et al. Telaprevir substantially improved SVR rates accross all IL28B genotypes in the ADVANCE trial. Journal of Hepatology 2011, 54:S543.
    • (2011) Journal of Hepatology , vol.54
    • Jacobson, I.M.1    Catlett, I.2    Marcellin, P.3
  • 15
    • 68249154875 scopus 로고    scopus 로고
    • Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection
    • McHutchison J.G., Lawitz E.J., Shiffman M.L., et al. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. The New England Journal of Medicine 2009, 361:580-593.
    • (2009) The New England Journal of Medicine , vol.361 , pp. 580-593
    • McHutchison, J.G.1    Lawitz, E.J.2    Shiffman, M.L.3
  • 16
    • 79960447952 scopus 로고    scopus 로고
    • Similar SVR rates in IL28B CC, CT or TT prior relapser, partial or null-responder patients treated with telaprevir/peg-IFN/ribavirin: retrospective analysis of the REALIZE study
    • Pol A., Aerssen J., Zeuzem S., et al. Similar SVR rates in IL28B CC, CT or TT prior relapser, partial or null-responder patients treated with telaprevir/peg-IFN/ribavirin: retrospective analysis of the REALIZE study. Journal of Hepatology 2011, 54:S6.
    • (2011) Journal of Hepatology , vol.54
    • Pol, A.1    Aerssen, J.2    Zeuzem, S.3
  • 17
    • 77953881002 scopus 로고    scopus 로고
    • Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virological response in genotype 1 hepatitis C virus
    • Thompson A.J., Muir A.J., Sulkowski M.S., et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virological response in genotype 1 hepatitis C virus. Gastroenterology 2010, 139:120-129.
    • (2010) Gastroenterology , vol.139 , pp. 120-129
    • Thompson, A.J.1    Muir, A.J.2    Sulkowski, M.S.3
  • 18
    • 79958816097 scopus 로고    scopus 로고
    • Rapid virological response is the most important predictor of sustained virological response across genotypes in patients with chronic hepatitis C virus infection
    • Fried M.W., Hadziyannis S.J., Shiffman M.L., et al. Rapid virological response is the most important predictor of sustained virological response across genotypes in patients with chronic hepatitis C virus infection. Journal of Hepatology 2011, 55:69-75.
    • (2011) Journal of Hepatology , vol.55 , pp. 69-75
    • Fried, M.W.1    Hadziyannis, S.J.2    Shiffman, M.L.3
  • 19
    • 84865494240 scopus 로고    scopus 로고
    • Factors that predict response of patients with hepatitis C virus infection to boceprevir
    • Poordad F., Bronowicki J.P., Gordon S.C., et al. Factors that predict response of patients with hepatitis C virus infection to boceprevir. Gastroenterology 2012, 143:608-618.
    • (2012) Gastroenterology , vol.143 , pp. 608-618
    • Poordad, F.1    Bronowicki, J.P.2    Gordon, S.C.3
  • 20
    • 75449106958 scopus 로고    scopus 로고
    • Efficacy and safety of peginterferon alfa-2a (40KD) plus ribavirin in hepatitis C patients with advanced fibrosis and cirrhosis
    • Bruno S., Shiffman M.L., Roberts S.K., et al. Efficacy and safety of peginterferon alfa-2a (40KD) plus ribavirin in hepatitis C patients with advanced fibrosis and cirrhosis. Hepatology 2010, 51:388-397.
    • (2010) Hepatology , vol.51 , pp. 388-397
    • Bruno, S.1    Shiffman, M.L.2    Roberts, S.K.3
  • 21
    • 77956268664 scopus 로고    scopus 로고
    • Low virological response and high relapse rates in hepatitis C genotype 1 patients with advanced fibrosis despite adequate therapeutic dosing
    • Cheng W.S., Roberts S.K., McCaughan G., et al. Low virological response and high relapse rates in hepatitis C genotype 1 patients with advanced fibrosis despite adequate therapeutic dosing. Journal of Hepatology 2010, 53:616-623.
    • (2010) Journal of Hepatology , vol.53 , pp. 616-623
    • Cheng, W.S.1    Roberts, S.K.2    McCaughan, G.3
  • 22
    • 84874117254 scopus 로고    scopus 로고
    • Efficacy and safety of boceprevir plus peginterferon-ribavirin in patients with HCV G1 infection and advanced fibrosis/cirrhosis
    • Bruno S., Vierling J.M., Esteban R., et al. Efficacy and safety of boceprevir plus peginterferon-ribavirin in patients with HCV G1 infection and advanced fibrosis/cirrhosis. Journal of Hepatology 2013, 58:479-487.
    • (2013) Journal of Hepatology , vol.58 , pp. 479-487
    • Bruno, S.1    Vierling, J.M.2    Esteban, R.3
  • 23
    • 84867554717 scopus 로고    scopus 로고
    • Sustained virological response (SVR) in prior peginterferon/ribavirin (PR) treatment failure after retreatment with boceprevir + PR: the PROVIDE study interim results
    • Bronowicki J.P., Davis M., Flamm S., et al. Sustained virological response (SVR) in prior peginterferon/ribavirin (PR) treatment failure after retreatment with boceprevir + PR: the PROVIDE study interim results. Journal of Hepatology 2012, 56:S611.
    • (2012) Journal of Hepatology , vol.56
    • Bronowicki, J.P.1    Davis, M.2    Flamm, S.3
  • 24
    • 84874116206 scopus 로고    scopus 로고
    • Sustained virological response rates with telaprevir by response after 4 weeks of lead-in therapy in patients with prior treatment failure
    • Foster G.R., Zeuzem S., Andreone P., et al. Sustained virological response rates with telaprevir by response after 4 weeks of lead-in therapy in patients with prior treatment failure. Journal of Hepatology 2013, 58:488-494.
    • (2013) Journal of Hepatology , vol.58 , pp. 488-494
    • Foster, G.R.1    Zeuzem, S.2    Andreone, P.3
  • 25
    • 84892373637 scopus 로고    scopus 로고
    • Agency EM. Victrelis [Boceprevir]. Accessed: 17 August 2011.
    • Agency EM. Victrelis [Boceprevir]. In: Accessed: 17 August 2011. http://www.ema.europa.eu/ema/index.jsp%3Fcurl=pages/medicines/human/medicines/002332/human_med_001464.jsp.
  • 26
    • 84892373141 scopus 로고    scopus 로고
    • Agency EM. Incivo [Telaprevir]
    • Agency EM. Incivo [Telaprevir] In: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_product_Information/human/002313/WC500115529.pdf.
  • 27
    • 84861188886 scopus 로고    scopus 로고
    • Predictors of Sustained Virological Response (SVR) among poor Interferon (IFN) responders when Boceprevir (BOC) is added to Peginterferon Alfa-2b/Ribavirin (PR)
    • Bacon B.R., Bruno S., Schiff E.R., et al. Predictors of Sustained Virological Response (SVR) among poor Interferon (IFN) responders when Boceprevir (BOC) is added to Peginterferon Alfa-2b/Ribavirin (PR). Hepatology 2011, 54:33A.
    • (2011) Hepatology , vol.54
    • Bacon, B.R.1    Bruno, S.2    Schiff, E.R.3
  • 28
    • 79955103901 scopus 로고    scopus 로고
    • Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus
    • Pawlotsky J.M. Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus. Hepatology 2011, 53:1742-1751.
    • (2011) Hepatology , vol.53 , pp. 1742-1751
    • Pawlotsky, J.M.1
  • 29
    • 82955182885 scopus 로고    scopus 로고
    • Boceprevir resistance-associated variants (RAVS) are observed more frequently in HCV (GT1)-infected patients with poor response to peginterferon alfa-2b/ribavirin
    • Zeuzem S., Pooard F., Gordon S.C., et al. Boceprevir resistance-associated variants (RAVS) are observed more frequently in HCV (GT1)-infected patients with poor response to peginterferon alfa-2b/ribavirin. Journal of Hepatology 2011, 54:S8.
    • (2011) Journal of Hepatology , vol.54
    • Zeuzem, S.1    Pooard, F.2    Gordon, S.C.3
  • 30
    • 75149151884 scopus 로고    scopus 로고
    • Resistance to direct antiviral agents in patients with hepatitis C virus infection
    • Sarrazin C., Zeuzem S. Resistance to direct antiviral agents in patients with hepatitis C virus infection. Gastroenterology 2010, 138:447-462.
    • (2010) Gastroenterology , vol.138 , pp. 447-462
    • Sarrazin, C.1    Zeuzem, S.2
  • 31
    • 84863519517 scopus 로고    scopus 로고
    • Safety and efficacy of telaprevir and boceprevir in combination with peginterferon alfa/ribavirin in 497 cirrhotic non responders: week 16 analysis of the French early access program (ANRS CO20-CUPIC) in real-life setting
    • Hezode C., Dorival C., Zoulim F., et al. Safety and efficacy of telaprevir and boceprevir in combination with peginterferon alfa/ribavirin in 497 cirrhotic non responders: week 16 analysis of the French early access program (ANRS CO20-CUPIC) in real-life setting. Hepatology 2012, 56:S51.
    • (2012) Hepatology , vol.56
    • Hezode, C.1    Dorival, C.2    Zoulim, F.3
  • 32
    • 84873275651 scopus 로고    scopus 로고
    • Eligibility and safety of triple therapy for hepatitis C: lessons learned from the first experience in a real world setting
    • Maasoumy B., Port K., Markova A.A., et al. Eligibility and safety of triple therapy for hepatitis C: lessons learned from the first experience in a real world setting. PLoS One 2013, 8:e55528.
    • (2013) PLoS One , vol.8
    • Maasoumy, B.1    Port, K.2    Markova, A.A.3
  • 33
    • 84892364515 scopus 로고    scopus 로고
    • Treatment of hepatitis C genotype 1 patients with severe fibrosis or compensated cirrhosis: the Italian telaprevir early access program
    • Colombo M., Andreone P.A., Babudieri P.S., et al. Treatment of hepatitis C genotype 1 patients with severe fibrosis or compensated cirrhosis: the Italian telaprevir early access program. Digestive and Liver Disease 2013, 45:OC-26.
    • (2013) Digestive and Liver Disease , vol.45
    • Colombo, M.1    Andreone, P.A.2    Babudieri, P.S.3
  • 34
    • 61749087148 scopus 로고    scopus 로고
    • Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients: the French national Mortalite 2005 study
    • Salmon-Ceron D., Rosenthal E., Lewden C., et al. Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients: the French national Mortalite 2005 study. Journal of Hepatology 2009, 50:736-745.
    • (2009) Journal of Hepatology , vol.50 , pp. 736-745
    • Salmon-Ceron, D.1    Rosenthal, E.2    Lewden, C.3
  • 35
    • 70350061700 scopus 로고    scopus 로고
    • Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus/hepatitis C virus
    • Macias J., Berenguer J., Japon M.A., et al. Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus/hepatitis C virus. Hepatology 2009, 50:1056-1063.
    • (2009) Hepatology , vol.50 , pp. 1056-1063
    • Macias, J.1    Berenguer, J.2    Japon, M.A.3
  • 36
    • 84864323143 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for HIV-HCV genotype 1 coinfected patients: a randomized international trial
    • Rodriguez-Torres M., Slim J., Bhatti L., et al. Peginterferon alfa-2a plus ribavirin for HIV-HCV genotype 1 coinfected patients: a randomized international trial. HIV Clinical Trials 2012, 13:142-152.
    • (2012) HIV Clinical Trials , vol.13 , pp. 142-152
    • Rodriguez-Torres, M.1    Slim, J.2    Bhatti, L.3
  • 38
    • 84885475374 scopus 로고    scopus 로고
    • Telaprevir in combination with peginterferon alfa-2a/ribavirin in HCV/HIV co-infected patients: SVR24 final study results
    • Sulkowski M.S., Sherman K.E., Soriano V., et al. Telaprevir in combination with peginterferon alfa-2a/ribavirin in HCV/HIV co-infected patients: SVR24 final study results. Hepatology 2012, 56:54A.
    • (2012) Hepatology , vol.56
    • Sulkowski, M.S.1    Sherman, K.E.2    Soriano, V.3
  • 39
    • 0033807694 scopus 로고    scopus 로고
    • Natural history of clinically compensated hepatitis C virus-related graft cirrhosis after liver transplantation
    • Berenguer M., Prieto M., Rayon J.M., et al. Natural history of clinically compensated hepatitis C virus-related graft cirrhosis after liver transplantation. Hepatology 2000, 32:852-858.
    • (2000) Hepatology , vol.32 , pp. 852-858
    • Berenguer, M.1    Prieto, M.2    Rayon, J.M.3
  • 40
    • 58249086156 scopus 로고    scopus 로고
    • Hepatitis C virus therapy in liver transplant recipients: response predictors, effect on fibrosis progression, and importance of the initial stage of fibrosis
    • Roche B., Sebagh M., Canfora M.L., et al. Hepatitis C virus therapy in liver transplant recipients: response predictors, effect on fibrosis progression, and importance of the initial stage of fibrosis. Liver Transplantation 2008, 14:1766-1770.
    • (2008) Liver Transplantation , vol.14 , pp. 1766-1770
    • Roche, B.1    Sebagh, M.2    Canfora, M.L.3
  • 41
    • 84892368810 scopus 로고    scopus 로고
    • A multicenter study of protease inhibitor-triple therapy in HCV-infected liver transplant recipient: report from the CRUSH-C group
    • Verna E.C., Burton J.R., O'Leary J.G., et al. A multicenter study of protease inhibitor-triple therapy in HCV-infected liver transplant recipient: report from the CRUSH-C group. Journal of Hepatology 2013, 58(Suppl. 1):S10.
    • (2013) Journal of Hepatology , vol.58 , Issue.SUPPL. 1
    • Verna, E.C.1    Burton, J.R.2    O'Leary, J.G.3
  • 42
    • 84892369945 scopus 로고    scopus 로고
    • High rates of undetectable HCV RNA in liver transplant recipients treated with protease inhibitor-based antiviral therapy for recurrent hepatitis C
    • Lilly L., Selzner N., Levy G., et al. High rates of undetectable HCV RNA in liver transplant recipients treated with protease inhibitor-based antiviral therapy for recurrent hepatitis C. Journal of Hepatology 2013, 58(Suppl. 1):S75.
    • (2013) Journal of Hepatology , vol.58 , Issue.SUPPL. 1
    • Lilly, L.1    Selzner, N.2    Levy, G.3
  • 43
    • 84892372669 scopus 로고    scopus 로고
    • End of treatment response after protease inhibitor (PI)-based therapy for hepatitis C recurrence after liver transplantation: a multicenter European experience
    • Coilly A., Dumortier J., Botta-Fridlund D., et al. End of treatment response after protease inhibitor (PI)-based therapy for hepatitis C recurrence after liver transplantation: a multicenter European experience. Journal of Hepatology 2013, 58(Suppl. 1):S572.
    • (2013) Journal of Hepatology , vol.58 , Issue.SUPPL. 1
    • Coilly, A.1    Dumortier, J.2    Botta-Fridlund, D.3
  • 44
    • 84868208266 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between the hepatitis C virus protease inhibitor boceprevir and cyclosporine and tacrolimus in healthy volunteers
    • Hulskotte E., Gupta S., Xuan F., et al. Pharmacokinetic interaction between the hepatitis C virus protease inhibitor boceprevir and cyclosporine and tacrolimus in healthy volunteers. Hepatology 2012, 56:1622-1630.
    • (2012) Hepatology , vol.56 , pp. 1622-1630
    • Hulskotte, E.1    Gupta, S.2    Xuan, F.3
  • 45
    • 79959561437 scopus 로고    scopus 로고
    • Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus
    • Garg V., van Heeswijk R., Lee J.E., et al. Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus. Hepatology 2011, 54:20-27.
    • (2011) Hepatology , vol.54 , pp. 20-27
    • Garg, V.1    van Heeswijk, R.2    Lee, J.E.3
  • 46
    • 84892374093 scopus 로고    scopus 로고
    • Boceprevir triple therapy in patients with mixed cryoglobulinemia
    • Triboli E., Fabbrizzi A., Monti M., et al. Boceprevir triple therapy in patients with mixed cryoglobulinemia. Digestive and Liver Disease 2013, 45:OC28.
    • (2013) Digestive and Liver Disease , vol.45
    • Triboli, E.1    Fabbrizzi, A.2    Monti, M.3
  • 47
    • 84880925452 scopus 로고    scopus 로고
    • Clinical management of drug-drug interactions in HCV therapy: challenges and solutions
    • Burger D., Back D., Buggisch P., et al. Clinical management of drug-drug interactions in HCV therapy: challenges and solutions. Journal of Hepatology 2012, 58:792-800.
    • (2012) Journal of Hepatology , vol.58 , pp. 792-800
    • Burger, D.1    Back, D.2    Buggisch, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.