-
1
-
-
0037699208
-
Fatal lactic acidosis and pancreatitis associated with ribavirin and didanosine therapy
-
A.A. Butt Fatal lactic acidosis and pancreatitis associated with ribavirin and didanosine therapy AIDS Read 13 2003 344 348 (Pubitemid 36890378)
-
(2003)
AIDS Reader
, vol.13
, Issue.7
, pp. 344-348
-
-
Butt, A.A.1
-
2
-
-
84880990691
-
Concomitant medication use in patients with hepatitis C genotype 1 treated with boceprevir combination therapy
-
San Francisco, California, November 4-8, 2011 [poster 937]
-
Poordad F, Lawitz E, Gordon S, Bourlière M, Vierling J, Poynard T, et al. Concomitant medication use in patients with hepatitis C genotype 1 treated with boceprevir combination therapy. In: Sixty second annual meeting of the American Association for the Study of Liver Diseases, San Francisco, California, November 4-8, 2011 [poster 937].
-
Sixty Second Annual Meeting of the American Association for the Study of Liver Diseases
-
-
Poordad F, L.1
-
3
-
-
77952118055
-
-
EMA [cited 2012]; Available from
-
EMA. Incivo; Summary of product characteristics. 2012 [cited 2012]; Available from: http://www.ema.europa.eu/docs/en-GB/document-library/EPAR- Product-Information/human/002313/WC500115529.pdf.
-
(2012)
Incivo; Summary of Product Characteristics
-
-
-
4
-
-
84871821171
-
-
EMA [cited 2012]
-
EMA. Victrelis; Summary of product characteristics. 2012 [cited 2012]; Available from: http://www.ema.europa.eu/docs/en-GB/document-library/EPAR- Product-Information/human/002332/WC500109786.pdf.
-
Victrelis; Summary of Product Characteristics
-
-
-
5
-
-
79951868202
-
Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor
-
A. Ghosal, Y. Yuan, W. Tong, A.D. Su, C. Gu, and S.K. Chowdhury Characterization of human liver enzymes involved in the biotransformation of boceprevir, a hepatitis C virus protease inhibitor Drug Metab Dispos 39 2011 510 521
-
(2011)
Drug Metab Dispos
, vol.39
, pp. 510-521
-
-
Ghosal, A.1
Yuan, Y.2
Tong, W.3
Su, A.D.4
Gu, C.5
Chowdhury, S.K.6
-
6
-
-
33646536542
-
Drug and bile acid transporters in rosuvastatin hepatic uptake: Function, expression, and pharmacogenetics
-
R.H. Ho, R.G. Tirona, B.F. Leake, H. Glaeser, W. Lee, and J. Lemke Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics Gastroenterology 130 2006 1793 1806
-
(2006)
Gastroenterology
, vol.130
, pp. 1793-1806
-
-
Ho, R.H.1
Tirona, R.G.2
Leake, B.F.3
Glaeser, H.4
Lee, W.5
Lemke, J.6
-
7
-
-
33749360242
-
Rapid Decline of Viral RNA in Hepatitis C Patients Treated With VX-950: A Phase Ib, Placebo-Controlled, Randomized Study
-
DOI 10.1053/j.gastro.2006.07.013, PII S0016508506015393
-
H.W. Reesink, S. Zeuzem, C.J. Weegink, N. Forestier, A. van Vliet, and J. Van de Wetering de Rooij Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study Gastroenterology 131 2006 997 1002 (Pubitemid 44498690)
-
(2006)
Gastroenterology
, vol.131
, Issue.4
, pp. 997-1002
-
-
Reesink, H.W.1
Zeuzem, S.2
Weegink, C.J.3
Forestier, N.4
Van Vliet, A.5
Van De Wetering De Rooij, J.6
McNair, L.7
Purdy, S.8
Kauffman, R.9
Alam, J.10
Jansen, P.L.M.11
-
8
-
-
84871788762
-
Assessment of boceprevir pharmacokinetic/pharmacodynamic relationships for sustained viral response and occurrence of anemia from phase 3 data
-
San Francisco, California, November 4-8, 2011 [poster 1342]
-
Stone J, Wenning L, Hang Y, Su J, Gupta S, Tsai K, et al. Assessment of boceprevir pharmacokinetic/pharmacodynamic relationships for sustained viral response and occurrence of anemia from phase 3 data. In: 62nd Annual meeting of the American association for the study of liver diseases, San Francisco, California, November 4-8, 2011 [poster 1342].
-
62nd Annual Meeting of the American Association for the Study of Liver Diseases
-
-
Stone, J.1
Wenning, L.2
Hang, Y.3
Su, J.4
Gupta, S.5
Tsai, K.6
-
9
-
-
56649122109
-
Usefulness of monitoring ribavirin plasma concentrations to improve treatment response in patients with chronic hepatitis C
-
J. Morello, S. Rodriguez-Novoa, I. Jimenez-Nacher, and V. Soriano Usefulness of monitoring ribavirin plasma concentrations to improve treatment response in patients with chronic hepatitis C J Antimicrob Chemother 62 2008 1174 1180
-
(2008)
J Antimicrob Chemother
, vol.62
, pp. 1174-1180
-
-
Morello, J.1
Rodriguez-Novoa, S.2
Jimenez-Nacher, I.3
Soriano, V.4
-
10
-
-
79959549897
-
Telaprevir, boceprevir, cytochrome P450 and immunosuppressive agents-a potentially lethal cocktail
-
M. Charlton Telaprevir, boceprevir, cytochrome P450 and immunosuppressive agents-a potentially lethal cocktail Hepatology 54 2011 3 5
-
(2011)
Hepatology
, vol.54
, pp. 3-5
-
-
Charlton, M.1
-
11
-
-
79959561437
-
Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus
-
V. Garg, R. van Heeswijk, J.E. Lee, K. Alves, P. Nadkarni, and X. Luo Effect of telaprevir on the pharmacokinetics of cyclosporine and tacrolimus Hepatology 54 2011 20 27
-
(2011)
Hepatology
, vol.54
, pp. 20-27
-
-
Garg, V.1
Van Heeswijk, R.2
Lee, J.E.3
Alves, K.4
Nadkarni, P.5
Luo, X.6
-
12
-
-
84874069405
-
Pharmacokinetic interaction between the HCV protease inhibitor boceprevir and the calcineurin inhibitors cyclosporine and tracolimus
-
Koloa, Hawaii, December 4-8, 2011 [poster 123]
-
Hulskotte E, Gupta S, Xuan Y, Zutven van M, O'Mara E, Galitz L, et al. Pharmacokinetic interaction between the HCV protease inhibitor boceprevir and the calcineurin inhibitors cyclosporine and tracolimus. In: Sixteenth annual meeting of HEP DART, Koloa, Hawaii, December 4-8, 2011 [poster 123].
-
Sixteenth Annual Meeting of HEP DART
-
-
Hulskotte, E.1
Gupta, S.2
Xuan, Y.3
Van M, Z.4
O'Mara, E.5
Galitz, L.6
-
13
-
-
84880934465
-
Efficacy and safety of protease inhibitors for severe hepatitis c recurrence after liver transplantation: A first multicentric experience
-
April 18-22, 2012 [oral presentation 47]
-
Coilly A, Roche B, Botta-Fridlund D, Leroy V, Pageaux P, Si-Ahmed S, et al. Efficacy and safety of protease inhibitors for severe hepatitis c recurrence after liver transplantation: a first multicentric experience. In: Fortyseventh annual meeting of the European association for the study of the liver, April 18-22, 2012 [oral presentation 47].
-
Fortyseventh Annual Meeting of the European Association for the Study of the Liver
-
-
Coilly, A.1
Roche, B.2
Botta-Fridlund, D.3
Leroy, V.4
Pageaux, P.5
Si-Ahmed, S.6
-
14
-
-
84880937289
-
Darunavir/ritonavir does not significantly increase plasma concentrations of orally inhaled beclomethasone in healthy volunteers
-
March 5-8 2012, Seattle [poster 611]
-
Boyd S, Hadigan C, Pau A, Kovacs J, Alfaro R, Chairez C, et al. Darunavir/ritonavir does not significantly increase plasma concentrations of orally inhaled beclomethasone in healthy volunteers. In: Nineteenth conference on retroviruses and opportunistic infections (CROI), March 5-8 2012, Seattle [poster 611].
-
Nineteenth Conference on Retroviruses and Opportunistic Infections (CROI)
-
-
Boyd, S.1
Hadigan, C.2
Pau, A.3
Kovacs, J.4
Alfaro, R.5
Chairez, C.6
-
15
-
-
84880948450
-
The effect of CYP3A inhibitors and inducers on the pharmacokinetics of telaprevir
-
Cambridge, MA, June 22-23, 2011 [abstract PK-13]
-
Garg V, Chandorkar G, Yang Y, Adda N, McNair L, Alves K, et al. The effect of CYP3A inhibitors and inducers on the pharmacokinetics of telaprevir. In: Sixth international workshop on clinical pharmacology of hepatitis therapy, Cambridge, MA, June 22-23, 2011 [abstract PK-13].
-
Sixth International Workshop on Clinical Pharmacology of Hepatitis Therapy
-
-
Garg, V.1
Chandorkar, G.2
Yang, Y.3
Adda, N.4
McNair, L.5
Alves, K.6
-
16
-
-
80855146132
-
Clinical pharmacology of BOC: Metabolism, excretion and drug-drug interactions
-
Boston, Massachusetts, Ferbruary 27-March 2, 2011 [abstract 118]
-
Kassera C, Hughes E, Treitel M, Gupta S, O'Mara E. Clinical pharmacology of BOC: metabolism, excretion and drug-drug interactions. In: Eighteenth conference on retroviruses and opportunistic infections, Boston, Massachusetts, Ferbruary 27-March 2, 2011 [abstract 118].
-
Eighteenth Conference on Retroviruses and Opportunistic Infections
-
-
Kassera, C.1
Hughes, E.2
Treitel, M.3
Gupta, S.4
O'Mara, E.5
-
17
-
-
84880952743
-
The pharmacokinetic interaction between methadone and the investigational HCV protease inhibitor telaprevir
-
Berlin, Germany, March 30-April 3, 2011 [poster 1244]
-
Heeswijk van R, Vandevoorde A, Verboven P, Boogaerts G, De Paepe E, Solingen-Ristea van R, et al. The pharmacokinetic interaction between methadone and the investigational HCV protease inhibitor telaprevir. 46th Annual meeting of the European association for the study of the liver (The International Liver Congress™ 2011), Berlin, Germany, March 30-April 3, 2011 [poster 1244].
-
46th Annual Meeting of the European Association for the Study of the Liver (the International Liver Congress™ 2011)
-
-
Van R, H.1
Vandevoorde, A.2
Verboven, P.3
Boogaerts, G.4
De Paepe, E.5
Van R, S.6
-
18
-
-
84880964644
-
Pharmacokinetic interaction between HCV protease inhibitor boceprevir and methadone or buprenorphine in subjects on stable maintenance therapy
-
Cambridge, MS, USA, June 27-28, 2012 [abstract PK-09]
-
Hulskotte EGJ, Feng HP, Bruce RD, Webster LR, Xuan F, Lin WH, et al. Pharmacokinetic interaction between HCV protease inhibitor boceprevir and methadone or buprenorphine in subjects on stable maintenance therapy. In: Seventh international workshop on clinical pharmacology of hepatitis therapy, Cambridge, MS, USA, June 27-28, 2012 [abstract PK-09].
-
Seventh International Workshop on Clinical Pharmacology of Hepatitis Therapy
-
-
Egj, H.1
Feng, H.P.2
Bruce, R.D.3
Webster, L.R.4
Xuan, F.5
Lin, W.H.6
-
19
-
-
84880927922
-
No significant effect of the HCV protease inhibitor telaprevir on pharmacokinetics and pharmacodynamics of buprenorphine in HCv-negative volunteers
-
Koloa, Hawaii, December 4-8, 2011 [poster 132]
-
Luo X, Trevejo J, Heeswijk van R, Garg V. No significant effect of the HCV protease inhibitor telaprevir on pharmacokinetics and pharmacodynamics of buprenorphine in HCv-negative volunteers. In: Sixteenth annual meeting of HEP DART, Koloa, Hawaii, December 4-8, 2011 [poster 132].
-
Sixteenth Annual Meeting of HEP DART
-
-
Luo, X.1
Trevejo, J.2
Van R, H.3
Garg, V.4
-
20
-
-
84880944020
-
The pharmacokinetic interaction between escitalopram and the investigational HCV protease inhibitor telaprevir
-
June 23-24, 2010 [abstract 12]
-
Heeswijk van R, Boogaerts G, Paepe de E, Solingen-Ristea van R, Garg V, Beumont M. The pharmacokinetic interaction between escitalopram and the investigational HCV protease inhibitor telaprevir. In: Fifth international workshop on clinical pharmacology of hepatitis therapy, June 23-24, 2010 [abstract 12].
-
Fifth International Workshop on Clinical Pharmacology of Hepatitis Therapy
-
-
Van R, H.1
Boogaerts, G.2
De E, P.3
Van R, S.4
Garg, V.5
Beumont, M.6
-
21
-
-
84872062328
-
Coadministration of the HCV protease inhibitor boceprevir has no clinically meaningful effect on the pharmacokinetics of the selective serotonin reuptake inhibitor escitalopram in healthy volunteers
-
Koloa, Hawaii, December 4-8, 2011 [poster 121]
-
Hulskotte E, Gupta S, Xuan Y, Zutven van M, O'Mara E, Galitz L, et al. Coadministration of the HCV protease inhibitor boceprevir has no clinically meaningful effect on the pharmacokinetics of the selective serotonin reuptake inhibitor escitalopram in healthy volunteers. In: Sixteenth annual meeting of HEP DART, Koloa, Hawaii, December 4-8, 2011 [poster 121].
-
Sixteenth Annual Meeting of HEP DART
-
-
Hulskotte, E.1
Gupta, S.2
Xuan, Y.3
Van M, Z.4
O'Mara, E.5
Galitz, L.6
-
22
-
-
84880948450
-
The effect of telaprevir on the pharmacokinetics of midazolam and digoxin
-
Cambridge, MA, June 22-23, 2011 [abstract PK-12]
-
Garg V, Chandorkar G, Smith F, Alves K, Heeswijk van R. The effect of telaprevir on the pharmacokinetics of midazolam and digoxin. In: Sixth international workshop on clinical pharmacology of hepatitis therapy, Cambridge, MA, June 22-23, 2011 [abstract PK-12].
-
Sixth International Workshop on Clinical Pharmacology of Hepatitis Therapy
-
-
Garg, V.1
Chandorkar, G.2
Smith, F.3
Alves, K.4
Van, H.R.5
-
23
-
-
84880932556
-
The effect of telaprevir on the pharmacokinetics of alprazolam and zolpidem in healthy volunteers
-
Cambridge, MA, June 22-23, 2011 [abstract PK-11]
-
Luo X, Van Heeswijk R, Alves K, Garg V. The effect of telaprevir on the pharmacokinetics of alprazolam and zolpidem in healthy volunteers. In: Sixth international workshop on clinical pharmacology of hepatitis therapy, Cambridge, MA, June 22-23, 2011 [abstract PK-11].
-
Sixth International Workshop on Clinical Pharmacology of Hepatitis Therapy
-
-
Luo, X.1
Van Heeswijk, R.2
Alves, K.3
Garg, V.4
-
24
-
-
80052836825
-
Effect of the hepatitis C virus protease inhibitor telaprevir on the pharmacokinetics of amlodipine and atorvastatin
-
J.E. Lee, R. van Heeswijk, K. Alves, F. Smith, and V. Garg Effect of the hepatitis C virus protease inhibitor telaprevir on the pharmacokinetics of amlodipine and atorvastatin Antimicrob Agents Chemother 55 2011 4569 4574
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 4569-4574
-
-
Lee, J.E.1
Van Heeswijk, R.2
Alves, K.3
Smith, F.4
Garg, V.5
-
25
-
-
84874069405
-
Pharmacokinetic evaluation of the interaction between the HCV protease inhibitor boceprevir and the HMG-CoA reductase inhibitors atorvastatin and pravastatin
-
Koloa, Hawaii, December 4-8, 2011 [poster 122]
-
Hulskotte E, Gupta S, Xuan Y, Zutven van M, O'Mara E, Galitz L, et al. Pharmacokinetic evaluation of the interaction between the HCV protease inhibitor boceprevir and the HMG-CoA reductase inhibitors atorvastatin and pravastatin. In: Sixteenth annual meeting of HEP DART, Koloa, Hawaii, December 4-8, 2011 [poster 122].
-
Sixteenth Annual Meeting of HEP DART
-
-
Hulskotte, E.1
Gupta, S.2
Xuan, Y.3
Van M, Z.4
O'Mara, E.5
Galitz, L.6
-
26
-
-
84880960894
-
In vitro assessment of drug-drug interaction potential of boceprevir as an inhibitor and inducer of drug metabolizing enzymes and transporters
-
San Francisco, California, November 4-8, 2011 [poster 378]
-
Chu X, Cai X, Cui D, Evers R, Green M, Ghosal A, et al. In vitro assessment of drug-drug interaction potential of boceprevir as an inhibitor and inducer of drug metabolizing enzymes and transporters. In: Sixty second annual meeting of the American Association for the Study of Liver Diseases, San Francisco, California, November 4-8, 2011 [poster 378].
-
Sixty Second Annual Meeting of the American Association for the Study of Liver Diseases
-
-
Chu, X.1
Cai, X.2
Cui, D.3
Evers, R.4
Green, M.5
Ghosal, A.6
-
27
-
-
84874043324
-
Pharmacokinetic interaction between the HCV protease inhibitor boceprevir and digoxin in healthy adult volunteers
-
Cambridge, MS, USA, June 27-28, 2012 [abstract PK-05]
-
Jumes P, Feng HP, Xuan F, Youngberg S, Wagner J, Butterton J. Pharmacokinetic interaction between the HCV protease inhibitor boceprevir and digoxin in healthy adult volunteers. In: Seventh international workshop on clinical pharmacology of hepatitis therapy, Cambridge, MS, USA, June 27-28, 2012 [abstract PK-05].
-
Seventh International Workshop on Clinical Pharmacology of Hepatitis Therapy
-
-
Jumes, P.1
Feng, H.P.2
Xuan, F.3
Youngberg, S.4
Wagner, J.5
Butterton, J.6
-
28
-
-
84880934868
-
The pharmacokinetic interaction between an oral contraceptive containing ethinyl estradiol and norethindrone and telaprevir
-
Cambridge, MA, June 22-23, 2011 [abstract PK-17]
-
Garg V, Yang Y, Smith F, Adda N, Van Heeswijk R. The pharmacokinetic interaction between an oral contraceptive containing ethinyl estradiol and norethindrone and telaprevir. In: Sixth international workshop on clinical pharmacology of hepatitis therapy, Cambridge, MA, June 22-23, 2011 [abstract PK-17].
-
Sixth International Workshop on Clinical Pharmacology of Hepatitis Therapy
-
-
Garg, V.1
Yang, Y.2
Smith, F.3
Adda, N.4
Van Heeswijk, R.5
-
29
-
-
13944258563
-
Peginterferon alfa-2a does not alter the pharmacokinetics of methadone in patients with chronic hepatitis C undergoing methadone maintenance therapy
-
DOI 10.1016/j.clpt.2004.09.008
-
M. Sulkowski, T. Wright, S. Rossi, S. Arora, M. Lamb, and K. Wang Peginterferon alfa-2a does not alter the pharmacokinetics of methadone in patients with chronic hepatitis C undergoing methadone maintenance therapy Clin Pharmacol Ther 77 2005 214 224 (Pubitemid 40269136)
-
(2005)
Clinical Pharmacology and Therapeutics
, vol.77
, Issue.3
, pp. 214-224
-
-
Sulkowski, M.1
Wright, T.2
Rossi, S.3
Arora, S.4
Lamb, M.5
Wang, K.6
Gries, J.-M.7
Yalamanchili, S.8
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