Bone marrow-derived mononuclear cells do not exert acute neuroprotection after stroke in spontaneously hypertensive rats

Frontiers in Cellular Neuroscience

Volumn 7, Issue JAN, 2014, Pages

  Minnerup, Jens ^a   Wagner, Daniel Christoph ^b   Strecker, Jan Kolja ^a   Pösel, Claudia ^b   Sevimli Abdis, Sevgi ^a,c   Schmidt, Antje ^a   Schilling, Matthias ^a   Boltze, Johannes ^b,d   Diederich, Kai ^a   Schäbitz, Wolf Rüdiger ^e  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c CATO Europe GmbH   (Germany)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e EVK Bielefeld Bethel Neurologische Klinik   (Germany)

Author keywords

Bone marrow derived mononuclear cells; Dose response; Middle cerebral artery occlusion; Spontaneously hypertensive rats; Stroke

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BRAIN BLOOD FLOW; CEREBROVASCULAR ACCIDENT; COMORBIDITY; CONTROLLED STUDY; HYPERTENSION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLAMMATION; LASER DOPPLER FLOWMETRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MONONUCLEAR CELL; MORTALITY; NONHUMAN; RAT; TREATMENT OUTCOME;

EID: 84892188651     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2013.00288     Document Type: Article

References (31)

1. Baker, A. H., Sica, V., Work, L. M., Williams-Ignarro, S., de Nigris, F., Lerman, L. O., et al. (2007). Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia. Proc. Natl. Acad. Sci. U S A 104, 3597-3602. doi: 10.1073/pnas.0611112104
2. Brenneman, M., Sharma, S., Harting, M., Strong, R., Cox, C. S. Jr., Aronowski, J., et al. (2010). Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats. J. Cereb. Blood Flow Metab. 30, 140-149. doi: 10.1038/jcbfm.2009.198
3. Crossley, N. A., Sena, E., Goehler, J., Horn, J., van der Worp, B., Bath, P. M. W., et al. (2008). Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke 39, 929-934. doi: 10.1161/STROKEAHA. 107.498725
4. Dickhout, J. G., and Lee, R. M. (1998). Blood pressure and heart rate development in young spontaneously hypertensive rats. Am. J. Physiol. 274, H794-H800.
5. Dirnagl, U. (2006). Bench to bedside: the quest for quality in experimental stroke research. J. Cereb. Blood Flow Metab. 26, 1465-1478. doi: 10.1038/sj.jcbfm. 9600298
6. Dirnagl, U., Iadecola, C., and Moskowitz, M. A. (1999). Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22, 391-397. doi: 10.1016/s01662236(99)01401-0
7. Fisher, M., Feuerstein, G., Howells, D. W., Hurn, P. D., Kent, T. A., Savitz, S. I., et al. (2009). Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 40, 2244-2250. doi: 10.1161/STROKEAHA. 108.541128
8. Giraldi-Guimarães, A., Rezende-Lima, M., Bruno, F. P., and Mendez-Otero, R. (2009). Treatment with bone marrow mononuclear cells induces functional recovery and decreases neurodegeneration after sensorimotor cortical ischemia in rats. Brain Res. doi: 10.1016/j.brainres.2009.01.062. [Epub ahead of print].
9. Hacke, W., Kaste, M., Bluhmki, E., Brozman, M., Dávalos, A., Guidetti, D., et al. (2008). Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N. Engl. J. Med. 359, 1317-1329. doi: 10.1056/NEJMoa0804656
10. Iihoshi, S., Honmou, O., Houkin, K., Hashi, K., and Kocsis, J. D. (2004). A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats. Brain Res. 1007, 1-9. doi: 10.1016/j.brainres. 2003.09.084
11. Kamiya, N., Ueda, M., Igarashi, H., Nishiyama, Y., Suda, S., Inaba, T., et al. (2008). Intra-arterial transplantation of bone marrow mononuclear cells immediately after reperfusion decreases brain injury after focal ischemia in rats. Life Sci. 83: 433-437. doi: 10.1016/j.lfs.2008.07.018
12. Kilkenny, C., Browne, W., Cuthill, I. C., Emerson, M., and Altman, D. G. (2011). Animal research: reporting in vivo experiments-the ARRIVE guidelines. J. Cereb. Blood Flow Metab. 31, 991-993. doi: 10.1038/jcbfm.2010. 220
13. Lee, S.-T., Chu, K., Jung, K.-H., Kim, S.-J., Kim, D.-H., Kang, K.-M., et al. (2008). Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke. Brain 131, 616-629. doi: 10.1093/brain/awm306
14. Longa, E. Z., Weinstein, P. R., Carlson, S., and Cummins, R. (1989). Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20, 84-91. doi: 10.1161/01.STR.20.1.84
15. Menzies, S. A., Hoff, J. T., and Betz, A. L. (1992). Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model. Neurosurgery 31, 100-106; discussion 106-107. doi: 10.1227/00006123-19920700000014
16. Minnerup, J., Kim, J. B., Schmidt, A., Diederich, K., Bauer, H., Schilling, M., et al. (2011). Effects of neural progenitor cells on sensorimotor recovery and endogenous repair mechanisms after photothrombotic stroke. Stroke 42, 1757-1763. doi: 10.1161/STROKEAHA.110.599282
17. Minnerup, J., Seeger, F. H., Kuhnert, K., Diederich, K., Schilling, M., Dimmeler, S., et al. (2010). Intracarotid administration of human bone marrow mononuclear cells in rat photothrombotic ischemia. Exp. Transl. Stroke Med. 2:3. doi: 10. 1186/2040-7378-2-3
18. Nakano-Doi, A., Nakagomi, T., Fujikawa, M., Nakagomi, N., Kubo, S., Lu, S., et al. (2010). Bone marrow mononuclear cells promote proliferation of endogenous neural stem cells through vascular niches after cerebral infarction. Stem Cells 28, 1292-1302. doi: 10.1002/stem.454
19. Pösel, C., Möller, K., Fröhlich, W., Schulz, I., Boltze, J., and Wagner, D.-C. (2012). Density gradient centrifugation compromises bone marrow mononuclear cell yield. PLoS One 7:e50293. doi: 10.1371/journal.pone.0050293
20. Saver, J. L., Jahan, R., Levy, E. I., Jovin, T. G., Baxter, B., Nogueira, R. G., et al. (2012). Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial. Lancet 380, 1241-1249. doi: 10.1016/S0140-6736(12)61384-1
21. Savitz, S. I., Chopp, M., Deans, R., Carmichael, S. T., Phinney, D., and Wechsler, L. (2011a). Stem cell therapy as an emerging paradigm for stroke (STEPS) II. Stroke 42, 825-829. doi: 10.1161/strokeaha.110.601914
22. Savitz, S. I., Misra, V., Kasam, M., Juneja, H., Cox, C. S. Jr., Alderman, S., et al. (2011b). Intravenous autologous bone marrow mononuclear cells for ischemic stroke. Ann. Neurol. 70, 59-69. doi: 10.1002/ana.22458
23. Schäbitz, W.-R., Kollmar, R., Schwaninger, M., Juettler, E., Bardutzky, J., Schölzke, M. N., et al. (2003). Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke 34, 745-751. doi: 10.1161/01.str. 0000057814.70180.17
24. Schneider, A., Krüger, C., Steigleder, T., Weber, D., Pitzer, C., Laage, R., et al. (2005). The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J. Clin. Invest. 115, 2083-2098. doi: 10.1172/jci23559
25. Schwarting, S., Litwak, S., Hao, W., Bähr, M., Weise, J., and Neumann, H. (2008). Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury. Stroke 39, 2867-2875. doi: 10.1161/strokeaha.108.51 3978
26. Sevimli, S., Diederich, K., Strecker, J.-K., Schilling, M., Klocke, R., Nikol, S., et al. (2009). Endogenous brain protection by granulocyte-colony stimulating factor after ischemic stroke. Exp. Neurol. 217, 328-335. doi: 10.1016/j.expneurol.2009.03.018
27. Sharma, S., Yang, B., Strong, R., Xi, X., Brenneman, M., Grotta, J. C., et al. (2010). Bone marrow mononuclear cells protect neurons and modulate microglia in cell culture models of ischemic stroke. J. Neurosci. Res. 88, 2869-2876. doi: 10. 1002/jnr.22452
28. Stem Cell Therapies as an Emerging Paradigm in Stroke Participants. (2009). Stem cell therapies as an emerging paradigm in stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke. Stroke 40, 510-515. doi: 10.1161/STROKEAHA.108.52 6863
29. Wagner, D.-C., Bojko, M., Peters, M., Lorenz, M., Voigt, C., Kaminski, A., et al. (2012). Impact of age on the efficacy of bone marrow mononuclear cell transplantation in experimental stroke. Exp. Transl. Stroke Med. 4:17. doi: 10. 1186/2040-7378-4-17
30. Walczak, P., Zhang, J., Gilad, A. A., Kedziorek, D. A., Ruiz-Cabello, J., Young, R. G., et al. (2008). Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia. Stroke 39, 1569-1574. doi: 10. 1161/strokeaha.107.502047
31. Zhang, X.-M., Du, F., Yang, D., Wang, R., Yu, C.-J., Huang, X.-N., et al. (2011). Granulocyte colony-stimulating factor increases the therapeutic efficacy of bone marrow mononuclear cell transplantation in cerebral ischemia in mice. BMC Neurosci. 12:61. doi: 10.1186/1471-2202-12-61