Cytoplasmic expression of laminin γ2 chain correlates with postoperative hepatic metastasis and poor prognosis in patients with pancreatic ductal adenocarcinoma

Cancer

Volumn 94, Issue 6, 2002, Pages 1894-1901

  Takahashi, Shinichiro ^a,b   Hasebe, Takahiro ^a   Oda, Tatsuya ^b   Sasaki, Satoshi ^a   Kinoshita, Taira ^b   Konishi, Masaru ^b   Ochiai, Takenori ^c   Ochiai, Atsushi ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

Hepatic metastasis; Immunohistochemistry; Laminin 2 chain; Pancreatic ductal adenocarcinoma

Indexed keywords

KALININ; LAMININ;

ADULT; AGED; ARTICLE; BASEMENT MEMBRANE; CANCER GRADING; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL FEATURE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MALE; METASTASIS; PANCREAS ADENOCARCINOMA; PANCREAS DUCT; PERITONEUM METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STAINING; TUMOR DIFFERENTIATION;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, PANCREATIC DUCTAL; CYTOPLASM; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LAMININ; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; PANCREATIC NEOPLASMS; PROGNOSIS; SURVIVAL ANALYSIS;

EID: 0037086455     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cncr.10395     Document Type: Article

References (31)

1. Kalinin: An epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments
2. The laminins
3. Structure and function of laminin: Anatomy of a multidomain glycoprotein
4. Wide distribution of laminin-5 gamma 2 chain in basement membranes of various human tissues
5. Oral squamous cell carcinoma invasion is associated with a laminin-5 matrix re-organization but independent of basement membrane and hemidesmosome formation. Clues from an in vitro invasion model
6. Expression of laminin-5 in ameloblastomas and human fetal teeth
7. Laminin-5 as a marker of invasiveness in cervical lesions
8. Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas
9. A large cell-adhesive scatter factor secreted by human gastric carcinoma cells
10. Alpha 6 beta 4 integrin and newly deposited laminin-1 and laminin-5 form the adhesion mechanism of gastric carcinoma, Continuous expression of laminins but not that of collagen VII is preserved in invasive parts of the carcinomas: Implications for acquisition of the invading phenotype
11. The gamma 2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers
12. Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5
13. Clinocopathologic significance of laminin-5 gamma 2 chain expression in squamous cell carcinoma of the tongue: Immunohistochemical analysis of 67 lesions
14. Sole Expression of laminin gamma 2 chain in invading tumor cells and its association with stromal fibrosis in lung adenocarcinomas
15. Overexpression of laminin γ2 chain monomer in invading gastric carcinoma cells
16. Expression of the laminin gamma 2 chain in pancreatic adenocarcinoma
17. Histological typing of tumors of the exocrine pancreas
18. Wide distribution of laminin-5 gamma 2 chain in basement membranes of various human tissues
19. Nonparametric estimation from incomplete observations
20. Regression models and life tables (with discussion)
21. The alpha 6 beta 4 integrin is a receptor for both laminin and kalinin
22. Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes
23. Pancreatic carcinomas deposit laminin-5, preferably adhere to laminin-5, and migrate on the newly deposited basement membrane
24. Laminin interactions with ductal pancreatic adenocarcinoma cells: Identification of laminin- and collagen-binding proteins
25. Patterns of growth and metastases of induced pancreatic cancer in relation to the prognosis and its clinical implications
26. Perineural invasion of carcinoma of the pancreas and biliary tract
27. Clinical significance of carcinoma invasion of the extrapancreatic nerve plexus in pancreatic cancer
28. Beta 4 integrin expression in myelinating Schwann cells is polarized, developmentally regulated and axonally dependent
29. Axonal regulation of Schwann cell integrin expression suggests a role for alpha 6 beta 4 in myelination