Ameliorative effect of morin hydrate, a flavonoid against gentamicin induced oxidative stress and nephrotoxicity in Sprague-Dawley rats

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 6, Issue 1, 2014, Pages 852-856

  Jonnalagadda, Venu Gopal ^a   Pittala, Srinivas ^a   Lahkar, Mangala ^a   Pradeep, Vattikundala ^b  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b Bristol Myers Squibb India Ltd BBRC   (India)

Author keywords

Aminoglycosides; Morin hydrate; Nephrotoxicity; Oxidative stress

Indexed keywords

CATALASE; FLAVONOID; FREE RADICAL; GENTAMICIN; GLUTATHIONE; MORIN HYDRATE; NITRITE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; HISTOPATHOLOGY; KIDNEY FUNCTION TEST; LIPID PEROXIDATION; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RAT; UREA NITROGEN BLOOD LEVEL; WEIGHT REDUCTION;

EID: 84891959897     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Choi JJ, Moffett BS, McDade EJ, Palazzi DL. Altered Gentamicin serum concentrations in obese pediatric patients. Pediatr Infect Dis J.1999; 30:347-9.
2. Ali BH. Agents ameliorating or augmenting experimental Gentamicin nephrotoxicity: some recent research. Food Chem Toxicol. 2003; 41:1447-52.
3. Edwards JR, Diamantakos EA, Peuler JD, Lamar PC, Prozialeck WC. A novel method for the evaluation of proximal tubule epithelial cellular necrosis in the intact rat kidney using ethidium homodimer. BMC Physiol.2007; 7:1.
4. Li J, Li QX, Xie XF, Ao Y, Tie CR, Song RJ. Differential roles of dihydropyridine calcium antagonist nifedipine, nitrendipine and amlodipine on Gentamicin-induced renal tubular toxicity in rats. Eur J Pharmacol.2009; 620:97-104.
5. Banday AA, Farooq N, Priyamvada S, Yusufi AN, Khan F. Time dependent effects of Gentamicin on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in rat kidney tissues. Life Sci. 2008; 82:450-459.
6. Ali BH, Al Za'abi M, Blunden G, Nemmar A. Experimental Gentamicin nephrotoxicity and agents that modify it: a mini-review of recent research. Basic Clin Pharmacol & Toxicol.2011; 109:225-232.
7. Balakumar P, Rohilla A, Thangathirupathi A. Gentamicin-induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it? Pharmacol Res.2010; 62:179-186.
8. Wu TW, Zeng LH, Wu J, Fung KP. Morin: a wood pigment that protects three types of human cells in the cardiovascular system against oxyradical damage. Biochem Pharmacol.1994; 47:1099-103.
9. Venu Gopal J. Morin Hydrate: Botanical origin, Pharmacological activity and its applications:A mini Review. Pharmacognosy Journal.2013;5:123-126.
10. Zeng LH, Fung KP, and Wu TW. Morin Hydrate protects cultured rat glomerular mesangial cells against oxyradical damage. Life Sci.1994; 55:351-7.
11. Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Di Paola R, Britti D, De Sarro A, Pierpaoli S, Caputi AP, Masini E, Salvemini D. A role for superoxide in Gentamicin-mediated nephropathy in rats. Eur J Pharmacol.2002; 450:67-76.
12. Maiti P, Singh SB, Ilavazhagan G. Nitric oxide system is involved in hypobaric hypoxia-induced oxidative stress in rat brain: Acta Histochem.2009; 112:222-32.
13. Gonzalez-Barrios J. A, Escalante B, Valdes J, Leon-Chavez, B. A. Nitric oxide and nitric oxide synthases in the fetal cerebral cortex of rats following transient uteroplacental ischemia. Brain Res.2002; 945:114-122.
14. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem.1951; 193:265-275.
15. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem.1979; 95:351-358.
16. Ellman GL. Tissue sulfahydryl group. Arch Biochem Biophys.1959; 82:70-77.
17. Aebi HC. In: Bergmeyer HU (ed). Methods of enzymatic analysis: Academic press: New York and London.1974; 673-677.
18. Parlakpinar SH, Tasdemir A, Polat et al. Protective role of caffeic acid phenethyl ester (cape) on Gentamicin-induced acute renal toxicity in rats. Toxicology. 2005; 207:169-177.
19. Langley SC, Brown RK, Kelly FJ. Reduced free-radical-trapping capacity and altered Plasma antioxidant status in cystic fibrosis. Pediatr Res.1993; 33:247-50.
20. Venkatesan RS, Mohammed sadiq JA, Suresh kumar G et al. Effect of Morin on mercury chloride induced nephrotoxicity. The Ecoscan.2010; 4:193-196.
21. Hugches PKAK, Stricklett E, Padilla, Kohan DE. Effect of reactive oxygen species on endothelin-1 production by human Mesangial cells. Kidney international.1996; 49:181-189.
22. Tang LWW, Feng JC, Mathison, Wilson CB. Cytokine expression, upregulation of intercellular adhesion molecule-1, and leukocyte infiltration in experimental in experimental tubulointerstitial nephritis. Laboratory investigation.1994; 70: 631-638.
23. Kaur H, Halli B. Detection of hydroxyl radicals by aromatic hydroxylation. Methods in Enzymology.1994; 233: 67-82.
24. Kumar KV, Shifow AA, Naidu MUR, Ratnakar KS. Carvedilol: a beta blocker with antioxidant property protects against Gentamicin-induced nephrotoxicity in rats. Life sciences.2000; 66: 2603-2611.
25. Stojiljkovic N, Veljkovic S, Mihailovic D et al. Protective effects of pentoxifylline treatment on Gentamicin induced nephrotoxicity in rats. Renal failure.2009; 31: 54-61.