Methylglyoxal (MG) and cerebro-renal interaction: Does long-term orally administered MG cause cognitive impairment in normal sprague-dawley rats?

Toxins

Volumn 6, Issue 1, 2013, Pages 254-269

  Watanabe, Kimio ^a   Okada, Kana ^b   Fukabori, Ryoji ^a   Hayashi, Yoshimitsu ^a   Asahi, Koichi ^a   Terawaki, Hiroyuki ^a   Kobayashi, Kazuto ^a   Watanabe, Tsuyoshi ^a   Nakayama, Masaaki ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Cerebro renal interaction; Chronic kidney disease; Cognitive impairment; Methylglyoxal

Indexed keywords

ANGIOTENSINOGEN; GLUTATHIONE PEROXIDASE; METHYLGLYOXAL; SUPEROXIDE DISMUTASE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; HISTOLOGY; KIDNEY FUNCTION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; OXIDATIVE STRESS; RADIAL ARM MAZE TEST; RAT;

ADMINISTRATION, ORAL; ANGIOTENSINOGEN; ANIMALS; ANTIOXIDANTS; COGNITION; COGNITION DISORDERS; GLUTATHIONE PEROXIDASE; KIDNEY; MALE; MAZE LEARNING; OXIDATIVE STRESS; PYRUVALDEHYDE; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

EID: 84891953303     PISSN: 20726651     EISSN: None     Source Type: Journal    
DOI: 10.3390/toxins6010254     Document Type: Article

References (42)

1. Odani, H.; Shinzato, T.; Matsumoto, Y.; Usami, J.; Maeda, K. Increase in three alpha, beta-dicarbonyl compound levels in human uremic plasma: Specific in vivo determination of intermediates in advanced maillard reaction. Biochem. Biophys. Res. Commun. 1999, 256, 89-93.
2. Matafome, P.; Sena, C.; Seica, R. Methylglyoxal, obesity, and diabetes. Endocrine 2013, 43, 472-484.
3. McQuillan, R.; Jassal, S.V. Neuropsychiatric complications of chronic kidney disease. Nat. Rev. Nephrol. 2010, 6, 471-479.
4. Murray, A.M.; Tupper, D.E.; Knopman, D.S.; Gilbertson, D.T.; Pederson, S.L.; Li, S.; Smith, G.E.; Hochhalter, A.K.; Collins, A.J.; Kane, R.L. Cognitive impairment in hemodialysis patients is common. Neurology 2006, 67, 216-223.
5. Kurella, M.; Yaffe, K.; Shlipak, M.G.; Wenger, N.K.; Chertow, G.M. Chronic kidney disease and cognitive impairment in menopausal women. Am. J. Kidney Dis. 2005, 45, 66-76.
6. Khatri, M.; Nickolas, T.; Moon, Y.P.; Paik, M.C.; Rundek, T.; Elkind, M.S.; Sacco, R.L.; Wright, C.B. CKD Associates with cognitive decline. J. Am. Soc. Nephrol. 2009, 20, 2427-2432.
7. Rakowski, D.A.; Caillard, S.; Agodoa, L.Y.; Abbott, K. Dementia as a predictor of mortality in dialysis patients. Clin. J. Am. Soc. Nephrol. 2006, 1, 1000-1005.
8. Beeri, M.S.; Moshier, E.; Schmeidler, J.; Godbold, J.; Uribarri, J.; Reddy, S.; Sano, M.; Grossman, H.T.; Cai, W.; Vlassara, H.; et al. Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals. Mech. Ageing Dev. 2011, 132, 583-587.
9. Srikanth, V.; Westcott, B.; Forbes, J.; Phan, T.G.; Beare, R.; Venn, A.; Pearson, S.; Greenaway, T.; Parameswaran, V.; Munch, G. Methylglyoxal, cognitive function and cerebral atrophy in older people. J. Gerontol. A 2013, 68, 68-73.
10. Ahmed, N.; Ahmed, U.; Thornalley, P.J.; Hager, K.; Fleischer, G.; Münch, G. Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment. J. Neurochem. 2005, 92, 255-263.
11. Nakayama, K.; Nakayama, M.; Iwabuchi, M.; Terawaki, H.; Sato, T.; Kohno, M.; Ito, S. Plasma alpha-oxoaldehyde levels in diabetic and nondiabetic chronic kidney disease patients. Am. J. Nephrol. 2008, 28, 871-878.
12. Di Loreto, S.; Caracciolo, V.; Colafarina, S.; Sebastiani, P.; Gasbarri, A.; Amicarelli, F. Methylglyoxal induces oxidative stress-dependent cell injury and up-regulation of interleukin-1beta and nerve growth factor in cultured hippocampal neuronal cells. Brain Res. 2004, 1006, 157-167.
13. Kikuchi, S.; Shinpo, K.; Moriwaka, F.; Makita, Z.; Miyata, T.; Tashiro, K. Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: Synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases. J. Neurosci. Res. 1999, 57, 280-289.
14. Rutten, B.P.F.; Schmitz, C.; Gerlach, O.H.H.; Oyen, H.M.; De Mesquita, E.B.; Steinbusch, H.W.M.; Kon, H. The aging brain: Accumulation of DNA damage or neuron loss? Neurobiol. Aging 2007, 28, 91-98.
15. Huang, X.; Wang, F.; Chen, W.; Chen, Y.; Wang, N.; Von Maltzan, K. Possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of methylglyoxal. Brain Res. 2012, 1469, 82-91.
16. Chen, X.; Mori, T.; Guo, Q.; Hu, C.; Ohsaki, Y.; Yoneki, Y.; Zhu, W.; Jiang, Y.; Endo, S.; Nakayama, K.; et al. Carbonyl stress induces hypertension and cardio-renal vascular injury in dahl salt-sensitive rats. Hypertens. Res. 2013, 36, 361-367.
17. Ogawa, S.; Nakayama, K.; Nakayama, M.; Mori, T.; Matsushima, M.; Okamura, M.; Senda, M.; Nako, K.; Miyata, T.; Ito, S. Methylglyoxal is a Predictor in Type 2 Diabetic Patients of Intima-media Thickening and Elevation of Blood Pressure. Hypertension 2010, 56, 471-476.
18. Guo, Q.; Mori, T.; Jiang, Y.; Hu, C.; Osaki, Y.; Yoneki, Y.; Sun, Y.; Hosoya, T.; Kawamata, A.; Ogawa, S. Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in sprague-dawley rats. J. Hypertens. 2009, 27, 1664-1671.
19. Wong-Goodrich, S.J.; Glenn, M.J.; Mellott, T.J.; Blusztajn, J.K.; Meck, W.H.; Williams, C.L. Spatial memory and hippocampal plasticity are differentially sensitive to the availability of choline in adulthood as a function of choline supply in utero. Brain Res. 2008, 1237, 153-166.
20. Silva, A.F.; Aguiar, M.S.; Carvalho, O.S.; de Nazare Santana, L.; Franco, E.C.; Lima, R.R.; de Siqueira, N.V.; Feio, R.A.; Faro, L.R.; Gomes-Leal, W. Hippocampal neuronal loss, decreased GFAP immunoreactivity and cognitive impairment following experimental intoxication of rats with aluminum citrate. Brain Res. 2013, 1491, 23-33.
21. Kocahan, S.; Akillioglu, K.; Binokay, S.; Sencar, L.; Polat, S. The effects of N-Methyl-D-Aspartate receptor blockade during the early neurodevelopmental period on emotional behaviors and cognitive functions of adolescent Wistar rats. Neurochem. Res. 2013, 38, 989-996.
22. Rushaidhi, M.; Zhang, H.; Liu, P. Effects of prolonged agmatine treatment in aged male Sprague-Dawley rats. Neuroscience 2013, 234, 116-124.
23. Wang, W.; Tian, L.; Li, Y.; Wang, X.; Xia, F.; Li, L.; Li, J.; Zhang, Z. Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning. J. Emerg. Med. 2013, 44, 107-115.
24. Fedotova, J.; Soultanov, V.; Nikitina, T.; Roschin, V.; Ordayn, N. Ropren(R) is a polyprenol preparation from coniferous plants that ameliorates cognitive deficiency in a rat model of beta-amyloid peptide-(25-35)-induced amnesia. Phytomedicine 2012, 19, 451-456.
25. Levin, E.D.; Caldwell, D.P. Low-dose mecamylamine improves learning of rats in the radial-arm maze repeated acquisition procedure. Neurobiol. Learn. Mem. 2006, 86, 117-122.
26. Di Loreto, S.; Zimmitti, V.; Sebastiani, P.; Cervelli, C.; Falone, S.; Amicarelli, F. Methylglyoxal causes strong weakening of detoxifying capacity and apoptotic cell death in rat hippocampal neurons. Int. J. Biochem. Cell Biol. 2008, 40, 245-257.
27. Heimfarth, L.; Loureiro, S.O.; Pierozan, P.; de Lima, B.O.; Reis, K.P.; Torres, E.B.; Pessoa-Pureur, R. Methylglyoxal-induced cytotoxicity in neonatal rat brain: A role for oxidative stress and MAP kinases. Metab. Brain Dis. 2013, 28, 429-438.
28. Amicarelli, F.; Colafarina, S.; Cattani, F.; Cimini, A.; Di Ilio, C.; Ceru, M.P.; Miranda, M. Scavenging system efficiency is crucial for cell resistance to ros-mediated methylglyoxal injury. Free Radic. Biol. Med. 2003, 35, 856-871.
29. Paget, C.; Lecomte, M.; Ruggiero, D.; Wiernsperger, N.; Lagarde, M. Modification of enzymatic antioxidants in retinal microvascular cells by glucose or advanced glycation end products. Free Radic. Biol. Med. 1998, 25, 121-129.
30. Nakayama, M.; Saito, K.; Sato, E.; Nakayama, K.; Terawaki, H.; Ito, S.; Kohno, M. Radical generation by the non-enzymatic reaction of methylglyoxal and hydrogen peroxide. Redox. Rep. 2007, 12, 125-133.
31. Hoffmann, G.R. A perspective on the scientific, philosophical, and policy dimensions of hormesis. Dose Response 2009, 7, 1-51.
32. Falone, S.; D'Alessandro, A.; Mirabilio, A.; Petruccelli, G.; Cacchio, M.; Di Ilio, C.; Di Loreto, S.; Amicarelli, F. Long term running biphasically improves methylglyoxal-related metabolism, redox homeostasis and neurotrophic support within adult mouse brain cortex. PLoS ONE 2012, 7, e31401.
33. Benzie, I.F. Evolution of antioxidant defence mechanisms. Eur. J. Nutr. 2000, 39, 53-61.
34. Miura, Y. Oxidative stress, radiation-adaptive responses, and aging. J. Radiat. Res. 2004, 45, 357-372.
35. Arumugam, T.V.; Gleichmann, M.; Tang, S.C.; Mattson, M.P. Hormesis/preconditioning mechanisms, the nervous system and aging. Ageing Res. Rev. 2006, 5, 165-178.
36. Falone, S.; D'Alessandro, A.; Mirabilio, A.; Cacchio, M.; Di Ilio, C.; Di Loreto, S.; Amicarelli, F. Late-onset running biphasically improves redox balance, energy-and methylglyoxal-related status, as well as SIRT1 expression in mouse hippocampus. PLoS ONE 2013, 7, e48334.
37. Save, E.; Poucet, B.; Foreman, N.; Buhot, M.C. Object exploration and reactions to spatial and nonspatial changes in hooded rats following damage to parietal cortex or hippocampal formation. Behav. Neurosci. 1992, 106, 447-456.
38. Okaichi, H.; Oshima, Y.; Jarrard, L.E. Scopolamine impairs both working and reference memory in rats: A replication and extension. Pharmacol. Biochem. Behav. 1989, 34, 599-602.
39. Cutler, R.G. Antioxidants and aging. Am. J. Clin. Nutr. 1991, 53, 373-379.
40. De Zwart, L.L.; Meerman, J.H.; Commandeur, J.N.; Vermeulen, N.P. Biomarkers of free radical damage applications in experimental animals and in humans. Free Radic. Biol. Med. 1999, 26, 202-226.
41. Paglia, D.E.; Valentine, W.N. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 1967, 70, 158-169.
42. Martin, J.P., Jr.; Dailey, M.; Sugarman, E. Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. Arch. Biochem. Biophys. 1987, 255, 329-336.