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Volumn 8, Issue 12, 2013, Pages

Celecoxib-induced cytotoxic effect is potentiated by inhibition of autophagy in human urothelial carcinoma cells

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; AUTOPHAGY PROTEIN 5; BAFILOMYCIN A1; CELECOXIB; CYCLOOXYGENASE 2; GREEN FLUORESCENT PROTEIN; JANUS KINASE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE;

EID: 84891934329     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082034     Document Type: Article
Times cited : (22)

References (53)
  • 2
    • 75449108138 scopus 로고    scopus 로고
    • Bladder cancer detection, treatment and outcomes: Opportunities and challenges
    • Latini DM, Lerner SP, Wade SW, Lee DW, Quale DZ (2010) Bladder cancer detection, treatment and outcomes: opportunities and challenges. Urology 75: 334-339.
    • (2010) Urology , vol.75 , pp. 334-339
    • Latini, D.M.1    Lerner, S.P.2    Wade, S.W.3    Lee, D.W.4    Quale, D.Z.5
  • 3
    • 0022360630 scopus 로고
    • Cisplatin, methotrexate, and vinblastine (CMV): An effective chemotherapy regimen for metastatic transitional cell carcinoma of the urinary tract. A Northern California Oncology Group study
    • Harker WG, Meyers FJ, Freiha FS, Palmer JM, Shortliffe LD, et al. (1985) Cisplatin, methotrexate, and vinblastine (CMV): an effective chemotherapy regimen for metastatic transitional cell carcinoma of the urinary tract. A Northern California Oncology Group study. J Clin Oncol 3: 1463-1470. (Pubitemid 16246757)
    • (1985) Journal of Clinical Oncology , vol.3 , Issue.11 , pp. 1463-1470
    • Harker, W.G.1    Meyers, F.J.2    Freiha, F.S.3
  • 6
    • 0033857218 scopus 로고    scopus 로고
    • Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: Results of a large, randomized, multinational, multicenter, phase III study
    • von der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, et al. (2000) Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol 18: 3068-3077.
    • (2000) J Clin Oncol , vol.18 , pp. 3068-3077
    • Von Der Maase, H.1    Hansen, S.W.2    Roberts, J.T.3    Dogliotti, L.4    Oliver, T.5
  • 7
    • 0346368096 scopus 로고    scopus 로고
    • Targeting cyclooxygenase-2 in human neoplasia: Rationale and promise
    • DOI 10.1016/S1535-6108(03)00310-6
    • Dannenberg AJ, Subbaramaiah K (2003) Targeting cyclooxygenase-2 in human neoplasia: rationale and promise. Cancer Cell 4: 431-436. (Pubitemid 38050040)
    • (2003) Cancer Cell , vol.4 , Issue.6 , pp. 431-436
    • Dannenberg, A.J.1    Subbaramaiah, K.2
  • 8
    • 42249088089 scopus 로고    scopus 로고
    • Cyclooxygenase-2 dependent and independent antitumor effects induced by celecoxib in urinary bladder cancer cells
    • DOI 10.1158/1535-7163.MCT-07-0313
    • Dhawan D, Jeffreys AB, Zheng R, Stewart JC, Knapp DW (2008) Cyclooxygenase-2 dependent and independent antitumor effects induced by celecoxib in urinary bladder cancer cells. Mol Cancer Ther 7: 897-904. (Pubitemid 351551043)
    • (2008) Molecular Cancer Therapeutics , vol.7 , Issue.4 , pp. 897-904
    • Dhawan, D.1    Jeffreys, A.B.2    Zheng, R.3    Stewart, J.C.4    Knapp, D.W.5
  • 9
    • 20444475397 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition: A potential mechanism for increasing the efficacy of bacillus Calmette-Guerin immunotherapy for bladder cancer
    • DOI 10.1097/01.ju.0000161589.85869.ae
    • Dovedi SJ, Kirby JA, Atkins H, Davies BR, Kelly JD (2005) Cyclooxygenase-2 inhibition: a potential mechanism for increasing the efficacy of bacillus calmetteguerin immunotherapy for bladder cancer. J Urol 174: 332-337; discussion 337. (Pubitemid 40825752)
    • (2005) Journal of Urology , vol.174 , Issue.1 , pp. 332-337
    • Dovedi, S.J.1    Kirby, J.A.2    Atkins, H.3    Davies, B.R.4    Kelly, J.D.5
  • 10
    • 1242271219 scopus 로고    scopus 로고
    • kip1 and Cell Cycle Arrest
    • DOI 10.1158/0008-5472.CAN-03-1086
    • Han C, Leng J, Demetris AJ, Wu T (2004) Cyclooxygenase-2 promotes human cholangiocarcinoma growth: evidence for cyclooxygenase-2-independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest. Cancer Res 64: 1369-1376. (Pubitemid 38235605)
    • (2004) Cancer Research , vol.64 , Issue.4 , pp. 1369-1376
    • Han, C.1    Leng, J.2    Demetris, A.J.3    Wu, T.4
  • 11
    • 1642407595 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells
    • DOI 10.1016/j.bcp.2003.12.014, PII S0006295203009535
    • Maier TJ, Schilling K, Schmidt R, Geisslinger G, Grosch S (2004) Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells. Biochem Pharmacol 67: 1469-1478. (Pubitemid 38388209)
    • (2004) Biochemical Pharmacology , vol.67 , Issue.8 , pp. 1469-1478
    • Maier, T.J.1    Schilling, K.2    Schmidt, R.3    Geisslinger, G.4    Grosch, S.5
  • 12
    • 33646585939 scopus 로고    scopus 로고
    • Selective cyclooxygenase-2 inhibitors inhibit growth and induce apoptosis of bladder cancer
    • Gee J, Lee IL, Jendiroba D, Fischer SM, Grossman HB, et al. (2006) Selective cyclooxygenase-2 inhibitors inhibit growth and induce apoptosis of bladder cancer. Oncol Rep 15: 471-477.
    • (2006) Oncol Rep , vol.15 , pp. 471-477
    • Gee, J.1    Lee, I.L.2    Jendiroba, D.3    Fischer, S.M.4    Grossman, H.B.5
  • 13
    • 0034667354 scopus 로고    scopus 로고
    • Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer -344 rats
    • Grubbs CJ, Lubet RA, Koki AT, Leahy KM, Masferrer JL, et al. (2000) Celecoxib inhibits N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder cancers in male B6D2F1 mice and female Fischer-344 rats. Cancer Res 60: 5599-5602.
    • (2000) Cancer Res , vol.60 , pp. 5599-5602
    • Grubbs, C.J.1    Lubet, R.A.2    Koki, A.T.3    Leahy, K.M.4    Masferrer, J.L.5
  • 14
    • 61349185227 scopus 로고    scopus 로고
    • In vitro and in vivo inhibitory effect evaluation of cyclooxygenase-2 inhibitors, antisense cyclooxygenase-2 cDNA, and their combination on the growth of human bladder cancer cells
    • Qin J, Yuan J, Li L, Liu H, Qin R, et al. (2009) In vitro and in vivo inhibitory effect evaluation of cyclooxygenase-2 inhibitors, antisense cyclooxygenase-2 cDNA, and their combination on the growth of human bladder cancer cells. Biomed Pharmacother 63: 241-248.
    • (2009) Biomed Pharmacother , vol.63 , pp. 241-248
    • Qin, J.1    Yuan, J.2    Li, L.3    Liu, H.4    Qin, R.5
  • 15
    • 56449127196 scopus 로고    scopus 로고
    • OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma
    • Gao M, Yeh PY, Lu YS, Hsu CH, Chen KF, et al. (2008) OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma. Cancer Res 68: 9348-9357.
    • (2008) Cancer Res , vol.68 , pp. 9348-9357
    • Gao, M.1    Yeh, P.Y.2    Lu, Y.S.3    Hsu, C.H.4    Chen, K.F.5
  • 16
    • 84863346573 scopus 로고    scopus 로고
    • Downregulation of glucose-regulated protein (GRP) 78 potentiates cytotoxic effect of celecoxib in human urothelial carcinoma cells
    • Huang KH, Kuo KL, Chen SC, Weng TI, Chuang YT, et al. (2012) Downregulation of glucose-regulated protein (GRP) 78 potentiates cytotoxic effect of celecoxib in human urothelial carcinoma cells. PLoS One 7: e33615.
    • (2012) PLoS One , vol.7
    • Huang, K.H.1    Kuo, K.L.2    Chen, S.C.3    Weng, T.I.4    Chuang, Y.T.5
  • 17
    • 77953530983 scopus 로고    scopus 로고
    • Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells
    • Huang S, Sinicrope FA (2010) Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells. Autophagy 6: 256-269.
    • (2010) Autophagy , vol.6 , pp. 256-269
    • Huang, S.1    Sinicrope, F.A.2
  • 18
    • 0041703017 scopus 로고    scopus 로고
    • Celecoxib activates a novel mitochondrial apoptosis signaling pathway
    • Jendrossek V, Handrick R, Belka C (2003) Celecoxib activates a novel mitochondrial apoptosis signaling pathway. FASEB J 17: 1547-1549.
    • (2003) FASEB J , vol.17 , pp. 1547-1549
    • Jendrossek, V.1    Handrick, R.2    Belka, C.3
  • 19
    • 10644257370 scopus 로고    scopus 로고
    • Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells
    • DOI 10.1093/jnci/djh322
    • Liu X, Yue P, Zhou Z, Khuri FR, Sun SY (2004) Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst 96: 1769-1780. (Pubitemid 39654571)
    • (2004) Journal of the National Cancer Institute , vol.96 , Issue.23 , pp. 1769-1780
    • Liu, X.1    Yue, P.2    Zhou, Z.3    Khuri, F.R.4    Sun, S.-Y.5
  • 21
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer G, Marino G, Levine B (2010) Autophagy and the integrated stress response. Mol Cell 40: 280-293.
    • (2010) Mol Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Marino, G.2    Levine, B.3
  • 22
    • 35448980704 scopus 로고    scopus 로고
    • Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation
    • DOI 10.1158/0008-5472.CAN-07-1462
    • Sato K, Tsuchihara K, Fujii S, Sugiyama M, Goya T, et al. (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res 67: 9677-9684. (Pubitemid 47621214)
    • (2007) Cancer Research , vol.67 , Issue.20 , pp. 9677-9684
    • Sato, K.1    Tsuchihara, K.2    Fujii, S.3    Sugiyama, M.4    Goya, T.5    Atomi, Y.6    Ueno, T.7    Ochiai, A.8    Esumi, H.9
  • 23
    • 33846244269 scopus 로고    scopus 로고
    • Role of autophagy in cancer: Management of metabolic stress
    • Jin S, White E (2007) Role of autophagy in cancer: management of metabolic stress. Autophagy 3: 28-31. (Pubitemid 46100707)
    • (2007) Autophagy , vol.3 , Issue.1 , pp. 28-31
    • Jin, S.1    White, E.2
  • 25
    • 0033794636 scopus 로고    scopus 로고
    • Characterization of chemoresistance mechanisms in a series of cisplatin-resistant transitional carcinoma cell lines
    • Hour TC, Chen J, Huang CY, Guan JY, Lu SH, et al. (2000) Characterization of chemoresistance mechanisms in a series of cisplatin-resistant transitional carcinoma cell lines. Anticancer Res 20: 3221-3225.
    • (2000) Anticancer Res , vol.20 , pp. 3221-3225
    • Hour, T.C.1    Chen, J.2    Huang, C.Y.3    Guan, J.Y.4    Lu, S.H.5
  • 26
    • 0026880572 scopus 로고
    • Characterization of a newly established human bladder carcinoma cell line, NTUB1
    • Yu HJ, Tsai TC, Hsieh TS, Chiu TY (1992) Characterization of a newly established human bladder carcinoma cell line, NTUB1. J Formos Med Assoc 91: 608-613.
    • (1992) J Formos Med Assoc , vol.91 , pp. 608-613
    • Yu, H.J.1    Tsai, T.C.2    Hsieh, T.S.3    Chiu, T.Y.4
  • 27
    • 79957612142 scopus 로고    scopus 로고
    • UBE2M-mediated p27(Kip1) degradation in gemcitabine cytotoxicity
    • Huang AM, Kao YT, Toh S, Lin PY, Chou CH, et al. (2011) UBE2M-mediated p27(Kip1) degradation in gemcitabine cytotoxicity. Biochem Pharmacol 82: 35-42.
    • (2011) Biochem Pharmacol , vol.82 , pp. 35-42
    • Huang, A.M.1    Kao, Y.T.2    Toh, S.3    Lin, P.Y.4    Chou, C.H.5
  • 28
    • 77953359913 scopus 로고    scopus 로고
    • Transcriptional up-regulation of SOD1 by CEBPD: A potential target for cisplatin resistant human urothelial carcinoma cells
    • Hour TC, Lai YL, Kuan CI, Chou CK, Wang JM, et al. (2010) Transcriptional up-regulation of SOD1 by CEBPD: a potential target for cisplatin resistant human urothelial carcinoma cells. Biochem Pharmacol 80: 325-334.
    • (2010) Biochem Pharmacol , vol.80 , pp. 325-334
    • Hour, T.C.1    Lai, Y.L.2    Kuan, C.I.3    Chou, C.K.4    Wang, J.M.5
  • 29
    • 79952283054 scopus 로고    scopus 로고
    • Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS
    • Cheng JH, Huang AM, Hour TC, Yang SC, Pu YS, et al. (2011) Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS. Eur J Med Chem 46: 1222-1231.
    • (2011) Eur J Med Chem , vol.46 , pp. 1222-1231
    • Cheng, J.H.1    Huang, A.M.2    Hour, T.C.3    Yang, S.C.4    Pu, Y.S.5
  • 30
    • 84863982260 scopus 로고    scopus 로고
    • Cytotoxic and antioxidant constituents from Garcinia subelliptica
    • Lin KW, Huang AM, Yang SC, Weng JR, Hour TC, et al. (2012) Cytotoxic and antioxidant constituents from Garcinia subelliptica. Food Chem 135: 851-859.
    • (2012) Food Chem , vol.135 , pp. 851-859
    • Lin, K.W.1    Huang, A.M.2    Yang, S.C.3    Weng, J.R.4    Hour, T.C.5
  • 31
    • 84879486831 scopus 로고    scopus 로고
    • Dual inhibitor of phosphoinositide 3-kinase/mammalian target of rapamycin NVP-BEZ235 effectively inhibits cisplatin-resistant urothelial cancer cell growth through autophagic flux
    • Li JR, Cheng CL, Yang CR, Ou YC, Wu MJ, et al. (2013) Dual inhibitor of phosphoinositide 3-kinase/mammalian target of rapamycin NVP-BEZ235 effectively inhibits cisplatin-resistant urothelial cancer cell growth through autophagic flux. Toxicol Lett 220: 267-276.
    • (2013) Toxicol Lett , vol.220 , pp. 267-276
    • Li, J.R.1    Cheng, C.L.2    Yang, C.R.3    Ou, Y.C.4    Wu, M.J.5
  • 32
    • 77951689083 scopus 로고    scopus 로고
    • Combination of bifunctional alkylating agent and arsenic trioxide synergistically suppresses the growth of drug-resistant tumor cells
    • Lee PC, Kakadiya R, Su TL, Lee TC (2010) Combination of bifunctional alkylating agent and arsenic trioxide synergistically suppresses the growth of drug-resistant tumor cells. Neoplasia 12: 376-387.
    • (2010) Neoplasia , vol.12 , pp. 376-387
    • Lee, P.C.1    Kakadiya, R.2    Su, T.L.3    Lee, T.C.4
  • 34
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132: 27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 35
    • 79952166584 scopus 로고    scopus 로고
    • Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction
    • Suzuki SW, Onodera J, Ohsumi Y (2011) Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction. PLoS One 6: e17412.
    • (2011) PLoS One , vol.6
    • Suzuki, S.W.1    Onodera, J.2    Ohsumi, Y.3
  • 36
    • 75149171923 scopus 로고    scopus 로고
    • Control of basal autophagy by calpain1 mediated cleavage of ATG5
    • Xia HG, Zhang L, Chen G, Zhang T, Liu J, et al. (2010) Control of basal autophagy by calpain1 mediated cleavage of ATG5. Autophagy 6: 61-66.
    • (2010) Autophagy , vol.6 , pp. 61-66
    • Xia, H.G.1    Zhang, L.2    Chen, G.3    Zhang, T.4    Liu, J.5
  • 37
    • 33745088813 scopus 로고    scopus 로고
    • Structure-function relationship of Atg12, a ubiquitin-like modifier essential for autophagy
    • Hanada T, Ohsumi Y (2005) Structure-function relationship of Atg12, a ubiquitin-like modifier essential for autophagy. Autophagy 1: 110-118.
    • (2005) Autophagy , vol.1 , pp. 110-118
    • Hanada, T.1    Ohsumi, Y.2
  • 38
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, et al. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. The EMBO journal 19: 5720-5728.
    • (2000) The EMBO Journal , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3    Yamamoto, A.4    Kirisako, T.5
  • 39
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    • Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, et al. (2006) Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10: 51-64.
    • (2006) Cancer Cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3    Bray, K.4    Anderson, D.5
  • 40
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, et al. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19: 5720-5728.
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3    Yamamoto, A.4    Kirisako, T.5
  • 42
    • 59349111783 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and autophagy as targets for cancer therapy
    • Schonthal AH (2009) Endoplasmic reticulum stress and autophagy as targets for cancer therapy. Cancer Lett 275: 163-169.
    • (2009) Cancer Lett , vol.275 , pp. 163-169
    • Schonthal, A.H.1
  • 44
    • 61449168122 scopus 로고    scopus 로고
    • Cell death induced by nutritional starvation in mouse macrophage-like RAW264.7 cells
    • Sakagami H, Kishino K, Amano O, Kanda Y, Kunii S, et al. (2009) Cell death induced by nutritional starvation in mouse macrophage-like RAW264.7 cells. Anticancer research 29: 343-347.
    • (2009) Anticancer Research , vol.29 , pp. 343-347
    • Sakagami, H.1    Kishino, K.2    Amano, O.3    Kanda, Y.4    Kunii, S.5
  • 46
    • 27644484061 scopus 로고    scopus 로고
    • Autophagy: Molecular machinery for selfeating
    • Yorimitsu T, Klionsky DJ (2005) Autophagy: molecular machinery for selfeating. Cell death and differentiation 12 Suppl 2: 1542-1552.
    • (2005) Cell Death and Differentiation , vol.12 , Issue.SUPPL. 2 , pp. 1542-1552
    • Yorimitsu, T.1    Klionsky, D.J.2
  • 47
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis JM, Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81: 807-869. (Pubitemid 32267078)
    • (2001) Physiological Reviews , vol.81 , Issue.2 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 48
    • 33947386684 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress: A new pathway to induce aytophagy
    • Yorimitsu T, Klionsky DJ (2007) Endoplasmic reticulum stress: a new pathway to induce autophagy. Autophagy 3: 160-162. (Pubitemid 46449112)
    • (2007) Autophagy , vol.3 , Issue.2 , pp. 160-162
    • Yorimitsu, T.1    Klionsky, D.J.2
  • 49
    • 33749579383 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress triggers autophagy
    • DOI 10.1074/jbc.M607007200
    • Yorimitsu T, Nair U, Yang Z, Klionsky DJ (2006) Endoplasmic reticulum stress triggers autophagy. The Journal of biological chemistry 281: 30299-30304. (Pubitemid 44537037)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.40 , pp. 30299-30304
    • Yorimitsu, T.1    Nair, U.2    Yang, Z.3    Klionsky, D.J.4
  • 50
    • 0034062275 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of celecoxib. A selective cyclo-oxygenase-2 inhibitor
    • Davies NM, McLachlan AJ, Day RO, Williams KM (2000) Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclooxygenase- 2 inhibitor. Clin Pharmacokinet 38: 225-242. (Pubitemid 30156623)
    • (2000) Clinical Pharmacokinetics , vol.38 , Issue.3 , pp. 225-242
    • Davies, N.M.1    McLachlan, A.J.2    Day, R.O.3    Williams, K.M.4
  • 51
    • 77649090075 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and cancer treatment: Understanding the risk should be worth the reward
    • Menter DG, Schilsky RL, DuBois RN (2010) Cyclooxygenase-2 and cancer treatment: understanding the risk should be worth the reward. ClinCancer Res 16: 1384-1390.
    • (2010) ClinCancer Res , vol.16 , pp. 1384-1390
    • Menter, D.G.1    Schilsky, R.L.2    Dubois, R.N.3
  • 52
    • 0033665248 scopus 로고    scopus 로고
    • Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: A randomized, controlled trial
    • Leese PT, Hubbard RC, Karim A, Isakson PC, Yu SS, et al. (2000) Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: a randomized, controlled trial. J Clin Pharmacol 40: 124-132.
    • (2000) J Clin Pharmacol , vol.40 , pp. 124-132
    • Leese, P.T.1    Hubbard, R.C.2    Karim, A.3    Isakson, P.C.4    Yu, S.S.5
  • 53
    • 0034326837 scopus 로고    scopus 로고
    • Celecoxib prevents tumor growth in vivo without toxicity to normal gut: Lack of correlation between in vitro and in vivo models
    • Williams CS, Watson AJ, Sheng H, Helou R, Shao J, et al. (2000) Celecoxib prevents tumor growth in vivo without toxicity to normal gut: lack of correlation between in vitro and in vivo models. Cancer Res 60: 6045-6051.
    • (2000) Cancer Res , vol.60 , pp. 6045-6051
    • Williams, C.S.1    Watson, A.J.2    Sheng, H.3    Helou, R.4    Shao, J.5


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