Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: A randomized, controlled trial

Journal of Clinical Pharmacology

Volumn 40, Issue 2, 2000, Pages 124-132

  Leese, P T ^a   Hubbard, R C ^b   Karim, A ^b   Isakson, P C ^b   Yu, S S ^b   Geis, G S ^b  

^a Innovex Inc   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ARACHIDONIC ACID; CELECOXIB; COLLAGEN; CYCLOOXYGENASE 2 INHIBITOR; NAPROXEN; PLACEBO; THROMBOXANE A2 RECEPTOR STIMULATING AGENT; THROMBOXANE B2;

ABDOMINAL PAIN; ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLEEDING TIME; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRUG SAFETY; ENZYME INHIBITION; FEMALE; FLATULENCE; HEADACHE; HEMOSTASIS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE FUNCTION;

EID: 0033665248     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/00912700022008766     Document Type: Article

References (38)

1. Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs
2. Effects of non-steroidal anti-inflammatory drugs on fatty acid cyclooxygenase and prostaglandin hyperperoxidase activities
3. Arachidonic acid metabolism
4. Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxidase synthase (cyclooxygenase)
5. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence
6. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic
7. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
8. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
9. Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis
10. Effect on platelet aggregation of oral administration of 10 non-steroidal analgesics to humans
11. Haemostatic effects of ketorolac with and without concomitant heparin in normal volunteers
12. Improvement in early saphenous vein graft patency after coronary artery bypass surgery with antiplatelet therapy: Results of a Veterans Administration Cooperative Study
13. Preoperative aspirin therapy and reoperation for bleeding after coronary artery bypass surgery
14. Effects of diflunisal on platelet function and fecal blood loss
15. The effect of continuous intravenous indomethacin infusion on bleeding time and postoperative pain in patients undergoing emergency surgery of the lower extremities
16. Effects of ketorolac tromethamine on hemostasis in volunteers
17. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs: A meta-analysis
18. Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs
19. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs
20. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs: A randomized, double-blind, placebo-controlled trial
21. Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly patients at high risk for hemorrhagic peptic ulcer disease
22. Drug interaction with coumarin derivative anti-coagulants
23. Interaction between oral anti-coagulant drugs and non-steroidal anti-inflammatory agents: A review
24. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluromethyl)-1H-pyrazol-1-yl] benzenesulfonamide (SC-58635, celecoxib)
25. Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: Efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects
26. Normal and abnormal platelet activity
27. The aggregation of blood platelets
28. The bleeding time as a screening test for evaluation of platelet function
29. Should nonsteroidal anti-inflam-matory drugs be stopped before elective surgery?
30. Drug-induced epistaxis?
31. Effect of naproxen and of aspirin on bleeding time and platelet aggregation
32. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment
33. Inhibition of platelet thromboxane synthesis by 7-(1-imidazolyl) heptanoic acid: Dissociation from inhibition of aggregation
34. Inhibition of thromboxane formation in vivo and ex vivo: Implications for therapy with platelet inhibitory drugs
35. Effect of drug-induced platelet dysfunction on surgical bleeding
36. The anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: A randomized controlled trial
37. Randomised double-blind comparison of celecoxib versus diclofenac in long-term management of rheumatoid arthritis
38. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice