Composite PLDLLA/TCP Scaffolds for Bone Engineering: Mechanical and In Vitro Evaluations

IFMBE Proceedings

Volumn 23, Issue , 2009, Pages 1480-1483

  Lam, C X F ^a   Olkowski, R ^b   Swieszkowski, W ^c   Tan, K C ^d   Gibson, I ^a   Hutmacher, D W ^a,e  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c WARSAW UNIVERSITY OF TECHNOLOGY   (Poland)

^d TEMASEK POLYTECHNIC   (Singapore)

^e QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

bioresorbable scaffolds; bone; Composite; PLDLLA; tissue engineering

Indexed keywords

BIORESORBABLE SCAFFOLDS; BONE MARROW STROMAL CELLS; BONE TISSUE ENGINEERING; COMPRESSIVE MECHANICAL PROPERTIES; PLDLLA; RAPID PROTOTYPING TECHNOLOGY; TISSUE CULTURE PLASTICS; WESTERN-BLOT ANALYSIS;

BIOCERAMICS; BIOCOMPATIBILITY; BIOMECHANICS; BIOMEDICAL ENGINEERING; BIOPOLYMERS; BONE; CELL PROLIFERATION; COMPOSITE MATERIALS; MECHANICAL PROPERTIES; SCANNING ELECTRON MICROSCOPY; TISSUE; TISSUE ENGINEERING;

SCAFFOLDS (BIOLOGY);

EID: 84891920237     PISSN: 16800737     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1007/978-3-540-92841-6_366     Document Type: Conference Paper

References (17)

1. Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000 Dec;21(24):2529-2543.
2. Hutmacher DW, Schantz JT, Lam CX, Tan KC, Lim TC. State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective. Journal of tissue engineering and regenerative medicine 2007 Jul-Aug;1(4):245-260.
3. Chu TM, Orton DG, Hollister SJ, Feinberg SE, Halloran JW. Mechanical and in vivo performance of hydroxyapatite implants with controlled architectures. Biomaterials 2002 Mar;23(5):1283-1293.
4. De Groot JH, Kuijper HW, Pennings AJ. A novel method for fabrication of biodegradable scaffolds with high compression moduli. Journal of Materials Science-Materials in Medicine 1997 Nov;8(11):707-712.
5. Ishaug SL, Crane GM, Miller MJ, Yasko AW, Yaszemski MJ, Mikos AG. Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. J Biomed Mater Res 1997 Jul;36(1):17-28.
6. Ramay HR, Zhang M. Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering. Biomaterials 2004 Sep;25(21):5171-5180.
7. Chistolini P, Ruspantini I, Bianco P, Corsi A, Cancedda R, Quarto R. Biomechanical evaluation of cell-loaded and cell-free hydroxyapatite implants for the reconstruction of segmental bone defects. J Mater Sci Mater Med 1999 Dec;10(12):739-742.
8. Schumann D, Ekaputra AK, Lam CXF, Hutmacher DW. Biomaterials/ Scaffolds - Design of Bioactive, Multiphasic PCL/collagen Type I and Type II - PCL-TCP/collagen Composite Scaffolds for Functional Tissue Engineering of Osteochondral Repair Tissue by Using Electrospinning and FDM Techniques. In: Hauser H, Fussenegger M, editors. Tissue Engineering (Methods in Molecular Medicine). 2nd ed. New Jersey: Humana Press, 2007. p. 101-124.
9. Kim HW. Biomedical nanocomposites of hydroxyapatite/ polycaprolactone obtained by surfactant mediation. J Biomed Mater Res A 2007 Mar 27.
10. Liao S, Wang W, Uo M, Ohkawa S, Akasaka T, Tamura K, et al. A three-layered nano-carbonated hydroxyapatite/collagen/PLGA composite membrane for guided tissue regeneration. Biomaterials 2005 Dec;26(36):7564-7571.
11. Zhou YF, Hutmacher DW, Varawan SL, Lim TM. In vitro bone engineering based on polycaprolactone and polycaprolactonetricalcium phosphate composites. Polym Int 2007 Mar;56(3):333-342.
12. Hutmacher DW, Schantz T, Zein I, Ng KW, Teoh SH, Tan KC. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J Biomed Mater Res 2001 May;55(2):203-216.
13. Zein I, Hutmacher DW, Tan KC, Teoh SH. Fused deposition modeling of novel scaffold architectures for tissue engineering applications. Biomaterials 2002 Feb;23(4):1169-1185.
14. Athanasiou KA, Zhu C, Lanctot DR, Agrawal CM, Wang X. Fundamentals of biomechanics in tissue engineering of bone. Tissue Eng 2000 Aug;6(4):361-381.
15. Lam CXF, Teoh SH, Hutmacher DW. Comparison of Degradation of PCL & PCL-TCP scaffolds in Alkaline Medium. Polym Int 2007;56(6):718-728.
16. Gibson LJ, Ashby MF. Cellular Solids: Structure and Properties 2nd ed ed: Cambridge University Press, 1997.
17. Thomson RC, Yaszemski MJ, Powers JM, Mikos AG. Fabrication of Biodegradable Polymer Scaffolds to Engineer Trabecular Bone. Journal of Biomaterials Science-Polymer Edition 1995;7(1):23-38.