PHBV Microspheres as Tissue Engineering Scaffold for Neurons

IFMBE Proceedings

Volumn 23, Issue , 2009, Pages 1208-1212

  Chen, W H ^a   Tang, B L ^a   Tong, Y W ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Neural Tissue Engineering; Poly(3 hydroxyburate co 3 hydroxyvalerate); Polymeric microspheres

Indexed keywords

CELL-MATERIAL INTERACTION; CONFOCAL LASER SCANNING MICROSCOPY; FUNCTIONAL INTEGRATION; NEURAL TISSUE ENGINEERING; OIL-IN-WATER EMULSIONS; POLY(3-HYDROXYBURATE-CO-3-HYDROXYVALERATE); POLYMERIC MICROSPHERE; TISSUE ENGINEERING SCAFFOLD;

ASSAYS; BIOCOMPATIBILITY; BIOMEDICAL ENGINEERING; CELLS; CYTOLOGY; DRUG DELIVERY; EMULSIONS; MICROSPHERES; NEURONS; POLYMERS; REPAIR; SCANNING ELECTRON MICROSCOPY; TISSUE;

SCAFFOLDS (BIOLOGY);

EID: 84891914351     PISSN: 16800737     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1007/978-3-540-92841-6_296     Document Type: Conference Paper

References (20)

1. Ofira E, Tamir BH. The changing face of neural stem cell therapy in neurologic diseases. Arch neurol 2008; 65(4): 452-456.
2. Guzman R, Choi R, Gera A, Angeles ADL, Andres RH, Steinberg GK. Intravascular cell replacement therapy for stroke. Neurosurg Focus 2008; 24 (3&4): E14.
3. Eftekharpour E, Karimi-Abdolrezaee S, Fehlings MG. Current status of experimental cell replacement approaches to spinal cord injury. Neurosurg Focus 2008; 24 (3&4): E18.
4. Chen CP, Kiel ME, Sadowski D, McKinnon RD. From stem cells to oligodendrocytes: Prospects for Brain Therapy. Stem Cell Rev 2007; 3: 280-288.
5. O'Donnell PB, McGinit JW. Preparation of microspheres by the solvent evaporation technique. Adv Drug Deliv Rev 1997; 28: 25-42.
6. Xu XJ, Sy JC, Prasad SV. Towards developing surface eroding PHAs. Biomaterials 2006; 27(15): 3012-3030.
7. Chen J, Davis SS. The release of diazepam from poly(hydroxybutyrate-hydroxyvalerate) microspheres. J Microencapsul 2002: 19(2): 191-201.
8. Van Tomme SR, Van Steenbergen MJ, De Smedt SC, Van Nostrum CF, Hennink WE. Self-gelling hydrogels based on oppositely charged dextran microspheres. Biomaterials 2005; 26(14): 2129-2135.
9. Payne RG, Yasko AW, Yaszemski MJ, Mikos AG. Temporary encapsulation of rat marrow osteoblasts in gelatin microspheres for bone tissue engineering. Materials Research Society Symposium-Proceedings (2001).
10. Wong MS, Causey TB, Mantzaris N, Bennett GN, San KY. Engineering poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer composition in E. Coli. Biotechnol Bioeng 2008; 99(4): 919-928.
11. Squio CR, Marangoni C, De Vecchi CS, Aragao GMF. Phosphate feeding strategy during production phase improves poly(3-hydroxybutyrate-co-3-hydroxyvalerate) storage by Ralstonia eutropha. Appl Microbiol Biotechnol 2003; 61: 257-260.
12. Hankermeyer CR, Tjeerdema RS. Polyhydroxyburate: plastic made and degraded by microorganisms. Rev Environ Contam Toxicol 1999; 159: 1-24.
13. Gürsel İ, Korkusuz F, Türesin F, Alaeddinǧlu N. G, Hasi{dotless}rci{dotless} V. In vivo application of biodegradable controlled antibiotic release systems for the treatment of implant-related osteomyelitis. Biomaterials 2001; 22: 73-80.
14. Willerth SM, Sakiyama-Elbert SE. Approaches to neural tissue engineering using scaffolds for drug delivery. Adv Drug Deliv Rev 2007; 59: 325-338.
15. Kallos MS, Sen A, Behie LA. Large scale expansion of mammalian neural stem cells: a review. Med Biol Eng Comput 2003; 41: 271-282.
16. Schmidt CE, Leach JB. Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng 2003; 5: 293-347.
17. Yang YY, Chia HH, Chung TS. Effect of preparation temperature on the characteristics and release profile of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/ evapouration method. J Control Release 2000; 69: 81-96.
18. Ciapetti G, Cenni E, Pratelli L, Pizzoferrato A. In vitro evaluation of cell/biomaterial interaction by MTT assay. Biomaterials 1993: 14(5): 359-364.
19. Rago R, Mitchen J, Wilding G. DNA fluorometric assay in 96-well tissue culture plates using Hoechst 33258 after cell lysis by freezing in distilled water. Anal Biochem 1990; 191: 31-34.
20. Moskowitz PF, Oblinger MM. Sensory neurons selectively upregulate synthesis and transport of the beta-III-tubulin protein during axonal regeneration. J neurosci 1995; 15(2): 1545-1555.