Hepatoprotective and antidiabetic effect of methanol extract of Caralluma fimbriata in streptatozocin induced diabetic albino rats

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 6, Issue 1, 2014, Pages 665-668

  Latha, S ^a   Rajaram, K ^a   Suresh Kumar, P ^a  

^a ANNA UNIVERSITY   (India)

Author keywords

Anti diabetic; Caralluma fimbriata; Hepatoprotective; MCF; Streptatozocin

Indexed keywords

ALKALINE PHOSPHATASE; CARALLUMA FIMBRIATA EXTRACT; GLIBENCLAMIDE; GLYCOSYLATED HEMOGLOBIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CELL VACUOLE; CONTROLLED STUDY; DIABETES MELLITUS; GLOMERULOSCLEROSIS; GLUCOSE BLOOD LEVEL; GLUCOSURIA; HISTOPATHOLOGY; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; LIVER CELL; LIVER FATTY DEGENERATION; LIVER PROTECTION; MALE; NONHUMAN; RAT;

EID: 84891910980     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Andrade-Cetto A, Heinrich M. Mexican plants with hypoglycemic effect used in the treatment of diabetes. J Ethnopharmacol 2005; 73:325-348.
2. Attele AS, Zhou Y, Xie J, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan C. Antidiabetic effects of Panax ginseng Berry extract and the identification of an effective component. Diabetes 2002; 51:1851-1858.
3. Prince PSM, Menon VP, Pari L. Hypoglycaemic activity of Syzygium cumini seeds: effect on lipid peroxidation in alloxan diabetic rats. J Ethnopharmacol 1998; 61:1-7.
4. Babu V, Gangadevi T, Subranabuab A. Anihyperglycemic effect of Cassia keinii leaf extract in glucose feed normal rats and alloxan induced diabetic rats. Indian J Pharmacol 2002; 34:409-415.
5. Saifi AQ, Shinde S, Kavishwar WK, Gupta SR. Some aspects of phytochemistry and hypoglycemic actions of Pterocarpus marsupium. J Res Indian Med 1971; 6 (2):205-207.
6. Mukherjee K, Ghosh NC, Datta T. Coccinia indica Linn. as potential hypoglycemic agent. Indian J Exp Bio 1972; 10 (5):347-349.
7. Coimbra TC, Danni FF, Blotta RM, Da-Periara CA, Guedes MD, Graf RG. Plants employed in the treatment of diabetes mellitus results of an ethnopharmacological survey in Porto Alegre, Brazil. Fitoterapia 1992; 63(4):320-322.
8. Ajit K, Choudhary BK, Bandhopadhyay NG. Preliminary studies on the inorganic constituents of some indigenous hypoglycemic herbs on oral glucose tolerance test. J Ethnopharmacol 1999; 64:179-184.
9. Zakaria MNM, Islam MW, Radhakrishnan R, Chen HB, Kamil M, Al-Gifri AN, Chan K, Al-Attas A. Anti-nociceptive and anti-inflammatory properties of Caralluma Arabica. J. Ethnopharmacol 2001; 76:155-158.
10. Kamalakannan S, Rajendran R, Venkatesh R, Clayton P, Akbarsha AK. Anti-obesegenic and Anti-Atherosclerotic Properties of Caralluma fimbriata Extract. J Nut Metabolism 2011; Article ID 285301:6.
11. Sekar N, Kanthasamy S, William S, Subramanian S, Govindasasamy S. Insulinic actions of vanadate in diabetic rats. Pharmocology Res 1990; 22:207-217.
12. Sasaki T, Matsy S, Sonae A. Effect of acetic acid concentration on the color reaction in the O-toluidine boric acid method for blood glucose estimation. Rinsho kagaku 1972; 1:346-353.
13. Sudhakar NS, Pattabiraman TN. A new colorimetric method for the estimation of glycosylated hemoglobin. Clin Chin Acta 1981; 109:267-274.
14. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein Measurement with the Folin Phenol Reagent. J Biol Chem 1951; 193:265-275.
15. Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am J Clin Pathol 1957; 28:56-63.
16. Bessey OA, Lowery DH, Brock MJ. A method for the rapid determination of alkaline phosphatase with five cubic meters of serum. J Biol Chem 1964; 164:321.
17. Barcelo A, Rajpathak S. Incidence and prevalence of diabetes mellitus in the Americas. Am J Public Health 2001; 10:300-308.
18. Weidmann P, Boehlen LM, De-courten M. Pathogenesis and treatment of hypertension associated with diabetes mellitus. Am Heart J 1993; 125:1498-1513.
19. Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 2001; 50(6):537-546.
20. Maiti R, Jana D, Das UK, Ghosh D. Antidiabetic effect of aqueous extract of seed of Tamarindus indica in streptozotocin induced diabetic rats. J Ethnopharmacol 2004; 92: 85-91.
21. Sayantan R, Abhishek S. Antidiabetic activity of Caralluma edulis bark and leaf extract against streptozotocin induced diabetic rats. NSHM J Pharm Healthcare Management 2012; 03:76-81.
22. Paramasivam R, Shanmugasundaram K. Potent antihyperglycaemic activity of Calocybe indica in streptozotocin induced diabetic rats antihyperglycemic activity of Calocybe indica. Int J Pharm Pharm Sci 2013; 5(2):512-515.
23. Shivani S, Sunil S. Antidiabetic effect of Helianthus Annuus L., seeds ethanolic etract in streptozotocin-nicotinamide induced type 2 diabetes mellitus. Int J Pharm Pharm Sci 2013; 5(2):382-387.
24. Vinod KV, Khomedndra KS, Kamaruz ZMD. Antihyperglycemic activity of Swertia chirayita and Andrographis paniculata plant extracts in streptozotocin induced diabetic rats. Int J Pharm Pharm Sci 2013; 5(3):305-311.
25. Shajeela PS, Kalpanadevi V, Mohan VR, Potential antidiabetic, hypolipidaemic and antioxidant effects of Xanthosoma sagittifolium extract in alloxan induced diabetic rats. Int J Pharm Pharm Sci 2013; 5(1):27-31.
26. Oliveira HC, Dos SMP, Grigulom R, Lima LL, Martins DTO, Lima JCS, Stoppiglia LF, Lopes CF, Kawashita NF, Antidiabetic activity of Vatairea macrocarpa extract in rats. J Ethnopharmacol 2008; 115:515-519.
27. Pandikumar P, Prakash BN, Ignaciumuthu S. Hypoglycemic and antihyperglycemic effect of Begonia malabarica Lam. In normal and streptozotocin induced diabetic rats. J Ethnopharmacol 2009; 124:111-115.
28. Lemieux J, Pichette C, Vinay P, Gougoux A. Cellular Mechanism of antiammoniagenic effect of ketone bodies in the dog. Am J Physiol-Renal 1980; 239(5):420-426.