Potential antidiabetic, hypolipidaemic and antioxidant effects of Xanthosoma sagittifolium extract in alloxan induced diabetic rats

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 5, Issue SUPPL.1, 2013, Pages 27-31

  Shajeela, P S ^a   Kalpanadevi, V ^b   Mohan, V R ^b  

^a St John's College   (India)

^b V O CHIDAMBARAM COLLEGE   (India)

Author keywords

Alloxan; Antioxidant; Diabetes; Xanthosoma sagittifolium

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CREATININE; GLOBULIN; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHOLIPID; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; XANTHOSOMA SAGITTIFOLIUM EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPOLIPIDEMIC ACTIVITY; LIPID PEROXIDATION; MALE; NONHUMAN; PHYTOCHEMISTRY; RAT; SINGLE DRUG DOSE; TOXICITY TESTING;

EID: 84875472765     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Edem DO. Hypoglycemic effects of ethanolic extracts of Alligator Pear seed (Persea Americana Mill) in rats. Euro J Sci Res 2009; 33: 669-678.
2. Kristova V, Liskoya S, Sotnikava S, Vojtko R and Kurtansky A. Sulodexide improve Endothelial Dysfunction in Streptozotocin-induced diabetes in rats. Physiol Res 2008; 5: 491-498.
3. Sridhar GR. Diabetes in India: Snapshot of a panorama. Curr Sci 2000; 83: 791.
4. Aravind K, Pradeepa R and Deepa R. Diabetes and coronary artery disease. Ind J Med Res 2002; 116: 163-176.
5. Yoon SL, Horne CH and Adams C. Herbal product used by African American older women. Clin Nurs Res 2004; 13: 271-288.
6. Khosla P, Sangeeta B, Singh J, Seth S and Srivastava RK. A study of hypoglycemic effects of Azadirachta indica (Neem) in normal and alloxan diabetic rabbits. Ind J Physiol Pharmacol 2000; 44: 69-74.
7. Chandra A, Singh RK, Singh VK, Tewari L and Mahdi AA. Antioxidative potential of herbal hypoglycemic agents in diabetes-An overview SFRR-Ind Bull 2004; 3: 24-26.
8. Brinda P, Sasikala P and Purushothaman KK. Pharmacognostic studies on Merugan kizhangu. Bull Med Ethnobot Res 1981; 3: 84-96.
9. Anonymous. Phytochemical investigation of certain medicinal plants used in Ayurveda. Central Council for Research in Ayurveda and Siddha, New Delhi. 1990.
10. Lala PK. Lab manuals of Pharmacognosy CSI Publishers and Distributers, Kolkata. 1993.
11. OECD, (Organisation for Economic co-operation and Development). OECD guidelines for the testing of chemicals/Section 4: Health Effects Test No. 423; Acute oral Toxicity-Acute Toxic Class method. OECD. Paris. 2002.
12. Nagappa AN, Thakurdesai PA, Venkat Rao N and Sing J. Antidiabetic activity of Terminalia catappa Linn. Fruits. J Ethnopharmacol 2003; 88: 45-50.
13. Sasaki T, Matsuy S and Sanae A. Effect of acetic acid concentration on the colour reaction in the O-toluidine boric acid method for blood glucose determination. Ransho Kagajci 1972; 1: 346-350.
14. Anderson L, Dinesen B, Jorgonsen PN, Poulsen F and Roder ME. Enzyme immune assay for intact human insulin in serum or plasma. Clin Chem 1993; 39: 578-582.
15. Varley H. Practical clinical biochemistry, Arnold Heinemann Publication Pvt. Ltd. 1976; p, 452.
16. Owen JA, Iggo JB, Scangrett FJ and Steward IP. Determination of creatinine in plasma serum, a critical examination. J Biochem 1954; 58: 426-437.
17. Karunanayake EH and Chandrasekharan NV. An evaluation of a colorimetric procedure for the estimation of glycosylated haemoglobin and establishment of reference values for Sri Lanka. J Nat Sci Coun Sri Lanka. 1985; 13: 235-258.
18. Parekh AC and Jung. Cholesterol determination with ferric acetate, uranium acetate and sulphuric acid, ferrous sulphate reagent. Anal Chem 1970; 112: 1423-1427.
19. Rice EW. Triglycerides in Serum In: Standard Methods. Clinical Chemistry. 9ed Roderick MP, Academic press, New York. 1970; 215-222.
20. Friedwald WT, Levy RI and Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultra centrifuge. Clin Chem 1972; 18: 499-502.
21. Warnick GR, Nguyan T and Albers AA. Comparison of improved precipitation methods for quantification of high density lipoprotein cholesterol. Clin Chem 1985; 31: 217.
22. Takayama M, Itoh S, Nagasaki T and Tanimizu I. A new enzymatic method for determination of serum phospholipids. Clin Chem Acta 1977; 79: 93-98.
23. Lowry OH, Rosenbrough NJ, Farr AL and Randall RJ. Protein measurement with the folin's phenol reagent. J Bio Chem 1951; 193: 265-275.
24. Reitman S and Frankel SA. Colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Amer J Clin Path 1957; 28: 56-63.
25. King EJ and Armstrong AR. Determination of serum and bile phosphatase activity. Cannad Med Assoc J 1934; 31: 56-63.
26. Rehman S. Lead-induced regional lipid peroxidation in brain. Toxicol Lett 1984; 21: 333-337.
27. Prins HK and Loos JA. In Glutathione; Biochemical methods in red cell genetics, edited by J. J Yunis. Academic Press, New York. 1969; 127-129.
28. Owen Joshua B, Butterfield D A. Measurement of Oxidized/Reduced Glutathione Ratio. Methods Mol Biol 2010; 648: 269-77.
29. Goldbery DM, Spooner RJ. Glutathione Reductase, In: Methods in Enzymatic Analysis, VCH Weinhem, Germany. 1983; 258-265.
30. Pagila DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin med 1967; 70: 158-169.
31. Habig WH, Pabst MJ and Jacob WB. Glutathione s-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249: 7130-7139.
32. Jelodar G, Mohren M and Shahram S. Effect of walnut leaf, coriander and pomegranate on blood glucose and histopathology of pancreas of alloxan-induced diabetic rats. Afr J Trad Com Alt med 2003; 3: 299-305.
33. Prince SM and Menon VP. Hypoglcemic and other related actions of Tinospora cardifolia roots in alloxan induced diabetic rats. J Ethnopharmacol 2000; 70: 9-15.
34. Grover JK, Vats V and Rathi SS. Antihyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism, J Ethnopharmacol 2000; 73: 461-470.
35. Begum W and Shanmugasundaram KR. Tissue phosphates in experimental diabetes. Arogya: J Health science 1978; 4: 129-139.
36. Shanmugasundaram KR, Panneerselvam SP and Shanmugasundaram ERB. Enzyme changes and glucose utilization in diabetic rabbit. The effect of Gymnema sylvestrae, R, Br. J Ethnopharmacology 1983; 7: 205-216.
37. Sharma N and Garg V. Antidiabetic and antioxidant potential of ethanolic extract of Butea monosperma leaves in alloxan induced diabetic mice. Ind J Biochem Biophys 2009; 46: 99-105.
38. Masih M, Banerjee T, Banerjee B and Pal A. Antidiabetic activity of Acalypha indica Linn. on normal and alloxan induced diabetic rats. Int J Pharm Pharm Sci 2011; 3: 51-54.
39. Sarasa D, Sridhar S and Prabakaran E. Effect of an antidiabetic extract of Trigonella foenum graceum on alloxan induced diabetic mice. Int J Pharm Pharm Sci 2012; 4: 63-65.
40. Thai AC, Yeo PPB, Chan L, Wang KW, Tan BY and Jocobs E. Glycoslated haemoglobin and diabetic control. Singapore Medical Journal 1983; 24: 210-212.
41. Maruthupandian A, Mohan VR and Sampathraj R. Antidiabetic, antihyperlipidaemic and antioxidant activity of Wattakaka volubilis (L. F) Stapf. Leaf. Int J Pharm Sci Res 2010; 11: 83-90.
42. Maruthupandian A and Mohan VR. Antidiabetic, antihyperlipidaemic and antioxidant activity of Pterocarpus marsupium Roxb. In alloxan induced diabetic rats. Int J PharmTech Res 2011; 3: 1681-1687.
43. Stanely P, Prince M and Menon V. Hypoglycemic and other related actions of Tinospora cordifolia roots in alloxan induced diabetic rats. J Ethnopharmacol 1999; 70: 9-15.
44. Mc Kenney JM. Pharmacotherapy of dyslipidemia. Cardiovasc Durg Ther 2001; 15: 413-422.
45. Fumelli P, Romagnoli F, Carlino G, Fumelli C and Bomei M. Diabetes mellitus and chronic heart failure. Arch Gerontol Geriatr 1996; 23: 277-281.
46. Brewer HB. Focus on high density lipoproteins in reducing cardiovascular risk. Am Heart J 2004; 148: 514-518.
47. Cohn RM and Roth KS. Lipid and lipoprotein metabolism In: Biochemistry and Diseases. Williams and Wilkins publishers, Baltimore 1996. p. 280.
48. Venkateswaran S, Pari L and Saravanan G. Effect of Phaseolus vulgaris on circulatory antioxidants and lipids in streptozotocin-induced diabetic rats. J Med Food 2002; 5: 97-104.
49. Pari L and Satheesh AM. Antidiabetic effect of Boerhavia diffusa: effect on serum and tissue lipids in experimental diabetes. J Med Food 2004; 7: 472-476.
50. Kesavulu MM, Rao Bk, Giri R, Vijya JS and Subramanyam ACH. Lipid peroxidation and antioxidant enzymes status in type 2 diabetics with coronary heart disease. Diabetes Res Clin Prac 2001; 53: 33-39.
51. Matkovics B, Varga SI, Szabo L and Witas H. The effect of diabetes on the activities of the peroxide metabolism enzymes. Horm Metab Res 1982; 14: 77-79.
52. Yu BP. Cellular defense against damage from reactive oxygen species. Physiological Rev 1994; 74: 139-162.
53. Sohal R and Dubey A. Mitochondria oxidative damage, hydrogen peroxide release and aging. Free Rad Biol Med 1994; 16: 621-626.
54. Kyu BK and Byung ML. Oxidative stress to DNA, protein and antioxidant enzymes in rats treated with Benzo(a)Pyrene Cancer Lett 1997; 113: 205-212.
55. Uday B, Das D and Banerjee K. Reactive oxygen species: oxidative damage and pathogenesis. Curr Sci 1999; 77: 658-665.
56. Valenzuela A, Lagos C, Schmidt K and Videla K. Silymarin Protection against hepatic lipid peroxidation induced by acute ethanol intoxication in the rat. Biochem Pharmacol 1985; 3: 2209-2212.
57. Krishnakumar K, Augusti KT and Vjayammal PL. Hypoglycemic and anti-oxidant activity of Salacia oblonga wall. Extract in streptozotocin-induced diabetic rats. Indian J Physiol Pharmacol 1999; 43: 510-514.
58. Gilbert HF. Biological disulfides: the third messenger: Modulation of phosphofructokinase activity by thiol/disulfide exchange. J Biol chem 1982; 257: 12086-12091.
59. Eklow L, Thor H and Orrenius S. Formation and efflux of glutathione disulfide studied in isolated rat hepatocytes. FEBS Let 1981; 127: 125-129.