Expression of Mortalin Detected in Human Liver Cancer by Tissue Microarrays

Anatomical Record

Volumn 294, Issue 8, 2011, Pages 1344-1351

  Chen, Xi ^a   Xu, Bo ^a   Li, Hongyan ^a   Yang, Ling ^a   Zuo, Ji ^a   Liu, Wen ^a   Liu, Chenghai ^b  

^a FUDAN UNIVERSITY   (China)

^b SHUGUANG HOSPITAL AFFILIATED TO SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

HL 7702 cell line; Mortalin; SMMC7721 cell line; Tissues microarrays; Tumor

Indexed keywords

CHAPERONE; MORTALIN; UNCLASSIFIED DRUG;

ARTICLE; BENIGN TUMOR; CANCER CELL; CANCER CELL CULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIVER CANCER; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; WESTERN BLOTTING;

BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; GLUCOSE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE ARRAY ANALYSIS; TRANSFECTION; UP-REGULATION;

EID: 79960532049     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.21433     Document Type: Article

References (29)

1. Beere HM. 2004. The stress of dying: the role of heat shock proteins in the regulation of apoptosis. J Cell Sin 117: 2641-2651.
2. Camp RL, Charette LA, Rimm DL. 2000. Validation of tissue microarray technology in breast carcinoma. Lab Invest 80: 1943.
3. Czarnecka AM, Campanella C, Zummo G, Cappello F. 2006. Mortalin: when a close friend becomes a close enemy. Cancer Biol Ther 5: 714-720.
4. Deocaris CC, Kaul SC, Wadhwa R. 2007. Heat shock chaperone Mortalin and carcinogenesis. Heat Shock Prot Cancer 21: 141-157.
5. Deocaris CC, Widodo N, Ishii T, Kaul SC, Wadhwa R. 2007. Functional significance of minor structural and expression changes in stress chaperone mortalin. Ann N Y Acad Sci 1119: 165-175.
6. Hinterberger M, Reineke T, Storz M, Weder W, Vogt P, Moch H. 2007. D2-40 and calretinin-a tissue microarray analysis of 341 malignant mesotheliomas with emphasis on sarcomatoid differentiation. Mod Pathol 20: 248-255.
7. Hsu WM, Lee H, Juan HF, Shih YY, Wang BJ, Pan CY, Jeng YM, Chang HH, Lu MY, Lin KH, Lai HS, Chen WJ, Tsay YG, Liao YF, Hsieh FJ. 2008. Identification of GRP75 as an independent favorable prognostic marker of neuroblastoma by a proteomics analysis. Clin Cancer Res 14: 6237-6245.
8. Kaul SC, Deocaris CC, Wadhwa R. 2007. Three faces of Mortalin: a housekeeper, guardian and killer. Exp Gerontol 42: 263-274.
9. Kaul SC, Taira K, Pereira-Smith OM, Wadhwa R. 2002. Mortalin: present and prospective. Exp Gerontol 37: 1157-1164.
10. Kaul Z, Yaguchi T, Kaul SC, Hirano T, Wadhwa R, Taira K. 2003. Mortalin imaging in normal and cancer cells with quantum dot immunoconjugates. Cell Res 13: 503-507.
11. Lanneau D, Brunet M, Frisan E, Solary E, Fontenay M, Garrido C. 2008. Heat shock proteins:essential proteins for apoptosis regulation. J Cell Mol Med 12: 743-761.
12. Lanneau D, Thonel A, Maurel S, Didelot C, Garrido C. 2007. Apoptosis versus cell differentiation role of heat shock proteins HSP90, HSP70, and HSP27. Prion 1: 53-60.
13. Liu Y, Liu W, Song XD, Zuo J. 2005. Effect of GRP75/mthsp70/PBP74/mortalin overexpression on intracellular ATP level, mitochondrial membrane potential and ROS accumulation following glucose deprivation in PC12 cells. Mol Cell Biochem 268: 45-51.
14. Massa SM, Zuo J, Longo FR, Wang J, Sharp FR. 1995. Cloning of rat grp75, an hsp70 family member, and its expression in normal and ischemic brain. J Neurosci Res 40: 807-819.
15. Mosser DD, Morimoto RI. 2004. Molecular chaperones and the stress of oncogenesis. Oncogene 23: 2907-2918.
16. Mizukoshi E, Suzuki M, Misono T, Loupatov A, Munekata E, Kaul SC, Wadhwa R, Imamura T. 2001. Cell-cycle dependent tyrosine phosphorylation on Mortalin regulates its interaction with fibroblast growth factor-1. Biochem Biophys Res Commun 280: 1203-1209.
17. Rupert L, Marcus F, Joerg RS, Hans-Juergen W, Heinz H. 2008. Expression and clinical significance of Glucose Regulated Proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus. BMC Cancer 8: 70.
18. Takano S, Wadhwa R, Mitsui Y, Kaul SC. 2001. Identification and characterization of molecular interactions between glucose-regulated proteins (GRPs) Mortalin/GRP75/peptide- binding protein 74 (PBP74) and GRP94. Biochem J 357: 393-398.
19. Wadhwa R, Kaul SC, Ikawa Y, Sugimoto Y. 1993. Identification of a novel member of mouse hsp 70 family: its association with cellular mortal phenotype. J Biol Chem 268: 6615-6621.
20. Wadhwa R, Kaul SC, Mitsui Y. 1994. Cellular mortality to immortalization: mortalin. Cell Struct Funct 19: 1-10.
21. Wadhwa R, Sugihara T, Yoshida A, Nomura H, Reddel RR, Simpson R, Maruta H, Kaul SC. 2000. Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res 60: 6818-6821.
22. Wadhwa R, Taira K, Kaul SC. 2002. An Hsp70 family chaperone, Mortalin/mthsp70/PBP74/Grp75: what, when, and where? Cell Stress Chaperones 7: 309-316.
23. Wadhwa R, Takano S, Kaur K, Deocaris CC, Pereira-Smith OM, Reddel RR, Kaul SC. 2006. Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis. Int J Cancer 118: 2973-2980.
24. Wadhwa R, Takano S, Rober M, Yoshida A, Nomura H, Reddeli RR, Mitsui Y, Kaul SC. 1998. Inactivation of tumor suppressor p53 by Mot-2, a hsp70 family member. J Biol Chem 273: 29586-29591.
25. Wadhwa R, Yaguchi T, Hasan MK, Taira K, Kaul SC. 2003. Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation. Biochem Biophys Res Commun 302: 735.
26. Walker CW, Böttger SA. 2008. A naturally occurring cancer with molecular connectivity to human diseases. Cell Cycle 7: 2286-2289.
27. Wang S, Fusaro G, Padmanabhan J, Chellappan SP. 2002. Prohibitin colocalizes with Rb in thenucleus and recruits N-CoR and HDAC1 for transcriptional repression. Oncogene 21: 8388-8396.
28. Yang L, Liu X, Hao J, Yang Y, Zhao M, Zuo J, Liu W. 2008. Glucose-regulated protein 75 suppresses apoptosis induced by glucose deprivation in PC12 cells through inhibition of Bax conformational change. Acta Biochim Biophys Sin 339-348.
29. Yi X, Luk JM, Lee NP, Peng J, Leng X, Guan XY, Lau GK, Beretta L, Fan ST. 2008. Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence. Mol Cell Proteomics 7: 315-325.