PPAR-γ activator induces neuroprotection in hypercholesterolemic rats subjected to global cerebral ischemia/reperfusion injury: In vivo and in vitro inhibition of oxidative stress

Experimental Gerontology

Volumn 51, Issue 1, 2014, Pages 1-7

  Al Rouq, Fawzia ^a   El Eter, Eman ^a,b  

^a KING KHALID UNIVERSITY HOSPITAL   (Saudi Arabia)

^b ALEXANDRIA UNIVERSITY   (Egypt)

Author keywords

Global cerebral ischemia reperfusion; Hypercholesterolemia; PPAR agonists; Reactive oxygen species; Rosiglitazone

Indexed keywords

GLUTATHIONE; INTERLEUKIN 6; MYELOPEROXIDASE; REACTIVE OXYGEN METABOLITE; ROSIGLITAZONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN DAMAGE; BRAIN EDEMA; BRAIN ISCHEMIA; BRAIN REGION; CELL VIABILITY; DISEASE EXACERBATION; HIPPOCAMPAL CA1 REGION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; LIPID PEROXIDATION; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; TREATMENT OUTCOME;

GLOBAL CEREBRAL ISCHEMIA/REPERFUSION; HYPERCHOLESTEROLEMIA; PPAR-Γ AGONISTS; REACTIVE OXYGEN SPECIES; ROSIGLITAZONE;

ANIMALS; BRAIN EDEMA; BRAIN ISCHEMIA; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE; HYPERCHOLESTEROLEMIA; INTERLEUKIN-6; LIPID PEROXIDATION; MALE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PEROXIDASE; PPAR GAMMA; RATS; RATS, WISTAR; REPERFUSION INJURY; THIAZOLIDINEDIONES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84891895226     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2013.12.008     Document Type: Article

References (40)

1. Akai F., Yanagihara T. Identity of the dorsal hippocampal region most vulnerable to cerebral ischemia. Brain Res. 1993, 603:87-95.
2. Aytan N., Jung T., Tamturk F., Grune T., Kartal-Ozer N. Oxidative stress related changes in the brain of hypercholesterolemic rabbits. Bio. Factors 2008, 33(3):225-236.
3. Bots M.L., Elwood P.C., Nikitin Y., Salonen J.T., Freire de Concalves A., Inzitari D., Sivenius J., Benetou V., Tuomilehto J., Koudstaal P.J., Grobbee D.E. Total and HDL cholesterol and risk of stroke. EUROSTROKE: a collaborative study among research centres in Europe. J. Epidemiol. Community Health 2002, 56(Suppl. 1):i19-i25.
4. Breckwoldt M.O., Chen J.W., Stangenberg L., Aikawa E., Rodriguez E., Qui S., Moskowitz M.A., Weissleder R. Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(47):18584-18589.
5. Cadenas E., Davies K.J. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic. Biol. Med. 2000, 29:222-230.
6. Collino M., Aragno M., Mastrocola R., Gallicchio M., Rosa A.C., Dianzani C., Danni O., Thiemermann C., Fantozzi R. Modulation of oxidative stress and inflammatory response by PPAR-γ agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. Eur. J. Pharmacol. 2006, 530:70-80.
7. Demchuk A.M., Hess D.C., Brass L.M., Yatsu F.M. Is cholesterol a risk factor for stroke? Yes. Arch. Neurol. 1999, 56:1518-1520.
8. Escher P., Wahli W. Peroxisome proliferator-activated receptors: insight into multiple cellular functions. Mutat. Res. 2000, 448:121-138.
9. Felix-Redondo F.J., Grau M., Fernadez-Berges D. Cholesterol and cardio-vascular disease in elderly. Facts and gaps. Aging Dis. 2013, 4(3):154-169.
10. Ferrer I., Plana A.M. Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra. J. Neuropathol. Exp. Neurol. 2003, 62:329-339.
11. Fuenzalida K., Quintanilla R., Ramos P., Piderit D., Fuentealba R.A., Martinez G., Inestrosa N.C., Bronfman M. Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis. J. Biol. Chem. 2007, 282(51):37006-37015.
12. Ghribi O., Golovko M.Y., Larsen B., Schrag M., Murphy E.J. Deposition of iron and beta-amyloid plaques is associated with cortical cellular damage in rabbits fed with long-term cholesterol-enriched diets. J. Neurochem. 2006, 99:438-449.
13. Goldstein L.B., Adams R., Alberts M.J., Appel L.J., Brass L.M., Bushnell C.D., Culebras A., DeGraba T.J., Gorelick P.B., Guyton J.R., Hart R.G., Howard G., Kelly-Hayes M., Nixon J.V., Sacco R.L. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: the American Academy of Neurology affirms the value of this guideline. Stroke 2006, 37:1583-1633.
14. Heverin M., Meaney S., Lutjohann D., Diczfalusy U., Wahren J., Bjorkhem I. Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain. J. Lipid Res. 2005, 46:1047-1052.
15. Horenstein R.B., Smith D.E., Mosca L. Cholesterol predicts stroke mortality in the Women's Pooling Project. Stroke 2002, 33:1863-1868.
16. Iso H., Jacobs D.R., Wentworth D., Neaton J.D., Cohen J.D. Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the Multiple Risk Factor Intervention Trial. N. Engl. J. Med. 1989, 320:904-910.
17. Kaste M., Koivisto P. Risk of brain infarction in familial hypercholesterolemia. Stroke 1988, 19(9):1097-1100.
18. Lange Y., Ye J., Rigney M., Steck T.L. Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol. J. Lipid Res. 1999, 40:2264-2270.
19. Liu H.R., Tao L., Gao E., Lopez B.L., Christopher T.A., Willette R.N., Ohlstien R.N., Yue T.L., Ma X.L. Anti-apoptotic effects of rosiglitazone in hypercholesterolemic rabbits subjected to myocardial ischemia and reperfusion. Cardiovasc. Res. 2004, 62:135-144.
20. Liu H.R., Tao L., Gao E., Qu Y., Lau W.B., Lopez B.L., Christopher T.A., Koch W., Yue T.L., Ma X.L. Rosiglitazone inhibits hypercholesterolemia-induced myeloperoxidase upregulation-PPAR-γ agonists. Cardiovasc. Res. 2009, 81(2):344-352.
21. Llinas R., Barbut D., Caplan L.R. Neurologic complications of cardiac surgery. Prog. Cardiovasc. Dis. 2000, 43:101-112.
22. Lu X., Guo X., Karathanasis S.K., Zimmerman K.M., Onyia J.E., Peterson R.G., Kassab G.S. Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats. Cardiovasc. Diabetol. 2010, 9:9-19.
23. Luo Y., Yin W., Signore A.P., Zhang F., Hong Z., Wang S., Graham H.S., Chen J. Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. J. Neurochem. 2006, 97(2):435-448.
24. Matsuo Y., Onodera H., Shiga Y., Nakamura M., Ninomiya M., Kihara T., Kogure K. Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat: effects of neutrophil depletion. Stroke 1994, 25:1469-1475.
25. Mocatta T.J., Pilbrow A.P., Cameron V.A., Senthilmohan R., Frampton C.M., Richards A.M., Winterbourn C.C. Plasma concentration of myeloperoxidase predicts mortality after myocardial infarction. J. Am. Coll. Cardiol. 2007, 49:1993-2000.
26. Nita D.A., Nita V., Spulber S., Moldovan M., Popa D.P., Zagrean A.M., Zagrean L. Oxidative damage following cerebral ischemia depends on reperfusion-a biochemical study in rat. J. Cell. Mol. Med. 2001, 5:163-170.
27. Onody A.C., Csonka C.Z., Giricz Z., Ferdinandy P. Hyperlipidemia induced by cholesterol-rich diet leads to enhanced peroxynitrite formation in rat hearts. Cardiovasc. Res. 2003, 58(3):663-670.
28. Park S.W., Yi J.H., Miranpuri G., Satriotomo I., Bowen K., Resnick D.K., Vemuganti R. Thiazolidine class of peroxisome proliferator-activated receptor gamma agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats. J. Pharmacol. Exp. Ther. 2007, 320:1002-1012.
29. Pulsinelli W.A. Selective neuronal vulnerability: morphological and molecular characteristics. Prog. Brain Res. 1995, 63:29-37.
30. Pulsinelli W.A., Brierley J.B. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 1979, 10:267-272.
31. Schuschke D.A., Joshua J.G., Miller F.N. Comparison of early microcirculatory and aortic changes in hypercholesterolemic rats. Arter. Throm. 1991, 11(1):154-160.
32. Sharma S., Prasanthi R.P., Schommer E., Feist G., Ghribi O. Hypercholesterolemia-induced AB accumulation in rabbit brain is associated with alteration in IGF-1 signalling. Neurobiol. Dis. 2008, 32(3):426-432.
33. Shimazu T., Inoue I., Araki N., Asano Y., Sawada M., Furuya D., Nagoya H., Greenberg J.H. A peroxisome proliferator-activated receptor gamma agonist reduces infarct size in transient but not in permanent ischemia. Stroke 2005, 36:353-359.
34. Sundararajan S., Gamboa J.L., Victor N.A., Wanderi E.W., Lust W.D., Landreth G.E. Peroxisome proliferator-activated receptor gamma ligands reduce inflammation and infarction size in transient focal ischemia. Neuroscience 2005, 130:685-696.
35. Uchiyama M., Mihara M. Determination of malondehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem. 1979, 86(1):271-278.
36. Van Dyke K., Van Dyke C., Udeinya J., Brister C., Wilson M. A new screening system for nonsteroidal anti-inflammatory drugs based upon inhibition of chemiluminescence produced from human cells (granulocytes). Clin. Chem. 1979, 25:1655-1661.
37. Wang Q., Tang X.N., Yenari M.A. The inflammatory response in stroke. J. Neuroimmunol. 2007, 184:53-68.
38. Wang T.D., Chen W.J., Su S.S., Lo S.C., Lin W.W., Lee Y.T. Increased cardiomyocyte apoptosis following ischemia and reperfusion in diet-induced hypercholesterolemia: relation to Bcl-2 and Bax proteins and caspase-3 activity. Lipids 2002, 37:385-394.
39. Weisbord R.M., Griswold M.C., Du Y., Bolotinia V.M., Cohen R.A. Reduced responsiveness of hypercholesterolemic rabbit aortic smooth muscle cells to nitric oxide. Arterioscler. Thromb. Vasc. Biol. 1997, 17:394-402.
40. Zhang X., Patel A., Horibe H., Wu Z., Barzi F., Rodgers A., MacMahan S., Woodward M. Cholesterol, coronary heart disease, and stroke in the Asia Pacific region. Int. J. Epidemiol. 2003, 32:563-572.