-
1
-
-
72949093335
-
From pathogenesis to treatment of chronic lymphocytic leukaemia
-
10.1038/nrc2764 1:CAS:528:DC%2BD1MXhsFSgt7jN 19956173
-
Zenz T, Mertens D, Kuppers R, Dohner H, Stilgenbauer S (2010) From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer 10:37-50. doi: 10.1038/nrc2764
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 37-50
-
-
Zenz, T.1
Mertens, D.2
Kuppers, R.3
Dohner, H.4
Stilgenbauer, S.5
-
2
-
-
84867154468
-
Molecular pathogenesis of chronic lymphocytic leukemia
-
10.1172/JCI64101 1:CAS:528:DC%2BC38XhsV2itrbP 3461921 23023714 10.1172/JCI64101
-
Gaidano G, Foa R, Dalla-Favera R (2012) Molecular pathogenesis of chronic lymphocytic leukemia. J Clin Invest 122:3432-3438. doi: 10.1172/JCI64101
-
(2012)
J Clin Invest
, vol.122
, pp. 3432-3438
-
-
Gaidano, G.1
Foa, R.2
Dalla-Favera, R.3
-
3
-
-
79960036578
-
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
-
10.1038/nature10113 1:CAS:528:DC%2BC3MXmvFyqtbY%3D 3322590 21642962 10.1038/nature10113
-
Puente XS, Pinyol M, Quesada V, Conde L, Ordonez GR, Villamor N, Escaramis G, Jares P, Bea S, Gonzalez-Diaz M et al (2011) Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 475:101-105. doi: 10.1038/nature10113
-
(2011)
Nature
, vol.475
, pp. 101-105
-
-
Puente, X.S.1
Pinyol, M.2
Quesada, V.3
Conde, L.4
Ordonez, G.R.5
Villamor, N.6
Escaramis, G.7
Jares, P.8
Bea, S.9
Gonzalez-Diaz, M.10
-
4
-
-
84858859064
-
Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia
-
10.1182/blood-2011-12-395673 1:CAS:528:DC%2BC38XkvFaltb4%3D 22308293 10.1182/blood-2011-12-395673
-
Rossi D, Fangazio M, Rasi S, Vaisitti T, Monti S, Cresta S, Chiaretti S, Del Giudice I, Fabbri G, Bruscaggin A et al (2012) Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia. Blood 119:2854-2862. doi: 10.1182/blood-2011-12-395673
-
(2012)
Blood
, vol.119
, pp. 2854-2862
-
-
Rossi, D.1
Fangazio, M.2
Rasi, S.3
Vaisitti, T.4
Monti, S.5
Cresta, S.6
Chiaretti, S.7
Del Giudice, I.8
Fabbri, G.9
Bruscaggin, A.10
-
5
-
-
0034651739
-
Modulation of NF-κB activity and apoptosis in chronic lymphocytic leukemia B cells
-
Furman RR, Asgary Z, Mascarenhas JO, Liou HC, Schattner EJ (2000) Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells. J Immunol 164:2200-2206 (Pubitemid 30108780)
-
(2000)
Journal of Immunology
, vol.164
, Issue.4
, pp. 2200-2206
-
-
Furman, R.R.1
Asgary, Z.2
Mascarenhas, J.O.3
Liou, H.-C.4
Schattner, E.J.5
-
6
-
-
4344664011
-
A sustained activation of PI3K/NF-κB pathway is critical for the survival of chronic lymphocytic leukemia B cells
-
DOI 10.1038/sj.leu.2403398
-
Cuni S, Perez-Aciego P, Perez-Chacon G, Vargas JA, Sanchez A, Martin-Saavedra FM, Ballester S, Garcia-Marco J, Jorda J, Durantez A (2004) A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells. Leukemia 18:1391-1400. doi: 10.1038/sj.leu.24033982403398 (Pubitemid 39136749)
-
(2004)
Leukemia
, vol.18
, Issue.8
, pp. 1391-1400
-
-
Cuni, S.1
Perez-Aciego, P.2
Perez-Chacon, G.3
Vargas, J.A.4
Sanchez, A.5
Martin-Saavedra, F.M.6
Ballester, S.7
Garcia-Marco, J.8
Jorda, J.9
Durantez, A.10
-
7
-
-
77149154324
-
NF-kappaB as a therapeutic target in chronic lymphocytic leukemia
-
10.1517/14728221003598930 1:CAS:528:DC%2BC3cXhvF2rsr4%3D 20148715 10.1517/14728221003598930
-
Lopez-Guerra M, Colomer D (2010) NF-kappaB as a therapeutic target in chronic lymphocytic leukemia. Expert Opin Ther Targets 14:275-288. doi: 10.1517/14728221003598930
-
(2010)
Expert Opin Ther Targets
, vol.14
, pp. 275-288
-
-
Lopez-Guerra, M.1
Colomer, D.2
-
8
-
-
67650724069
-
Regulation and function of NF-kappaB transcription factors in the immune system
-
10.1146/annurev.immunol.021908.132641 1:CAS:528:DC%2BD1MXlsFSlt7o%3D 19302050 10.1146/annurev.immunol.021908.132641
-
Vallabhapurapu S, Karin M (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27:693-733. doi: 10.1146/annurev.immunol.021908.132641
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 693-733
-
-
Vallabhapurapu, S.1
Karin, M.2
-
9
-
-
84858718448
-
NF-kappaB and the link between inflammation and cancer
-
10.1111/j.1600-065X.2012.01099.x 22435567 10.1111/j.1600-065X.2012.01099. x
-
DiDonato JA, Mercurio F, Karin M (2012) NF-kappaB and the link between inflammation and cancer. Immunol Rev 246:379-400. doi: 10.1111/j.1600-065X.2012. 01099.x
-
(2012)
Immunol Rev
, vol.246
, pp. 379-400
-
-
Didonato, J.A.1
Mercurio, F.2
Karin, M.3
-
10
-
-
50849130122
-
Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis
-
10.1182/blood-2007-11-125930 1:CAS:528:DC%2BD1cXpsVajuro%3D 18505785 10.1182/blood-2007-11-125930
-
Guo F, Tanzer S, Busslinger M, Weih F (2008) Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis. Blood 112:551-559. doi: 10.1182/blood-2007-11-125930
-
(2008)
Blood
, vol.112
, pp. 551-559
-
-
Guo, F.1
Tanzer, S.2
Busslinger, M.3
Weih, F.4
-
11
-
-
0141567432
-
Regulation of secondary lymphoid organ development by the nuclear factor-κB signal transduction pathway
-
DOI 10.1034/j.1600-065X.2003.00064.x
-
Weih F, Caamano J (2003) Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway. Immunol Rev 195:91-105 (Pubitemid 37153456)
-
(2003)
Immunological Reviews
, vol.195
, pp. 91-105
-
-
Weih, F.1
Caamano, J.2
-
12
-
-
33847185843
-
Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells
-
10.1038/sj.onc.1209897 1:CAS:528:DC%2BD2sXhvF2jurc%3D 16924235 10.1038/sj.onc.1209897
-
Pickering BM, de Mel S, Lee M, Howell M, Habens F, Dallman CL, Neville LA, Potter KN, Mann J, Mann DA et al (2007) Pharmacological inhibitors of NF-kappaB accelerate apoptosis in chronic lymphocytic leukaemia cells. Oncogene 26:1166-1177. doi: 10.1038/sj.onc.1209897
-
(2007)
Oncogene
, vol.26
, pp. 1166-1177
-
-
Pickering, B.M.1
De Mel, S.2
Lee, M.3
Howell, M.4
Habens, F.5
Dallman, C.L.6
Neville, L.A.7
Potter, K.N.8
Mann, J.9
Mann, D.A.10
-
13
-
-
0032147205
-
Triggering of CD40 antigen inhibits fludarabine-induced apoptosis in B chronic lymphocytic leukemia cells
-
Romano MF, Lamberti A, Tassone P, Alfinito F, Costantini S, Chiurazzi F, Defrance T, Bonelli P, Tuccillo F, Turco MC et al (1998) Triggering of CD40 antigen inhibits fludarabine-induced apoptosis in B chronic lymphocytic leukemia cells. Blood 92:990-995 (Pubitemid 28355483)
-
(1998)
Blood
, vol.92
, Issue.3
, pp. 990-995
-
-
Romano, M.F.1
Lamberti, A.2
Tassone, P.3
Alfinito, F.4
Costantini, S.5
Chiurazzi, F.6
Defrance, T.7
Bonelli, P.8
Tuccillo, F.9
Turco, M.C.10
Venuta, S.11
-
14
-
-
47149090375
-
The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target
-
10.1182/blood-2007-11-125278 1:CAS:528:DC%2BD1cXlsVSrs7k%3D 18227347 10.1182/blood-2007-11-125278
-
Hewamana S, Alghazal S, Lin TT, Clement M, Jenkins C, Guzman ML, Jordan CT, Neelakantan S, Crooks PA, Burnett AK et al (2008) The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target. Blood 111:4681-4689. doi: 10.1182/blood-2007-11-125278
-
(2008)
Blood
, vol.111
, pp. 4681-4689
-
-
Hewamana, S.1
Alghazal, S.2
Lin, T.T.3
Clement, M.4
Jenkins, C.5
Guzman, M.L.6
Jordan, C.T.7
Neelakantan, S.8
Crooks, P.A.9
Burnett, A.K.10
-
15
-
-
60149094697
-
Rel a is an independent biomarker of clinical outcome in chronic lymphocytic leukemia
-
10.1200/JCO.2008.19.1114 19124804 10.1200/JCO.2008.19.1114
-
Hewamana S, Lin TT, Rowntree C, Karunanithi K, Pratt G, Hills R, Fegan C, Brennan P, Pepper C (2009) Rel a is an independent biomarker of clinical outcome in chronic lymphocytic leukemia. J Clin Oncol 27:763-769. doi: 10.1200/JCO.2008.19.1114
-
(2009)
J Clin Oncol
, vol.27
, pp. 763-769
-
-
Hewamana, S.1
Lin, T.T.2
Rowntree, C.3
Karunanithi, K.4
Pratt, G.5
Hills, R.6
Fegan, C.7
Brennan, P.8
Pepper, C.9
-
16
-
-
77951719556
-
Classical and/or alternative NF-kappaB pathway activation in multiple myeloma
-
10.1182/blood-2009-09-243535 1:CAS:528:DC%2BC3cXmtFylur0%3D 20053756 10.1182/blood-2009-09-243535
-
Demchenko YN, Glebov OK, Zingone A, Keats JJ, Bergsagel PL, Kuehl WM (2010) Classical and/or alternative NF-kappaB pathway activation in multiple myeloma. Blood 115:3541-3552. doi: 10.1182/blood-2009-09-243535
-
(2010)
Blood
, vol.115
, pp. 3541-3552
-
-
Demchenko, Y.N.1
Glebov, O.K.2
Zingone, A.3
Keats, J.J.4
Bergsagel, P.L.5
Kuehl, W.M.6
-
17
-
-
49749145583
-
RelB-dependent stromal cells promote T-cell leukemogenesis
-
10.1371/journal.pone.0002555 2440518 18596915 10.1371/journal.pone. 0002555
-
dos Santos NR, Williame M, Gachet S, Cormier F, Janin A, Weih D, Weih F, Ghysdael J (2008) RelB-dependent stromal cells promote T-cell leukemogenesis. PLoS One 3:e2555. doi: 10.1371/journal.pone.0002555
-
(2008)
PLoS One
, vol.3
, pp. 2555
-
-
Dos Santos, N.R.1
Williame, M.2
Gachet, S.3
Cormier, F.4
Janin, A.5
Weih, D.6
Weih, F.7
Ghysdael, J.8
-
18
-
-
67650388511
-
TRAF1 is involved in the classical NF-kappaB activation and CD30-induced alternative activity in Hodgkin's lymphoma cells
-
10.1016/j.molimm.2009.05.178 1:CAS:528:DC%2BD1MXos1Omtb0%3D 19540595 10.1016/j.molimm.2009.05.178
-
Guo F, Sun A, Wang W, He J, Hou J, Zhou P, Chen Z (2009) TRAF1 is involved in the classical NF-kappaB activation and CD30-induced alternative activity in Hodgkin's lymphoma cells. Mol Immunol 46:2441-2448. doi: 10.1016/j.molimm.2009.05.178
-
(2009)
Mol Immunol
, vol.46
, pp. 2441-2448
-
-
Guo, F.1
Sun, A.2
Wang, W.3
He, J.4
Hou, J.5
Zhou, P.6
Chen, Z.7
-
19
-
-
84868540424
-
Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival
-
10.1182/blood-2012-01-405951 1:CAS:528:DC%2BC38Xhs12gsr3J 22968463 10.1182/blood-2012-01-405951
-
Ranuncolo SM, Pittaluga S, Evbuomwan MO, Jaffe ES, Lewis BA (2012) Hodgkin lymphoma requires stabilized NIK and constitutive RelB expression for survival. Blood 120:3756-3763. doi: 10.1182/blood-2012-01-405951
-
(2012)
Blood
, vol.120
, pp. 3756-3763
-
-
Ranuncolo, S.M.1
Pittaluga, S.2
Evbuomwan, M.O.3
Jaffe, E.S.4
Lewis, B.A.5
-
20
-
-
82455212908
-
Maspin expression is regulated by the non-canonical NF-kappaB subunit in androgen-insensitive prostate cancer cell lines
-
10.1016/j.molimm.2011.07.013 1:CAS:528:DC%2BC3MXhtlyjtb7L 21856005 10.1016/j.molimm.2011.07.013
-
Guo F, Kang S, Zhou P, Guo L, Ma L, Hou J (2011) Maspin expression is regulated by the non-canonical NF-kappaB subunit in androgen-insensitive prostate cancer cell lines. Mol Immunol 49:8-17. doi: 10.1016/j.molimm.2011.07. 013
-
(2011)
Mol Immunol
, vol.49
, pp. 8-17
-
-
Guo, F.1
Kang, S.2
Zhou, P.3
Guo, L.4
Ma, L.5
Hou, J.6
-
21
-
-
0037413709
-
RelB is required for Peyer's patch development: Differential regulation of p52-RelB by lymphotoxin and TNF
-
DOI 10.1093/emboj/cdg004
-
Yilmaz ZB, Weih DS, Sivakumar V, Weih F (2003) RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF. EMBO J 22:121-130. doi: 10.1093/emboj/cdg004 (Pubitemid 36091275)
-
(2003)
EMBO Journal
, vol.22
, Issue.1
, pp. 121-130
-
-
Yilmaz, Z.B.1
Weih, D.S.2
Sivakumar, V.3
Weih, F.4
-
22
-
-
20044372326
-
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
-
DOI 10.1172/JCI200523409
-
Messmer BT, Messmer D, Allen SL, Kolitz JE, Kudalkar P, Cesar D, Murphy EJ, Koduru P, Ferrarini M, Zupo S et al (2005) In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest 115:755-764. doi: 10.1172/JCI23409 (Pubitemid 40322252)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.3
, pp. 755-764
-
-
Messmer, B.T.1
Messmer, D.2
Allen, S.L.3
Kolitz, J.E.4
Kudalkar, P.5
Cesar, D.6
Murphy, E.J.7
Koduru, P.8
Ferrarini, M.9
Zupo, S.10
Cutrona, G.11
Damle, R.N.12
Wasil, T.13
Rai, K.R.14
Hellerstein, M.K.15
Chiorazzi, N.16
-
23
-
-
0035158101
-
Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion
-
Aalto Y, El-Rifa W, Vilpo L, Ollila J, Nagy B, Vihinen M, Vilpo J, Knuutila S (2001) Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion. Leukemia 15:1721-1728 (Pubitemid 33061839)
-
(2001)
Leukemia
, vol.15
, Issue.11
, pp. 1721-1728
-
-
Aalto, Y.1
El-Rifai, W.2
Vilpo, L.3
Ollila, J.4
Nagy, B.5
Vihinen, M.6
Vilpo, J.7
Knuutila, S.8
-
24
-
-
84859398461
-
Nurture versus nature: The microenvironment in chronic lymphocytic leukemia
-
10.1182/asheducation-2011.1.96 22160019 10.1182/asheducation-2011.1.96
-
Burger JA (2011) Nurture versus nature: the microenvironment in chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program 2011:96-103. doi: 10.1182/asheducation-2011.1.96
-
(2011)
Hematology Am Soc Hematol Educ Program
, vol.2011
, pp. 96-103
-
-
Burger, J.A.1
-
25
-
-
78751549662
-
The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia
-
10.1182/blood-2010-05-284984 1:CAS:528:DC%2BC3MXht1aqtr8%3D 20940416 10.1182/blood-2010-05-284984
-
Herishanu Y, Perez-Galan P, Liu D, Biancotto A, Pittaluga S, Vire B, Gibellini F, Njuguna N, Lee E, Stennett L et al (2011) The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia. Blood 117:563-574. doi: 10.1182/blood-2010-05-284984
-
(2011)
Blood
, vol.117
, pp. 563-574
-
-
Herishanu, Y.1
Perez-Galan, P.2
Liu, D.3
Biancotto, A.4
Pittaluga, S.5
Vire, B.6
Gibellini, F.7
Njuguna, N.8
Lee, E.9
Stennett, L.10
-
26
-
-
84891882187
-
Stromal tumor microenvironment in chronic lymphocytic leukemia: Regulation of leukemic progression
-
10.4172/2329-6917.1000113 10.4172/2329-6917.1000113
-
Shukla A, Chaturvedi NK, Ahrens AK, Cutucache CE, Mittal AK, Bierman P, Weisenburger DD, Lu R, Joshi SS (2013) Stromal tumor microenvironment in chronic lymphocytic leukemia: regulation of leukemic progression. J Leuk 1:113-121. doi: 10.4172/2329-6917.1000113
-
(2013)
J Leuk
, vol.1
, pp. 113-121
-
-
Shukla, A.1
Chaturvedi, N.K.2
Ahrens, A.K.3
Cutucache, C.E.4
Mittal, A.K.5
Bierman, P.6
Weisenburger, D.D.7
Lu, R.8
Joshi, S.S.9
-
27
-
-
79954997822
-
Prognostic markers and stratification of chronic lymphocytic leukemia
-
10.1182/asheducation-2010.1.77 21239774 10.1182/asheducation-2010.1.77
-
Furman RR (2010) Prognostic markers and stratification of chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program 2010:77-81. doi: 10.1182/asheducation-2010.1.77
-
(2010)
Hematology Am Soc Hematol Educ Program
, vol.2010
, pp. 77-81
-
-
Furman, R.R.1
-
28
-
-
79955846227
-
IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells
-
10.1038/leu.2011.12 1:CAS:528:DC%2BC3MXlvFCks7w%3D 21372840 10.1038/leu.2011.12
-
Coscia M, Pantaleoni F, Riganti C, Vitale C, Rigoni M, Peola S, Castella B, Foglietta M, Griggio V, Drandi D et al (2011) IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells. Leukemia 25:828-837. doi: 10.1038/leu.2011.12
-
(2011)
Leukemia
, vol.25
, pp. 828-837
-
-
Coscia, M.1
Pantaleoni, F.2
Riganti, C.3
Vitale, C.4
Rigoni, M.5
Peola, S.6
Castella, B.7
Foglietta, M.8
Griggio, V.9
Drandi, D.10
-
29
-
-
65949109942
-
RelB enhances prostate cancer growth: Implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity
-
10.1158/0008-5472.CAN-08-4635 1:CAS:528:DC%2BD1MXksV2hs7Y%3D 2756761 19351823 10.1158/0008-5472.CAN-08-4635
-
Xu Y, Josson S, Fang F, Oberley TD, St Clair DK, Wan XS, Sun Y, Bakthavatchalu V, Muthuswamy A, St Clair WH (2009) RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity. Cancer Res 69:3267-3271. doi: 10.1158/0008-5472.CAN- 08-4635
-
(2009)
Cancer Res
, vol.69
, pp. 3267-3271
-
-
Xu, Y.1
Josson, S.2
Fang, F.3
Oberley, T.D.4
St Clair, D.K.5
Wan, X.S.6
Sun, Y.7
Bakthavatchalu, V.8
Muthuswamy, A.9
St Clair, W.H.10
-
30
-
-
77955292644
-
RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells
-
10.1111/j.1749-6632.2010.05613.x 1:CAS:528:DC%2BC3cXhtFegsLvP 3107504 20649549 10.1111/j.1749-6632.2010.05613.x
-
Holley AK, Xu Y, St Clair DK, St Clair WH (2010) RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells. Ann N Y Acad Sci 1201:129-136. doi: 10.1111/j.1749-6632.2010. 05613.x
-
(2010)
Ann N y Acad Sci
, vol.1201
, pp. 129-136
-
-
Holley, A.K.1
Xu, Y.2
St Clair, D.K.3
St Clair, W.H.4
-
31
-
-
34047095373
-
Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2
-
DOI 10.1038/ncb1559, PII NCB1559
-
Wang X, Belguise K, Kersual N, Kirsch KH, Mineva ND, Galtier F, Chalbos D, Sonenshein GE (2007) Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2. Nat Cell Biol 9:470-478. doi: 10.1038/ncb1559 (Pubitemid 46511081)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.4
, pp. 470-478
-
-
Wang, X.1
Belguise, K.2
Kersual, N.3
Kirsch, K.H.4
Mineva, N.D.5
Galtier, F.6
Chalbos, D.7
Sonenshein, G.E.8
-
32
-
-
67650034863
-
RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1
-
10.1128/MCB.00032-09 1:CAS:528:DC%2BD1MXos1Gns74%3D 2704748 19433448 10.1128/MCB.00032-09
-
Wang X, Belguise K, O'Neill CF, Sanchez-Morgan N, Romagnoli M, Eddy SF, Mineva ND, Yu Z, Min C, Trinkaus-Randall V et al (2009) RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1. Mol Cell Biol 29:3832-3844. doi: 10.1128/MCB.00032-09
-
(2009)
Mol Cell Biol
, vol.29
, pp. 3832-3844
-
-
Wang, X.1
Belguise, K.2
O'Neill, C.F.3
Sanchez-Morgan, N.4
Romagnoli, M.5
Eddy, S.F.6
Mineva, N.D.7
Yu, Z.8
Min, C.9
Trinkaus-Randall, V.10
-
33
-
-
67650351201
-
Inhibition of RelB by 1,25-dihydroxyvitamin D3 promotes sensitivity of breast cancer cells to radiation
-
10.1002/jcp.21765 1:CAS:528:DC%2BD1MXpsV2ntL4%3D 2900382 19373868 10.1002/jcp.21765
-
Mineva ND, Wang X, Yang S, Ying H, Xiao ZX, Holick MF, Sonenshein GE (2009) Inhibition of RelB by 1,25-dihydroxyvitamin D3 promotes sensitivity of breast cancer cells to radiation. J Cell Physiol 220:593-599. doi: 10.1002/jcp.21765
-
(2009)
J Cell Physiol
, vol.220
, pp. 593-599
-
-
Mineva, N.D.1
Wang, X.2
Yang, S.3
Ying, H.4
Xiao, Z.X.5
Holick, M.F.6
Sonenshein, G.E.7
-
34
-
-
33846258010
-
BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-κB pathway
-
DOI 10.1182/blood-2006-06-027755
-
Endo T, Nishio M, Enzler T, Cottam HB, Fukuda T, James DF, Karin M, Kipps TJ (2007) BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood 109:703-710. doi: 10.1182/blood-2006-06-027755 (Pubitemid 46105972)
-
(2007)
Blood
, vol.109
, Issue.2
, pp. 703-710
-
-
Endo, T.1
Nishio, M.2
Enzler, T.3
Cottam, H.B.4
Fukuda, T.5
James, D.F.6
Karin, M.7
Kipps, T.J.8
-
35
-
-
84855854025
-
Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
-
10.1182/blood-2011-09-379966 1:CAS:528:DC%2BC38XhsVKltrs%3D 22077063 10.1182/blood-2011-09-379966
-
Rossi D, Rasi S, Fabbri G, Spina V, Fangazio M, Forconi F, Marasca R, Laurenti L, Bruscaggin A, Cerri M et al (2012) Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 119:521-529. doi: 10.1182/blood-2011-09-379966
-
(2012)
Blood
, vol.119
, pp. 521-529
-
-
Rossi, D.1
Rasi, S.2
Fabbri, G.3
Spina, V.4
Fangazio, M.5
Forconi, F.6
Marasca, R.7
Laurenti, L.8
Bruscaggin, A.9
Cerri, M.10
-
36
-
-
84877635463
-
NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome
-
10.1038/leu.2012.357
-
Villamor N, Conde L, Martinez-Trillos A, Cazorla M, Navarro A, Bea S, Lopez C, Colomer D, Pinyol M, Aymerich M et al (2012) NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome. Leukemia. doi: 10.1038/leu.2012.357
-
(2012)
Leukemia
-
-
Villamor, N.1
Conde, L.2
Martinez-Trillos, A.3
Cazorla, M.4
Navarro, A.5
Bea, S.6
Lopez, C.7
Colomer, D.8
Pinyol, M.9
Aymerich, M.10
-
37
-
-
0030048565
-
Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro
-
Panayiotidis P, Jones D, Ganeshaguru K, Foroni L, Hoffbrand AV (1996) Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro. Br J Haematol 92:97-103 (Pubitemid 26018774)
-
(1996)
British Journal of Haematology
, vol.92
, Issue.1
, pp. 97-103
-
-
Panayiotidis, P.1
Jones, D.2
Ganeshaguru, K.3
Foroni, L.4
Hoffbrand, A.V.5
-
38
-
-
0032055818
-
Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells
-
1:CAS:528:DyaK1cXitF2hs7s%3D 9516138
-
Lagneaux L, Delforge A, Bron D, De Bruyn C, Stryckmans P (1998) Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells. Blood 91:2387-2396
-
(1998)
Blood
, vol.91
, pp. 2387-2396
-
-
Lagneaux, L.1
Delforge, A.2
Bron, D.3
De Bruyn, C.4
Stryckmans, P.5
-
39
-
-
73349126115
-
Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: Development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance
-
10.1182/blood-2009-07-233718 1:CAS:528:DC%2BD1MXhsVGrsLvF 19762485 10.1182/blood-2009-07-233718
-
Kurtova AV, Balakrishnan K, Chen R, Ding W, Schnabl S, Quiroga MP, Sivina M, Wierda WG, Estrov Z, Keating MJ et al (2009) Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. Blood 114:4441-4450. doi: 10.1182/blood-2009-07-233718
-
(2009)
Blood
, vol.114
, pp. 4441-4450
-
-
Kurtova, A.V.1
Balakrishnan, K.2
Chen, R.3
Ding, W.4
Schnabl, S.5
Quiroga, M.P.6
Sivina, M.7
Wierda, W.G.8
Estrov, Z.9
Keating, M.J.10
-
40
-
-
34250788040
-
Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-κB (RelB/p52) in non-Hodgkin's lymphoma cells
-
DOI 10.1038/sj.leu.2404723, PII 2404723
-
Lwin T, Hazlehurst LA, Li Z, Dessureault S, Sotomayor E, Moscinski LC, Dalton WS, Tao J (2007) Bone marrow stromal cells prevent apoptosis of lymphoma cells by upregulation of anti-apoptotic proteins associated with activation of NF-kappaB (RelB/p52) in non-Hodgkin's lymphoma cells. Leukemia 21:1521-1531. doi: 10.1038/sj.leu.2404723 (Pubitemid 46965295)
-
(2007)
Leukemia
, vol.21
, Issue.7
, pp. 1521-1531
-
-
Lwin, T.1
Hazlehurst, L.A.2
Li, Z.3
Dessureault, S.4
Sotomayor, E.5
Moscinski, L.C.6
Dalton, W.S.7
Tao, J.8
-
41
-
-
70350459031
-
Bi-directional activation between mesenchymal stem cells and CLL B-cells: Implication for CLL disease progression
-
10.1111/j.1365-2141.2009.07868.x 1:CAS:528:DC%2BD1MXhsFKjtb%2FL 2783570 19751240 10.1111/j.1365-2141.2009.07868.x
-
Ding W, Nowakowski GS, Knox TR, Boysen JC, Maas ML, Schwager SM, Wu W, Wellik LE, Dietz AB, Ghosh AK et al (2009) Bi-directional activation between mesenchymal stem cells and CLL B-cells: implication for CLL disease progression. Br J Haematol 147:471-483. doi: 10.1111/j.1365-2141.2009.07868.x
-
(2009)
Br J Haematol
, vol.147
, pp. 471-483
-
-
Ding, W.1
Nowakowski, G.S.2
Knox, T.R.3
Boysen, J.C.4
Maas, M.L.5
Schwager, S.M.6
Wu, W.7
Wellik, L.E.8
Dietz, A.B.9
Ghosh, A.K.10
-
42
-
-
84862627044
-
Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL, and CD40L
-
10.4049/jimmunol.1102066 1:CAS:528:DC%2BC38XotFGrt7o%3D 3370079 22593611 10.4049/jimmunol.1102066
-
Cols M, Barra CM, He B, Puga I, Xu W, Chiu A, Tam W, Knowles DM, Dillon SR, Leonard JP et al (2012) Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL, and CD40L. J Immunol 188:6071-6083. doi: 10.4049/jimmunol.1102066
-
(2012)
J Immunol
, vol.188
, pp. 6071-6083
-
-
Cols, M.1
Barra, C.M.2
He, B.3
Puga, I.4
Xu, W.5
Chiu, A.6
Tam, W.7
Knowles, D.M.8
Dillon, S.R.9
Leonard, J.P.10
-
43
-
-
51649115498
-
BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells
-
10.1038/leu.2008.175 1:CAS:528:DC%2BD1cXhtVyqu7%2FI 18596739 10.1038/leu.2008.175
-
Perez-Galan P, Roue G, Lopez-Guerra M, Nguyen M, Villamor N, Montserrat E, Shore GC, Campo E, Colomer D (2008) BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells. Leukemia 22:1712-1720. doi: 10.1038/leu.2008.175
-
(2008)
Leukemia
, vol.22
, pp. 1712-1720
-
-
Perez-Galan, P.1
Roue, G.2
Lopez-Guerra, M.3
Nguyen, M.4
Villamor, N.5
Montserrat, E.6
Shore, G.C.7
Campo, E.8
Colomer, D.9
-
44
-
-
33747875167
-
Phase II study of single-agent bortezomib for the treatment of patients with fludarabine-refractory B-cell chronic lymphocytic leukemia
-
DOI 10.1002/cncr.22097
-
Faderl S, Rai K, Gribben J, Byrd JC, Flinn IW, O'Brien S, Sheng S, Esseltine DL, Keating MJ (2006) Phase II study of single-agent bortezomib for the treatment of patients with fludarabine-refractory B-cell chronic lymphocytic leukemia. Cancer 107:916-924. doi: 10.1002/cncr.22097 (Pubitemid 44291139)
-
(2006)
Cancer
, vol.107
, Issue.5
, pp. 916-924
-
-
Faderl, S.1
Rai, K.2
Gribben, J.3
Byrd, J.C.4
Flinn, I.W.5
O'Brien, S.6
Sheng, S.7
Esseltine, D.-L.8
Keating, M.J.9
-
45
-
-
14544286868
-
TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-κB pathway by TRAF-binding TNFRs
-
DOI 10.1073/pnas.0500187102
-
Hauer J, Puschner S, Ramakrishnan P, Simon U, Bongers M, Federle C, Engelmann H (2005) TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. Proc Natl Acad Sci U S A 102:2874-2879. doi: 10.1073/pnas.0500187102 (Pubitemid 40299884)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.8
, pp. 2874-2879
-
-
Hauer, J.1
Puschner, S.2
Ramakrishnan, P.3
Simon, U.4
Bongers, M.5
Federle, C.6
Engelmann, H.7
-
46
-
-
70449428166
-
TRAF3 in B cells: Too much, too little, too bad
-
10.1182/blood-2009-01-199810 1:CAS:528:DC%2BD1MXnvVyqtL4%3D 19423738 10.1182/blood-2009-01-199810
-
Bergsagel PL (2009) TRAF3 in B cells: too much, too little, too bad. Blood 113:4481-4482. doi: 10.1182/blood-2009-01-199810
-
(2009)
Blood
, vol.113
, pp. 4481-4482
-
-
Bergsagel, P.L.1
-
47
-
-
34748830337
-
Gene mutation revelation points to new target for myeloma treatment, studies say
-
10.1093/jnci/djm164 17848662 10.1093/jnci/djm164
-
Garber K (2007) Gene mutation revelation points to new target for myeloma treatment, studies say. J Natl Cancer Inst 99:1362-1364. doi: 10.1093/jnci/djm164
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 1362-1364
-
-
Garber, K.1
-
48
-
-
59449095496
-
AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance
-
10.1182/blood-2008-02-138560 1:CAS:528:DC%2BD1MXmtFSrtA%3D%3D 18836097 10.1182/blood-2008-02-138560
-
Balakrishnan K, Burger JA, Wierda WG, Gandhi V (2009) AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood 113:149-153. doi: 10.1182/blood-2008-02-138560
-
(2009)
Blood
, vol.113
, pp. 149-153
-
-
Balakrishnan, K.1
Burger, J.A.2
Wierda, W.G.3
Gandhi, V.4
-
49
-
-
84858299100
-
Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner
-
10.1111/j.1365-2141.2011.08984.x 1:CAS:528:DC%2BC38XmsFOnsLg%3D 22171982 10.1111/j.1365-2141.2011.08984.x
-
Masood A, Chitta K, Paulus A, Khan AN, Sher T, Ersing N, Miller KC, Manfredi D, Ailawadhi S, Borrelo I et al (2012) Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner. Br J Haematol 157:59-66. doi: 10.1111/j.1365-2141.2011. 08984.x
-
(2012)
Br J Haematol
, vol.157
, pp. 59-66
-
-
Masood, A.1
Chitta, K.2
Paulus, A.3
Khan, A.N.4
Sher, T.5
Ersing, N.6
Miller, K.C.7
Manfredi, D.8
Ailawadhi, S.9
Borrelo, I.10
-
50
-
-
77950550858
-
The role of chemokines in B cell chronic lymphocytic leukaemia: Pathophysiological aspects and clinical impact
-
10.1007/s00277-009-0876-6 20020127 10.1007/s00277-009-0876-6
-
Schrottner P, Leick M, Burger M (2010) The role of chemokines in B cell chronic lymphocytic leukaemia: pathophysiological aspects and clinical impact. Ann Hematol 89:437-446. doi: 10.1007/s00277-009-0876-6
-
(2010)
Ann Hematol
, vol.89
, pp. 437-446
-
-
Schrottner, P.1
Leick, M.2
Burger, M.3
-
51
-
-
0033485625
-
Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells
-
1:CAS:528:DyaK1MXnslykt70%3D 10572077
-
Burger JA, Burger M, Kipps TJ (1999) Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells. Blood 94:3658-3667
-
(1999)
Blood
, vol.94
, pp. 3658-3667
-
-
Burger, J.A.1
Burger, M.2
Kipps, T.J.3
-
52
-
-
34249776687
-
Bone biopsy derived marrow stromal elements rescue chronic lymphocytic leukemia B-cells from spontaneous and drug induced cell death and facilitates an angiogenic switch
-
DOI 10.1016/j.leukres.2006.11.024, PII S0145212606004619
-
Kay NE, Shanafelt TD, Strege AK, Lee YK, Bone ND, Raza A (2007) Bone biopsy derived marrow stromal elements rescue chronic lymphocytic leukemia B-cells from spontaneous and drug induced cell death and facilitates an "angiogenic switch". Leuk Res 31:899-906. doi: 10.1016/j.leukres.2006. 11.024 (Pubitemid 46856727)
-
(2007)
Leukemia Research
, vol.31
, Issue.7
, pp. 899-906
-
-
Kay, N.E.1
Shanafelt, T.D.2
Strege, A.K.3
Lee, Y.K.4
Bone, N.D.5
Raza, A.6
-
53
-
-
34948859010
-
Constitutive alternative NF-κB signaling promotes marginal zone B-cell development but disrupts the marginal sinus and induces HEV-like structures in the spleen
-
DOI 10.1182/blood-2007-02-075143
-
Guo F, Weih D, Meier E, Weih F (2007) Constitutive alternative NF-kappaB signaling promotes marginal zone B-cell development but disrupts the marginal sinus and induces HEV-like structures in the spleen. Blood 110:2381-2389. doi: 10.1182/blood-2007-02-075143 (Pubitemid 47523158)
-
(2007)
Blood
, vol.110
, Issue.7
, pp. 2381-2389
-
-
Guo, F.1
Weih, D.2
Meier, E.3
Weih, F.4
-
54
-
-
79951498701
-
Cellular origin(s) of chronic lymphocytic leukemia: Cautionary notes and additional considerations and possibilities
-
10.1182/blood-2010-07-155663 1:CAS:528:DC%2BC3MXisFKqsrY%3D 21148333 10.1182/blood-2010-07-155663
-
Chiorazzi N, Ferrarini M (2011) Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood 117:1781-1791. doi: 10.1182/blood-2010-07-155663
-
(2011)
Blood
, vol.117
, pp. 1781-1791
-
-
Chiorazzi, N.1
Ferrarini, M.2
|