Artificial sweeteners have no effect on gastric emptying, glucagon-like peptide-1, or glycemia after oral glucose in healthy humans

Diabetes Care

Volumn 36, Issue 12, 2013, Pages

  Wu, Tongzhi ^a   Bound, Michelle J ^a   Standfield, Scott D ^a   Bellon, Max ^b   Young, Richard L ^a,b   Jones, Karen L ^a   Horowitz, Michael ^a   Rayner, Christopher K ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACESULFAME; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; SUCRALOSE; SWEET PROTEIN; SWEETENING AGENT; TASTE RECEPTOR TYPE 1; TASTE RECEPTOR TYPE 2; TASTE RECEPTOR TYPE 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL M5; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL;

ADULT; BREATH ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LETTER; MALE; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; PROTEIN SECRETION; STOMACH EMPTYING; BLOOD; DRUG EFFECTS; HYPERGLYCEMIA; METABOLISM; ORAL DRUG ADMINISTRATION; RADIOIMMUNOASSAY;

ADMINISTRATION, ORAL; ADULT; BLOOD GLUCOSE; ENZYME-LINKED IMMUNOSORBENT ASSAY; GASTRIC EMPTYING; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; HEALTHY VOLUNTEERS; HUMANS; HYPERGLYCEMIA; MALE; RADIOIMMUNOASSAY; SWEETENING AGENTS;

EID: 84891881412     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc13-0958     Document Type: Letter

References (5)

1. Steinert RE, Gerspach AC, Gutmann H, Asarian L, Drewe J, Beglinger C. The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Clin Nutr 2011;30: 524-532
2. Brown RJ, Walter M, Rother KI. Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion. Diabetes Care 2009;32:2184-2186
3. Steinert RE, Frey F, Töpfer A, Drewe J, Beglinger C. Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides. Br J Nutr 2011;105:1320-1328
4. Ma J, Bellon M, Wishart JM, et al. Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects. Am J Physiol Gastrointest Liver Physiol 2009;296: G735-G739
5. Ma J, Chang J, Checklin HL, et al. Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjects. Br J Nutr 2010;104:803-806