Intracellular acidification alters myogenic responsiveness and vasomotion of mouse middle cerebral arteries

Journal of Cerebral Blood Flow and Metabolism

Volumn 34, Issue 1, 2014, Pages 161-168

  Thomsen, Axel B K ^a   Kim, Sukhan ^a   Aalbaek, Filip ^a   Aalkjaer, Christian ^a   Boedtkjer, Ebbe ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Ca2+ sensitivity; intracellular pH; myogenic tone; Na+,HCO3 cotransport; nitric oxide; rho kinase

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; BICARBONATE SODIUM COTRANSPORTER; N(G) NITROARGININE METHYL ESTER; RHO KINASE;

ACIDIFICATION; ANIMAL CELL; ARTICLE; BRAIN BLOOD FLOW; BRAIN PERFUSION; CELL PH; CONTROLLED STUDY; KNOCKOUT MOUSE; MEMBRANE POTENTIAL; MIDDLE CEREBRAL ARTERY; MOUSE; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEADY STATE; VASCULAR RESISTANCE;

EID: 84891833371     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.192     Document Type: Article

References (38)

1. +-dependent bicarbonate transport important for regulation of intracellular pH in mouse vascular smooth muscle cells. Circ Res 2006; 98: 515-523.
2. 2 +-sensitivity and hypertension development in mice. Circulation 2011; 124: 1819-1829.
3. 2 and tyrosine phosphatase SHP-2. Am J Physiol Heart Circ Physiol 2009; 296: H247-H255.
4. Boedtkjer E, Damkier HH, Aalkjaer C. NHE1 knockout reduces blood pressure and arterial media/lumen ratio with no effect on resting pHi in the vascular wall. J Physiol 2012; 590: 1895-1906.
5. Danielsen AA, Parker MD, Lee S, Boron WF, Aalkjaer C, Boedtkjer E. Splice cassette II of NBCn1 (slc4a7) interacts with calcineurin A: implications for transporter activity and intracellular pH control during rat artery contractions. J Biol Chem 2013; 288: 8146-8155.
6. Aalkjaer C, Mulvany MJ. Effect of changes in intracellular pH on the contractility of rat resistance vessels. Prog Biochem Pharmacol 1988; 23: 150-158.
7. Boedtkjer E, Kim S, Aalkjaer C. Endothelial alkalinisation inhibits gap junction communication and endothelium-derived hyperpolarisations in mouse mesenteric arteries. J Physiol 2013; 591: 1447-1461.
8. 3~ cotransporter NBCn1 (slc4a7) in mice. Am J Physiol Cell Physiol 2008; 294: C591-C603.
9. Hogestatt ED, Uski TK. Actions of some prostaglandins and leukotrienes on rat cerebral and mesenteric arteries. Gen Pharmacol 1987; 18: 111-117.
10. Lagaud GJ, Skarsgard PL, Laher I, van Breemen C. Heterogeneity of endothelium-dependent vasodilation in pressurized cerebral and small mesenteric resistance arteries of the rat. J Pharmacol Exp Ther 1999; 290: 832-839.
11. Phillips JK, Vidovic M, Hill CE. Variation in mRNA expression of alpha-adrenergic, neurokinin and muscarinic receptors amongst four arteries of the rat. JAuton Nerv Syst 1997; 62: 85-93.
12. Fenger-Gron J, Mulvany MJ, Christensen KL. Mesenteric blood pressure profile of conscious, freely moving rats. J Physiol 1995; 488: 753-760.
13. Johnson PC. Autoregulation of blood flow. Circ Res 1986; 59: 483-495.
14. Bayliss WM. On the local reactions of the arterial wall to changes of internal pressure. J Physiol 1902; 28: 220-231.
15. Gokina NI, Park KM, McElroy-Yaggy K, Osol G. Effects of Rho kinase inhibition on cerebral artery myogenic tone and reactivity. J Appl Physiol 2005; 98: 1940-1948.
16. 2+ sensitivity in the male but not the female gerbil spiral modiolar artery. PLoS One 2013; 8: e53655.
17. Fleming I, Hecker M, Busse R. Intracellular alkalinization induced by bradykinin sustains activation of the constitutive nitric oxide synthase in endothelial cells. Circ Res 1994; 74: 1220-1226.
18. Aalkjaer C, Hughes A. Chloride and bicarbonate transport in rat resistance arteries. J Physiol 1991; 436: 57-73.
19. Boedtkjer E, Aalkjaer C. Intracelullar pH in the resistance vasculature: regulation and functional implications. J Vasc Res 2012; 49: 479-496.
20. 3)-and ryanodine-sensitive calcium stores in rat basilar artery vasomotion. J Physiol 2002; 545: 615-627.
21. Dirnagl U, Lindauer U, Villringer A. Nitric oxide synthase blockade enhances vasomotion in the cerebral microcirculation of anesthetized rats. Microvasc Res 1993; 45: 318-323.
22. Ca channel of rat small artery smooth muscle cells. J Vasc Res 2001; 38: 30-38.
23. Tare M, Parkington HC, Coleman HA, Neild TO, Dusting GJ. Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium. Nature 1990; 346: 69-71.
24. 2 sensitivity regulation in promoting myogenic vasoconstriction. Cardiovasc Res 2008; 77: 8-18.
25. Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011; 478: 103-109.
26. Cao X, Yang F, Zheng J, Wang K. Intracellular proton-mediated activation of TRPV3 channels accounts for the exfoliation effect of alpha-hydroxyl acids on keratino-cytes. J Biol Chem 2012; 287: 25905-25916.
27. 2 channels. J Gen Physiol 1994; 103: 647-663.
28. 2 injections on intracellular calcium and pH in voltage-clamped snail (Helix aspersa) neurons. J Gen Physiol 2002; 120: 567-579.
29. Abercrombie RF, Hart CE. Calcium and proton buffering and diffusion in isolated cytoplasm from Myxicola axons. Am J Physiol 1986; 250: C391-C405.
30. Batlle DC, Peces R, LaPointe MS, Ye M, Daugirdas JT. Cytosolic free calcium regulation in response to acute changes in intracellular pH in vascular smooth muscle. Am J Physiol 1993; 264: C932-C943.
31. Jarajapu YP, Knot HJ. Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension. Am J Physiol Heart Circ Physiol 2005; 289: H1917-H1922.
32. Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000; 351: 95-105.
33. 2 sensitivity as a key mechanism of PKC-induced constriction in pressurized cerebral arteries. Am J Physiol 1999; 277: H1178-H1188.
34. 2 sensitization in stretch-induced myogenic tone. Cardiovasc Res 2002; 53: 431-438.
35. Crnich R, Amberg GC, Leo MD, Gonzales AL, Tamkun MM, Jaggar JH et al. Vaso-constriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells. Am J Physiol Cell Physiol 2010; 299: C682-C694.
36. Aalkjaer C, Boedtkjer D, Matchkov V. Vasomotion-what is currently thought? Acta Physiol (Oxf) 2011; 202: 253-269.
37. Ahn K, Beningo K, Olds G, Hupe D. The endothelin-converting enzyme from human umbilical vein is a membrane-bound metalloprotease similar to that from bovine aortic endothelial Cells. Proc Natl Acad Sci USA 1992; 89: 8606-8610.
38. Trivedi B, Danforth WH. Effect of pH on the kinetics of frog muscle phospho-fructokinase. J Biol Chem 1966; 241: 4110-4112.