메뉴 건너뛰기




Volumn 28, Issue 1, 2014, Pages 110-114

Effects of the GLP-1 receptor agonist lixisenatide on postprandial glucose and gastric emptying - Preclinical evidence

Author keywords

Gastric emptying; GLP 1 receptor agonists; Lixisenatide; Postprandial glucose; Type 2 diabetes mellitus

Indexed keywords

GLUCAGON; GLUCOSE; HEMOGLOBIN A1C; INSULIN; LIRAGLUTIDE; LIXISENATIDE; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; GLUCOSE BLOOD LEVEL; PEPTIDE; ZP10A PEPTIDE;

EID: 84891827870     PISSN: 10568727     EISSN: 1873460X     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2013.06.003     Document Type: Review
Times cited : (39)

References (43)
  • 1
    • 84878358313 scopus 로고    scopus 로고
    • Efficacy and safety of lixisenatide once daily morning or evening injections in type 2 diabetes inadequately controlled on metformin (GetGoal-M)
    • [Epub ahead of print]
    • B. Ahrén, A.L. Dimas, P. Miossec, S. Saubadu, and R. Aronson Efficacy and safety of lixisenatide once daily morning or evening injections in type 2 diabetes inadequately controlled on metformin (GetGoal-M) Diabetes Care 2013 [Epub ahead of print]
    • (2013) Diabetes Care
    • Ahrén, B.1    Dimas, A.L.2    Miossec, P.3    Saubadu, S.4    Aronson, R.5
  • 2
    • 80052559371 scopus 로고    scopus 로고
    • The safety and tolerability of GLP-1 receptor agonists in the treatment of type 2 diabetes: A review
    • V.R. Aroda, and R. Ratner The safety and tolerability of GLP-1 receptor agonists in the treatment of type 2 diabetes: a review Diabetes/Metabolism Research and Reviews 27 2011 528 542
    • (2011) Diabetes/Metabolism Research and Reviews , vol.27 , pp. 528-542
    • Aroda, V.R.1    Ratner, R.2
  • 3
    • 84866545755 scopus 로고    scopus 로고
    • Lixisenatide: Evidence for its potential use in the treatment of type 2 diabetes
    • A. Barnett Lixisenatide: evidence for its potential use in the treatment of type 2 diabetes Core Evidence 6 2011 67 79
    • (2011) Core Evidence , vol.6 , pp. 67-79
    • Barnett, A.1
  • 4
    • 84892529068 scopus 로고    scopus 로고
    • Efficacy and safety of lixisenatide once-daily versus placebo in people with type 2 diabetes insufficiently controlled on metformin (GetGoal-F1)
    • (in press)
    • G. Bolli, M. Munteanu, S. Dotsenko, E. Niemoeller, G. Boka, and Y. Wu et al. Efficacy and safety of lixisenatide once-daily versus placebo in people with type 2 diabetes insufficiently controlled on metformin (GetGoal-F1) Diabetic Medicine 2013 (in press)
    • (2013) Diabetic Medicine
    • Bolli, G.1    Munteanu, M.2    Dotsenko, S.3    Niemoeller, E.4    Boka, G.5    Wu, Y.6
  • 5
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • J.B. Buse, J. Rosenstock, G. Sesti, W.E. Schmidt, E. Montanya, and J.H. Brett et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6) The Lancet 374 2009 39 47
    • (2009) The Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3    Schmidt, W.E.4    Montanya, E.5    Brett, J.H.6
  • 6
    • 55649108863 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
    • J. de Heer, C. Rasmussen, D.H. Coy, and J.J. Holst Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas Diabetologia 51 2008 2263 2270
    • (2008) Diabetologia , vol.51 , pp. 2263-2270
    • De Heer, J.1    Rasmussen, C.2    Coy, D.H.3    Holst, J.J.4
  • 7
    • 58349104177 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of GLP-1 agonist AVE0010 in type 2 diabetes patients
    • L. Distiller, and P. Ruus Pharmacokinetics and pharmacodynamics of GLP-1 agonist AVE0010 in type 2 diabetes patients Diabetes Care 57 Suppl 1 2008 A154
    • (2008) Diabetes Care , vol.57 , Issue.SUPPL. 1 , pp. 154
    • Distiller, L.1    Ruus, P.2
  • 8
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • A. Flint, A. Raben, A. Astrup, and J.J. Holst Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans The Journal of Clinical Investigation 101 1998 515 520
    • (1998) The Journal of Clinical Investigation , vol.101 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 9
    • 84861765116 scopus 로고    scopus 로고
    • Efficacy and safety of the once-daily GLP-1 receptor agonist lixisenatide in monotherapy: A randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes (GetGoal-Mono)
    • V.A. Fonseca, R. Alvarado-Ruiz, D. Raccah, G. Boka, P. Miossec, and J.E. Gerich et al. Efficacy and safety of the once-daily GLP-1 receptor agonist lixisenatide in monotherapy: a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes (GetGoal-Mono) Diabetes Care 35 2012 1225 1231
    • (2012) Diabetes Care , vol.35 , pp. 1225-1231
    • Fonseca, V.A.1    Alvarado-Ruiz, R.2    Raccah, D.3    Boka, G.4    Miossec, P.5    Gerich, J.E.6
  • 11
    • 0027184119 scopus 로고
    • Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells
    • R. Goke, H.C. Fehmann, T. Linn, H. Schmidt, M. Krause, and J. Eng et al. Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells The Journal of Biological Chemistry 268 1993 19650 19655
    • (1993) The Journal of Biological Chemistry , vol.268 , pp. 19650-19655
    • Goke, R.1    Fehmann, H.C.2    Linn, T.3    Schmidt, H.4    Krause, M.5    Eng, J.6
  • 12
    • 0037339148 scopus 로고    scopus 로고
    • Effect of altering gastric emptying on postprandial plasma glucose concentrations following a physiologic meal in type-II diabetic patients
    • S. Gonlachanvit, C.W. Hsu, G.H. Boden, L.C. Knight, A.H. Maurer, and R.S. Fisher et al. Effect of altering gastric emptying on postprandial plasma glucose concentrations following a physiologic meal in type-II diabetic patients Digestive Diseases and Sciences 48 2003 488 497
    • (2003) Digestive Diseases and Sciences , vol.48 , pp. 488-497
    • Gonlachanvit, S.1    Hsu, C.W.2    Boden, G.H.3    Knight, L.C.4    Maurer, A.H.5    Fisher, R.S.6
  • 13
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • J.J. Holst The physiology of glucagon-like peptide 1 Physiological Reviews 87 2007 1409 1439
    • (2007) Physiological Reviews , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 14
    • 84891642041 scopus 로고    scopus 로고
    • Mechanisms and clinical efficacy of lixisenatide for the management of type 2 diabetes
    • M. Horowitz, C.K. Rayner, and K.L. Jones Mechanisms and clinical efficacy of lixisenatide for the management of type 2 diabetes Advances in Therapy 30 2013 81 101
    • (2013) Advances in Therapy , vol.30 , pp. 81-101
    • Horowitz, M.1    Rayner, C.K.2    Jones, K.L.3
  • 15
    • 0023877845 scopus 로고
    • Relationship of the motor activity of the antrum, pylorus, and duodenum to gastric emptying of a solid-liquid mixed meal
    • L.A. Houghton, N.W. Read, R. Heddle, M. Horowitz, P.J. Collins, and B. Chatterton et al. Relationship of the motor activity of the antrum, pylorus, and duodenum to gastric emptying of a solid-liquid mixed meal Gastroenterology 94 1988 1285 1291
    • (1988) Gastroenterology , vol.94 , pp. 1285-1291
    • Houghton, L.A.1    Read, N.W.2    Heddle, R.3    Horowitz, M.4    Collins, P.J.5    Chatterton, B.6
  • 18
    • 84878863716 scopus 로고    scopus 로고
    • Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin
    • C. Kapitza, T. Forst, H.-V. Coester, F. Poitiers, P. Ruus, and A. Hincelin-Méry Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin Diabetes, Obesity & Metabolism 15 2013 642 649
    • (2013) Diabetes, Obesity & Metabolism , vol.15 , pp. 642-649
    • Kapitza, C.1    Forst, T.2    Coester, H.-V.3    Poitiers, F.4    Ruus, P.5    Hincelin-Méry, A.6
  • 20
    • 56549107405 scopus 로고    scopus 로고
    • Effect of exenatide on gastric emptying and relationship to postprandial glycemia in type 2 diabetes
    • H. Linnebjerg, S. Park, P.A. Kothare, M.E. Trautmann, K. Mace, and M. Fineman et al. Effect of exenatide on gastric emptying and relationship to postprandial glycemia in type 2 diabetes Regulatory Peptides 151 2008 123 129
    • (2008) Regulatory Peptides , vol.151 , pp. 123-129
    • Linnebjerg, H.1    Park, S.2    Kothare, P.A.3    Trautmann, M.E.4    Mace, K.5    Fineman, M.6
  • 21
    • 84878549237 scopus 로고    scopus 로고
    • Effects of lixisenatide once daily on gastric emptying in type 2 diabetes - Relationship to postprandial glycemia
    • M. Lorenz, C. Pfeiffer, A. Steinsträßer, R.H. Becker, H. Rütten, and P. Ruus et al. Effects of lixisenatide once daily on gastric emptying in type 2 diabetes - Relationship to postprandial glycemia Regulatory Peptides 185C 2013 1 8
    • (2013) Regulatory Peptides , vol.185 C , pp. 1-8
    • Lorenz, M.1    Pfeiffer, C.2    Steinsträßer, A.3    Becker, R.H.4    Rütten, H.5    Ruus, P.6
  • 23
    • 0037667613 scopus 로고    scopus 로고
    • Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes
    • J.J. Meier, B. Gallwitz, S. Salmen, O. Goetze, J.J. Holst, and W.E. Schmidt et al. Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes The Journal of Clinical Endocrinology and Metabolism 88 2003 2719 2725
    • (2003) The Journal of Clinical Endocrinology and Metabolism , vol.88 , pp. 2719-2725
    • Meier, J.J.1    Gallwitz, B.2    Salmen, S.3    Goetze, O.4    Holst, J.J.5    Schmidt, W.E.6
  • 24
    • 21344454659 scopus 로고    scopus 로고
    • Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects
    • J.J. Meier, G. Kemmeries, J.J. Holst, and M.A. Nauck Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects Diabetes 54 2005 2212 2218
    • (2005) Diabetes , vol.54 , pp. 2212-2218
    • Meier, J.J.1    Kemmeries, G.2    Holst, J.J.3    Nauck, M.A.4
  • 25
    • 43049143998 scopus 로고    scopus 로고
    • Effect of the glucagon-like peptide-1 receptor agonist AVE0010 on postprandial hepatic glucose metabolism in the conscious dog
    • Abstract 0584
    • M. Moore, U. Werner, M. Smith, T. Rodewald, and A. Cherrington Effect of the glucagon-like peptide-1 receptor agonist AVE0010 on postprandial hepatic glucose metabolism in the conscious dog Diabetologia 50 Supp 1 2007 Abstract 0584
    • (2007) Diabetologia , vol.50 , Issue.SUPPL. 1
    • Moore, M.1    Werner, U.2    Smith, M.3    Rodewald, T.4    Cherrington, A.5
  • 26
    • 1642271221 scopus 로고    scopus 로고
    • Prandial subcutaneous injections of glucagon-like peptide-1 cause weight loss in obese human subjects
    • E. Naslund, N. King, S. Mansten, N. Adner, J.J. Holst, and M. Gutniak et al. Prandial subcutaneous injections of glucagon-like peptide-1 cause weight loss in obese human subjects The British Journal of Nutrition 91 2004 439 446
    • (2004) The British Journal of Nutrition , vol.91 , pp. 439-446
    • Naslund, E.1    King, N.2    Mansten, S.3    Adner, N.4    Holst, J.J.5    Gutniak, M.6
  • 27
    • 79959404178 scopus 로고    scopus 로고
    • Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans
    • M.A. Nauck, G. Kemmeries, J.J. Holst, and J.J. Meier Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans Diabetes 60 2011 1561 1565
    • (2011) Diabetes , vol.60 , pp. 1561-1565
    • Nauck, M.A.1    Kemmeries, G.2    Holst, J.J.3    Meier, J.J.4
  • 28
    • 84885331631 scopus 로고    scopus 로고
    • Efficacy and safety of lixisenatide once daily versus placebo in type 2 diabetes insufficiently controlled on pioglitazone (GetGoal-P)
    • [Epub ahead of print]
    • M. Pinget, R. Goldenberg, E. Niemoeller, I. Muehlen-Bartmer, H. Guo, and R. Aronson Efficacy and safety of lixisenatide once daily versus placebo in type 2 diabetes insufficiently controlled on pioglitazone (GetGoal-P) Diabetes, Obesity & Metabolism 2013 [Epub ahead of print]
    • (2013) Diabetes, Obesity & Metabolism
    • Pinget, M.1    Goldenberg, R.2    Niemoeller, E.3    Muehlen-Bartmer, I.4    Guo, H.5    Aronson, R.6
  • 29
    • 0043169338 scopus 로고    scopus 로고
    • Differential effects of acute and extended infusions of glucagon-like peptide-1 on first- and second-phase insulin secretion in diabetic and nondiabetic humans
    • S. Quddusi, T.P. Vahl, K. Hanson, R.L. Prigeon, and D.A. D'Alessio Differential effects of acute and extended infusions of glucagon-like peptide-1 on first- and second-phase insulin secretion in diabetic and nondiabetic humans Diabetes Care 26 2003 791 798
    • (2003) Diabetes Care , vol.26 , pp. 791-798
    • Quddusi, S.1    Vahl, T.P.2    Hanson, K.3    Prigeon, R.L.4    D'Alessio, D.A.5
  • 30
    • 84874626121 scopus 로고    scopus 로고
    • Efficacy and safety of lixisenatide in the treatment of type 2 diabetes mellitus: A review of phase III clinical data
    • D. Raccah Efficacy and safety of lixisenatide in the treatment of type 2 diabetes mellitus: A review of phase III clinical data Expert Review of Endocrinology and Metabolism 8 2013 105 121
    • (2013) Expert Review of Endocrinology and Metabolism , vol.8 , pp. 105-121
    • Raccah, D.1
  • 32
    • 84878592117 scopus 로고    scopus 로고
    • Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin: A 24-week, randomized, placebo-controlled comparison (GetGoal-L)
    • [Epub ahead of print]
    • M.C. Riddle, R. Aronson, P. Home, M. Marre, E. Niemoeller, and P. Miossec et al. Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin: A 24-week, randomized, placebo-controlled comparison (GetGoal-L) Diabetes Care 2013 [Epub ahead of print]
    • (2013) Diabetes Care
    • Riddle, M.C.1    Aronson, R.2    Home, P.3    Marre, M.4    Niemoeller, E.5    Miossec, P.6
  • 33
    • 84878603672 scopus 로고    scopus 로고
    • Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: A 24-week, randomized, placebo-controlled study (GetGoal-Duo 1)
    • [Epub ahead of print]
    • M.C. Riddle, T. Forst, R. Aronson, L. Sauque-Reyna, E. Souhami, and L. Ping et al. Adding once-daily lixisenatide for type 2 diabetes inadequately controlled with newly initiated and continuously titrated basal insulin glargine: A 24-week, randomized, placebo-controlled study (GetGoal-Duo 1) Diabetes Care 2013 [Epub ahead of print]
    • (2013) Diabetes Care
    • Riddle, M.C.1    Forst, T.2    Aronson, R.3    Sauque-Reyna, L.4    Souhami, E.5    Ping, L.6
  • 34
    • 84883324640 scopus 로고    scopus 로고
    • Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: A 24-week, randomized, open-label, active-controlled study (GetGoal-X)
    • [Epub ahead of print]
    • J. Rosenstock, D. Raccah, L. Koranyi, L. Maffei, G. Boka, and P. Miossec et al. Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label, active-controlled study (GetGoal-X) Diabetes Care 2013 [Epub ahead of print]
    • (2013) Diabetes Care
    • Rosenstock, J.1    Raccah, D.2    Koranyi, L.3    Maffei, L.4    Boka, G.5    Miossec, P.6
  • 35
    • 0034062386 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1(7-36)amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans
    • J. Schirra, P. Houck, U. Wank, R. Arnold, B. Goke, and M. Katschinski Effects of glucagon-like peptide-1(7-36)amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans Gut 46 2000 622 631
    • (2000) Gut , vol.46 , pp. 622-631
    • Schirra, J.1    Houck, P.2    Wank, U.3    Arnold, R.4    Goke, B.5    Katschinski, M.6
  • 37
    • 84865979163 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia)
    • Y. Seino, K.W. Min, E. Niemoeller, A. Takami, and Investigators EFC10887 GETGOAL-L Asia Study Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia) Diabetes, Obesity & Metabolism 14 2012 910 917
    • (2012) Diabetes, Obesity & Metabolism , vol.14 , pp. 910-917
    • Seino, Y.1    Min, K.W.2    Niemoeller, E.3    Takami, A.4
  • 39
    • 0026545063 scopus 로고
    • Relation of pyloric motility to pyloric opening and closure in healthy subjects
    • G. Tougas, M. Anvari, J. Dent, S. Somers, D. Richards, and G.W. Stevenson Relation of pyloric motility to pyloric opening and closure in healthy subjects Gut 33 1992 466 471
    • (1992) Gut , vol.33 , pp. 466-471
    • Tougas, G.1    Anvari, M.2    Dent, J.3    Somers, S.4    Richards, D.5    Stevenson, G.W.6
  • 40
    • 43049145248 scopus 로고    scopus 로고
    • Treatment of obese Zucker diabetic fatty rats with novel GLP-1 receptor agonist AVE0010 improves oral glucose tolerance and glycaemic control without risk of hypoglycaemia
    • (Abstract 0656-P)
    • U. Werner, M. Gerlach, M. Hofmann, and A. Herling Treatment of obese Zucker diabetic fatty rats with novel GLP-1 receptor agonist AVE0010 improves oral glucose tolerance and glycaemic control without risk of hypoglycaemia Diabetologia 49 Suppl 1 2006 398 399 (Abstract 0656-P)
    • (2006) Diabetologia , vol.49 , Issue.SUPPL. 1 , pp. 398-399
    • Werner, U.1    Gerlach, M.2    Hofmann, M.3    Herling, A.4
  • 42
    • 77955847376 scopus 로고    scopus 로고
    • Pharmacological profile of lixisenatide: A new GLP-1 receptor agonist for the treatment of type 2 diabetes
    • U. Werner, G. Haschke, A.W. Herling, and W. Kramer Pharmacological profile of lixisenatide: A new GLP-1 receptor agonist for the treatment of type 2 diabetes Regulatory Peptides 164 2010 58 64
    • (2010) Regulatory Peptides , vol.164 , pp. 58-64
    • Werner, U.1    Haschke, G.2    Herling, A.W.3    Kramer, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.