-
1
-
-
79952232216
-
Global cancer statistics
-
PID: 21296855
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.
-
(2011)
CA Cancer J Clin.
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
2
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
COI: 1:CAS:528:DC%2BD2cXktF2js7c%3D, PID: 15118073
-
Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350:2129–39.
-
(2004)
N Engl J Med.
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
3
-
-
2342624080
-
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
-
COI: 1:CAS:528:DC%2BD2cXksVGmsbs%3D, PID: 15118125
-
Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304:1497–1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
4
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib
-
COI: 1:CAS:528:DC%2BD2cXnvFems70%3D, PID: 15329413
-
Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA. 2004;101:13306–13311.
-
(2004)
Proc Natl Acad Sci USA.
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
-
5
-
-
84855310079
-
EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications
-
COI: 1:CAS:528:DC%2BC38XkslSltA%3D%3D, PID: 21764376
-
Yasuda H, Kobayashi S, Costa DB. EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications. Lancet Oncol. 2012;13:e23–e31.
-
(2012)
Lancet Oncol.
, vol.13
, pp. e23-e31
-
-
Yasuda, H.1
Kobayashi, S.2
Costa, D.B.3
-
6
-
-
51049116207
-
Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response
-
COI: 1:CAS:528:DC%2BD1cXpt1eju7w%3D
-
Wu JY, Wu SG, Yang CH, et al. Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response. Clin Canc Res. 2008;14:4877–4882.
-
(2008)
Clin Canc Res.
, vol.14
, pp. 4877-4882
-
-
Wu, J.Y.1
Wu, S.G.2
Yang, C.H.3
-
7
-
-
79957916527
-
Effectiveness of tyrosine kinase inhibitors on “uncommon” epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer
-
COI: 1:CAS:528:DC%2BC3MXmvFGjsr0%3D
-
Wu JY, Yu CJ, Chang YC, Yang CH, Shih JY, Yang PC. Effectiveness of tyrosine kinase inhibitors on “uncommon” epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer. Clin Canc Res.2011;17:3812–3821.
-
(2011)
Clin Canc Res.
, vol.17
, pp. 3812-3821
-
-
Wu, J.Y.1
Yu, C.J.2
Chang, Y.C.3
Yang, C.H.4
Shih, J.Y.5
Yang, P.C.6
-
8
-
-
85019212578
-
-
Yasuda HSN, Yeo W, Figueiredo-Pontes L, Kobayashi S, Costa D. Sensitivity of EGFR exon 20 insertion mutations to EGFR inhibitors is determined by their location within the tyrosine kinase domain of EGFR. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research. Canc Res. 2012;72(8 Suppl):23.
-
Yasuda HSN, Yeo W, Figueiredo-Pontes L, Kobayashi S, Costa D. Sensitivity of EGFR exon 20 insertion mutations to EGFR inhibitors is determined by their location within the tyrosine kinase domain of EGFR. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research. Canc Res. 2012;72(8 Suppl):23.
-
-
-
-
9
-
-
34047132314
-
Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib
-
COI: 1:STN:280:DC%2BD2s7os1Omsw%3D%3D, PID: 17317677
-
Hirsch FR, Varella-Garcia M, Cappuzzo F, et al. Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib. Ann Oncol. 2007;18:752–760.
-
(2007)
Ann Oncol.
, vol.18
, pp. 752-760
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
Cappuzzo, F.3
-
10
-
-
34250161814
-
Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: the ONCOBELL trial
-
COI: 1:CAS:528:DC%2BD2sXnsVShur0%3D, PID: 17538169
-
Cappuzzo F, Ligorio C, Janne PA, et al. Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: the ONCOBELL trial. J Clin Oncol. 2007;25:2248–2255.
-
(2007)
J Clin Oncol.
, vol.25
, pp. 2248-2255
-
-
Cappuzzo, F.1
Ligorio, C.2
Janne, P.A.3
-
11
-
-
27244443759
-
Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study
-
COI: 1:CAS:528:DC%2BD2MXhtFCrsb3K, PID: 15998906
-
Hirsch FR, Varella-Garcia M, McCoy J, et al. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study. J Clin Oncol. 2005;23:6838–6845.
-
(2005)
J Clin Oncol.
, vol.23
, pp. 6838-6845
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
McCoy, J.3
-
12
-
-
18344390418
-
ERBB receptors and cancer: the complexity of targeted inhibitors
-
COI: 1:CAS:528:DC%2BD2MXjslertb0%3D, PID: 15864276
-
Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer. 2005;5:341–354.
-
(2005)
Nat Rev Cancer.
, vol.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
13
-
-
0037145061
-
Ligand-induced, receptor-mediated dimerization and activation of EGF receptor
-
COI: 1:CAS:528:DC%2BD38XnsFKis7w%3D, PID: 12297041
-
Schlessinger J. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell. 2002;110:669–672.
-
(2002)
Cell
, vol.110
, pp. 669-672
-
-
Schlessinger, J.1
-
14
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
COI: 1:CAS:528:DC%2BD2sXltlOjt7g%3D, PID: 17463250
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007;316:1039–1043.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
15
-
-
24644445676
-
Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients
-
COI: 1:CAS:528:DC%2BD2MXpsFWmtLo%3D, PID: 16051952
-
Cappuzzo F, Varella-Garcia M, Shigematsu H, et al. Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients. J Clin Oncol. 2005;23:5007–5018.
-
(2005)
J Clin Oncol.
, vol.23
, pp. 5007-5018
-
-
Cappuzzo, F.1
Varella-Garcia, M.2
Shigematsu, H.3
-
16
-
-
14844366111
-
ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines
-
COI: 1:CAS:528:DC%2BD2MXisVOgtrc%3D, PID: 15731348
-
Engelman JA, Janne PA, Mermel C, et al. ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc Natl Acad Sci USA. 2005;102:3788–3793.
-
(2005)
Proc Natl Acad Sci USA.
, vol.102
, pp. 3788-3793
-
-
Engelman, J.A.1
Janne, P.A.2
Mermel, C.3
-
17
-
-
20244389188
-
Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib
-
COI: 1:CAS:528:DC%2BD2MXjvVyktL0%3D, PID: 15710947
-
Han SW, Kim TY, Hwang PG, et al. Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib. J Clin Oncol. 2005;23:2493–2501.
-
(2005)
J Clin Oncol.
, vol.23
, pp. 2493-2501
-
-
Han, S.W.1
Kim, T.Y.2
Hwang, P.G.3
-
18
-
-
8644234228
-
Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer
-
COI: 1:CAS:528:DC%2BD2cXhtVWgsL7P, PID: 15386420
-
Han SW, Hwang PG, Chung DH, et al. Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer. Int J Cancer.2005;113:109–115.
-
(2005)
Int J Cancer.
, vol.113
, pp. 109-115
-
-
Han, S.W.1
Hwang, P.G.2
Chung, D.H.3
-
19
-
-
79551563284
-
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma
-
PID: 21252716
-
Travis WD, Brambilla E, Noguchi M, et al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011;6:244–285.
-
(2011)
J Thorac Oncol.
, vol.6
, pp. 244-285
-
-
Travis, W.D.1
Brambilla, E.2
Noguchi, M.3
-
20
-
-
78049515002
-
Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases
-
PID: 20855837
-
Sun Y, Ren Y, Fang Z, et al. Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases. J Clin Oncol. 2010;28:4616–4620.
-
(2010)
J Clin Oncol.
, vol.28
, pp. 4616-4620
-
-
Sun, Y.1
Ren, Y.2
Fang, Z.3
-
21
-
-
84859397680
-
Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis
-
COI: 1:CAS:528:DC%2BC38XkvFOmu7k%3D, PID: 22317764
-
Zhang Y, Sun Y, Pan Y, et al. Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis. Clin Cancer Res. 2012;18:1947–1953.
-
(2012)
Clin Cancer Res.
, vol.18
, pp. 1947-1953
-
-
Zhang, Y.1
Sun, Y.2
Pan, Y.3
-
22
-
-
79958178416
-
Comprehensive analysis of epidermal growth factor receptor gene status in lung adenocarcinoma
-
PID: 21532505
-
Li C, Sun Y, Fang Z, et al. Comprehensive analysis of epidermal growth factor receptor gene status in lung adenocarcinoma. J Thorac Oncol. 2011;6:1016–1021.
-
(2011)
J Thorac Oncol.
, vol.6
, pp. 1016-1021
-
-
Li, C.1
Sun, Y.2
Fang, Z.3
-
23
-
-
84873821602
-
Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions
-
COI: 1:CAS:528:DC%2BC3sXht1Kms7k%3D, PID: 23328547
-
Oxnard GR, Lo PC, Nishino M, et al. Natural history and molecular characteristics of lung cancers harboring EGFR exon 20 insertions. J Thorac Oncol. 2013;8:179–184.
-
(2013)
J Thorac Oncol.
, vol.8
, pp. 179-184
-
-
Oxnard, G.R.1
Lo, P.C.2
Nishino, M.3
-
24
-
-
84874024717
-
EGFR exon 20 insertion mutations in lung adenocarcinomas: prevalence, molecular heterogeneity, and clinicopathologic characteristics
-
COI: 1:CAS:528:DC%2BC3sXitlWisrc%3D, PID: 23371856
-
Arcila ME, Nafa K, Chaft JE, et al. EGFR exon 20 insertion mutations in lung adenocarcinomas: prevalence, molecular heterogeneity, and clinicopathologic characteristics. Mol Cancer Ther. 2013;12:220–229.
-
(2013)
Mol Cancer Ther.
, vol.12
, pp. 220-229
-
-
Arcila, M.E.1
Nafa, K.2
Chaft, J.E.3
-
25
-
-
35748941360
-
EGFR exon 20 insertion mutation in Japanese lung cancer
-
PID: 17686547
-
Sasaki H, Endo K, Takada M, et al. EGFR exon 20 insertion mutation in Japanese lung cancer. Lung Cancer. 2007;58:324–328.
-
(2007)
Lung Cancer
, vol.58
, pp. 324-328
-
-
Sasaki, H.1
Endo, K.2
Takada, M.3
-
26
-
-
3042800393
-
ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface
-
COI: 1:CAS:528:DC%2BD2cXlt1amu7c%3D, PID: 15225657
-
Berger MB, Mendrola JM, Lemmon MA. ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface. FEBS Lett. 2004;569:332–336.
-
(2004)
FEBS Lett.
, vol.569
, pp. 332-336
-
-
Berger, M.B.1
Mendrola, J.M.2
Lemmon, M.A.3
-
27
-
-
29244450494
-
High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor
-
COI: 1:CAS:528:DC%2BD2MXhtlWiu7zE, PID: 16357156
-
Fujimoto N, Wislez M, Zhang J, et al. High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Res. 2005;65:11478–11485.
-
(2005)
Cancer Res.
, vol.65
, pp. 11478-11485
-
-
Fujimoto, N.1
Wislez, M.2
Zhang, J.3
|