-
1
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR et al (2002) Mutations of the BRAF gene in human cancer. Nature 417:949-954
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
-
2
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
Bollag G, Hirth P et al (2010) Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 467: 596-599
-
(2010)
Nature
, vol.467
, pp. 596-599
-
-
Bollag, G.1
Hirth, P.2
-
3
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I et al (2010) Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363:809-819
-
(2010)
N Engl J Med
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
-
4
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A et al (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364:2507-2516
-
(2011)
N Engl J Med
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
-
5
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
-
Hauschild A, Grob J-J et al (2012) Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial. Lancet 380:358-365
-
(2012)
Lancet
, vol.380
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.-J.2
-
6
-
-
84861083983
-
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: A phase 1 dose-escalation trial
-
Falchook GS, Long GV et al (2012) Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: A phase 1 dose-escalation trial. Lancet 379:1893-1901
-
(2012)
Lancet
, vol.379
, pp. 1893-1901
-
-
Falchook, G.S.1
Long, G.V.2
-
7
-
-
78650303507
-
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
-
Nazarian R, Shi H et al (2010) Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 468:973-977
-
(2010)
Nature
, vol.468
, pp. 973-977
-
-
Nazarian, R.1
Shi, H.2
-
8
-
-
78650309875
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
-
Johannessen CM, Boehm JS et al (2010) COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468: 968-972
-
(2010)
Nature
, vol.468
, pp. 968-972
-
-
Johannessen, C.M.1
Boehm, J.S.2
-
9
-
-
83455254767
-
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E
-
Poulikakos PI, Persaud Y et al (2011) RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature 480:387-390
-
(2011)
Nature
, vol.480
, pp. 387-390
-
-
Poulikakos, P.I.1
Persaud, Y.2
-
10
-
-
84859183431
-
Melanoma whole-exome sequencing identifi es V600EB-RAF amplifi cation-mediated acquired B-RAF inhibitor resistance
-
Shi H, Moriceau G et al (2012) Melanoma whole-exome sequencing identifi es V600EB-RAF amplifi cation-mediated acquired B-RAF inhibitor resistance. Nat Commun 3:724
-
(2012)
Nat Commun
, vol.3
, pp. 724
-
-
Shi, H.1
Moriceau, G.2
-
11
-
-
80051625929
-
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
-
Wagle N, Emery C et al (2011) Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J Clin Oncol 29:3085-3096
-
(2011)
J Clin Oncol
, vol.29
, pp. 3085-3096
-
-
Wagle, N.1
Emery, C.2
-
12
-
-
78650008177
-
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
-
Villanueva J, Vultur A et al (2010) Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 18:683-695
-
(2010)
Cancer Cell
, vol.18
, pp. 683-695
-
-
Villanueva, J.1
Vultur, A.2
-
13
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad A, Sun C et al (2012) Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483:100-103
-
(2012)
Nature
, vol.483
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
-
14
-
-
84861863158
-
EGFRmediated reactivation of MAPK signaling contributes to insensitivity of BRAF-mutant colorectal cancers to RAF inhibition with vemurafenib
-
Corcoran RB, Ebi H et al (2012) EGFRmediated reactivation of MAPK signaling contributes to insensitivity of BRAF-mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discov 2:227-235
-
(2012)
Cancer Discov
, vol.2
, pp. 227-235
-
-
Corcoran, R.B.1
Ebi, H.2
-
15
-
-
84864994126
-
Reactivation of mitogen-activated protein kinase (MAPK) pathway by FGF receptor 3 (FGFR3)/ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma
-
Yadav V, Zhang X et al (2012) Reactivation of mitogen-activated protein kinase (MAPK) pathway by FGF receptor 3 (FGFR3)/ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma. J Biol Chem 287:28087-28098
-
(2012)
J Biol Chem
, vol.287
, pp. 28087-28098
-
-
Yadav, V.1
Zhang, X.2
-
16
-
-
84859765844
-
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
-
Duncan JS, Whittle MC et al (2012) Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell 149:307-321
-
(2012)
Cell
, vol.149
, pp. 307-321
-
-
Duncan, J.S.1
Whittle, M.C.2
-
17
-
-
79960946383
-
Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition
-
Shi H, Kong X et al (2011) Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition. Cancer Res 71:5067-5074
-
(2011)
Cancer Res
, vol.71
, pp. 5067-5074
-
-
Shi, H.1
Kong, X.2
-
18
-
-
78649487698
-
Ras superfamily GEFs and GAPs: Validated and tractable targets for cancer therapy?
-
Vigil D, Cherfi ls J et al (2010) Ras superfamily GEFs and GAPs: Validated and tractable targets for cancer therapy? Nat Rev Cancer 10: 842-857
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 842-857
-
-
Vigil, D.1
Cherfils, J.2
-
19
-
-
84879410422
-
NRAS mutant melanoma: Biological behavior and future strategies for therapeutic management
-
Fedorenko IV, Gibney GT et al (2013) NRAS mutant melanoma: Biological behavior and future strategies for therapeutic management. Oncogene 32(25):3009-3018
-
(2013)
Oncogene
, vol.32
, Issue.25
, pp. 3009-3018
-
-
Fedorenko, I.V.1
Gibney, G.T.2
-
20
-
-
84868224906
-
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
-
Flaherty KT, Infante JR et al (2012) Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 367: 1694-1703
-
(2012)
N Engl J Med
, vol.367
, pp. 1694-1703
-
-
Flaherty, K.T.1
Infante, J.R.2
-
21
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefi tinib
-
Kobayashi S, Boggon TJ et al (2005) EGFR mutation and resistance of non-small-cell lung cancer to gefi tinib. N Engl J Med 352: 786-792
-
(2005)
N Engl J Med
, vol.352
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
-
22
-
-
84863234102
-
Selumetinib (AZD6244; ARRY-142886) in the treatment of metastatic melanoma
-
Patel SP, Kim KB (2012) Selumetinib (AZD6244; ARRY-142886) in the treatment of metastatic melanoma. Expert Opin Investig Drugs 21:531-539
-
(2012)
Expert Opin Investig Drugs
, vol.21
, pp. 531-539
-
-
Patel, S.P.1
Kim, K.B.2
-
23
-
-
73949083834
-
MEK1 mutations confer resistance to MEK and B-RAF inhibition
-
Emery CM, Vijayendran KG et al (2009) MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc Natl Acad Sci 106:20411-20416
-
(2009)
Proc Natl Acad Sci
, vol.106
, pp. 20411-20416
-
-
Emery, C.M.1
Vijayendran, K.G.2
-
24
-
-
84861901164
-
Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors
-
Shi H, Moriceau G et al (2012) Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. Cancer Discov 2:414-424
-
(2012)
Cancer Discov
, vol.2
, pp. 414-424
-
-
Shi, H.1
Moriceau, G.2
-
25
-
-
33745685149
-
An improved method for RNA isolation and removal of melanin contamination from melanoma tissue: Implications for tumor antigen detection and amplifi cation
-
Dörrie J, Wellner V et al (2006) An improved method for RNA isolation and removal of melanin contamination from melanoma tissue: Implications for tumor antigen detection and amplifi cation. J Immunol Method 313: 119-128
-
(2006)
J Immunol Method
, vol.313
, pp. 119-128
-
-
Dörrie, J.1
Wellner, V.2
-
26
-
-
2642579788
-
CTAB-urea method purifi es RNA from melanin for cDNA microarray analysis
-
Lagonigro MS, De Cecco L et al (2004) CTAB-urea method purifi es RNA from melanin for cDNA microarray analysis. Pigment Cell Res 17:312-315
-
(2004)
Pigment Cell Res
, vol.17
, pp. 312-315
-
-
Lagonigro, M.S.1
De Cecco, L.2
|