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Volumn 1102, Issue , 2014, Pages 163-174

Detecting mechanisms of acquired BRAF inhibitor resistance in melanoma

Author keywords

BRAF; Drug resistance; MAPK; MEK; Molecular diagnosis; NRAS; RTK

Indexed keywords

B RAF KINASE; B RAF KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PROTEIN TYROSINE KINASE; RAS PROTEIN;

EID: 84891819709     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-727-3_10     Document Type: Article
Times cited : (12)

References (26)
  • 1
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR et al (2002) Mutations of the BRAF gene in human cancer. Nature 417:949-954
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2
  • 2
    • 77956513286 scopus 로고    scopus 로고
    • Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
    • Bollag G, Hirth P et al (2010) Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 467: 596-599
    • (2010) Nature , vol.467 , pp. 596-599
    • Bollag, G.1    Hirth, P.2
  • 3
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty KT, Puzanov I et al (2010) Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 363:809-819
    • (2010) N Engl J Med , vol.363 , pp. 809-819
    • Flaherty, K.T.1    Puzanov, I.2
  • 4
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A et al (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364:2507-2516
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2
  • 5
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild A, Grob J-J et al (2012) Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial. Lancet 380:358-365
    • (2012) Lancet , vol.380 , pp. 358-365
    • Hauschild, A.1    Grob, J.-J.2
  • 6
    • 84861083983 scopus 로고    scopus 로고
    • Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: A phase 1 dose-escalation trial
    • Falchook GS, Long GV et al (2012) Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: A phase 1 dose-escalation trial. Lancet 379:1893-1901
    • (2012) Lancet , vol.379 , pp. 1893-1901
    • Falchook, G.S.1    Long, G.V.2
  • 7
    • 78650303507 scopus 로고    scopus 로고
    • Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
    • Nazarian R, Shi H et al (2010) Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 468:973-977
    • (2010) Nature , vol.468 , pp. 973-977
    • Nazarian, R.1    Shi, H.2
  • 8
    • 78650309875 scopus 로고    scopus 로고
    • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
    • Johannessen CM, Boehm JS et al (2010) COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468: 968-972
    • (2010) Nature , vol.468 , pp. 968-972
    • Johannessen, C.M.1    Boehm, J.S.2
  • 9
    • 83455254767 scopus 로고    scopus 로고
    • RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E
    • Poulikakos PI, Persaud Y et al (2011) RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature 480:387-390
    • (2011) Nature , vol.480 , pp. 387-390
    • Poulikakos, P.I.1    Persaud, Y.2
  • 10
    • 84859183431 scopus 로고    scopus 로고
    • Melanoma whole-exome sequencing identifi es V600EB-RAF amplifi cation-mediated acquired B-RAF inhibitor resistance
    • Shi H, Moriceau G et al (2012) Melanoma whole-exome sequencing identifi es V600EB-RAF amplifi cation-mediated acquired B-RAF inhibitor resistance. Nat Commun 3:724
    • (2012) Nat Commun , vol.3 , pp. 724
    • Shi, H.1    Moriceau, G.2
  • 11
    • 80051625929 scopus 로고    scopus 로고
    • Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
    • Wagle N, Emery C et al (2011) Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J Clin Oncol 29:3085-3096
    • (2011) J Clin Oncol , vol.29 , pp. 3085-3096
    • Wagle, N.1    Emery, C.2
  • 12
    • 78650008177 scopus 로고    scopus 로고
    • Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
    • Villanueva J, Vultur A et al (2010) Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 18:683-695
    • (2010) Cancer Cell , vol.18 , pp. 683-695
    • Villanueva, J.1    Vultur, A.2
  • 13
    • 84863230465 scopus 로고    scopus 로고
    • Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
    • Prahallad A, Sun C et al (2012) Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483:100-103
    • (2012) Nature , vol.483 , pp. 100-103
    • Prahallad, A.1    Sun, C.2
  • 14
    • 84861863158 scopus 로고    scopus 로고
    • EGFRmediated reactivation of MAPK signaling contributes to insensitivity of BRAF-mutant colorectal cancers to RAF inhibition with vemurafenib
    • Corcoran RB, Ebi H et al (2012) EGFRmediated reactivation of MAPK signaling contributes to insensitivity of BRAF-mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discov 2:227-235
    • (2012) Cancer Discov , vol.2 , pp. 227-235
    • Corcoran, R.B.1    Ebi, H.2
  • 15
    • 84864994126 scopus 로고    scopus 로고
    • Reactivation of mitogen-activated protein kinase (MAPK) pathway by FGF receptor 3 (FGFR3)/ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma
    • Yadav V, Zhang X et al (2012) Reactivation of mitogen-activated protein kinase (MAPK) pathway by FGF receptor 3 (FGFR3)/ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma. J Biol Chem 287:28087-28098
    • (2012) J Biol Chem , vol.287 , pp. 28087-28098
    • Yadav, V.1    Zhang, X.2
  • 16
    • 84859765844 scopus 로고    scopus 로고
    • Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
    • Duncan JS, Whittle MC et al (2012) Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell 149:307-321
    • (2012) Cell , vol.149 , pp. 307-321
    • Duncan, J.S.1    Whittle, M.C.2
  • 17
    • 79960946383 scopus 로고    scopus 로고
    • Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition
    • Shi H, Kong X et al (2011) Combinatorial treatments that overcome PDGFRβ-driven resistance of melanoma cells to V600EB-RAF inhibition. Cancer Res 71:5067-5074
    • (2011) Cancer Res , vol.71 , pp. 5067-5074
    • Shi, H.1    Kong, X.2
  • 18
    • 78649487698 scopus 로고    scopus 로고
    • Ras superfamily GEFs and GAPs: Validated and tractable targets for cancer therapy?
    • Vigil D, Cherfi ls J et al (2010) Ras superfamily GEFs and GAPs: Validated and tractable targets for cancer therapy? Nat Rev Cancer 10: 842-857
    • (2010) Nat Rev Cancer , vol.10 , pp. 842-857
    • Vigil, D.1    Cherfils, J.2
  • 19
    • 84879410422 scopus 로고    scopus 로고
    • NRAS mutant melanoma: Biological behavior and future strategies for therapeutic management
    • Fedorenko IV, Gibney GT et al (2013) NRAS mutant melanoma: Biological behavior and future strategies for therapeutic management. Oncogene 32(25):3009-3018
    • (2013) Oncogene , vol.32 , Issue.25 , pp. 3009-3018
    • Fedorenko, I.V.1    Gibney, G.T.2
  • 20
    • 84868224906 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
    • Flaherty KT, Infante JR et al (2012) Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 367: 1694-1703
    • (2012) N Engl J Med , vol.367 , pp. 1694-1703
    • Flaherty, K.T.1    Infante, J.R.2
  • 21
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefi tinib
    • Kobayashi S, Boggon TJ et al (2005) EGFR mutation and resistance of non-small-cell lung cancer to gefi tinib. N Engl J Med 352: 786-792
    • (2005) N Engl J Med , vol.352 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2
  • 22
    • 84863234102 scopus 로고    scopus 로고
    • Selumetinib (AZD6244; ARRY-142886) in the treatment of metastatic melanoma
    • Patel SP, Kim KB (2012) Selumetinib (AZD6244; ARRY-142886) in the treatment of metastatic melanoma. Expert Opin Investig Drugs 21:531-539
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 531-539
    • Patel, S.P.1    Kim, K.B.2
  • 23
    • 73949083834 scopus 로고    scopus 로고
    • MEK1 mutations confer resistance to MEK and B-RAF inhibition
    • Emery CM, Vijayendran KG et al (2009) MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc Natl Acad Sci 106:20411-20416
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 20411-20416
    • Emery, C.M.1    Vijayendran, K.G.2
  • 24
    • 84861901164 scopus 로고    scopus 로고
    • Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors
    • Shi H, Moriceau G et al (2012) Preexisting MEK1 exon 3 mutations in V600E/KBRAF melanomas do not confer resistance to BRAF inhibitors. Cancer Discov 2:414-424
    • (2012) Cancer Discov , vol.2 , pp. 414-424
    • Shi, H.1    Moriceau, G.2
  • 25
    • 33745685149 scopus 로고    scopus 로고
    • An improved method for RNA isolation and removal of melanin contamination from melanoma tissue: Implications for tumor antigen detection and amplifi cation
    • Dörrie J, Wellner V et al (2006) An improved method for RNA isolation and removal of melanin contamination from melanoma tissue: Implications for tumor antigen detection and amplifi cation. J Immunol Method 313: 119-128
    • (2006) J Immunol Method , vol.313 , pp. 119-128
    • Dörrie, J.1    Wellner, V.2
  • 26
    • 2642579788 scopus 로고    scopus 로고
    • CTAB-urea method purifi es RNA from melanin for cDNA microarray analysis
    • Lagonigro MS, De Cecco L et al (2004) CTAB-urea method purifi es RNA from melanin for cDNA microarray analysis. Pigment Cell Res 17:312-315
    • (2004) Pigment Cell Res , vol.17 , pp. 312-315
    • Lagonigro, M.S.1    De Cecco, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.