Psychopathology and cognition in children with 22q11.2 deletion syndrome

British Journal of Psychiatry

Volumn 204, Issue 1, 2014, Pages 46-54

  Niarchou, Maria ^a   Zammit, Stanley ^a   Van Goozen, Stephanie H M ^b   Thapar, Anita ^a   Tierling, Hayley M ^a   Owen, Michael J ^a   Van Den Bree, Marianne B M ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ARTICLE; CHILD; CHROMOSOME DELETION 22Q11; CHROMOSOME DELETION 22Q11.2; COGNITION; CONTROLLED STUDY; DSM-IV-TR; FEMALE; GENE DELETION; HUMAN; INTELLECTUAL IMPAIRMENT; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PEDIATRICS; PRESCHOOL CHILD; PREVALENCE; SCHOOL CHILD; SIBLING; 22Q11 DELETION SYNDROME; CASE CONTROL STUDY; COMORBIDITY; GENETICS; INTELLECTUAL DISABILITY; INTELLIGENCE TEST; MENTAL DISORDERS; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGIC TEST; PSYCHOLOGY; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA;

22Q11 DELETION SYNDROME; ADOLESCENT; CASE-CONTROL STUDIES; CHILD; COMORBIDITY; FEMALE; HUMANS; INTELLECTUAL DISABILITY; INTELLIGENCE TESTS; INTERVIEW, PSYCHOLOGICAL; MALE; MENTAL DISORDERS; MODELS, STATISTICAL; NEUROPSYCHOLOGICAL TESTS; PREVALENCE; PSYCHOPATHOLOGY; SIBLINGS;

EID: 84891808781     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.113.132324     Document Type: Article

References (35)

1. Bish JP, Chiodo R, Mattei V, Simon TJ. Domain specific attentional impairments in children with chromosome 22q11.2 deletion syndrome. Brain Cogn 2007; 64: 265-73. (Pubitemid 47002112)
2. Murphy KC, Jones LA, Owen MJ. High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry 1999; 56: 940-5. (Pubitemid 29480131)
3. Bassett AS, Chow EWC, Husted J, Weksberg R, Caluseriu O, Webb GD, et al. Clinical features of 78 adults with 22q11 deletion syndrome. Am J Med Genet A 2005; 138A: 307-13. (Pubitemid 41532946)
4. Green T, Gothelf D, Glaser B, Debbane M, Frisch A, Kotler M, et al. Psychiatric disorders and intellectual functioning throughout development in velocardiofacial (22q11.2 deletion) syndrome. J Am Acad Child Adolesc Psychiatry 2009; 48: 1060-8.
5. Shashi V, Veerapandiyan A, Schoch K, Kwapil T, Keshavan M, Ip E, et al. Social skills and associated psychopathology in children with chromosome 22q11.2 deletion syndrome: implications for interventions. J Intellect Disabil Res 2012; 56: 865-78.
6. Hooper SR, Curtiss K, Schoch K, Keshavan MS, Allen A, Shashi V. A longitudinal examination of the psychoeducational, neurocognitive, and psychiatric functioning in children with 22q11.2 deletion syndrome. Res Dev Disabil 2013; 34: 1758-69.
7. Karayiorgou M, Simon TJ, Gogos JA. 22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia. Nat Rev Neurosci 2010; 11: 402-16.
8. Walters JTR, Owen MJ. Endophenotypes in psychiatric genetics. Mol Psychiatry 2007; 12: 886-90. (Pubitemid 47482705)
9. O'Donovan MC, Kirov G, Owen MJ. Phenotypic variations on the theme of CNVs. Nat Genet 2008; 40: 1392-3.
10. Angold A, Prendergast M, Cox A, Harrington R, Simonoff E, Rutter M. The Child and Adolescent Psychiatric Assessment (CAPA). Psychol Med 1995; 25: 739-53.
11. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th edn, text revision) (DSM-IV-TR). APA, 2000.
12. Rutter M, Bailey A, Lord C. Social Communication Questionnaire 2003. Western Psychological Services, 2003.
13. Wechsler D. Wechsler Abbreviated Scale of Intelligence (WASI) Manual. Psychological Corporation, 1999.
14. Heaton RK, Chelune GJ, Talley JL, Kay GG, Curtiss G. Wisconsin Card Sorting Test manual. Revised and Expanded. Psychological Assessment Resources, 1993.
15. Cohen J, Cohen P. Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences. Erlbaum, 1983.
16. Kirkwood BR, Sterne AC. Essential Medical Statistics (2nd edn). Blackwell Science, 2003.
17. MacKinnon DP, Lockwood CM, Hoffman JM, West SG, Sheets V. A comparison of methods to test mediation and other intervening variable effects. Psychol Methods 2002; 7: 83-104.
18. Royal College of Psychiatrists. Enabling People with Mild Intellectual Disabilities and Mental Health Problems to Access Healthcare Services (College Report CR175). Royal College of Psychiatrists, 2012.
19. Emerson E. Prevalence of psychiatric disorders in children and adolescents with and without intellectual disability. J Intellect Disabil Res 2003; 47: 51-8. (Pubitemid 36367492)
20. Antshel KM, Faraone SV, Fremont W, Monuteaux MC, Kates WR, Doyle A, et al. Comparing ADHD in velocardiofacial syndrome to idiopathic ADHD: a preliminary study. J Atten Disord 2007; 11: 64-73.
21. Jansen P, Duijff S, Beemer F, Vorstman J, Klaassen P, Morcus M, et al. Behavioral problems in relation to intelligence in children with 22q11.2 deletion syndrome: a matched control study. Am J Med Genet A 2007; 143A: 574-80. (Pubitemid 46348898)
22. Miller DT, Shen Y, Weiss LA, Korn J, Anselm I, Bridgemohan C, et al. Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J Med Genet 2009; 46: 242-8.
23. Tranfaglia MR. The psychiatric presentation of fragile x: evolution of the diagnosis and treatment of the psychiatric comorbidities of fragile X syndrome. Dev Neurosci 2011; 33: 337-48.
24. Langley K, Martin J, Agha SS, Davies C, Stergiakouli E, Holmans P, et al. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. Br J Psychiatry 2011; 199: 398-403.
25. Rommelse NN, Altink ME, Oosterlaan J, Buschgens CJ, Buitelaar J, Sergeant JA. Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families. Psychol Med 2008; 38: 1595-606.
26. Fry AF, Hale S. Processing speed, working memory, and fluid intelligence: evidence for a developmental cascade. Psychol Sci 1996; 7: 237-41.
27. Niarchou M, Zammit S, Walters J, Lewis G, Owen MJ, van den Bree MBM. Defective processing speed and nonclinical psychotic experiences inchildren: longitudinal analyses in a large birth cohort. Am J Psychiatry 2013; 170: 550-7.
28. Rockers K, Ousley O, Sutton T, Schoenberg E, Coleman K, Walker E, et al. Performance on the Modified Card Sorting Test and its relation to psychopathology in adolescents and young adults with 22q11.2 deletion syndrome. J Intellect Disabil Res 2009; 53: 665-76.
29. Lewandowski KE, Shashi V, Berry PM, Kwapil TR. Schizophrenic-like neurocognitive deficits in children and adolescents with 22q11 deletion syndrome. Am J Med Genet B Neuropsychiatr Genet 2007; 144: 27-36. (Pubitemid 46127391)
30. De Smedt B, Devriendt K, Fryns JP, Vogels A, Gewillig M, Swillen A. Intellectual abilities in a large sample of children with Velo-Cardio-Facial Syndrome: an update. J Intellect Disabil Res 2007; 51: 666-70. (Pubitemid 47249742)
31. Moss EM, Batshaw ML, Solot CB, Gerdes M, McDonald-McGinn DM, Driscoll DA, et al. Psychoeducational profile of the 22q11.2 microdeletion: a complex pattern. J Pediatr 1999; 134: 193-8. (Pubitemid 29089044)
32. Antshel KM, Fremont W, Roizen NJ, Shprintzen R, Higgins AM, Dhamoon A, et al. ADHD, major depressive disorder, and simple phobias are prevalent psychiatric conditions in youth with velocardiofacial syndrome. J Am Acad Child Adolesc Psychiatry 2006; 45: 596-603.
33. Williams NM. Molecular mechanisms in 22q11 deletion syndrome. Schizophr Bull 2011; 37: 882-9.
34. Karayiorgou M, Simon TJ, Gogos JA. 22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia. Nat Rev Neurosci 2010; 11: 402-16.
35. Fowler T, Zammit S, Owen MJ, Rasmussen F. A population-based study of shared genetic variation between premorbid IQ and psychosis among male twin pairs and sibling pairs from Sweden. Arch Gen Psychiatry 2012; 69: 460-6.