Natural killer T cells mediate alveolar bone resorption and a systemic inflammatory response in response to oral infection of mice with Porphyromonas gingivalis

Journal of Periodontal Research

Volumn 49, Issue 1, 2014, Pages 69-76

  Aoki Nonaka, Y ^a,b   Nakajima, T ^a,c   Miyauchi, S ^a,b   Miyazawa, H ^a,b   Yamada, H ^a,b   Domon, H ^a   Tabeta, K ^a   Yamazaki, K ^a,b  

^a NIIGATA UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c NIIGATA UNIVERSITY MEDICAL AND DENTAL HOSPITAL   (Japan)

Author keywords

Inflammation; Natural killer T cell; Periodontal infection; Porphyromonas gingivalis

Indexed keywords

ALPHA-GALACTOSYLCERAMIDE; BACTERIUM ANTIBODY; CD1D ANTIGEN; CD1D ANTIGEN, MOUSE; GALACTOSYLCERAMIDE; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 4; OSTEOCLAST DIFFERENTIATION FACTOR; SERUM AMYLOID A; TNFSF11 PROTEIN, MOUSE;

ALVEOLAR BONE LOSS; ANIMAL; BACTEROIDACEAE INFECTION; BLOOD; C57BL MOUSE; DRUG EFFECTS; IMMUNOLOGY; INBRED MOUSE STRAIN; INFLAMMATION; LIVER; MALE; MICROBIOLOGY; NATURAL KILLER CELL; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; SPLEEN; TH1 CELL; TH2 CELL;

ALVEOLAR BONE LOSS; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, CD1D; BACTEROIDACEAE INFECTIONS; GALACTOSYLCERAMIDES; IMMUNOGLOBULIN G; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-4; KILLER CELLS, NATURAL; LIVER; MALE; MICE, INBRED C57BL; MICE, INBRED STRAINS; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; RANK LIGAND; SERUM AMYLOID A PROTEIN; SPLEEN; TH1 CELLS; TH2 CELLS;

EID: 84891806581     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/jre.12080     Document Type: Article

References (27)

1. +T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect Immun 1999;67:2804-2809.
2. + Th-cell-mediated alveolar bone destruction in vivo. Infect Immun 2005;73:3453-3461.
3. Yu JJ, Ruddy MJ, Wong GC et al. An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals. Blood 2007;109:3794-3802.
4. Baker PJ, Boutaugh NR, Tiffany M, Roopenian DC. B cell IgD deletion prevents alveolar bone loss following murine oral infection. Interdiscip Perspect Infect Dis 2009;2009:864359.
5. Yamazaki K, Ohsawa Y, Yoshie H. Elevated proportion of natural killer T cells in periodontitis lesions: a common feature of chronic inflammatory diseases. Am J Pathol 2001;158:1391-1398.
6. Brigl M, Brenner MB. CD1: antigen presentation and T cell function. Annu Rev Immunol 2004;22:817-890.
7. Kronenberg M. Toward an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol 2005;23:877-900.
8. Tupin E, Kinjo Y, Kronenberg M. The unique role of natural killer T cells in the response to microorganisms. Nat Rev Microbiol 2007;5:405-417.
9. Mendiratta SK, Martin WD, Hong S, Boesteanu A, Joyce S, Van KaerL. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 1997;6:469-477.
10. Baker PJ, Evans RT, Roopenian DC. Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice. Arch Oral Biol 1994;39:1035-1040.
11. Yamazaki K, Honda T, Domon H et al. Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease. Clin Exp Immunol 2007;149:445-452.
12. Maekawa T, Takahashi N, Tabeta K et al. Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. PLoS ONE 2011;6:e20240.
13. Miyauchi S, Maekawa T, Aoki Y et al. Oral infection with Porphyromonas gingivalis and systemic cytokine profile in C57BL/6.KOR-ApoE shl mice. J Periodontal Res 2012;47:402-408.
14. Lalla E, Lamster IB, Hofmann MA et al. Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol 2003;23:1405-1411.
15. Hu M, Bassett JH, Danks L et al. Activated invariant NKT cells regulate osteoclast development and function. J Immunol 2011;186:2910-2917.
16. Matsuda JL, Mallevaey T, Scott-Browne J, Gapin L. CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system. Curr Opin Immunol 2008;20:358-368.
17. Kong YY, Feige U, Sarosi I et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 1999;402:304-309.
18. Page G, Miossec P. RANK and RANKL expression as markers of dendritic cell-T cell interactions in paired samples of rheumatoid synovium and lymph nodes. Arthritis Rheum 2005;52:2307-2312.
19. Garlet GP, Cardoso CR, Mariano FS et al. Regulatory T cells attenuate experimental periodontitis progression in mice. J Clin Periodontol 2010;37:591-600.
20. Kobayashi R, Kono T, Bolerjack BA et al. Induction of IL-10-producing CD4+ T-cells in chronic periodontitis. J Dent Res 2011;90:653-658.
21. Honda T, Domon H, Okui T, Kajita K, Amanuma R, Yamazaki K. Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions. Clin Exp Immunol 2006;144:35-40.
22. Takayanagi H, Ogasawara K, Hida S et al. T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ. Nature 2000;408:600-605.
23. Godfrey DI, Kronenberg M. Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest 2004;114:1379-1388.
24. Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol 2003;4:1230-1237.
25. Mattner J, Debord KL, Ismail N et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 2005;434:525-529.
26. Galli G, Pittoni P, Tonti E et al. Invariant NKT cells sustain specific B cell responses and memory. Proc Natl Acad Sci USA 2007;104:3984-3989.
27. Amanuma R, Nakajima T, Yoshie H, Yamazaki K. Increased infiltration of CD1d and natural killer T cells in periodontal disease tissues. J Periodontal Res 2006;41:73-79.