Selective lesioning of nucleus incertus with corticotropin releasing factor-saporin conjugate

Brain Research

Volumn 1543, Issue , 2014, Pages 179-190

  Lee, Liying Corinne ^a,b,c   Rajkumar, Ramamoorthy ^a,b,c   Dawe, Gavin Stewart ^a,b,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c Singapore Institute for Neurotechnology (SINAPSE) 5F   (Singapore)

Author keywords

CRF saporin; Fear conditioning; Lesion; Nucleus incertus; Rat; Relaxin 3

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; GLUTAMATE DECARBOXYLASE 65; NEUROTRANSMITTER; RELAXIN 3; SAPORIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DAMAGE; BRAIN NUCLEUS; BRAIN STEM; CONDITIONING; CONTROLLED STUDY; FEAR; MALE; NEUROTOXICITY; NONHUMAN; NUCLEUS INCERTUS; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MAMMALIA; RATTUS;

CRF-SAPORIN; FEAR CONDITIONING; LESION; NUCLEUS INCERTUS; RAT; RELAXIN-3;

ANIMALS; CONDITIONING (PSYCHOLOGY); CORTICOTROPIN-RELEASING HORMONE; ELECTROSHOCK; FEAR; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOTOXINS; MALE; PONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RELAXIN; RIBOSOME INACTIVATING PROTEINS, TYPE 1; TIME FACTORS; TRYPTOPHAN HYDROXYLASE;

EID: 84891741906     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.11.021     Document Type: Article

References (46)

1. A. Banerjee, P.J. Shen, S. Ma, R.A.D. Bathgate, and A.L. Gundlach Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation Neuropharmacology 58 1 2010 145 155
2. J.C. Bittencourt, and P.E. Sawchenko Do centrally administered neuropeptides access cognate receptors? An analysis in the central corticotropin-releasing factor system J. Neurosci. 20 3 2000 1142 1156
3. T.C. Burazin, R.A. Bathgate, M. Macris, S. Layfield, A.L. Gundlach, and G.W. Tregear Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain J. Neurochem. 82 6 2002 1553 1557
4. G.E. Callander, S. Ma, D.E. Ganella, V.C. Wimmer, A.L. Gundlach, W.G. Thomas, and R.A. Bathgate Silencing relaxin-3 in nucleus incertus of adult rodents: a viral vector-based approach to investigate neuropeptide function PLoS One 7 8 2012 e42300 10.1371/journal.pone.0042300
5. A. Cervera-Ferri, J. Guerrero-Martinez, M. Bataller-Mompean, A. Taberner-Cortes, J. Martinez-Ricos, A. Ruiz-Torner, and V. Teruel-Marti Theta synchronization between the hippocampus and the nucleus incertus in urethane-anaesthetised rats Exp. Brain Res. 211 2 2011 177 192 10.1007/s00221-011-2666-3
6. J. Chen, C. Kuei, S.W. Sutton, P. Bonaventure, D. Nepomuceno, E. Eriste, R. Sillard, T.W. Lovenberg, and C. Liu Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species J. Pharmacol. Exp. Ther. 312 1 2005 83 95
7. Y. Chen, K.L. Brunson, M.B. Muller, W. Cariaga, and T.Z. Baram Immunocytochemical distribution of corticotropin-releasing hormone receptor type-1 (CRF(1))-like immunoreactivity in the mouse brain: light microscopt analysis using an antibody directed against the C-terminus J. Comp. Neurol. 420 3 2000 305 323
8. B.M. Chronwall, L.R. Skirboll, and T.L. O'Donohue Demonstration of a pontine-hippocampal projection containing a ranatensin-like peptide Neurosci. Lett. 53 1 1985 109 114
9. Farooq, U., Rajkumar, R., Sukumaran, S., Wu, Y., Tan, W.H., & Dawe, G.S. 2013. Corticotropin-releasing factor infusion into nucleus incertus suppresses medial prefrontal cortical activity and hippocampo-medial prefrontal cortical long-term potentiation. Eur. J. Neurosci. 38 (4), 2013, 2516-2525, http://dx.doi.org/10.1111/ejn.12242.
10. B. Ford, C.J. Holmes, L. Mainville, and B.E. Jones GABAergic neurons in the rat pontomesencephalic tegmentum: codistribution with cholinergic and other tegmental neurons projecting to the posterior lateral hypothalamus J. Comp. Neurol. 363 2 1995 177 196
11. M. Goto, L.W. Swanson, and N.S. Canteras Connexions of the nucleus incertus J. Comp. Neurol. 438 1 2001 86 122
12. S. Heckers, T. Ohtake, R.G. Wiley, D.A. Lappi, C. Geula, and M.M. Mesulam Complete and selective cholinergic denervation of rat neocortex and hippocampus but not amygdala by an immunotoxin against the p75 NGF receptor J. Neurosci. 14 3 Pt 1 1994 1271 1289
13. W.B. Hoover, and R.P. Vertes Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat Brain Struct. Funct. 212 2 2007 149 179 10.1007/s00429-007-0150-4
14. M. Hummel, T. Cummons, P. Lu, L. Mark, J.E. Harrison, J.D. Kennedy, and G.T. Whiteside Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors Neuropharmacology 59 3 2010 160 166 10.1016/j.neuropharm.2010.05.001
15. S.O. King 2nd, and C.L. Williams Novelty-induced arousal enhances memory for cued classical fear conditioning: interactions between peripheral adrenergic and brainstem glutamatergic systems Learn. Mem. 16 10 2009 625 634 10.1101/lm.1513109
16. H. Kizawa, K. Nishi, Y. Ishibashi, M. Harada, T. Asano, Y. Ito, and M. Fujino Production of recombinant human relaxin 3 in AtT20 cells Regul. Pept. 113 1-3 2003 79 84
17. Y. Kubota, S. Inagaki, S. Shiosaka, H.J. Cho, K. Tateishi, E. Hashimura, and M. Tohyama The distribution of cholecystokinin octapeptide-like structures in the lower brain stem of the rat: an immunohistochemical analysis Neuroscience 9 3 1983 587 604
18. A.J. Li, T.T. Dinh, and S. Ritter Hyperphagia and obesity produced by arcuate injection of NPY-saporin do not require upregulation of lateral hypothalamic orexigenic peptide genes Peptides 29 10 2008 1732 1739 10.1016/j.peptides.2008.05.026
19. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 4 2001 402 408
20. S. Ma, P. Bonaventure, T. Ferraro, P.J. Shen, T.C. Burazin, R.A. Bathgate, and A.L. Gundlach Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat Neuroscience 144 1 2007 165 190
21. S. Ma, F.E. Olucha-Bordonau, M.A. Hossain, F. Lin, C. Kuei, C. Liu, and A.L. Gundlach Modulation of hippocampal theta oscillations and spatial memory by relaxin-3 neurons of the nucleus incertus Learn. Mem. 16 11 2009 730 742
22. D. Maciejewski-Lenoir, S.C. Heinrichs, X.J. Liu, N. Ling, A. Tucker, Q. Xie, and D.E. Grigoriadis Selective impairment of corticotropin-releasing factor1 (CRF1) receptor-mediated function using CRF coupled to saporin Endocrinology 141 2 2000 498 504
23. B.M. McGowan, S.A. Stanley, K.L. Smith, J.S. Minnion, J. Donovan, E.L. Thompson, and S.R. Bloom Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats Regul. Pept. 136 1-3 2006 72 77
24. B.M. McGowan, S.A. Stanley, K.L. Smith, N.E. White, M.M. Connolly, E.L. Thompson, and S.R. Bloom Central relaxin-3 administration causes hyperphagia in male Wistar rats Endocrinology 146 8 2005 3295 3300
25. Y. Miyamoto, Y. Watanabe, and M. Tanaka Developmental expression and serotonergic regulation of relaxin 3/INSL7 in the nucleus incertus of rat brain Regul. Pept. 145 1-3 2008 54 59
26. J. Munro, O. Skrobot, M. Sanyoura, V. Kay, M.T. Susce, P.E. Glaser, and M.J. Arranz Relaxin polymorphisms associated with metabolic disturbance in patients treated with antipsychotics J. Psychopharmacol. 26 3 2012 374 379
27. A. Nunez, A. Cervera-Ferri, F. Olucha-Bordonau, A. Ruiz-Torner, and V. Teruel Nucleus incertus contribution to hippocampal theta rhythm generation Eur. J. Neurosci. 23 10 2006 2731 2738
28. F.E. Olucha-Bordonau, V. Teruel, J. Barcia-Gonzalez, A. Ruiz-Torner, A.A. Valverde-Navarro, and F. Martinez-Soriano Cytoarchitecture and efferent projections of the nucleus incertus of the rat J. Comp. Neurol. 464 1 2003 62 97
29. J. Pascual, and S.C. Heinrich Olfactory neophobia and seizure susceptibility phenotypes in an animal model of epilepsy are normalised by impairment of brain corticotropin releasing factor Epilepsia 48 4 2007 827 833
30. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates 6th ed. 2007 Elsevier Singapore
31. C.W. Pereira, F.N. Santos, A.M. Sanchez-Perez, M. Otero-Garcia, M. Marchioro, S. Ma, and F.E. Olucha-Bordonau Electrolytic lesion of the nucleus incertus retards extinction of auditory conditioned fear Behav. Brain Res. 247 2013 201 210
32. E. Potter, S. Sutton, C. Donaldson, R. Chen, M. Perrin, K. Lewis, and W. Vale Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary Proc. Natl. Acad. Sci. USA 91 19 1994 8777 8781
33. R. Rajkumar, L.K. See, and G.S. Dawe Acute antipsychotic treatments induce distinct c-Fos expression patterns in appetite-related neuronal structures of the rat brain Brain Res. 1508 2013 34 43
34. P.J. Ryan, S. Ma, F.E. Olucha-Bordonau, and A.L. Gundlach Nucleus incertus - an emerging modulatory role in arousal, stress and memory Neurosci. Biobehav. Rev. 35 6 2011 1326 1341
35. C.M. Smith, I.T. Hosken, S.W. Sutton, A.J. Lawrence, and A.L. Gundlach Relaxin-3 null mutation mice display a circadian hypoactivity phenotype Genes Brain Behav. 11 1 2012 94 104
36. C.M. Smith, A.J. Lawrence, S.W. Sutton, and A.L. Gundlach Behavioral phenotyping of mixed background (129S5:B6) relaxin-3 knockout mice Ann. N.Y. Acad. Sci. 1160 2009 236 241
37. C.M. Smith, P.J. Ryan, I.T. Hosken, S. Ma, and A.L. Gundlach Relaxin-3 systems in the brain - the first 10 years J. Chem. Neuroanat. 42 4 2011 262 275
38. F. Stirpe, A. Gasperi-Campani, L. Barbieri, A. Falasca, A. Abbondanza, and W.A. Stevens Ribosome-inactivating proteins from the seeds of Saponaria officinalis L. (soapwort), of Agrostemma githago L. (corn cockle) and of Asparagus officinalis L. (asparagus), and from the latex of Hura crepitans L. (sandbox tree) Biochem. J. 16 3 1983 617 625
39. S.W. Sutton, P. Bonaventure, C. Kuei, B. Roland, J. Chen, D. Nepomuceno, and C. Liu Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing Neuroendocrinology 80 5 2004 298 307
40. M. Tanaka, N. Iijima, Y. Miyamoto, S. Fukusumi, Y. Itoh, H. Ozawa, and Y. Ibata Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress Eur. J. Neurosci. 21 6 2005 1659 1670
41. P.E. Thorpe, A.N. Brown, J.A. Bremner Jr., B.M. Foxwell, and F. Stirpe An immunotoxin composed of monoclonal anti-Thy 1.1 antibody and a ribosome-inactivating protein from Saponaria officinalis: potent antitumor effects in vitro and in vivo J. Natl. Cancer Inst. 75 1 1985 151 159
42. E.T. van der Westhuizen, M.L. Halls, C.S. Samuel, R.A. Bathgate, E.N. Unemori, S.W. Sutton, and R.J. Summers Relaxin family peptide receptors - from orphans to therapeutic targets Drug Discov. Today 13 15-16 2008 640 651
43. K. Van Pett, V. Viau, and J.C. Bittencourt Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse J. Comp. Neurol. 428 2 2000 191 212
44. E. Wada, J. Way, A.M. Lebacq-Verheyden, and J.F. Battey Neuromedin B and gastrin-releasing peptide mRNAs are differentially distributed in the rat nervous system J. Neurosci. 10 9 1990 2917 2930
45. J.J. Waite, M.L. Wardlow, A.C. Chen, D.A. Lappi, R.G. Wiley, and L.J. Thal Time course of cholinergic and monoaminergic changes in rat brain after immunolesioning with 192 IgG-saporin Neurosci. Lett. 169 1-2 1994 154 158
46. Y. Watanabe, A. Tsujimura, K. Takao, K. Nishi, Y. Ito, Y. Yasuhara, and M. Tanaka Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior Front. Behav. Neurosci. 5 2011 50