Simultaneous analysis of urinary phthalate metabolites of residents in Korea using isotope dilution gas chromatography-mass spectrometry

Science of the Total Environment

Volumn 470-471, Issue , 2014, Pages 1408-1413

  Kim, Miok ^a   Song, Na Rae ^b   Choi, Jong Ho ^c   Lee, Jeongae ^a   Pyo, Heesoo ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Korea University   (South Korea)

Author keywords

Biomonitoring; Gas chromatography mass spectrometry; Isotope dilution; Trimethylsilylation; Urinary phthalate metabolites

Indexed keywords

BIOMOLECULES; BODY FLUIDS; CHEMICAL ANALYSIS; FUNCTIONAL POLYMERS; GAS CHROMATOGRAPHY; ISOTOPES; METABOLITES; POTASSIUM COMPOUNDS; SOLVENTS;

BIOMONITORING; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; ISOTOPE DILUTIONS; PHTHALATE METABOLITES; TRIMETHYL SILYLATION;

ESTERS;

ETHER; HEXANE; MONO N BUTYLPHTHALATE; MONO(2 ETHYL 5 HYDROXYHEXYL)PHTHALATE; MONO(2 ETHYL 5 OXOHEXYL)PHTHALATE; MONOBENZYLPHTHALATE; MONOETHYLHEXYLPHTHALATE; MONOETHYLPHTHALATE; MONOISOBUTYLPHTHALATE; MONOISONONYLPHTHALATE; PHTHALIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

BIOMONITORING; CONCENTRATION (COMPOSITION); GAS CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; PHTHALATE; URINE;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HYDROLYSIS; ISOTOPE DILUTION ASSAY; LIMIT OF DETECTION; MALE; MASS FRAGMENTOGRAPHY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SEX DIFFERENCE; SILYLATION; SOUTH KOREA; URBAN RURAL DIFFERENCE; URINALYSIS;

SOUTH KOREA;

BIOMONITORING; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; ISOTOPE DILUTION; TRIMETHYLSILYLATION; URINARY PHTHALATE METABOLITES;

ADULT; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; PHTHALIC ACIDS; PLASTICIZERS; REPUBLIC OF KOREA;

EID: 84891741624     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2013.07.037     Document Type: Article

References (22)

1. Agency for Toxic Substances, Disease Registry (ATSDR) Toxicological Profile for Di(2-ethylhexyl)phthalate Update [online] [Available at URL: http://www.atsdr.cdc.gov/toxprofiles/tp.aspid=684&tid=65].
2. Albro P.W., Corbett J.T., Schroeder J.L., Jordan S., Matthews H.B. Pharmacokinetics, interactions with macromolecules and species differences in metabolism of DEHP. Environ Health Perspect 1982, 45:19-25.
3. Blount B.C., Milgram K.E., Silva M.J., Malek N.A., Reidy J.A., Needham L.L., et al. Quantitative detection of eight phthalate metabolites in human urine using HPLC-APCI-MS/MS. Anal Chem 2000 Sep 1, 72(17):4127-4134.
4. Bornehag C.G., Lundgren B., Weschler C.J., Sigsgaard T., Hagerhed-Engman L., Sundell J. Phthalates in indoor dust and their association with building characteristics. Environ Health Perspect 2005, 113(10):1399-1404.
5. Calafat A.M., Slakman A.R., Silva M.J., Herbert A.R., Needham L.L. Automated solid phase extraction and quantitative analysis of human milk for 13 phthalate metabolites. J Chromatogr B 2004, 805:49-56.
6. CDC (Centers for Disease control, Prevention), Department of Health and Human Services Fourth National Report on Human Exposure to Environmental Chemicals. Atlanta (GA), USA 2009, [Available online at http://www.cdc.gov/exposurereport/pdf/FourthReport.pdf. [Assessed 10 December 2012].
7. Ema M., Miyawaki E. Effects of monobutyl phthalate on reproductive function in pregnant and pseudopregnant rats. Reprod Toxicol 2001, 15:261-267.
8. Faouzi M.A., Dine T., Gressier B., Kambia K., Luyckx M., Pagniez D., et al. Exposure of hemodialysis patients to di-2-ethyl-hexyl-phthalate. Int J Pharm 1999, 180:113-121.
9. Guo Y., Wu Q., Kannan K. Phthalate metabolites in urine from China, and implications for human exposures. Environ Int 2011, 37:893-898.
10. Kamrin M.A. Phthalate risks, phthalate regulation and public health. J Toxicol Environ Health 2009, 12:157-174.
11. Kasper- Sonnenbeg M., Koch H.M., Wittsiepe J., Wilhelm M. Levels of phthalate metabolites in urine among mother-child-pairs-results from the Duisburg birth cohort study, Germany. Int J Hyg Environ Health 2012, 215(3):373-382.
12. Kato K., Silva M.J., Reidy J.A., Hurtz D., Malek N.A., Needham L.L., et al. Mono(2-ethyl-5-hydroxyhexyl) phthalate and mono(2-ethyl-5-oxohexyl) phthalate as biomarkers for human exposure assessment to di(2-ethylhexyl) phthalate. Environ Health Perspect 2004, 112:327-330.
13. Koch H.M., Drexler H., Angerer J. An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population. Int J Hyg Environ Health 2003, 206:77-83.
14. Koch H.M., Rossbach B., Drexler H., Angerer J. Internal exposure of the general population to DEHP and other phthalates-determination of secondary and primary phthalate monoester metabolites in urine. Environ Res 2003, 93:177-185.
15. Latini G. Monitoring phthalate exposure in humans. Clin Chim Acta 2005, 361:20-29.
16. Pietrogrande M.C., Rossi D., Paganetto G. Gas chromatographic-mass spectrometric analysis of di(2-ethylhexyl) phthalate and its metabolites in hepatic microsomal incubations. Anal Chim Acta 2003, 480:1-10.
17. Preuss R., Koch H.M., Angerer J. Biological monitoring of the five major metabolites of di-(2-ethylhexyl)phthalate (DEHP) in human urine using column-switching liquid chromatography-tandem mass spectrometry. J Chromatogr B 2005, 816:269-280.
18. Rhodes C., Orton T.C., Pratt I.A., Batten P.L., Bratt H., Jackson S.J., et al. Comparative pharmacokinetics and subacute toxicity of di(2-ethylhexyl)phthalate (DEHP) in rats and marmosets: Extrapolation of effects in rodents to man. Environ Health Perspect 1986, 65:299-308.
19. Romero-Franco M., Hernandez-Ramirez R.U., Calafat A.M., Cebrian M.E., Needham L.L., Teitelbaum S., et al. Personal care product use and urinary levels of phthalate metabolites in Mexican women. Environ Int 2011, 37:867-871.
20. Rusyn I., Peters J.M., Cunningham M.L. Modes of action and species-specific effects of di-(2-ethylhexyl) phthalate in the liver. Crit Rev Toxicol 2006, 36:459-479.
21. Silva M.J., Slakman A.R., Reidy J.A., Preau J.L., Herbert A.R., Samandar E., et al. Analysis of human urine for fifteen phthalate metabolites using automated solid-phase extraction. J Chromatogr B 2004, 805:161-167.
22. Song N.R., On J.W., Lee J.A., Park J.D., Kwon H.J., Yoon H.J., et al. Biomonitoring of urinary di(ethylhexyl) phthalate metabolites of mother and child pairs in South Korea. Environ Int 2013, 54:65-73.