Gas chromatographic-mass spectrometric analysis of di(2-ethylhexyl) phthalate and its metabolites in hepatic microsomal incubations

Analytica Chimica Acta

Volumn 480, Issue 1, 2003, Pages 1-10

  Pietrogrande, M C ^a   Rossi, D ^b   Paganetto, G ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b CAT Group srl   (Italy)

Author keywords

Di(2 ethylhexyl) phthalate; GC MS analysis; Hepatic microsomal incubations; In vitro oxidative metabolism

Indexed keywords

BYPRODUCTS; COMPOSITION; DEGRADATION; GAS CHROMATOGRAPHY; HYDROLYSIS; MASS SPECTROMETRY;

VITRO METABOLISMS;

METABOLITES;

ACID; ALCOHOL; AROCLOR; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID DERIVATIVE;

ALCOHOL METABOLISM; ALCOHOL OXIDATION; ANIMAL CELL; ARTICLE; ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; ENDOCRINE FUNCTION; GAS CHROMATOGRAPHY; HYDROLYSIS; INCUBATION TIME; ION MONITORING; KINETICS; LIVER MICROSOME; MASS SPECTROMETRY; MOUSE; NONHUMAN; PEROXISOME; PRIORITY JOURNAL;

EID: 0037451611     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2670(02)01652-5     Document Type: Article

References (34)

1. Jaeger R.J., Rubin R.J. Science. 170:1970;460.
2. Austrian J. Environ. Health Perspect. 4:1973;3.
3. Laurence W.H. Clin. Toxicol. 13:1978;89.
4. J.W. Bridges, in: M. Richardson (Ed.), Toxic Hazard Assessment of Chemicals, Royal Society of Chemistry, London, 1988, p. 233.
5. Castle L., Mercer A.J., Startin G.R., Gilbert J. Food Addit. Contam. 4:1987;399.
6. Group E.F. Jr. Environ. Health Perspect. 65:1986;337.
7. Law R.J., Fileman T.W., Matthiessen P. Water Sci. Tech. 24:1991;127.
8. Rock G., Labow R.S., Tocchi M. Environ. Health Perspect. 65:1986;309.
9. Russell D.J., McDuffie B., Fineberg S. J. Environ. Sci. Health. 20:1985;927.
10. Singh A.R., Lawrence W.H., Autian J. J. Pharm. Sci. 61:1972;51.
11. Yagi Y., Nakamura Y., Tomita I., Tsuchikawa K., Shimoi N. J. Environ. Pathol. Toxicol. 4:1980;533.
12. Dirven H.A.A.M., Van den Broek P.H.H., Peters J.G.P., Noordhoek J., Jongeneelen F.J. Biochem. Pharmacol. 43:1992;2621.
13. Dirven H.A.A.M., Van den Broek P.H.H., Peeters M.C.E., Peters J.G., Mennes W.C., Blaauboer B.J., Noordhoek J., Jongeneelen F.J. Biochem. Pharmacol. 45:1993;2425.
14. Tsutui T., Watanabe E., Barret J.C. Carcinogenesis. 14:1993;611.
15. Harris C.A., Henttu P., Parker M.G., Sumpter J.P. Environ. Health Perspect. 105:1997;8.
16. Guess W.L., Haberman S., Roiwan D.F., Bower R.K., Autian J. Am. J. Hosp. Pharm. 24:1967;494.
17. Haberman S., Guess W.L., Roiwan D.F., Bowman R.O., Bower R.K. SPE (Soc. Plast. Eng.) J. 24:1968;62.
18. Bower R.K., Haberman S., Minton P.D. J. Pharmacol. Exp. Ther. 171:1970;314.
19. Paganetto G., Campi F., Varani K., Piffanelli A., Giovannini G. Pharmacol. Toxicol. 86:2000;24.
20. Albro P.W. Environ. Health Perspect. 65:1986;293.
21. Adas F., Picart D., Berhou F., Simon B., Amet Y. J. Chromatogr. A. 714:1998;133.
22. Albro P.W., Jordan S.T., Schroeder J.L., Corbett J.T. J. Chromatogr. 244:1982;65.
23. Leibowitz J.N., Sarmiento R., Dugar S.M., Ethridge M.W. J. AOAC Int. 78:1995;3.
24. Kelly M.T., Larroque M. J. Chromatogr. A. 841:1999;177.
25. E. Atlas, C.S. Giam, in: F.W. Karasek, O. Hutzinger, S. Safe (Eds.), Mass Spectrometry in Environmental Sciences, Plenum Press, New York, London, 1995, p. 341.
26. Egestad B., Green G., Sjoberg P., Klasson-Wehler E., Gustafsson J. J. Chromatogr. B. 677:1996;99.
27. F.P. Guengerich, T. Shimada, in: L.J. Marnett (Ed.), Frontiers in Molecular Toxicology, American Chemistry Society, Washington, 1992, p. 99.
28. Di Bella G., Satta M., Pellegrino M., Salvo F., Dugo G. J. Agric. Food Chem. 47:1999;1009.
29. Penalver A., Pocurull E., Borrull F., Morcé M.M. J. Chromatogr. A. 872:2000;191.
30. Luks-Betlej K., Popp P., janoszka B., Paschke H. J. Chromatogr. A. 938:2001;93.
31. Jonsson S., Boren H. J. Chromatogr. A. 963:2002;393.
32. Niino T., Ishibashi T., Itho T., Sakai S., Ishiwata H., Yamada T., Onodera S. J. Chromatogr. B. 780:2002;35.
33. Baltes M.R.H., Dubois J.G., Hanocq M. J. Chromatogr. B. 706:1998;201.
34. Ema M., Miyawaki E., Harazono A., Kawashima K. Toxicol. Lett. 93:1997;109.