Levels of phthalate metabolites in urine among mother-child-pairs - Results from the Duisburg birth cohort study, Germany

International Journal of Hygiene and Environmental Health

Volumn 215, Issue 3, 2012, Pages 373-382

  Kasper Sonnenberg, Monika ^a   Koch, Holger M ^a   Wittsiepe, Jürgen ^a   Wilhelm, Michael ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Children, Duisburg birth cohort study; Human biomonitoring; Mother child pairs; Phthalate metabolites; Phthalates; Women

Indexed keywords

PHTHALIC ACID DERIVATIVE;

ADULT; ARTICLE; CHILD; COHORT ANALYSIS; FEMALE; GERMANY; HUMAN; MALE; METABOLISM; POLLUTANT; URINE;

ADULT; CHILD; COHORT STUDIES; ENVIRONMENTAL POLLUTANTS; FEMALE; GERMANY; HUMANS; MALE; PHTHALIC ACIDS;

EID: 82255197486     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2011.09.004     Document Type: Article

References (38)

1. Angerer J., Ewers U., Wilhelm M. Human biomonitoring: state of the art. Int. J. Hyg. Environ. Health 2007, 210:201-228.
2. Barr D.B., Silva M.J., Kato K., Reidy J.A., Malek N.A., Hurtz D., Sadowski M., Needham L.L., Calafat A.M. Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers. Environ. Health Perspect. 2003, 111:1148-1151.
3. Becker, K., Kaus, S., Krause, C., Lepom, P., Schulz, C., Seiwert, M., Seifert, B., 2002. Umwelt-Survey 1998, Band III: Human-Biomonitoring Stoffgehalte in Blut und Urin der Bevölkerung in Deutschland. WaBoLu Hefte. Berlin, Germany, Umweltbundesamt, 1/02.
4. Becker K., Seiwert M., Angerer J., Heger W., Koch H.M., Nagorka R., Rosskamp E., Schluter C., Seifert B., Ullrich D. DEHP metabolites in urine of children and DEHP in house dust. Int. J. Hyg. Environ. Health 2004, 207:409-417.
5. Becker K., Gön T., Seiwert M., Conrad A., Pick-Fuss H., Muller J., Wittassek M., Schulz C., Kolossa-Gehring M. GerES IV: phthalate metabolites and bisphenol A in urine of German children. Int. J. Hyg. Environ. Health 2009, 212:685-692.
6. Bizzari, S. N., Blagoev, M., Kishi, A., 2009. Plasticisers. Chemical Economics Handbook - SRI Consulting. 94025 California, USA, CEH Marketing Research Report.
7. Boas M., Frederiksen H., Feldt-Rasmussen U., Skakkebaek N.E., Hegedus L., Hilsted L., Juul A., Main K.M. Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth. Environ. Health Perspect. 2010, 118:1458-1464.
8. Braun J.M., Kalkbrenner A.E., Calafat A.M., Bernert J.T., Ye X., Silva M.J., Barr D.B., Sathyanarayana S., Lanphear B.P. Variability and predictors of urinary bisphenol A concentrations during pregnancy. Environ. Health Perspect. 2011, 119:131-137.
9. Cao Y., Winneke G., Wilhelm M., Wittsiepe J., Lemm F., Furst P., Ranft U., Imohl M., Kraft M., Oesch-Bartlomowicz B., Kramer U. Environmental exposure to dioxins and polychlorinated biphenyls reduce levels of gonadal hormones in newborns: results from the Duisburg cohort study. Int. J. Hyg. Environ. Health 2008, 211:30-39.
10. Casas L., Fernandez M.F., Llop S., Guxens M., Ballester F., Olea N., Irurzun M.B., Rodriguez L.S., Riano I., Tardon A., Vrijheid M., Calafat A.M., Sunyer J. Urinary concentrations of phthalates and phenols in a population of Spanish pregnant women and children. Environ. Int. 2011, 37:858-866.
11. CDC, 2011. Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, February 2011. Atlanta, Center for Disease Control and Prevention, USA. http://www.cdc.gov/exposurereport/.
12. He Y., Miao M., Herrinton L.J., Wu C., Yuan W., Zhou Z., Li D.K. Bisphenol A levels in blood and urine in a Chinese population and the personal factors affecting the levels. Environ. Res. 2009, 109:629-633.
13. Heudorf U., Mersch-Sundermann V., Angerer J. Phthalates: toxicology and exposure. Int. J. Hyg. Environ. Health 2007, 210:623-634.
14. Johnson C.E. Development of cigarette components to meet industry needs. 52nd Tobacco Science Research Conference 1998.
15. Jurewicz J., Hanke W. Exposure to phthalates: reproductive outcome and children health. A review of epidemiological studies. Int. J. Hyg. Environ. Health 2011, 24:115-141.
16. Kamrin M.A. Phthalate risks, phthalate regulation, and public health: a review. J. Toxicol. Environ. Health B: Crit. Rev. 2009, 12:157-174.
17. Koch H.M., Gonzalez-Reche L.M., Angerer J. On-line clean-up by multidimensional liquid chromatography-electrospray ionization tandem mass spectrometry for high throughput quantification of primary and secondary phthalate metabolites in human urine. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2003, 784:169-182.
18. Koch H.M., Drexler H., Angerer J. An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population. Int. J. Hyg. Environ. Health 2003, 206:77-83.
19. Koch H.M., Preuss R., Drexler H., Angerer J. Exposure of nursery school children and their parents and teachers to di-n-butylphthalate and butylbenzylphthalate. Int. Arch. Occup. Environ. Health 2005, 78:223-229.
20. Koch H.M., Müller J., Angerer J. Determination of secondary, oxidised di-iso-nonylphthalate (DINP) metabolites in human urine representative for the exposure to commercial DINP plasticizers. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2007, 847:114-125.
21. Koch H.M., Becker K., Wittassek M., Seiwert M., Angerer J., Kolossa-Gehring M. Di-n-butylphthalate and butylbenzylphthalate - urinary metabolite levels and estimated daily intakes: pilot study for the German Environmental Survey on children. J. Expo. Sci. Environ. Epidemiol. 2007, 17:378-387.
22. Koch H.M., Calafat A.M. Human body burdens of chemicals used in plastic manufacture. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364:2063-2078.
23. Koch H.M., Wittassek M., Bruning T., Angerer J., Heudorf U. Exposure to phthalates in 5-6 years old primary school starters in Germany - A human biomonitoring study and a cumulative risk assessment. Int. J. Hyg. Environ. Health 2011, 214:188-195.
24. Lin S., Ku H.Y., Su P.H., Chen J.W., Huang P.C., Angerer J., Wang S.L. Phthalate exposure in pregnant women and their children in central Taiwan. Chemosphere 2011, 82:655-947.
25. Lorber M., Angerer J., Koch H.M. A simple pharmacokinetic model to characterize exposure of Americans to di-2-ethylhexyl phthalate. J. Expo. Sci. Environ. Epidemiol. 2010, 20:38-53.
26. Milford, E.C., Hal, E.G., Chapman, P.S., Dunn, R.S., Perfetti, P.F., 1991. Cigarette and paper wrapper therefore. United State Patent. United States, R.J. Reynolds Tobacco Company, Winston-Salem, N.C.
27. Peck J.D., Sweeney A.M., Symanski E., Gardiner J., Silva M.J., Calafat A.M., Schantz S.L. Intra- and inter-individual variability of urinary phthalate metabolite concentrations in Hmong women of reproductive age. J. Expo. Sci. Environ. Epidemiol. 2010, 20:90-100.
28. Preuss R., Koch H.M., Angerer J. Biological monitoring of the five major metabolites of di-(2-ethylhexyl)phthalate (DEHP) in human urine using column-switching liquid chromatography-tandem mass spectrometry. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2005, 816:269-280.
29. Sathyanarayana S., Calafat A.M., Liu F., Swan S.H. Maternal and infant urinary phthalate metabolite concentrations: are they related?. Environ. Res. 2008, 108:413-418.
30. Schulz C., Wilhelm M., Heudorf U., Kolossa-Gehring M. The German Human Biomonitoring Commission - update of the reference and human biomonitorng values. Int. J. Hyg. Environ. Health 2011, 10.1016/j.ijheh.2011.06.007.
31. Taussky H.H. A microcolorimetric determination of creatine in urine by the Jaffe reaction 1954, 208:853-861.
32. Tuomi T., Johnsson T., Reijula K. Analysis of nicotine, 3-hydroxycotinine, cotinine, and caffeine in urine of passive smokers by HPLC-tandem mass spectrometry. Clin. Chem. 1999, 45:2164-2172.
33. Wilhelm M., Wittsiepe J., Lemm F., Ranft U., Krämer U., Fürst P., Röseler S.C., Greshake M., Imöhl M., Eberwein G., Rauchfuss K., Kraft M., Winneke G. The Duisburg birth cohort study: influence of the prenatal exposure to PCDD/Fs and dioxin-like PCBs on thyroid hormone status in newborns and neurodevelopment of infants until the age of 24 months. Mutat. Res. 2008, 659:83-92.
34. Wittassek M., Heger W., Koch H.M., Becker K., Angerer J., Kolossa-Gehring M. Daily intake of di(2-ethylhexyl) phthalate (DEHP) by German children - a comparison of two estimation models based on urinary DEHP metabolite levels. Int. J. Hyg. Environ. Health 2007, 210:35-42.
35. Wittassek M., Koch H.M., Angerer J., Bruning T. Assessing exposure to phthalates - the human biomonitoring approach. Mol. Nutr. Food Res. 2011, 55:7-31.
36. Wittsiepe J., Fürst P., Schrey P., Lemm F., Kraft M., Eberwein G., Winneke G., Wilhelm M. PCDD/F and dioxin-like PCB in human blood and milk from German mothers. Chemosphere 2007, 67:S286-S294.
37. Wormuth M., Scheringer M., Vollenweider M., Hungerbuhler K. What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?. Risk Anal. 2006, 26:803-824.
38. Xu X., Iba M.M., Weisel C.P. Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography-tandem mass spectrometry. Clin. Chem. 2004, 50:2323-2330.