High-content cytometry and transcriptomic biomarker profiling of human B-cell activation

Journal of Allergy and Clinical Immunology

Volumn 133, Issue 1, 2014, Pages

  Hennig, Christian ^a   Ilginus, Claudia ^a   Boztug, Kaan ^a,b,c   Skokowa, Julia ^a   Marodi, Laszlo ^d   Szaflarska, Anna ^e   Sass, Mareike ^a   Pignata, Claudio ^f   Kilic, Sara Sebnem ^g   Caragol, Isabel ^h   Baumann, Ulrich ^a   Klein, Christoph ^a,i   Welte, Karl ^a   Hansen, Gesine ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF DEBRECEN   (Hungary)

^e JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^f UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^g ULUDAG UNIVERSITY   (Turkey)

^h HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

ⁱ UNIVERSITY OF MUNICH   (Germany)

Author keywords

B cell immunology; chip cytometry; primary antibody deficiency; Primary immunodeficiency

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; BIOLOGICAL MARKER; CD19 ANTIBODY; CD40 LIGAND; CHEMOKINE RECEPTOR CXCR3; CXCL9 CHEMOKINE; FAS ANTIGEN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN A1; IMMUNOGLOBULIN A2; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G4; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 21; KI 67 ANTIGEN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TRANSCRIPTION FACTOR T BET;

ARTICLE; B LYMPHOCYTE ACTIVATION; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SELECTION; CELL SIZE; CHIP CYTOMETRY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOMETRY; DNA DAMAGE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMORAL IMMUNE DEFICIENCY; MICROARRAY ANALYSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ACTIVATION-INDUCED CYTIDINE DEAMINASE; AID; B-CELL IMMUNOLOGY; CD40 LIGAND; CD40L; CHIP CYTOMETRY; CLASS-SWITCH RECOMBINATION; COMMON VARIABLE IMMUNODEFICIENCY; CSR; CVID; MACS; MAGNETIC-ACTIVATED CELL SORTING; PID; PRIMARY ANTIBODY DEFICIENCY; PRIMARY IMMUNODEFICIENCY;

ADOLESCENT; ADULT; B-LYMPHOCYTES; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELLS, CULTURED; CHEMOKINE CXCL10; CHEMOKINE CXCL9; CHILD; FEMALE; GENE EXPRESSION PROFILING; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMAGE CYTOMETRY; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOLOGIC DEFICIENCY SYNDROMES; INFANT, NEWBORN; LYMPHOCYTE ACTIVATION; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; RNA, MESSENGER; TRANSCRIPTOME; YOUNG ADULT;

EID: 84891738469     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.06.047     Document Type: Article

References (38)

1. S. Urschel, L. Kayikci, and U. Wintergerst et al. Common variable immunodeficiency disorders in children: delayed diagnosis despite typical clinical presentation J Pediatr 154 2009 888 894
2. S. Ferrari, S. Giliani, and A. Insalaco et al. Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM Proc Natl Acad Sci U S A 98 2001 12614 12619
3. R.K. Malhotra, and W. Li Poorly differentiated gastroenteropancreatic neuroendocrine carcinoma associated with X-linked hyperimmunoglobulin M syndrome Arch Pathol Lab Med 132 2008 847 850
4. D.A. Chistiakov, N.V. Voronova, and A.P. Chistiakov Ligase IV syndrome Eur J Med Genet 52 2009 373 378
5. M.F. Lavin Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer Nat Rev Mol Cell Biol 9 2008 759 769
6. S. Kracker, P. Gardes, F. Mazerolles, and A. Durandy Immunoglobulin class switch recombination deficiencies Clin Immunol 135 2010 193 203
7. B.M. Pietrucha, E. Heropolitańska-Pliszka, and A. Wakulińska et al. Ataxia-telangiectasia with hyper-IgM and Wilms tumor: fatal reaction to irradiation J Pediatr Hematol Oncol 32 2010 e28 e30
8. L. Distel, S. Neubauer, R. Varon, W. Holter, and G. Grabenbauer Fatal toxicity following radio- and chemotherapy of medulloblastoma in a child with unrecognized Nijmegen breakage syndrome Med Pediatr Oncol 41 2003 44 48
9. Anonymous. National Center for Biotechnology Information. OMIM: Online Mendelian Inheritance in Man. Available at: http://www.ncbi.nlm.nih.gov/omim? term=hypogammaglobulinemia. Accessed August 24, 2011.
10. M.C. van Zelm, I. Reisli, and M. van der Burg et al. An antibody-deficiency syndrome due to mutations in the CD19 gene N Engl J Med 354 2006 1901 1912
11. M.C. van Zelm, J. Smet, and B. Adams et al. CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency J Clin Invest 120 2010 1265 1274
12. B. Grimbacher, A. Hutloff, and M. Schlesier et al. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency Nat Immunol 4 2003 261 268
13. V. Lougaris, R. Badolato, S. Ferrari, and A. Plebani Hyper immunoglobulin M syndrome due to CD40 deficiency: clinical, molecular, and immunological features Immunol Rev 203 2005 48 66
14. G. Courtois, A. Smahi, and J. Reichenbach et al. A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency J Clin Invest 112 2003 1108 1115
15. P. Revy, T. Muto, and Y. Levy et al. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2) Cell 102 2000 565 575
16. J.G. Noordzij, N.M. Wulffraat, and A. Haraldsson et al. Ataxia-telangiectasia patients presenting with hyper-IgM syndrome Arch Dis Child 94 2009 448 449
17. L.D. Notarangelo, and R. Sorensen Is it necessary to identify molecular defects in primary immunodeficiency disease? J Allergy Clin Immunol 122 2008 1069 1073
18. C. Wehr, T. Kivioja, and C. Schmitt et al. The EUROclass trial: defining subgroups in common variable immunodeficiency Blood 111 2008 77 85
19. G. Mouillot, M. Carmagnat, and L. Gérard et al. B-cell and T-cell phenotypes in CVID patients correlate with the clinical phenotype of the disease J Clin Immunol 30 2010 746 755
20. M.A. Avanzini, R. Maccario, and C. Belloni et al. B lymphocyte subsets and their functional activity in the early months of life Int J Immunopathol Pharmacol 23 2010 247 254
21. K. Huck, O. Feyen, and S. Ghosh et al. Memory B-cells in healthy and antibody-deficient children Clin Immunol 131 2009 50 59
22. C. Hennig, U. Baumann, and C. Ilginus et al. Successful treatment of autoimmune and lymphoproliferative complications of patients with intrinsic B-cell immunodeficiencies with rituximab Br J Haematol 148 2010 445 448
23. M. Gigoux, J. Shang, and Y. Pak et al. Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase Proc Natl Acad Sci U S A 106 2009 20371 20376
24. S. Néron, P.J. Nadeau, A. Darveau, and J.-F. Leblanc Tuning of CD40-CD154 interactions in human B-lymphocyte activation: a broad array of in vitro models for a complex in vivo situation Arch Immunol Ther Exp (Warsz) 59 2011 25 40
25. S. Borte, Q. Pan-Hammarström, and C. Liu et al. Interleukin-21 restores immunoglobulin production ex vivo in patients with common variable immunodeficiency and selective IgA deficiency Blood 114 2009 4089 4098
26. B. Gathmann, B. Grimbacher, and J. Beauté et al. The European internet-based patient and research database for primary immunodeficiencies: results 2006-2008 Clin Exp Immunol 157 Suppl 1 2009 3 11
27. C. Hennig, N. Adams, and G. Hansen A versatile platform for comprehensive chip-based explorative cytometry Cytometry A 75 2009 362 370
28. W. Huber, A. von Heydebreck, H. Sültmann, A. Poustka, and M. Vingron Variance stabilization applied to microarray data calibration and to the quantification of differential expression Bioinformatics 18 Suppl 1 2002 S96 S104
29. I. Kupershmidt, Q.J. Su, and A. Grewal et al. Ontology-based meta-analysis of global collections of high-throughput public data PLoS One 2010 5
30. G. Cattoretti, R. Shaknovich, and P.M. Smith et al. Stages of germinal center transit are defined by B cell transcription factor coexpression and relative abundance J Immunol 177 2006 6930 6939
31. G. Cattoretti, M. Büttner, and R. Shaknovich et al. Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells Blood 107 2006 3967 3975
32. N. Liu, N. Ohnishi, L. Ni, S. Akira, and K.B. Bacon CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells Nat Immunol 4 2003 687 693
33. B. He, X. Qiao, and A. Cerutti CpG DNA induces IgG class switch DNA recombination by activating human B cells through an innate pathway that requires TLR9 and cooperates with IL-10 J Immunol 173 2004 4479 4491
34. N. Burdin, L. Galibert, and P. Garrone et al. Inability to produce IL-6 is a functional feature of human germinal center B lymphocytes J Immunol 156 1996 4107 4113
35. H. Ohtani, Z. Jin, and S. Takegawa et al. Abundant expression of CXCL9 (MIG) by stromal cells that include dendritic cells and accumulation of CXCR3+ T cells in lymphocyte-rich gastric carcinoma J Pathol 217 2009 21 31
36. A. Kato, T. Ogasawara, and T. Homma et al. CpG oligodeoxynucleotides directly induce CXCR3 chemokines in human B cells Biochem Biophys Res Commun 320 2004 1139 1147
37. E. Riballo, M. Kühne, and N. Rief et al. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci Mol Cell 16 2004 715 724
38. F.A. Derheimer, and M.B. Kastan Multiple roles of ATM in monitoring and maintaining DNA integrity FEBS Lett 584 2010 3675 3681