메뉴 건너뛰기




Volumn 27, Issue 1, 2014, Pages 96-106

High nuclear karyopherin 2 expression is a strong and independent predictor of biochemical recurrence in prostate cancer patients treated by radical prostatectomy

Author keywords

3p13; 5q21; 6q15; KPNA2; prostate cancer; PTEN; tissue microarray

Indexed keywords

KARYOPHERIN ALPHA; KARYOPHERIN ALPHA2; PROSTATE SPECIFIC ANTIGEN; TUMOR MARKER; UNCLASSIFIED DRUG;

EID: 84891736053     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2013.127     Document Type: Article
Times cited : (29)

References (50)
  • 2
    • 0033598989 scopus 로고    scopus 로고
    • Transport of proteins and RNAs in and out of the nucleus
    • Nakielny S, Dreyfuss G. Transport of proteins and RNAs in and out of the nucleus. Cell 1999;99: 677-690. (Pubitemid 30017639)
    • (1999) Cell , vol.99 , Issue.7 , pp. 677-690
    • Nakielny, S.1    Dreyfuss, G.2
  • 3
    • 33751279004 scopus 로고    scopus 로고
    • Importin KPNA2 NBS1 DNA repair and tumorigenesis
    • Teng SC, Wu KJ, Tseng SF, et al. Importin KPNA2, NBS1, DNA repair and tumorigenesis. J Mol Histol 2006;37:293-299.
    • (2006) J Mol Histol , vol.37 , pp. 293-299
    • Teng, S.C.1    Wu, K.J.2    Tseng, S.F.3
  • 4
    • 79952254227 scopus 로고    scopus 로고
    • KPNA2 expression is an independent adverse predictor of biochemical recurrence after radical prostatectomy
    • Mortezavi A, Hermanns T, Seifert HH, et al. KPNA2 expression is an independent adverse predictor of biochemical recurrence after radical prostatectomy. Clin Cancer Res 2011;17:1111-1121.
    • (2011) Clin Cancer Res , vol.17 , pp. 1111-1121
    • Mortezavi, A.1    Hermanns, T.2    Seifert, H.H.3
  • 5
    • 84859883633 scopus 로고    scopus 로고
    • Nuclear transport receptor karyopherin-alpha2 promotes malignant breast cancer phenotypes in vitro
    • Noetzel E, Rose M, Bornemann J, et al. Nuclear transport receptor karyopherin-alpha2 promotes malignant breast cancer phenotypes in vitro. Oncogene 2012;31:2101-2114.
    • (2012) Oncogene , vol.31 , pp. 2101-2114
    • Noetzel, E.1    Rose, M.2    Bornemann, J.3
  • 6
    • 34248595209 scopus 로고    scopus 로고
    • 1 and IFN-γ in normal human epidermal keratinocytes: Evident contribution of KPNA2 for nuclear translocation of IRF-1
    • DOI 10.1038/sj.jid.5700716, PII 5700716
    • Umegaki N, Tamai K, Nakano H, et al. Differential regulation of karyopherin alpha 2 expression by TGFbeta1 and IFN-gamma in normal human epidermal keratinocytes: evident contribution of KPNA2 for nuclear translocation of IRF-1. J Invest Dermatol 2007;127:1456-1464. (Pubitemid 46762977)
    • (2007) Journal of Investigative Dermatology , vol.127 , Issue.6 , pp. 1456-1464
    • Umegaki, N.1    Tamai, K.2    Nakano, H.3    Moritsugu, R.4    Yamazaki, T.5    Hanada, K.6    Katayama, I.7    Kaneda, Y.8
  • 7
    • 79953209000 scopus 로고    scopus 로고
    • Importin subunit alpha-2 is identified as a potential biomarker for nonsmall cell lung cancer by integration of the cancer cell secretome and tissue transcriptome
    • Wang CI, Wang CL, Wang CW, et al. Importin subunit alpha-2 is identified as a potential biomarker for nonsmall cell lung cancer by integration of the cancer cell secretome and tissue transcriptome. Int J Cancer 2011;128:2364-2372.
    • (2011) Int J Cancer , vol.128 , pp. 2364-2372
    • Wang, C.I.1    Wang, C.L.2    Wang, C.W.3
  • 8
    • 49749117528 scopus 로고    scopus 로고
    • Nuclear karyopherin alpha2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity
    • Gluz O, Wild P, Meiler R, et al. Nuclear karyopherin alpha2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensity. Int J Cancer 2008;123:1433-1438.
    • (2008) Int J Cancer , vol.123 , pp. 1433-1438
    • Gluz, O.1    Wild, P.2    Meiler, R.3
  • 9
    • 33645739022 scopus 로고    scopus 로고
    • Gene expression profiling of primary cutaneous melanoma and clinical outcome
    • Winnepenninckx V, Lazar V, Michiels S, et al. Gene expression profiling of primary cutaneous melanoma and clinical outcome. J Natl Cancer Inst 2006;98:472-482.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 472-482
    • Winnepenninckx, V.1    Lazar, V.2    Michiels, S.3
  • 10
    • 77957221380 scopus 로고    scopus 로고
    • Overexpression of karyopherin-2 in epithelial ovarian cancer and correlation with poor prognosis
    • Zheng M, Tang L, Huang L, et al. Overexpression of karyopherin-2 in epithelial ovarian cancer and correlation with poor prognosis. Obstet Gynecol 2010;116:884-891.
    • (2010) Obstet Gynecol , vol.116 , pp. 884-891
    • Zheng, M.1    Tang, L.2    Huang, L.3
  • 11
    • 84866043312 scopus 로고    scopus 로고
    • Nuclear karyopherin a2: A novel biomarker for infiltrative astrocytomas
    • Gousias K, Becker AJ, Simon M, et al. Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas. J Neurooncol 2012;109:545-553.
    • (2012) J Neurooncol , vol.109 , pp. 545-553
    • Gousias, K.1    Becker, A.J.2    Simon, M.3
  • 13
    • 77954255681 scopus 로고    scopus 로고
    • Integrative genomic profiling of human prostate cancer
    • Taylor BS, Schultz N, Hieronymus H, et al. Integrative genomic profiling of human prostate cancer. Cancer Cell 2010;18:11-22.
    • (2010) Cancer Cell , vol.18 , pp. 11-22
    • Taylor, B.S.1    Schultz, N.2    Hieronymus, H.3
  • 14
    • 79951497419 scopus 로고    scopus 로고
    • The genomic complexity of primary human prostate cancer
    • Berger MF, Lawrence MS, Demichelis F, et al. The genomic complexity of primary human prostate cancer. Nature 2011;470:214-220.
    • (2011) Nature , vol.470 , pp. 214-220
    • Berger, M.F.1    Lawrence, M.S.2    Demichelis, F.3
  • 15
    • 84879947917 scopus 로고    scopus 로고
    • Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions
    • Kluth M, Hesse J, Heinl A, et al. Genomic deletion of MAP3K7 at 6q12-22 is associated with early PSA recurrence in prostate cancer and absence of TMPRSS2:ERG fusions. Mod Pathol 2013;26:975-983.
    • (2013) Mod Pathol , vol.26 , pp. 975-983
    • Kluth, M.1    Hesse, J.2    Heinl, A.3
  • 16
    • 84877747485 scopus 로고    scopus 로고
    • CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer
    • Burkhardt L, Fuchs S, Krohn A, et al. CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer. Cancer Res 2013;73:2795-2805.
    • (2013) Cancer Res , vol.73 , pp. 2795-2805
    • Burkhardt, L.1    Fuchs, S.2    Krohn, A.3
  • 17
    • 84864141538 scopus 로고    scopus 로고
    • Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusionnegative prostate cancer
    • Krohn A, Diedler T, Burkhardt L, et al. Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusionnegative prostate cancer. Am J Pathol 2012;181:401-412.
    • (2012) Am J Pathol , vol.181 , pp. 401-412
    • Krohn, A.1    Diedler, T.2    Burkhardt, L.3
  • 18
    • 84866390624 scopus 로고    scopus 로고
    • Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness
    • Huang S, Gulzar ZG, Salari K, et al. Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness. Oncogene 2012;31:4164-4170.
    • (2012) Oncogene , vol.31 , pp. 4164-4170
    • Huang, S.1    Gulzar, Z.G.2    Salari, K.3
  • 19
    • 79952770944 scopus 로고    scopus 로고
    • Detection of ERG gene rearrangements and PTEN deletions in unsuspected prostate cancer of the transition zone
    • Liu S, Yoshimoto M, Trpkov K, et al. Detection of ERG gene rearrangements and PTEN deletions in unsuspected prostate cancer of the transition zone. Cancer Biol Ther 2011;11:562-566.
    • (2011) Cancer Biol Ther , vol.11 , pp. 562-566
    • Liu, S.1    Yoshimoto, M.2    Trpkov, K.3
  • 20
    • 57749108319 scopus 로고    scopus 로고
    • Clinical significance of p53 alterations in surgically treated prostate cancers
    • Schlomm T, Iwers L, Kirstein P, et al. Clinical significance of p53 alterations in surgically treated prostate cancers. Mod Pathol 2008;21:1371-1378.
    • (2008) Mod Pathol , vol.21 , pp. 1371-1378
    • Schlomm, T.1    Iwers, L.2    Kirstein, P.3
  • 21
    • 79952112156 scopus 로고    scopus 로고
    • Recipient block TMA technique
    • Mirlacher M, Simon R. Recipient block TMA technique. Methods Mol Biol 2010;664:37-44.
    • (2010) Methods Mol Biol , vol.664 , pp. 37-44
    • Mirlacher, M.1    Simon, R.2
  • 22
    • 80052841071 scopus 로고    scopus 로고
    • ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy
    • Minner S, Enodien M, Sirma H, et al. ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy. Clin Cancer Res 2011;17:5878-5888.
    • (2011) Clin Cancer Res , vol.17 , pp. 5878-5888
    • Minner, S.1    Enodien, M.2    Sirma, H.3
  • 23
    • 78951476072 scopus 로고    scopus 로고
    • High level PSMA expression is associated with early PSA recurrence in surgically treated prostate cancer
    • Minner S, Wittmer C, Graefen M, et al. High level PSMA expression is associated with early PSA recurrence in surgically treated prostate cancer. Prostate 2011;71:281-288.
    • (2011) Prostate , vol.71 , pp. 281-288
    • Minner, S.1    Wittmer, C.2    Graefen, M.3
  • 24
    • 84877050325 scopus 로고    scopus 로고
    • Cysteine-rich secretory protein 3 overexpression is linked to a subset of PTEN-deleted ERG fusion-positive prostate cancers with early biochemical recurrence
    • Grupp K, Kohl S, Sirma H, et al. Cysteine-rich secretory protein 3 overexpression is linked to a subset of PTEN-deleted ERG fusion-positive prostate cancers with early biochemical recurrence. Mod Pathol 2013; 26:733-742.
    • (2013) Mod Pathol , vol.26 , pp. 733-742
    • Grupp, K.1    Kohl, S.2    Sirma, H.3
  • 25
    • 84872922750 scopus 로고    scopus 로고
    • Loss of pSer2448-mTOR expression is linked to adverse prognosis and tumor progression in ERG-fusion-positive cancers
    • Muller J, Ehlers A, Burkhardt L, et al. Loss of pSer2448-mTOR expression is linked to adverse prognosis and tumor progression in ERG-fusion-positive cancers. Int J Cancer 2013;132:1333-1340.
    • (2013) Int J Cancer , vol.132 , pp. 1333-1340
    • Muller, J.1    Ehlers, A.2    Burkhardt, L.3
  • 26
    • 0029983124 scopus 로고    scopus 로고
    • Ki67 labelling index: An independent predictor of progression in prostate cancer treated by radical prostatectomy
    • DOI 10.1002/(SICI)1096-9896(199604) 178:4<437::AID-PATH484>3.0. CO;2-4
    • Bubendorf L, Sauter G, Moch H, et al. Ki67 labelling index: an independent predictor of progression in prostate cancer treated by radical prostatectomy. J Pathol 1996;178:437-441. (Pubitemid 26145136)
    • (1996) Journal of Pathology , vol.178 , Issue.4 , pp. 437-441
    • Bubendorf, L.1    Sauter, G.2    Moch, H.3    Schmid, H.-P.4    Gasser, T.C.5    Jordan, P.6    Mihatsch, M.J.7
  • 27
    • 74949116742 scopus 로고    scopus 로고
    • Chromosome 8p deletions and 8q gains are associated with tumor progression and poor prognosis in prostate cancer
    • El Gammal AT, Bruchmann M, Zustin J, et al. Chromosome 8p deletions and 8q gains are associated with tumor progression and poor prognosis in prostate cancer. Clin Cancer Res 2010;16:56-64.
    • (2010) Clin Cancer Res , vol.16 , pp. 56-64
    • El Gammal, A.T.1    Bruchmann, M.2    Zustin, J.3
  • 30
    • 84455163031 scopus 로고    scopus 로고
    • The impact of the number of cores on tissue microarray studies investigating prostate cancer biomarkers
    • Tennstedt P, Koster P, Bruchmann A, et al. The impact of the number of cores on tissue microarray studies investigating prostate cancer biomarkers. Int J Oncol 2012;40:261-268.
    • (2012) Int J Oncol , vol.40 , pp. 261-268
    • Tennstedt, P.1    Koster, P.2    Bruchmann, A.3
  • 31
    • 84871922832 scopus 로고    scopus 로고
    • Marked heterogeneity of ERG expression in large primary prostate cancers
    • Minner S, Gartner M, Freudenthaler F, et al. Marked heterogeneity of ERG expression in large primary prostate cancers. Mod Pathol 2013;26:106-116.
    • (2013) Mod Pathol , vol.26 , pp. 106-116
    • Minner, S.1    Gartner, M.2    Freudenthaler, F.3
  • 32
    • 0036321565 scopus 로고    scopus 로고
    • Morphologic and clinical significance of multifocal prostate cancers in radical prostatectomy specimens
    • DOI 10.1016/S0090-4295(02)01728-4, PII S0090429502017284
    • Wise AM, Stamey TA, McNeal JE, et al. Morphologic and clinical significance of multifocal prostate cancers in radical prostatectomy specimens. Urology 2002;60: 264-269. (Pubitemid 34831770)
    • (2002) Urology , vol.60 , Issue.2 , pp. 264-269
    • Wise, A.M.1    Stamey, T.A.2    McNeal, J.E.3    Clayton, J.L.4
  • 33
    • 84859426392 scopus 로고    scopus 로고
    • Upgrading and downgrading of prostate cancer from biopsy to radical prostatectomy: Incidence and predictive factors using the modified Gleason grading system and factoring in tertiary grades
    • Epstein JI, Feng Z, Trock BJ, et al. Upgrading and downgrading of prostate cancer from biopsy to radical prostatectomy: incidence and predictive factors using the modified Gleason grading system and factoring in tertiary grades. Eur Urol 2012;61:1019-1024.
    • (2012) Eur Urol , vol.61 , pp. 1019-1024
    • Epstein, J.I.1    Feng, Z.2    Trock, B.J.3
  • 35
    • 0034725636 scopus 로고    scopus 로고
    • Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53
    • Kim IS, Kim DH, Han SM, et al. Truncated form of importin alpha identified in breast cancer cell inhibits nuclear import of p53. J Biol Chem 2000;275: 23139-23145.
    • (2000) J Biol Chem , vol.275 , pp. 23139-23145
    • Kim, I.S.1    Kim, D.H.2    Han, S.M.3
  • 36
    • 0032513113 scopus 로고    scopus 로고
    • Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs
    • DOI 10.1074/jbc.273.11.6183
    • Li S, Ku CY, Farmer AA, et al. Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs. J Biol Chem 1998;273: 6183-6189. (Pubitemid 28144702)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.11 , pp. 6183-6189
    • Li, S.1    Ku, C.-Y.2    Farmer, A.A.3    Cong, Y.-S.4    Chen, C.-F.5    Lee, W.-H.6
  • 38
    • 84856023803 scopus 로고    scopus 로고
    • Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways
    • Yuen HF, Chan KK, Grills C, et al. Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways. Clin Cancer Res 2012;18:380-391.
    • (2012) Clin Cancer Res , vol.18 , pp. 380-391
    • Yuen, H.F.1    Chan, K.K.2    Grills, C.3
  • 40
    • 82655183787 scopus 로고    scopus 로고
    • TMPRSS2-ERG-specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-beta signaling
    • Brase JC, Johannes M, Mannsperger H, et al. TMPRSS2-ERG-specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-beta signaling. BMC Cancer 2011;11:507.
    • (2011) BMC Cancer , vol.11 , pp. 507
    • Brase, J.C.1    Johannes, M.2    Mannsperger, H.3
  • 41
    • 77956290679 scopus 로고    scopus 로고
    • FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelialto-mesenchymal transition in human prostate cancer cells
    • Gupta S, Iljin K, Sara H, et al. FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelialto-mesenchymal transition in human prostate cancer cells. Cancer Res 2010;70:6735-6745.
    • (2010) Cancer Res , vol.70 , pp. 6735-6745
    • Gupta, S.1    Iljin, K.2    Sara, H.3
  • 42
    • 70350231922 scopus 로고    scopus 로고
    • Overexpression of prostate-specific TMPRSS2(exon 0)-ERG fusion transcripts corresponds with favorable prognosis of prostate cancer
    • Hermans KG, Boormans JL, Gasi D, et al. Overexpression of prostate-specific TMPRSS2(exon 0)-ERG fusion transcripts corresponds with favorable prognosis of prostate cancer. Clin Cancer Res 2009;15:6398-6403.
    • (2009) Clin Cancer Res , vol.15 , pp. 6398-6403
    • Hermans, K.G.1    Boormans, J.L.2    Gasi, D.3
  • 44
    • 64249128160 scopus 로고    scopus 로고
    • Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer
    • Jhavar S, Brewer D, Edwards S, et al. Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer. BJU Int 2009;103:1256-1269.
    • (2009) BJU Int , vol.103 , pp. 1256-1269
    • Jhavar, S.1    Brewer, D.2    Edwards, S.3
  • 45
    • 77149174855 scopus 로고    scopus 로고
    • Wnt signaling from development to disease: Insights from model systems
    • Cadigan KM, Peifer M. Wnt signaling from development to disease: insights from model systems. Cold Spring Harb Perspect Biol 2009;1:a002881.
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Cadigan, K.M.1    Peifer, M.2
  • 46
    • 36448936383 scopus 로고    scopus 로고
    • TGFβ-SMAD signal transduction: Molecular specificity and functional flexibility
    • DOI 10.1038/nrm2297, PII NRM2297
    • Schmierer B, Hill CS. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 2007;8:970-982. (Pubitemid 350174642)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.12 , pp. 970-982
    • Schmierer, B.1    Hill, C.S.2
  • 47
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • DOI 10.1074/jbc.273.22.13375
    • Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998;273:13375-13378. (Pubitemid 28268370)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.22 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 48
    • 77949326178 scopus 로고    scopus 로고
    • Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation
    • Ly TK, Wang J, Pereira R, et al. Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation. J Biol Chem 2010; 285:5815-5826.
    • (2010) J Biol Chem , vol.285 , pp. 5815-5826
    • Ly, T.K.1    Wang, J.2    Pereira, R.3
  • 49
    • 7444250721 scopus 로고    scopus 로고
    • TOR kinase and Ran are downstream from PI3K/Akt in H2O2-induced mitosis
    • Radisavljevic ZM, Gonzalez-Flecha B. TOR kinase and Ran are downstream from PI3K/Akt in H2O2-induced mitosis. J Cell Biochem 2004;91:1293-1300.
    • (2004) J Cell Biochem , vol.91 , pp. 1293-1300
    • Radisavljevic, Z.M.1    Gonzalez-Flecha, B.2
  • 50
    • 66749188650 scopus 로고    scopus 로고
    • Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
    • Carver BS, Tran J, Gopalan A, et al. Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. Nat Genet 2009;41: 619-624.
    • (2009) Nat Genet , vol.41 , pp. 619-624
    • Carver, B.S.1    Tran, J.2    Gopalan, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.