Using mutagenesis and structural biology to map the binding site for the plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor

Journal of Biological Chemistry

Volumn 289, Issue 1, 2014, Pages 450-463

  Park, Hyon Ju ^a,f   Guariento, Mara ^b,g   Maciejewski, Mateusz ^b,h   Hauhart, Richard ^a   Tham, Wai Hong ^c,d   Cowman, Alan F ^c,d   Schmidt, Christoph Q ^b,i   Mertens, Haydyn D T ^e   Kathryn Liszewski, M ^a   Hourcade, Dennis E ^a   Barlow, Paul N ^b   Atkinson, John P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e AUSTRALIAN SYNCHROTRON   (Australia)

^f Emkey Arthritis and Osteoporosis   (United States)

^g FRIEDRICH MIESCHER LABORATORY OF THE MAX PLANCK SOCIETY   (Germany)

^h NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

ⁱ UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; BLOOD; CELL MEMBRANES; MUTAGENESIS; PROTEINS;

CO-IMMUNOPRECIPITATIONS; COMPLEMENT CONTROL PROTEINS; COMPLEMENT RECEPTOR TYPE 1; ERYTHROCYTE MEMBRANE; PLASMODIUM FALCIPARUM; SMALL ANGLE X-RAY SCATTERING; SOLUTION STRUCTURES; STRUCTURAL BIOLOGY;

BINDING SITES;

BINDING PROTEIN; COMPLEMENT COMPONENT C3B RECEPTOR; RETICULOCYTE BINDING HOMOLOGUE PROTEIN 4; UNCLASSIFIED DRUG; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C4B; CR1 PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTOZOAL PROTEIN; RH4 PROTEIN, PLASMODIUM FALCIPARUM;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MEROZOITE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY; CHEMISTRY; ERYTHROCYTE; GENETICS; HEK293 CELL LINE; METABOLISM; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE; PARASITOLOGY; SMALL ANGLE SCATTERING; X RAY DIFFRACTION;

BINDING SITES; COMPLEMENT C3B; COMPLEMENT C4B; ERYTHROCYTES; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MEROZOITES; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; RECEPTORS, COMPLEMENT 3B; SCATTERING, SMALL ANGLE; SURFACE PLASMON RESONANCE; X-RAY DIFFRACTION;

EID: 84891707973     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.520346     Document Type: Article

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