The effect of ketorolac tromethamine, methylprednisolone, and platelet-rich plasma on human chondrocyte and tenocyte viability

Arthroscopy - Journal of Arthroscopic and Related Surgery

Volumn 29, Issue 7, 2013, Pages 1164-1174

  Beitzel, Knut ^a,e   McCarthy, Mary Beth ^a   Cote, Mark P ^a   Apostolakos, John ^a   Russell, Ryan P ^a   Bradley, James ^b   ElAttrache, Neal S ^c   Romeo, Antony A ^d   Arciero, Robert A ^a   Mazzocca, Augustus D ^a,f  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c KERLAN JOBE ORTHOPAEDIC CLINIC   (United States)

^d RUSH UNIVERSITY MEDICAL CENTER   (United States)

^e BG UNFALLKLINIK MURNAU   (Germany)

^f UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETOROLAC TROMETAMOL; METHYLPREDNISOLONE; THYMIDINE; CORTICOSTEROID; LOCAL ANESTHETIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; ARTICLE; CARTILAGE CELL; CELL PROLIFERATION ASSAY; CELL VIABILITY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; LUMINESCENCE; MALE; MUSCLE CELL; NORMAL HUMAN; TENOCYTE; THROMBOCYTE RICH PLASMA; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; PHYSIOLOGY; TENDON; TIME;

ADRENAL CORTEX HORMONES; ADULT; ANESTHETICS, LOCAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL SURVIVAL; CELLS, CULTURED; CHONDROCYTES; FEMALE; HUMANS; KETOROLAC TROMETHAMINE; MALE; METHYLPREDNISOLONE; PLATELET-RICH PLASMA; TENDONS; TIME FACTORS;

EID: 84891695070     PISSN: 07498063     EISSN: 15263231     Source Type: Journal    
DOI: 10.1016/j.arthro.2013.04.006     Document Type: Article

References (53)

1. Harvey WF, Hunter DJ. The role of analgesics and intraarticular injections in disease management. Med Clin North Am 2009;93:201-211.
2. MacMahon PJ, Eustace SJ, Kavanagh EC. Injectable corticosteroid and local anesthetic preparations: A review for radiologists. Radiology 2009;252:647-661.
3. Behrens F, Shepard N, Mitchell N. Alterations of rabbit articular cartilage by intra-articular injections of glucocorticoids. J Bone Joint Surg Am 1975;57:70-76.
4. Papacrhistou G, Anagnostou S, Katsorhis T. The effect of intraarticular hydrocortisone injection on the articular cartilage of rabbits. Acta Orthop Scand Suppl 1997;275: 132-134.
5. Nichols AW. Complications associated with the use of corticosteroids in the treatment of athletic injuries. Clin J Sport Med 2005;15:370-375.
6. Farkas B, Kvell K, Czompoly T, Illes T, Bardos T. Increased chondrocyte death after steroid and local anesthetic combination. Clin Orthop Relat Res 2010;468:3112-3120.
7. Hall MP, Band PA, Meislin RJ, Jazrawi LM, Cardone DA. Platelet-rich plasma: Current concepts and application in sports medicine. J Am Acad Orthop Surg 2009;17:602-608.
8. Lopez-Vidriero E, Goulding KA, Simon DA, Sanchez M, Johnson DH. The use of platelet-rich plasma in arthroscopy and sports medicine: Optimizing the healing environment. Arthroscopy 2010;26:269-278.
9. van Buul GM, Koevoet WL, Kops N, et al. Platelet-rich plasma releasate inhibits inflammatory processes in osteoarthritic chondrocytes. Am J Sports Med 2011;39:2362-2370.
10. Filardo G, Kon E, Buda R, et al. Platelet-rich plasma intraarticular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc 2011;19:528-535.
11. Kon E, Buda R, Filardo G, et al. Platelet-rich plasma: Intra-articular knee injections produced favorable results on degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc 2010;18:472-479.
12. Sanchez M, Anitua E, Azofra J, Aguirre JJ, Andia I. Intraarticular injection of an autologous preparation rich in growth factors for the treatment of knee OA: A retrospective cohort study. Clin Exp Rheumatol 2008;26:910-913.
13. Calmet J, Esteve C, Boada S, Gine J. Analgesic effect of intra-articular ketorolac in knee arthroscopy: Comparison of morphine and bupivacaine. Knee Surg Sports Traumatol Arthrosc 2004;12:552-555.
14. Irwin MG, Cheung KM, Nicholls JM, Thompson N. Intraarticular injection of ketorolac in the rat knee joint: Effect on articular cartilage and synovium. Br J Anaesth 1998;80: 837-839.
15. Kostamovaara PA, Hendolin H, Kokki H, Nuutinen LS. Ketorolac, diclofenac and ketoprofen are equally efficacious for pain relief after total hip replacement surgery. Br J Anaesth 1998;81:369-372.
16. Morley-Forster P, Newton PT, Cook MJ. Ketorolac and indomethacin are equally efficacious for the relief of minor postoperative pain. Can J Anaesth 1993;40:1126-1130.
17. Lee SC, Rha DW, Chang WH. Rapid analgesic onset of intra-articular hyaluronic acid with ketorolac in osteoarthritis of the knee. J Back Musculoskelet Rehabil 2011;24:31-38.
18. Dogan N, Erdem AF, Gundogdu C, Kursad H, Kizilkaya M. The effects of ketorolac and morphine on articular cartilage and synovium in the rabbit knee joint. Can J Physiol Pharmacol 2004;82:502-505.
19. Shapiro PS, Rohde RS, Froimson MI, Lash RH, Postak P, Greenwald AS. The effect of local corticosteroid or ketorolac exposure on histologic and biomechanical properties of rabbit tendon and cartilage. Hand (NY) 2007;2:165-172.
20. Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma: From basic science to clinical applications. Am J Sports Med 2009;37:2259-2272.
21. Anitua E, Andia I, Sanchez M, et al. Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. J Orthop Res 2005;23:281-286.
22. de Mos M, van der Windt AE, Jahr H, et al. Can plateletrich plasma enhance tendon repair? A cell culture study. Am J Sports Med 2008;36:1171-1178.
23. Baboldashti NZ, Poulsen RC, Franklin SL, Thompson MS, Hulley PA. Platelet-rich plasma protects tenocytes from adverse side effects of dexamethasone and ciprofloxacin. Am J Sports Med 2011;39:1929-1935.
24. Wong MW, Tang YY, Lee SK, Fu BS. Glucocorticoids suppress proteoglycan production by human tenocytes. Acta Orthop 2005;76:927-931.
25. Wong MW, Tang YY, Lee SK, Fu BS, Chan BP, Chan CK. Effect of dexamethasone on cultured human tenocytes and its reversibility by platelet-derived growth factor. J Bone Joint Surg Am 2003;85:1914-1920.
26. Mazzocca AD, McCarthy MB, Chowaniec DM, et al. Platelet-rich plasma differs according to preparation method and human variability. J Bone Joint Surg Am 2012;94:308-316.
27. Mazzocca AD, McCarthy MB, Chowaniec DM, et al. The positive effects of different platelet-rich plasma methods on human muscle, bone, and tendon cells. Am J Sports Med 2012;40:1742-1749.
28. Haag J, Voigt R, Soeder S, Aigner T. Efficient non-viral transfection of primary human adult chondrocytes in a high-throughput format. Osteoarthritis Cartilage 2009;17: 813-817.
29. Pauly S, Klatte F, Strobel C, et al. Characterization of tendon cell cultures of the human rotator cuff. Eur Cell Mater 2010;20:84-97.
30. Yao L, Bestwick CS, Bestwick LA, Maffulli N, Aspden RM. Phenotypic drift in human tenocyte culture. Tissue Eng 2006;12:1843-1849.
31. Mazzocca AD, McCarthy MB, Intravia J, et al. An in vitro evaluation of the anti-inflammatory effects of platelet-rich plasma, ketorolac, and methylprednisolone. Arthroscopy 2013;29:675-683.
32. Baker JF, Byrne DP, Walsh PM, Mulhall KJ. Human chondrocyte viability after treatment with local anesthetic and/or magnesium: Results from an in vitro study. Arthroscopy 2011;27:213-217.
33. Maffulli N, Ewen SW, Waterston SW, Reaper J, Barrass V. Tenocytes from ruptured and tendinopathic achilles tendons produce greater quantities of type III collagen than tenocytes from normal achilles tendons. An in vitro model of human tendon healing. Am J Sports Med 2000;28: 499-505.
34. Ng KW, Leong DT, Hutmacher DW. The challenge to measure cell proliferation in two and three dimensions. Tissue Eng 2005;11:182-191.
35. Ay S, Kucuk D, Gumus C, Kara MI. Distribution and absorption of local anesthetics in inferior alveolar nerve block: Evaluation by magnetic resonance imaging. J Oral Maxillofac Surg 2011;69:2722-2730.
36. Carofino B, Chowaniec DM, McCarthy MB, et al. Corticosteroids and local anesthetics decrease positive effects of platelet-rich plasma: An in vitro study on human tendon cells. Arthroscopy 2012;28:711-719.
37. Dang AB, McCarthy MB, Chowaniec DM, Mazzocca AD. Effects of adding epinephrine to arthroscopic irrigation fluid on cultured chondrocyte survival in vitro. Arthroscopy 2011;27:1118-1122.
38. Burkhardt H, Schwingel M, Menninger H, Macartney HW, Tschesche H. Oxygen radicals as effectors of cartilage destruction. Direct degradative effect on matrix components and indirect action via activation of latent collagenase from polymorphonuclear leukocytes. Arthritis Rheum 1986;29:379-387.
39. Sharma P, Maffulli N. Tendon injury and tendinopathy: Healing and repair. J Bone Joint Surg Am 2005;87:187-202.
40. Lee SY, Suh JK, Choi JH, Jeon WJ, Cheong MA. Effect of ketorolac and diclofenac on the impairment of endotheliumdependent relaxation induced by reactive oxygen species in rabbit abdominal aorta. Korean J Anesthesiol 2010;59: 196-202.
41. Mei-Dan O, Carmont MR, Laver L, Mann G, Maffulli N, Nyska M. Platelet-rich plasma or hyaluronate in the management of osteochondral lesions of the talus. Am J Sports Med 2012;40:534-541.
42. Alsousou J, Thompson M, Hulley P, Noble A, Willett K. The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: A review of the literature. J Bone Joint Surg Br 2009;91:987-996.
43. Dhillon M, Patel S, Bali K. Platelet-rich plasma intraarticular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc 2011;19:863-864; author reply 855-856.
44. Sanchez M, Anitua E, Orive G, Mujika I, Andia I. Plateletrich therapies in the treatment of orthopaedic sport injuries. Sports Med 2009;39:345-354.
45. Cheng J, Abdi S. Complications of joint, tendon, and muscle injections. Tech Reg Anesth Pain Manag 2007;11: 141-147.
46. Sendzik J, Shakibaei M, Schafer-Korting M, Lode H, Stahlmann R. Synergistic effects of dexamethasone and quinolones on human-derived tendon cells. Int J Antimicrob Agents 2009;35:366-374.
47. Scutt N, Rolf CG, Scutt A. Glucocorticoids inhibit tenocyte proliferation and tendon progenitor cell recruitment. J Orthop Res 2006;24:173-182.
48. Oikarinen AI, Vuorio EI, Zaragoza EJ, Palotie A, Chu ML, Uitto J. Modulation of collagen metabolism by glucocorticoids. Receptor-mediated effects of dexamethasone on collagen biosynthesis in chick embryo fibroblasts and chondrocytes. Biochem Pharmacol 1988;37:1451-1462.
49. Davis D, Cyriac M, Ge D, You Z, Savoie FH. In vitro cytotoxic effects of benzalkonium chloride in corticosteroid injection suspension. J Bone Joint Surg Am 2010;92: 129-137.
50. Grishko V, Xu M, Wilson G, Pearsall AW. Apoptosis and mitochondrial dysfunction in human chondrocytes following exposure to lidocaine, bupivacaine, and ropivacaine. J Bone Joint Surg Am 2010;92:609-618.
51. Maffulli N, Longo UG, Denaro V. Novel approaches for the management of tendinopathy. J Bone Joint Surg Am 2010;92:2604-2613.
52. Coombes BK, Bisset L, Vicenzino B. Efficacy and safety of corticosteroid injections and other injections for management of tendinopathy: A systematic review of randomised controlled trials. Lancet 2010;376:1751-1767.
53. Axelsson K, Gupta A, Johanzon E, et al. Intraarticular administration of ketorolac, morphine, and ropivacaine combined with intraarticular patient-controlled regional analgesia for pain relief after shoulder surgery: A randomized, double-blind study. Anesth Analg 2008;106: 328-333, table of contents.